{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T10:47:21Z","timestamp":1761648441744,"version":"3.44.0"},"reference-count":52,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,10,1]],"date-time":"2017-10-01T00:00:00Z","timestamp":1506816000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"Agria and Swedish Kennel Club Research Fund","award":["N2013-007"],"award-info":[{"award-number":["N2013-007"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2017,10]]},"DOI":"10.1016\/j.rvsc.2017.04.008","type":"journal-article","created":{"date-parts":[[2017,4,19]],"date-time":"2017-04-19T16:48:22Z","timestamp":1492620502000},"page":"186-193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"C","title":["Cartilage lesions in feline stifle joints \u2013 Associations with articular mineralizations and implications for osteoarthritis"],"prefix":"10.1016","volume":"114","author":[{"given":"Alexandra","family":"Leijon","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Charles J.","family":"Ley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3566-650X","authenticated-orcid":false,"given":"Antonia","family":"Corin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Ley","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2017.04.008_bb0005","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0195-5616(00)50023-0","article-title":"Radiographic features of feline joint diseases","volume":"30","author":"Allan","year":"2000","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0010","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1007\/s00296-009-1183-1","article-title":"Which elements are involved in reversible and irreversible cartilage degradation in osteoarthritis?","volume":"30","author":"Bay-Jensen","year":"2010","journal-title":"Rheumatol. Int."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0015","first-page":"363","article-title":"Animal models of osteoarthritis","volume":"1","author":"Bendele","year":"2001","journal-title":"J. Musculoskelet. Neuronal Interact."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0020","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1177\/1098612X11432828","article-title":"Osteoarthritis in the cat: 1. How common is it and how easy to recognise?","volume":"14","author":"Bennett","year":"2012","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0025","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/S8756-3282(02)00982-1","article-title":"Changes in articular cartilage and subchondral bone histomorphometry in osteoarthritic knee joints in humans","volume":"32","author":"Bobinac","year":"2003","journal-title":"Bone"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0030","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1053\/joca.2001.0414","article-title":"Magnetic resonance imaging of the knee in chronic knee pain. A 2-year follow-up","volume":"9","author":"Boegard","year":"2001","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0035","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.joca.2004.11.004","article-title":"Long-term periarticular bone adaptation in a feline knee injury model for post-traumatic experimental osteoarthritis","volume":"13","author":"Boyd","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0040","doi-asserted-by":"crossref","first-page":"979","DOI":"10.2214\/ajr.176.4.1760979","article-title":"Musculoskeletal imaging with multislice CT","volume":"176","author":"Buckwalter","year":"2001","journal-title":"AJR Am. J. Roentgenol."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0045","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/jbmr.5650110904","article-title":"Osteoarthritis in cynomolgus macaques. III: effects of age, gender, and subchondral bone thickness on the severity of disease","volume":"11","author":"Carlson","year":"1996","journal-title":"J. Bone Miner. Res."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0050","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1002\/art.21148","article-title":"Association of cartilage defects with loss of knee cartilage in healthy, middle-age adults: a prospective study","volume":"52","author":"Cicuttini","year":"2005","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0055","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1136\/vr.157.25.793","article-title":"Prevalence of radiographic signs of degenerative joint disease in a hospital population of cats","volume":"157","author":"Clarke","year":"2005","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0060","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.joca.2012.10.013","article-title":"Alterations to the subchondral bone architecture during osteoarthritis: bone adaptation vs endochondral bone formation","volume":"21","author":"Cox","year":"2013","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0065","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.joca.2004.11.007","article-title":"Knee cartilage defects: association with early radiographic osteoarthritis, decreased cartilage volume, increased joint surface area and type II collagen breakdown","volume":"13","author":"Ding","year":"2005","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0070","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1001\/archinte.166.6.651","article-title":"Natural history of knee cartilage defects and factors affecting change","volume":"166","author":"Ding","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0075","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1532-950X.2010.00648.x","article-title":"Meniscal mineralization in domestic cats","volume":"39","author":"Freire","year":"2010","journal-title":"Vet. Surg."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0080","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1111\/j.1740-8261.2011.01803.x","article-title":"Radiographic evaluation of feline appendicular degenerative joint disease vs. macroscopic appearance of articular cartilage","volume":"52","author":"Freire","year":"2011","journal-title":"Vet. Radiol. Ultrasound"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0085","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1177\/0300985813516648","article-title":"Pathology of articular cartilage and synovial membrane from elbow joints with and without degenerative joint disease in domestic cats","volume":"51","author":"Freire","year":"2014","journal-title":"Vet. Pathol."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0090","first-page":"173","article-title":"Meniscal ossification. II. The normal pattern in the tiger knee","volume":"23","author":"Ganey","year":"1994","journal-title":"Skelet. Radiol."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0095","doi-asserted-by":"crossref","first-page":"628","DOI":"10.2460\/javma.2002.220.628","article-title":"Radiographic evidence of degenerative joint disease in geriatric cats: 100 cases (1994\u20131997)","volume":"220","author":"Hardie","year":"2002","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0100","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/S1063-4584(05)80330-9","article-title":"Hindlimb loading, morphology and biochemistry of articular cartilage in the ACL-deficient cat knee","volume":"1","author":"Herzog","year":"1993","journal-title":"Osteoarthr. Cartil."},{"issue":"165\u2013180","key":"10.1016\/j.rvsc.2017.04.008_bb0105","first-page":"vii","article-title":"Diagnostic imaging of lameness in small animals","volume":"31","author":"Hoskinson","year":"2001","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0110","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1055\/s-0038-1632656","article-title":"A radiological study of the sesamoid bones and os meniscus of the cheetah (Acinonyx jubatus)","volume":"13","author":"Kirberger","year":"2000","journal-title":"Vet. Comp. Orthop. Traumatol."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0115","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1111\/j.1365-2559.2006.02508.x","article-title":"Synovitis score: discrimination between chronic low-grade and high-grade synovitis","volume":"49","author":"Krenn","year":"2006","journal-title":"Histopathology"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0120","first-page":"410","article-title":"Evaluation of client-specific outcome measures and activity monitoring to measure pain relief in cats with osteoarthritis","volume":"21","author":"Lascelles","year":"2007","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0125","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1532-950X.2010.00708.x","article-title":"Cross-sectional study of the prevalence of radiographic degenerative joint disease in domesticated cats","volume":"39","author":"Lascelles","year":"2010","journal-title":"Vet. Surg."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0130","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/ar4405","article-title":"Subchondral bone in osteoarthritis: insight into risk factors and microstructural changes","volume":"15","author":"Li","year":"2013","journal-title":"Arthritis Res. Ther."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0135","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1002\/art.34453","article-title":"Osteoarthritis: a disease of the joint as an organ","volume":"64","author":"Loeser","year":"2012","journal-title":"Arthritis Rheum."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0140","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1177\/1098612X11432823","article-title":"Musculoskeletal imaging in the cat. What's normal? What's abnormal?","volume":"14","author":"Mahoney","year":"2012","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0145","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1751-0813.1999.tb11672.x","article-title":"Osteochondrodysplasia in Scottish fold cats","volume":"77","author":"Malik","year":"1999","journal-title":"Aust. Vet. J."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0150","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1002\/(SICI)1097-0029(19970515)37:4<333::AID-JEMT8>3.0.CO;2-L","article-title":"Cartilage and subchondral bone interaction in osteoarthrosis of human knee joint: a histological and histomorphometric study","volume":"37","author":"Matsui","year":"1997","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0155","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/j.bone.2005.08.020","article-title":"Role of endochondral ossification of articular cartilage and functional adaptation of the subchondral plate in the development of fatigue microcracking of joints","volume":"38","author":"Muir","year":"2006","journal-title":"Bone"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0160","doi-asserted-by":"crossref","first-page":"6093","DOI":"10.3390\/ijms16036093","article-title":"Osteoarthritis in the XXIst century: risk factors and behaviours that influence disease onset and progression","volume":"16","author":"Musumeci","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0165","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1002\/(SICI)1097-0029(19970515)37:4<324::AID-JEMT7>3.0.CO;2-K","article-title":"The interaction of the zone of calcified cartilage and subchondral bone in osteoarthritis","volume":"37","author":"Oegema","year":"1997","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0170","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1007\/s00167-015-3924-x","article-title":"Histological analysis of the tibial anterior cruciate ligament insertion","volume":"24","author":"Oka","year":"2016","journal-title":"Knee Surg. Sports Traumatol. Arthrosc."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0175","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.bone.2011.11.030","article-title":"Elevated cross-talk between subchondral bone and cartilage in osteoarthritic joints","volume":"51","author":"Pan","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0180","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1177\/1098612X14564000","article-title":"Morphometric description of the feline radius and ulna generated from computed tomography","volume":"17","author":"Preston","year":"2015","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0185","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0190","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1159\/000145860","article-title":"Anatomy of the knee joint of the cat","volume":"119","author":"Pros\u00e9","year":"1984","journal-title":"Acta Anat. (Basel)"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1746-6148-9-50","article-title":"Meniscal mineralisation in little spotted cats","volume":"9","author":"Rahal","year":"2013","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0200","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1186\/1746-6148-9-110","article-title":"Histological and molecular characterisation of feline humeral condylar osteoarthritis","volume":"9","author":"Ryan","year":"2013","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0205","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/ar148","article-title":"Articular cartilage and changes in arthritis. An introduction: cell biology of osteoarthritis","volume":"3","author":"Sandell","year":"2001","journal-title":"Arthritis Res."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0210","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.tvjl.2009.12.014","article-title":"Cross-sectional study of the prevalence and clinical features of osteoarthritis in 100 cats","volume":"187","author":"Slingerland","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0215","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.bone.2011.10.010","article-title":"Osteochondral alterations in osteoarthritis","volume":"51","author":"Suri","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0220","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S0021-9290(98)00041-4","article-title":"One-year changes in hind limb kinematics, ground reaction forces and knee stability in an experimental model of osteoarthritis","volume":"31","author":"Suter","year":"1998","journal-title":"J. Biomech."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0225","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1177\/1098612X15606774","article-title":"Association of mineralisations in the stifle joint of domestic cats with degenerative joint disease and cranial cruciate ligament pathology","volume":"19","author":"Voss","year":"2017","journal-title":"J. Feline Med. Surg."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0230","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/j.1740-8261.2002.tb00998.x","article-title":"Meniscal ossicles in large non-domestic cats","volume":"43","author":"Walker","year":"2002","journal-title":"Vet. Radiol. Ultrasound"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0235","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1016\/j.joca.2007.01.020","article-title":"Angiogenesis in the synovium and at the osteochondral junction in osteoarthritis","volume":"15","author":"Walsh","year":"2007","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0240","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1093\/rheumatology\/keq188","article-title":"Angiogenesis and nerve growth factor at the osteochondral junction in rheumatoid arthritis and osteoarthritis","volume":"49","author":"Walsh","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0245","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1093\/rheumatology\/kei108","article-title":"Factors affecting progression of knee cartilage defects in normal subjects over 2years","volume":"45","author":"Wang","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.rvsc.2017.04.008_bb0250","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/03008207.2016.1177036","article-title":"Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis","volume":"57","author":"Wei","year":"2016","journal-title":"Connect. Tissue Res."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0255","first-page":"579","article-title":"Intrameniscal calcification and ossification in the stifle joints of 3 domestic cats","volume":"21","author":"Whiting","year":"1985","journal-title":"J. Am. Anim. Hosp. Assoc."},{"key":"10.1016\/j.rvsc.2017.04.008_bb0260","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.bone.2003.07.011","article-title":"Vascularisation and osteochondrosis of the epiphyseal growth cartilage of the distal femur in pigs\u2013development with age, growth rate, weight and joint shape","volume":"34","author":"Ytrehus","year":"2004","journal-title":"Bone"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528816306658?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528816306658?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:08:51Z","timestamp":1758514131000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528816306658"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":52,"alternative-id":["S0034528816306658"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2017.04.008","relation":{},"ISSN":["0034-5288"],"issn-type":[{"type":"print","value":"0034-5288"}],"subject":[],"published":{"date-parts":[[2017,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cartilage lesions in feline stifle joints \u2013 Associations with articular mineralizations and implications for osteoarthritis","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2017.04.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}