{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T04:59:58Z","timestamp":1781240398206,"version":"3.54.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100012471","name":"Domain Foundation of Equipment Advance Research of 13th Five-year Plan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012471","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.rvsc.2019.11.006","type":"journal-article","created":{"date-parts":[[2019,11,13]],"date-time":"2019-11-13T11:28:24Z","timestamp":1573644504000},"page":"118-123","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Efficacy of gamithromycin injection administered intramuscularly against bacterial swine respiratory disease"],"prefix":"10.1016","volume":"128","author":[{"given":"Tianshi","family":"Xiao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongxiao","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruimeng","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad","family":"Ishfaq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuying","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2019.11.006_bb0005","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1007\/BF01975838","article-title":"Influence of the test medium on azithromycin and erythromycin regression statistics","volume":"10","author":"Barry","year":"1991","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0010","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2885.2004.00586.x","article-title":"Pharmacokinetics and lung tissue concentrations of tulathromycin in swine","volume":"27","author":"Benchaoui","year":"2004","journal-title":"J. Vet. Pharmacol. Ther."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0015","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1111\/j.1365-2885.2011.01292.x","article-title":"Plasma pharmacokinetics, pulmonary distribution, and in vitro activity of gamithromycin in foals","volume":"35","author":"Berghaus","year":"2012","journal-title":"J. Veterinary Pharmacol. Ther."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0020","series-title":"CLSI Document M07-A9","author":"CLSI","year":"2012"},{"issue":"Suppl 2 Pt. 1","key":"10.1016\/j.rvsc.2019.11.006_bb0025","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.eimc.2009.06.002","article-title":"Macrolides and ketolides","volume":"65","author":"Cobos-Trigueros","year":"2009","journal-title":"Enfermedades Infecciosas Y Microbiol. Cl\u00edn."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0030","article-title":"Porcine respiratory disease and complexes: the story to date","volume":"25","author":"Done","year":"2003","journal-title":"Practice"},{"key":"10.1016\/j.rvsc.2019.11.006_bb0035","series-title":"Zactran: EPAR - Product Information","author":"EMA","year":"2018"},{"key":"10.1016\/j.rvsc.2019.11.006_bb0040","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.vetmic.2007.11.033","article-title":"Susceptibility testing of tulathromycin: interpretative breakpoints and susceptibility of field isolates","volume":"129","author":"Godinho","year":"2008","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0045","doi-asserted-by":"crossref","first-page":"2332","DOI":"10.1128\/JCM.00123-15","article-title":"Molecular basis of resistance to selected antimicrobial agents in the emerging zoonotic pathogen Streptococcus suis","volume":"53","author":"Gurung","year":"2015","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0050","first-page":"86","article-title":"Evaluation of a killed vaccine against porcine pleuropneumonia due to haemophilus pleuropneumoniae","volume":"26","author":"Higgins","year":"1985","journal-title":"Can. Vet. J. La Rev. V\u00e9t. Can."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0055","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/1746-6148-5-14","article-title":"A novel respiratory health score (RHS) supports a role of acute lung damage and pig breed in the course of an Actinobacillus pleuropneumoniae infection","volume":"5","author":"Hoeltig","year":"2009","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0060","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/s40813-018-0089-2","article-title":"Efficacy of a one-shot marbofloxacin treatment on acute pleuropneumonia after experimental aerosol inoculation of nursery pigs","volume":"4","author":"Hoeltig","year":"2018","journal-title":"Porcine Health Manag"},{"key":"10.1016\/j.rvsc.2019.11.006_bb0065","first-page":"655","article-title":"Efficacy of tilmicosin phosphate (Pulmotil\u00ae premix) in feed for the treatment of a clinical outbreak of Actinobacilluspleuropneumoniae infection in growing\u2013finishing pigs. Zoonoses","volume":"48","author":"Hoflack","year":"2001","journal-title":"Public Health"},{"key":"10.1016\/j.rvsc.2019.11.006_bb0070","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1111\/j.1365-2885.2009.01125.x","article-title":"Pharmacokinetics of gamithromycin in cattle with comparison of plasma and lung tissue concentrations and plasma antibacterial activity","volume":"33","author":"Huang","year":"2010","journal-title":"J. Veterinary Pharmacol. Ther."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0075","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/0378-1135(95)00184-0","article-title":"Comparison of virulence of different Actinobacillus pleuropneumoniae serotypes and biotypes using an aerosol infection model","volume":"49","author":"Jacobsen","year":"1996","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0080","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2016.01618","article-title":"A TolC-like protein of Actinobacillus pleuropneumoniae is involved in antibiotic resistance and biofilm formation","volume":"7","author":"Li","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0085","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0034-5288(18)30687-8","article-title":"Sequential study of lesion development in experimental haemophilus pleuropneumonia","volume":"42","author":"Liggett","year":"1987","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0090","series-title":"Pattern Recognition, International Conference on","first-page":"3106","article-title":"Efficacy of tilmicosin phosphate in feed for the treatment of a clinical outbreak of Actinobacillus pleuropneumoniae infection in growing-finishing pigs","author":"Mateusen","year":"2000"},{"key":"10.1016\/j.rvsc.2019.11.006_bb0095","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1080\/01652176.2000.9695047","article-title":"Prevention of pleuropneumonia in pigs by in-feed medication with sulphadimethoxine and sulphamethoxazole in combination with trimethoprim","volume":"22","author":"Mengelers","year":"2000","journal-title":"Vet. Q."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0100","doi-asserted-by":"crossref","first-page":"1095","DOI":"10.2460\/javma.1993.202.07.1095","article-title":"Effect of subclinical infection with Actinobacillus pleuropneumoniae in commingled feeder swine","volume":"202","author":"Rohrbach","year":"1993","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0105","doi-asserted-by":"crossref","first-page":"1702","DOI":"10.2460\/javma.1989.195.12.1702","article-title":"Estimation of the cost of pneumonia in swine herds","volume":"195","author":"Straw","year":"1989","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0110","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/0167-5877(90)90074-R","article-title":"Effect of pneumonia on growth rate and feed efficiency of minimal disease pigs exposed to Actinobacillus pleuropneumoniae and Mycoplasma hyopneumoniae","volume":"9","author":"Straw","year":"1990","journal-title":"Prevent. Vet. Med."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0115","series-title":"Actinobacillus Pleuropneumoniae Transmission and Clinical Outbreaks","author":"Tobias","year":"2014"},{"key":"10.1016\/j.rvsc.2019.11.006_bb0120","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.vetmic.2016.03.014","article-title":"Monitoring of antimicrobial susceptibility of Streptococcus suis in the Netherlands, 2013-2015","volume":"194","author":"Van","year":"2016","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0125","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0167-5877(03)00082-5","article-title":"Design and analysis of an Actinobacillus pleuropneumoniae transmission experiment","volume":"60","author":"Velthuis","year":"2003","journal-title":"Prevent. Vet. Med."},{"key":"10.1016\/j.rvsc.2019.11.006_bb0130","doi-asserted-by":"crossref","first-page":"684","DOI":"10.3389\/fphar.2017.00684","article-title":"Pharmacodynamic evaluation and PK\/PD-based dose prediction of Tulathromycin: a potential new indication for Streptococcus suis infection","volume":"8","author":"Zhou","year":"2017","journal-title":"Front. Pharmacol."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528818353979?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528818353979?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:19:06Z","timestamp":1758514746000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528818353979"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":26,"alternative-id":["S0034528818353979"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.11.006","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of gamithromycin injection administered intramuscularly against bacterial swine respiratory disease","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.11.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}