{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T02:38:02Z","timestamp":1773283082354,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004901","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de Minas Gerais","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.rvsc.2014.05.013","type":"journal-article","created":{"date-parts":[[2014,6,6]],"date-time":"2014-06-06T07:16:06Z","timestamp":1402038966000},"page":"176-181","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Effect of the inhibitors phenylalanine arginyl \u00df-naphthylamide (PA\u00dfN) and 1-(1-naphthylmethyl)-piperazine (NMP) on expression of genes in multidrug efflux systems of Escherichia coli isolates from bovine mastitis"],"prefix":"10.1016","volume":"97","author":[{"given":"M.A.","family":"Ospina Barrero","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.A.G.","family":"Pietralonga","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D.G.G.","family":"Schwarz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Silva Junior","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.O.","family":"Paula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.A.S.","family":"Moreira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2014.05.013_bib0010","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1128\/AAC.41.10.2067","article-title":"Regulation of chromosomally mediated multiple antibiotic resistance: the mar regulon","volume":"41","author":"Alekshun","year":"1997","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0015","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.foodcont.2009.01.005","article-title":"Bacterial quality of raw milk investigated by Escherichia coli and isolates analysis for specific virulence-gene markers","volume":"20","author":"Altalhi","year":"2009","journal-title":"Food Control"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0020","author":"Anonymous"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0025","doi-asserted-by":"crossref","first-page":"157","DOI":"10.2174\/157489106777452692","article-title":"Inhibitors of bacterial efflux pumps as adjuvants in antibiotic treatments and diagnostic tools for detection of resistance by efflux","volume":"1","author":"Bambeke","year":"2006","journal-title":"Recent Patents on Anti-Infective Drug Discovery"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0030","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.1093\/jac\/dkl426","article-title":"Altered spectrum of multidrug resistance associated with a single point mutation in the Escherichia coli RND-type MDR efflux pump YhiV (MdtF)","volume":"59","author":"Bohnert","year":"2007","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0035","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1016\/j.vetmic.2012.05.036","article-title":"Increased production of biofilms by Escherichia coli in the presence of enrofloxacin","volume":"160","author":"Costa","year":"2012","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0040","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1177\/1040638711425581","article-title":"Escherichia coli from clinical mastitis: serotypes and virulence factors","volume":"23","author":"Fernandes","year":"2011","journal-title":"Journal of Veterinary Diagnostic Investigation"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0045","doi-asserted-by":"crossref","first-page":"620","DOI":"10.1111\/j.1365-2958.2004.04301.x","article-title":"Genetic evidence for functional interactions between TolC and AcrA proteins of a major antibiotic efflux pump of Escherichia coli","volume":"54","author":"Gerken","year":"2004","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0050","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1128\/MMBR.66.4.671-701.2002","article-title":"Regulation of bacterial drug export systems","volume":"66","author":"Grkovic","year":"2002","journal-title":"Microbiology and Molecular Biology Reviews"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0055","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1128\/JB.00190-08","article-title":"AcrS\/EnvR represses expression of the acrAB multidrug efflux genes in Escherichia coli","volume":"190","author":"Hirakawa","year":"2008","journal-title":"Journal of Bacteriology"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0060","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.prevetmed.2009.08.024","article-title":"Preferences of cost factors for mastitis management among Dutch dairy farmers using adaptive conjoint analysis","volume":"92","author":"Huijps","year":"2009","journal-title":"Preventive Veterinary Medicine"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0065","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1093\/jac\/dki445","article-title":"Effect of 1-(1-naphthylmethyl)-piperazine, a novel putative efflux pump inhibitor, on antimicrobial drug susceptibility in clinical isolates of Escherichia coli","volume":"57","author":"Kern","year":"2006","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0070","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1146\/annurev.biochem.73.011303.074104","article-title":"Structure and function of TolC: the bacterial exit duct for proteins and drugs","volume":"73","author":"Koronakis","year":"2004","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0075","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2165\/00003495-200464020-00004","article-title":"Efflux-mediated drug resistance in bacteria","volume":"64","author":"Li","year":"2004","journal-title":"Drugs"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0080","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.bcp.2005.12.008","article-title":"Practical applications and feasibility of efflux pump inhibitors in the clinic\u2013a vision for applied use","volume":"71","author":"Lomovskaya","year":"2006","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0085","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1128\/AAC.45.1.105-116.2001","article-title":"Identification and characterization of inhibitors of multidrug resistance efflux pumps in Pseudomonas aeruginosa: novel agents for combination therapy","volume":"45","author":"Lomovskaya","year":"2001","journal-title":"Antimicrobial Agents and Chemotherapy"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0090","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.vetmic.2007.05.019","article-title":"Extended antimicrobial susceptibility assay for Staphylococcus aureus isolates from bovine mastitis growing in biofilms","volume":"125","author":"Melchior","year":"2007","journal-title":"Veterinary Microbiology"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0095","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/nature05076","article-title":"Crystal structures of a multidrug transporter reveal a functionally rotating mechanism","volume":"443","author":"Murakami","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0100","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1146\/annurev.biochem.78.082907.145923","article-title":"Multidrug resistance in bacteria","volume":"78","author":"Nikaido","year":"2009","journal-title":"Annual Review of Biochemistry"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0105","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.bbapap.2008.10.004","article-title":"Mechanisms of RND multidrug efflux pumps","volume":"1794","author":"Nikaido","year":"2009","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0110","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1128\/CMR.19.2.382-402.2006","article-title":"Clinically relevant chromosomally encoded multidrug resistance efflux pumps in bacteria","volume":"19","author":"Piddock","year":"2006","journal-title":"Clinical Microbiology Reviews"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0115","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1080\/07853890701195262","article-title":"Efflux pumps as antimicrobial resistance mechanisms","volume":"39","author":"Poole","year":"2007","journal-title":"Annals of Medicine"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0120","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.bbapap.2008.12.015","article-title":"Drug transport mechanism of the AcrB efflux pump","volume":"1794","author":"Pos","year":"2009","journal-title":"Biochimica et Biophysica Acta"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0125","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1093\/jac\/dkp234","article-title":"Only for substrate antibiotics are a functional AcrAB-TolC efflux pump and RamA required to select multidrug-resistant Salmonella Typhimurium","volume":"64","author":"Ricci","year":"2009","journal-title":"The Journal of Antimicrobial Chemotherapy"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0130","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1046\/j.1365-2958.2003.03531.x","article-title":"Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein","volume":"48","author":"Rosenberg","year":"2003","journal-title":"Molecular Microbiology"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0135","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.ijantimicag.2007.05.010","article-title":"Partial characterisation of the acrAB locus in two Citrobacter freundii clinical isolates","volume":"30","author":"S\u00e1nchez-C\u00e9spedes","year":"2007","journal-title":"International Journal of Antimicrobial Agents"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0140","doi-asserted-by":"crossref","first-page":"6559","DOI":"10.1073\/pnas.1001460107","article-title":"Mechanism of recognition of compounds of diverse structures by the multidrug efflux pump AcrB of Escherichia coli","volume":"107","author":"Takatsuka","year":"2010","journal-title":"Proceedings of the National Academy of Sciences U.S.A."},{"key":"10.1016\/j.rvsc.2014.05.013_bib0145","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1016\/S0960-894X(01)00330-4","article-title":"3-Arylpiperidines as potentiators of existing antibacterial agents","volume":"11","author":"Thorarensen","year":"2001","journal-title":"Bioorganic & Medicinal Chemistry Letters"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0150","doi-asserted-by":"crossref","first-page":"e365","DOI":"10.1371\/journal.pone.0000365","article-title":"Antibiotic stress, genetic response and altered permeability of Escherichia coli","volume":"2","author":"Viveiros","year":"2007","journal-title":"PLoS ONE"},{"key":"10.1016\/j.rvsc.2014.05.013_bib0155","doi-asserted-by":"crossref","first-page":"3408","DOI":"10.3168\/jds.S0022-0302(06)72377-3","article-title":"Escherichia coli isolates\u2019 serotypes, genotypes, and virulence genes and clinical coliform mastitis severity","volume":"89","author":"Wenz","year":"2006","journal-title":"Journal of Dairy Science"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003452881400160X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003452881400160X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:00:38Z","timestamp":1758513638000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003452881400160X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":30,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S003452881400160X"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2014.05.013","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Effect of the inhibitors phenylalanine arginyl \u00df-naphthylamide (PA\u00dfN) and 1-(1-naphthylmethyl)-piperazine (NMP) on expression of genes in multidrug efflux systems of Escherichia coli isolates from bovine mastitis","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2014.05.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}