{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:44:20Z","timestamp":1780465460687,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31660707"],"award-info":[{"award-number":["31660707"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010829","name":"Department of Education, Xinjiang Uygur Autonomous Region","doi-asserted-by":"publisher","award":["2017A01002-2-6"],"award-info":[{"award-number":["2017A01002-2-6"]}],"id":[{"id":"10.13039\/501100010829","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.rvsc.2019.05.014","type":"journal-article","created":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T13:53:40Z","timestamp":1558533220000},"page":"82-88","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Antibody kinetics and immune profile analysis of a Streptococcus equi DNA vaccine expressing the FljB and SeM fusion protein in murine and equine models"],"prefix":"10.1016","volume":"125","author":[{"given":"Xiaohui","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caidie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baojiang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lining","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2019.05.014_bb0005","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1038\/90609","article-title":"Toll like receptors: critical proteins linking innate and acquired immunity","volume":"2","author":"Akira","year":"2001","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0010","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.ejpb.2006.04.007","article-title":"Microencapsulation of Streptococcus equi antigens in biodegradable microspheres and preliminary immunisation studies","volume":"64","author":"Azevedo","year":"2006","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0020","doi-asserted-by":"crossref","first-page":"3515","DOI":"10.1128\/iai.62.8.3515-3520.1994","article-title":"Inhibition of C3 deposition on Streptococcus equi subsp. equi by M protein: a mechanism for survival in equine blood","volume":"62","author":"Boschwitz","year":"1994","journal-title":"Infect. Immun."},{"issue":"2","key":"10.1016\/j.rvsc.2019.05.014_bb0025","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1111\/jvim.15043","article-title":"Streptococcus equi infections in horses: guidelines for treatment, control, and prevention of strangles-revised consensus statement","volume":"32","author":"Boyle","year":"2018","journal-title":"J. Vet. Intern. Med."},{"issue":"11","key":"10.1016\/j.rvsc.2019.05.014_bb0030","doi-asserted-by":"crossref","first-page":"2986","DOI":"10.1002\/eji.200425403","article-title":"Responses to the soluble flagellar protein FliC are Th2, while those to FliC on Salmonella are Th1","volume":"34","author":"Cunningham","year":"2004","journal-title":"Eur. J. Immunol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0035","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1089\/vim.2009.0107","article-title":"A recombinant flagellinpoxvirus fusion protein vaccine elicits complement-dependent protection against respiratory challenge with vaccinia virus in mice","volume":"23","author":"Delaney","year":"2010","journal-title":"Viral Immunol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0040","doi-asserted-by":"crossref","first-page":"3228","DOI":"10.1128\/IAI.72.6.3228-3236.2004","article-title":"Recombinant Streptococcus equi proteins protect mice in challenge experiments and induce immune response in horses","volume":"72","author":"Flock","year":"2004","journal-title":"Infect. Immun."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0045","doi-asserted-by":"crossref","first-page":"4144","DOI":"10.1016\/j.vaccine.2006.02.016","article-title":"Protective effect of vaccination with recombinant proteins from Streptococcus equi subspecies equi in a strangles model in the mouse","volume":"24","author":"Flock","year":"2006","journal-title":"Vaccine"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0050","doi-asserted-by":"crossref","first-page":"2190","DOI":"10.1128\/IAI.01074-12","volume":"81","author":"Ghose","year":"2013","journal-title":"Infect. Immun."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0055","doi-asserted-by":"crossref","first-page":"e8","DOI":"10.1038\/emi.2016.8","article-title":"Immunogenicity and protective efficacy of recombinant Clostridiu difficile flagellar protein FliC","volume":"5","author":"Ghose","year":"2016","journal-title":"Emerg. Microbes. Infect."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000584","article-title":"Getting to grips with strangles: an effective multi-component recombinant vaccine for the protection of horses from Streptococcus equi infection","volume":"5","author":"Guss","year":"2009","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0070","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1136\/vr.147.20.563","article-title":"Investigations towards an efficacious and safe strangles vaccine: submucosal vaccination with a live attenuated Streptococcus equi","volume":"147","author":"Jacobs","year":"2000","journal-title":"Vet. Rec."},{"issue":"6","key":"10.1016\/j.rvsc.2019.05.014_bb0075","first-page":"422","article-title":"HA1-2-fljB vaccine induces immune responses against pandemic swine-origin H1N1 influenza virus in mice","volume":"26","author":"Kang","year":"2016","journal-title":"J. Mol. Microbiol. Biotechnol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0080","doi-asserted-by":"crossref","first-page":"284","DOI":"10.2746\/042516407X195961","article-title":"Modified live Streptococcus equi (\u2018strangles\u2019) vaccination followed by clinically adverse reactions associated with bacterial replication","volume":"39","author":"Kemp-Symonds","year":"2007","journal-title":"Equine Vet. J."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0085","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1007\/s00262-007-0384-2","article-title":"A novel murine model of allogeneic vaccination against prostate cancer","volume":"57","author":"Labarthe","year":"2008","journal-title":"Cancer Immunol. Immun."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0090","first-page":"2546","article-title":"A bacterial flagellin, Vibrio vulnificus FlaB, has a strong mucosal adjuvant activity to induce protective immunity","volume":"72","author":"Lee","year":"2006","journal-title":"Infect. Immun."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0095","doi-asserted-by":"crossref","first-page":"17615","DOI":"10.1074\/jbc.M709844200","article-title":"A common theme in interaction of bacterial immunoglobulin-binding proteins with immunoglobulins illustrated in the equine system","volume":"283","author":"Lewis","year":"2008","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.rvsc.2019.05.014_bb9000","first-page":"1","article-title":"An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium\u00a0flagellin","volume":"79","author":"Song","year":"2015","journal-title":"BMC Biotechnol."},{"issue":"6","key":"10.1016\/j.rvsc.2019.05.014_bb0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0020928","article-title":"Immunogenicity and efficacy of flagellin-fused vaccine candidates targeting 2009 pandemic H1N1 influenza in mice","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0105","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.1086\/517613","article-title":"A West Nile virus recombinant protein vaccine that coactivates innate and adaptive immunity","volume":"195","author":"McDonald","year":"2007","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0110","doi-asserted-by":"crossref","first-page":"3311","DOI":"10.1099\/00221287-147-12-3311","article-title":"The fibrinogen-binding protein (FgBP) of Streptococcus equi subsp. equi additionally binds IgG and contributes to virulence in a mouse model","volume":"147","author":"Meehan","year":"2001","journal-title":"Microbiology"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0115","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/S0264-410X(00)00187-0","article-title":"Induction of mucosal and systemic antibody specific for SeMF3 of Streptococcus equi by intranasal vaccination using a sucrose acetate isobutyrate based delivery system","volume":"19","author":"Nally","year":"2001","journal-title":"Vaccine"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0120","doi-asserted-by":"crossref","first-page":"2158","DOI":"10.1128\/iai.59.6.2158-2165.1991","article-title":"Expression and immunogenicity of a Streptococcal M protein epitope inserted in Salmonella flagellin","volume":"59","author":"Newton","year":"1991","journal-title":"Infect. Immun."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0125","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/hae.12522","article-title":"Immune responses to human factor IX in haemophilia B mice of different genetic backgrounds are distinct and modified by TLR4","volume":"21","author":"Sack","year":"2015","journal-title":"Haemophilia"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0130","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jbiotec.2014.01.037","article-title":"In silico and in vivo studies of truncated forms of flagellin (FliC) of enteroaggregative Escherichia coli fused to FimH from uropathogenic Escherichia coli as a vaccine candidate against urinary tract infections","volume":"175","author":"Savar","year":"2014","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0135","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1016\/S0264-410X(01)00488-1","article-title":"Mucosal immunogenicity for the horse of a SeM peptide of Streptococcus equi genetically coupled to cholera toxin","volume":"20","author":"Sheoran","year":"2002","journal-title":"Vaccine"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0140","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1038\/ni1011","article-title":"Corrigendum: toll-like receptor 5 recognizes a conserved site on flagellin required for protofilament formation and bacterial motility","volume":"4","author":"Smith","year":"2003","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0145","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0002257","article-title":"Efficacious recombinant influenza vaccines produced by high yield bacterial expression: a solution to global pandemic and seasonal needs","volume":"3","author":"Song","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0150","doi-asserted-by":"crossref","first-page":"5875","DOI":"10.1016\/j.vaccine.2009.07.060","article-title":"Superior efficacy of a recombinant flagellin: H5N1 HA globular head vaccine is determined by the placement of the globular head within flagellin","volume":"27","author":"Song","year":"2009","journal-title":"Vaccine"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0155","first-page":"1","article-title":"An avian influenza A (H7N9) virus vaccine candidate based on the fusion protein of hemagglutinin globular head and Salmonella typhimurium flagellin","volume":"79","author":"Song","year":"2015","journal-title":"BMC Biotechnol."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0160","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1053\/j.ctep.2006.03.016","article-title":"Streptococcus equi subsp. equi (Strangles) infection","volume":"5","author":"Taylor","year":"2006","journal-title":"Clin. Tech. Equine Pract."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0165","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1128\/iai.48.1.29-34.1985","article-title":"Immunologically reactive proteins of Streptococcus equi","volume":"48","author":"Timoney","year":"1985","journal-title":"Infect. Immun."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0170","doi-asserted-by":"crossref","first-page":"5583","DOI":"10.1016\/j.vaccine.2007.02.040","article-title":"Vaccine potential of novel surface exposed and secreted proteins of Streptococcus equi","volume":"25","author":"Timoney","year":"2007","journal-title":"Vaccine"},{"key":"10.1016\/j.rvsc.2019.05.014_bb0180","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/S1773-2247(10)50044-3","article-title":"From single - dose vaccine delivery systems to nanovaccines","volume":"20","author":"Vicente","year":"2010","journal-title":"J. Drug Del. Sci. Tech."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0185","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.tvjl.2006.05.011","article-title":"Getting a grip on strangles: recent progress towards improved diagnostics and vaccines","volume":"173","author":"Waller","year":"2007","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2019.05.014_bb0190","doi-asserted-by":"crossref","first-page":"3629","DOI":"10.1016\/j.vaccine.2007.01.060","article-title":"Vaccination of horses against strangles using recombinant antigens from Streptococcus equi","volume":"25","author":"Waller","year":"2007","journal-title":"Vaccine"},{"issue":"1\u20132","key":"10.1016\/j.rvsc.2019.05.014_bb0195","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cellimm.2014.09.003","article-title":"Bursin-like peptide (BLP) enhances H9N2 influenza vaccine induced humoral and cell mediated immune responses","volume":"292","author":"Wang","year":"2014","journal-title":"Cell. Immunol."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528818315753?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528818315753?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:17:37Z","timestamp":1758514657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528818315753"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":37,"alternative-id":["S0034528818315753"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.05.014","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibody kinetics and immune profile analysis of a Streptococcus equi DNA vaccine expressing the FljB and SeM fusion protein in murine and equine models","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.05.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}