{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T04:31:17Z","timestamp":1770697877018,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,12,1]],"date-time":"2017-12-01T00:00:00Z","timestamp":1512086400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2017,12]]},"DOI":"10.1016\/j.rvsc.2017.01.019","type":"journal-article","created":{"date-parts":[[2017,1,25]],"date-time":"2017-01-25T13:52:51Z","timestamp":1485352371000},"page":"92-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"special_numbering":"C","title":["Diagnosis of resistance alleles in codon 167 of the beta-tubulin (Cya-tbb-1) gene from third-stage larvae of horse cyathostomins"],"prefix":"10.1016","volume":"115","author":[{"given":"Juliana Bana","family":"Ishii","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2912-9871","authenticated-orcid":false,"given":"Amilcar","family":"Arenal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aline","family":"Felix","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Yoshitani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"Beech","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo Beltr\u00e3o","family":"Molento","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2017.01.019_bb0005","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.jmgm.2013.07.008","article-title":"Molecular basis for benzimidazole resistance from a novel-tubulin binding site model","volume":"45","author":"Aguayo-Ortiz","year":"2013","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0010","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1007\/s00436-011-2426-0","article-title":"\u03b2-tubulin genotypes in six species of cyathostomins from anthelmintic-na\u00efve Przewalski and benzimidazole-resistant brood horses in Ukraine","volume":"109","author":"Blackhall","year":"2011","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0015","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.vetpar.2012.12.020","article-title":"Lack of Cyathostomin sp. reduction after anthelmintic treatment in horses in Brazil","volume":"194","author":"Canever","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0020","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13071-016-1624-0","article-title":"Microsatellite marker analysis of Haemonchus contortus populations from Pakistan suggests that frequent benzimidazole drug treatment does not result in a reduction of overall genetic diversity","volume":"9","author":"Chaudhry","year":"2016","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0025","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.ijpara.2004.12.010","article-title":"Isolation and characterization of a beta tubulin isotype (2 gene from two species of cyathostomin)","volume":"35","author":"Clark","year":"2005","journal-title":"Int. J. Parasitol."},{"issue":"Suppl. (2)","key":"10.1016\/j.rvsc.2017.01.019_bb0030","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1756-3305-2-S2-S1","article-title":"Equine cyathostomins: a review of biology, clinical significance and therapy","volume":"2","author":"Corning","year":"2009","journal-title":"Parasit Vector"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0035","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S0749-0739(17)30093-7","article-title":"Antimicrobic and anthelmintic resistance","volume":"16","author":"Dargatz","year":"2000","journal-title":"Vet. Clin. N. Am. Equine Pract."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0040","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1645\/GE3305RN","article-title":"Beta-tubulin complementary DNA sequence variations observed between cyathostomins from benzimidazole-susceptible and-resistant populations","volume":"90","author":"Drogemuller","year":"2004","journal-title":"J. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0045","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1534\/genetics.166.3.1269","article-title":"Mutation accumulation in populations of varying size: the distribution of mutational effects for fitness correlates in Caenorhabditis elegans","volume":"166","author":"Estes","year":"2004","journal-title":"Genetics"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0050","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1016\/j.vetpar.2006.10.003","article-title":"Phenotyping and genotyping of Haemonchus contortus isolates reveals a new putative candidate mutation for benzimidazole resistance in nematodes","volume":"144","author":"Ghisi","year":"2007","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0055","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1016\/j.ijpara.2008.02.001","article-title":"The role of polymorphisms at beta tubulin isotype 1 codons 167 and 200 in benzimidazole resistance in cyathostomins","volume":"38","author":"Hodgkinson","year":"2008","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0060","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1016\/j.pt.2004.08.001","article-title":"Drug resistance in nematodes of veterinary importance: a status report","volume":"20","author":"Kaplan","year":"2004","journal-title":"Trends Parasitol."},{"issue":"Suppl. 2","key":"10.1016\/j.rvsc.2017.01.019_bb0065","doi-asserted-by":"crossref","first-page":"S6","DOI":"10.1186\/1756-3305-2-S2-S6","article-title":"Determination of genomic DNA sequences for beta-tubulin isotype 1 from multiple species of cyathostomin and detection of resistance alleles in third-stage larvae from horses with naturally acquired infections","volume":"2","author":"Lake","year":"2009","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0070","first-page":"265","article-title":"Nematodes of the tribe Cyathostominea (Strongylidae) collected from horses in Scotland","volume":"68","author":"Lichtenfels","year":"2001","journal-title":"Comp. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0075","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/0166-6851(90)90025-H","article-title":"Specific interaction of benzimidazole anthelmintics with tubulin: high-affinity binding and benzimidazole resistance in H. contortus","volume":"38","author":"Lubega","year":"1990","journal-title":"Mol. Biochem. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0080","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0304-4017(99)00091-6","article-title":"Historical perspective of cyathostomes: prevalence, treatment and control programs","volume":"85","author":"Lyons","year":"1999","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0085","doi-asserted-by":"crossref","first-page":"1469","DOI":"10.1590\/S0103-84782005000600041","article-title":"Parasite resistance in helminths of equines and management strategy proposal","volume":"35","author":"Molento","year":"2005","journal-title":"Cienc. Rural"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0090","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1136\/vr.162.12.384","article-title":"Anthelmintic resistance in nematodes in Brazilian horses","volume":"168","author":"Molento","year":"2008","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/genetics\/170.1.1","article-title":"Bottlenecks, genetic polymorphism and speciation","volume":"170","author":"Nei","year":"2005","journal-title":"Genetics"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0100","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.vetpar.2013.10.016","article-title":"Equine parasite control under prescription-only conditions in Denmark\u2013awareness, knowledge, perception, and strategies applied","volume":"204","author":"Nielsen","year":"2013","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0105","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1017\/S0031182003003317","article-title":"Analysis of the beta-tubulin codon 200 genotype distribution in a benzimidazole-susceptible and -resistant cyathostome population","volume":"127","author":"Pape","year":"2003","journal-title":"Parasitology"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0110","first-page":"80","article-title":"Larval cyathostominosis in horses in Ontario: an emerging disease?","volume":"47","author":"Peregrine","year":"2006","journal-title":"Can. J. Vet. Res."},{"issue":"6","key":"10.1016\/j.rvsc.2017.01.019_bb0115","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.ijpara.2012.12.011","article-title":"Characterization and comparative analysis of the complete Haemonchus contortus \u03b2-tubulin gene family and implications for benzimidazole resistance in strongylid nematodes","volume":"43","author":"Saunders","year":"2013","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0120","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/S0166-6851(01)00455-8","article-title":"Mutation in position 167 of isotype 1beta-tubulin gene of trichostrongylid nematodes: role in benzimidazole resistance?","volume":"120","author":"Silvestre","year":"2002","journal-title":"Mol. Biochem. Parasitol."},{"issue":"Suppl. 2","key":"10.1016\/j.rvsc.2017.01.019_bb0125","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1186\/1756-3305-2-S2-S2","article-title":"Anthelmintic resistance in cyathostomin populations from horse yards in Italy, United Kingdom and Germany","volume":"2","author":"Traversa","year":"2009","journal-title":"Parasit. Vectors"},{"key":"10.1016\/j.rvsc.2017.01.019_bb0130","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1645\/0022-3395(2002)088[0254:ASPFTB]2.0.CO;2","article-title":"Allele-specific PCR for the beta-tubulin codon 200 TTC\/TAC polymorphism using single adult and larval small strongyle (Cyathostominae) stages","volume":"88","author":"Von Samson-Himmelstjerna","year":"2002","journal-title":"J. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0135","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0304-4017(02)00197-8","article-title":"Comparative use of faecal egg count reduction test, egg hatch assay and beta-tubulin codon 200 genotyping in small strongyles (cyathostominae) before and after benzimidazole treatment","volume":"108","author":"Von Samson-Himmelstjerna","year":"2002","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2017.01.019_bb0140","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1017\/S0031182007000054","article-title":"Single nucleotide polymorphism (SNP) markers for benzimidazole resistance in veterinary nematodes","volume":"134","author":"Von Samson-Himmelstjerna","year":"2007","journal-title":"Parasitology"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528816303885?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528816303885?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:07:37Z","timestamp":1758514057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528816303885"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,12]]},"references-count":28,"alternative-id":["S0034528816303885"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2017.01.019","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2017,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Diagnosis of resistance alleles in codon 167 of the beta-tubulin (Cya-tbb-1) gene from third-stage larvae of horse cyathostomins","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2017.01.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}