{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T04:49:39Z","timestamp":1789274979265,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,10,1]],"date-time":"2019-10-01T00:00:00Z","timestamp":1569888000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2019,10]]},"DOI":"10.1016\/j.rvsc.2019.08.028","type":"journal-article","created":{"date-parts":[[2019,8,28]],"date-time":"2019-08-28T11:25:20Z","timestamp":1566991520000},"page":"150-154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"special_numbering":"C","title":["Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome"],"prefix":"10.1016","volume":"126","author":[{"given":"A.","family":"Pierini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Gori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Lippi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Ceccherini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Lubas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Marchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2019.08.028_bb0005","doi-asserted-by":"crossref","first-page":"869","DOI":"10.4065\/78.7.869","article-title":"The hematologic system as a marker of organ dysfunction in sepsis","volume":"78","author":"Aird","year":"2003","journal-title":"Mayo Clin. Proc."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0010","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1111\/j.1939-1676.2009.0305.x","article-title":"Peripheral nucleated red blood cells as a prognostic indicator in heatstroke in dogs","volume":"23","author":"Aroch","year":"2009","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0015","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1177\/0003319714542997","article-title":"Neutrophil to lymphocyte ratio is related to stent thrombosis and high mortality in patients with acute myocardial infarction","volume":"66","author":"Ay\u00e7a","year":"2015","journal-title":"Angiology"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0020","series-title":"Schalm\u2019s Veterinary Hematology","first-page":"144","article-title":"Erythrocyte morphology","author":"Barger","year":"2010"},{"issue":"7","key":"10.1016\/j.rvsc.2019.08.028_bb1000","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1111\/jsap.12498","article-title":"A review of anaemia of inflammatory disease in dogs and cats.","volume":"57","author":"Chikazawa","year":"2016","journal-title":"Journal of Small Animal Practice"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0025","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1309\/D70F-HCC1-XX1T-4ETE","article-title":"Nucleated RBCs\u2014significance in the peripheral blood film","volume":"31","author":"Constantino","year":"2000","journal-title":"Lab. Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0030","series-title":"Williams Hematology","first-page":"156","article-title":"Neutropenia and neutrophilia","author":"Daleand","year":"2017"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0035","first-page":"690","article-title":"The hemogram and bone marrow profile of normal neonatal and weanling beagle dogs","volume":"23","author":"Earl","year":"1973","journal-title":"Lab. Anim. Sci."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0040","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1055\/s-2004-860979","article-title":"Hematologic changes in sepsis and their therapeutic implications","volume":"25","author":"Goyette","year":"2004","journal-title":"Semin. Respir. Crit. Care Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0045","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1111\/vec.12705","article-title":"Retrospective evaluation of plasma cholesterol concentration in septic dogs and its association with morbidity and mortality: 51 cases (2005-2015)","volume":"28","author":"Hardy","year":"2018","journal-title":"J. Vet. Emerg. Crit. Care"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0050","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1532-950X.1997.tb01699.x","article-title":"Evaluation of the sensitivity and specificity of diagnostic criteria for sepsis in dogs","volume":"26","author":"Hauptman","year":"1997","journal-title":"Vet. Surg."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0055","doi-asserted-by":"crossref","first-page":"1034","DOI":"10.1111\/j.1939-1676.2010.0552.x","article-title":"The acute patient physiologic and laboratory evaluation (APPLE) score: a severity of illness stratification system for hospitalized dogs","volume":"24","author":"Hayes","year":"2010","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0060","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.ajem.2016.10.055","article-title":"Neutrophil-to-lymphocyte ratio as a prognostic marker in critically-ill septic patients","volume":"35","author":"Hwang","year":"2017","journal-title":"Am. J. Emerg. Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0065","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1164\/ajrccm.159.3.9805087","article-title":"Regulation of adhesion molecules during human Endotoxemia","volume":"159","author":"Jilma","year":"2012","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0070","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bjc.2014.317","article-title":"The prognostic impact of the neutrophil-to-lymphocyte ratio in patients with small-cell lung cancer","volume":"111","author":"Kang","year":"2014","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0075","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1111\/jvim.13650","article-title":"Hospital-acquired Anemia in critically ill dogs and cats: a multi-institutional study","volume":"30","author":"Lynch","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0080","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1136\/vr.103650","article-title":"Use of neutrophil to lymphocyte ratio for predicting histopathological grade of canine mast cell tumours","volume":"179","author":"Macfarlane","year":"2016","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0085","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1111\/jsap.12435","article-title":"Diagnostic value of neutrophil-lymphocyte and albumin-globulin ratios in canine soft tissue sarcoma","volume":"57","author":"Macfarlane","year":"2016","journal-title":"J. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0090","series-title":"Meyer & Harvey Veterinary Laboratory Medicine: Interpretation and Diagnosis","first-page":"43","article-title":"Evaluation of erythrocytic disorders","author":"Meyer","year":"1998"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0095","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1136\/vr.102398","article-title":"Association of nucleated red blood cells with mortality in critically ill dogs","volume":"175","author":"M\u00fcller","year":"2014","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0100","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/vco.12045","article-title":"Prognostic value of baseline absolute lymphocyte concentration and neutrophil\/lymphocyte ratio in dogs with newly diagnosed multi-centric lymphoma","volume":"13","author":"Mutz","year":"2015","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0105","first-page":"345","article-title":"Anemia and red blood cell transfusion","volume":"33","author":"Napolitano","year":"2017","journal-title":"Adv. Crit. Care. Crit Care Clin"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0110","series-title":"Schalm\u2019s Veterinary Hematology","first-page":"321","article-title":"Interpretation of canine leukocyte responses","author":"Schultze","year":"2010"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0115","first-page":"e1","article-title":"Pretreatment leukocyte ratios and concentrations as predictors of outcome in dogs with cutaneous mast cell tumours","volume":"10","author":"Skor","year":"2016","journal-title":"Vet. Comp. Oncol."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0120","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000074228","article-title":"Cytokines and erythropoietin in the blood of patients with erythroblastemia","volume":"110","author":"Stachon","year":"2003","journal-title":"Acta Haematol."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0125","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/01.shk.0000164693.11649.91","article-title":"Association between nucleated red blood cells in blood and the levels of erythropoietin, interleukin 3, interleukin 6, and interleukin 12p70","volume":"24","author":"Stachon","year":"2005","journal-title":"Shock"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0130","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1515\/CCLM.2006.183","article-title":"Poor prognosis indicated by nucleated red blood cells in peripheral blood is not associated with organ failure of the liver or kidney","volume":"44","author":"Stachon","year":"2006","journal-title":"Clin. Chem. Lab. Med."},{"key":"10.1016\/j.rvsc.2019.08.028_bb0135","doi-asserted-by":"crossref","first-page":"R62","DOI":"10.1186\/cc5932","article-title":"Nucleated red blood cells in the blood of medical intensive care patients indicate increased mortality risk: a prospective cohort study","volume":"11","author":"Stachon","year":"2007","journal-title":"Crit. Care"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0140","series-title":"Small Animal Clinical Diagnosis by Laboratory Methods","first-page":"417","article-title":"Appendix II - reference values","author":"Tvedten","year":"2004"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0145","series-title":"Schalm\u2019s Veterinary Hematology","first-page":"152","article-title":"Laboratory and clinical diagnosis of anemia","author":"Tvedten","year":"2010"},{"key":"10.1016\/j.rvsc.2019.08.028_bb0150","first-page":"5","article-title":"Ratio of neutrophil to lymphocyte counts--rapid and simple parameter of systemic inflammation and stress in critically ill","volume":"102","author":"Zahorec","year":"2001","journal-title":"Bratisl. Lek. Listy"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528818313572?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528818313572?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:19:52Z","timestamp":1758514792000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528818313572"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10]]},"references-count":31,"alternative-id":["S0034528818313572"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.08.028","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2019,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neutrophil-to-lymphocyte ratio, nucleated red blood cells and erythrocyte abnormalities in canine systemic inflammatory response syndrome","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.08.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}