{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T20:21:51Z","timestamp":1789762911353,"version":"4.0.1"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,12,1]],"date-time":"2016-12-01T00:00:00Z","timestamp":1480550400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31101786"],"award-info":[{"award-number":["31101786"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"National Key Basic Research Program of China","award":["2014CB138502"],"award-info":[{"award-number":["2014CB138502"]}]},{"DOI":"10.13039\/501100012246","name":"PAPD","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2016,12]]},"DOI":"10.1016\/j.rvsc.2016.10.007","type":"journal-article","created":{"date-parts":[[2016,10,15]],"date-time":"2016-10-15T13:07:52Z","timestamp":1476536872000},"page":"135-141","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Melamine negatively affects testosterone synthesis in mice"],"prefix":"10.1016","volume":"109","author":[{"given":"Jiarui","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinan","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinchen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiling","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Endong","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingjun","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2016.10.007_bb0005","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/104063870701900510","article-title":"Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and2007","volume":"19","author":"Brown","year":"2007","journal-title":"J. Vet. Diagn. Investig."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reprotox.2014.02.008","article-title":"Acute testicular toxicity induced by melamine alone or a mixture of melamine and cyanuric acid in mice","volume":"46","author":"Chang","year":"2014","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0015","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.cca.2014.01.003","article-title":"Kidney stone distribution caused by melamine and cyanuric acid in rats","volume":"430","author":"Chen","year":"2014","journal-title":"Clin. Chim. Acta"},{"key":"10.1016\/j.rvsc.2016.10.007_bb0020","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1080\/19440049.2011.576401","article-title":"Analysis of melamine migration from melamine food contact articles","volume":"28","author":"Chik","year":"2011","journal-title":"Food Addit. Contam. A"},{"key":"10.1016\/j.rvsc.2016.10.007_bb0025","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/S0188-4409(01)00338-1","article-title":"Steroidogenic acute regulatory protein: an update on its regulation and mechanism of action","volume":"6","author":"Christenson","year":"2001","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0030","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1056\/NEJMoa0809550","article-title":"Melamine-contaminated powdered formula andurolithiasis in young children","volume":"360","author":"Guan","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0035","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.reprotox.2009.10.014","article-title":"Pubertal cadmium exposure impairs testicular development and spermatogenesis via disrupting testicular testosterone synthesis in adult mice","volume":"29","author":"Ji","year":"2010","journal-title":"Reprod. Toxicol."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0040","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00240-010-0254-9","article-title":"The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid","volume":"38","author":"Kobayashi","year":"2010","journal-title":"Urol. Res."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0045","doi-asserted-by":"crossref","first-page":"7218","DOI":"10.1073\/pnas.0709260105","article-title":"Involvement of testicular growth factors in fetal Leydig cell aggregation after exposure to phthalate in utero","volume":"20","author":"Lin","year":"2008","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0050","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.yrtph.2012.11.011","article-title":"Effect on morphology, oxidative stress and energy metabolism enzymes in the testes of mice after a 13-week oral administration of melamine and cyanuricv acid combination","volume":"65","author":"Lv","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0055","doi-asserted-by":"crossref","DOI":"10.1186\/s40550-015-0017-z","article-title":"The effect of PH on the migration of melamine from children's bowls","author":"Lynch","year":"2015","journal-title":"Int. J. Food Contam."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0060","first-page":"270","article-title":"Dose dependent effects of inhaled ethylene oxide on spermatogenesis in rats","volume":"48","author":"Mori","year":"1991","journal-title":"Br. J. Ind. Med."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0065","article-title":"Ovarian toxicity in female rats after oral administration of melamine or melamine and cyanuric acid","volume":"11","author":"Sun","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2016.10.007_bb0070","doi-asserted-by":"crossref","first-page":"3820","DOI":"10.1210\/jcem.86.8.7748","article-title":"Heterozygous mutation in the cholesterol side chain cleavage enzyme (P450scc) Gene in a patient with 46, XY sex reversal and adrenal insufficiency","volume":"8","author":"Tajima","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0075","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1677\/joe.0.1570317","article-title":"Leydig cell apoptosis in the rat testes after administration of the cytotoxin ethane dimethanesulphonate: role of the Bcl-2 family members","volume":"157","author":"Taylor","year":"1998","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0080","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1210\/endo.140.8.6919","article-title":"Leydig cell apoptosis after the administration of ethane dimethanesulfonate to the adult male rat is a Fas-mediated process","volume":"8","author":"Taylor","year":"1999","journal-title":"Endocrinology"},{"key":"10.1016\/j.rvsc.2016.10.007_bb0085","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1001\/jamainternmed.2013.1569","article-title":"A crossover study of noodle soup consumption in melamine bowls and total melamine excretion inurine","volume":"173","author":"Wu","year":"2013","journal-title":"JAMA Int. Med."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0090","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1016\/j.rvsc.2012.11.010","article-title":"The reproductive toxicity of melamine in the absence and presence of cyanuric acid in male mice","volume":"3","author":"Yin","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0095","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1002\/jat.1507","article-title":"Pubertal and early adult exposure to fenvalerate disrupts steroidogenesis and spermatogenesis in mice at adulthood","volume":"30","author":"Zhang","year":"2009","journal-title":"J. Appl. Toxicol."},{"key":"10.1016\/j.rvsc.2016.10.007_bb0100","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.yrtph.2011.03.004","article-title":"Melamine induces sperm DNA damage and abnormality, but not genetic toxicology","volume":"60","author":"Zhang","year":"2011","journal-title":"Regul. Toxicol. Pharmacol."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528816304611?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528816304611?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:06:32Z","timestamp":1758513992000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528816304611"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,12]]},"references-count":20,"alternative-id":["S0034528816304611"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2016.10.007","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2016,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melamine negatively affects testosterone synthesis in mice","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2016.10.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}