{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T03:25:46Z","timestamp":1791084346056,"version":"4.1.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.rvsc.2019.12.007","type":"journal-article","created":{"date-parts":[[2019,12,5]],"date-time":"2019-12-05T05:36:10Z","timestamp":1575524170000},"page":"269-274","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"special_numbering":"C","title":["Autoinducer-2 influences tetracycline resistance in Streptococcus suis by regulating the tet(M) gene via transposon Tn916"],"prefix":"10.1016","volume":"128","author":[{"given":"Baobao","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinpeng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenlong","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2019.12.007_bb0005","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1093\/jac\/dkm124","article-title":"AI-2 quorum sensing affects antibiotic susceptibility in Streptococcus anginosus","volume":"60","author":"Ahmed","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0010","doi-asserted-by":"crossref","first-page":"4258","DOI":"10.1128\/AAC.00546-09","article-title":"AI-2\/LuxS is involved in increased biofilm formation by Streptococcus intermedius in the presence of antibiotics","volume":"53","author":"Ahmed","year":"2009","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0015","doi-asserted-by":"crossref","first-page":"1236","DOI":"10.1016\/j.bmc.2010.12.036","article-title":"An efficient synthesis of the precursor of AI-2, the signalling molecule for inter-species quorum sensing","volume":"19","author":"Ascenso","year":"2011","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0020","doi-asserted-by":"crossref","first-page":"4114","DOI":"10.1099\/mic.0.032474-0","article-title":"AI-2 quorum-sensing inhibitors affect the starvation response and reduce virulence in several Vibrio species, most likely by interfering with LuxPQ","volume":"155","author":"Brackman","year":"2009","journal-title":"Microbiology"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0025","series-title":"Clinical and Laboratory Standards Institute (CLSI). Performance Standards for Antimicrobial Susceptibility Testing; Twenty-fifth Informational Supplement","author":"CLSI","year":"2015"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0030","first-page":"1241","article-title":"Evolutionary theory of bacterial quorum sensing: when is a signal not a signal?","volume":"362","author":"Diggle","year":"2007","journal-title":"Philos. Trans. R. Soc. Lond. Ser. B Biol. Sci."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0035","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1039\/C7OB02395B","article-title":"Analogues of Pseudomonas aeruginosa signalling molecules to tackle infections","volume":"16","author":"E","year":"2018","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0040","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1038\/s41396-018-0047-7","article-title":"Quorum-sensing control of antibiotic resistance stabilizes cooperation in Chromobacterium violaceum","volume":"12","author":"Evans","year":"2018","journal-title":"ISME J."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0045","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1021\/cr100109t","article-title":"Quorum sensing in gram-negative bacteria: small-molecule modulation of AHL and AI-2 quorum sensing pathways","volume":"111","author":"Galloway","year":"2011","journal-title":"Chem. Rev."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0050","article-title":"Occurrence of antimicrobial resistance among bacterial pathogens and indicator bacteria in pigs in different European countries from year 2002 - 2004: the ARBAO-II study","volume":"50","author":"Hendriksen","year":"2008","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0055","doi-asserted-by":"crossref","first-page":"917","DOI":"10.1007\/s10096-018-3208-8","article-title":"Genotypic diversity of Streptococcus suis strains isolated from humans in Thailand","volume":"37","author":"Kerdsin","year":"2018","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0060","doi-asserted-by":"crossref","DOI":"10.3390\/genes8010012","article-title":"Genetic regulation of virulence and antibiotic resistance in Acinetobacter baumannii","volume":"8","author":"Kroger","year":"2016","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0065","doi-asserted-by":"crossref","first-page":"5259","DOI":"10.1007\/s11356-016-8260-2","article-title":"Control of the pollution of antibiotic resistance genes in soils by quorum sensing inhibition","volume":"24","author":"Lai","year":"2017","journal-title":"Environ. Sci. Pollut. Res. Int."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0070","doi-asserted-by":"crossref","first-page":"2517","DOI":"10.1093\/jac\/dkz239","article-title":"Transfer dynamics of Tn6648, a composite integrative conjugative element generated by tandem accretion of Tn5801 and Tn6647 in Enterococcus faecalis","volume":"74","author":"Leon-Sampedro","year":"2019","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0075","first-page":"231","article-title":"Tetracycline and oxytetracycline resistance determinants detected in Bacillus cereus strains isolated from honey samples","volume":"40","author":"Lopez","year":"2008","journal-title":"Rev. Argent. Microbiol."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0080","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1637\/7212-05200R","article-title":"Autoinducer 2-like activity in poultry-associated enteric bacteria in response to subtherapeutic antibiotic exposure","volume":"49","author":"Lu","year":"2005","journal-title":"Avian Dis."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0085","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S1473-3099(07)70001-4","article-title":"Streptococcus suis: an emerging zoonotic pathogen","volume":"7","author":"Lun","year":"2007","journal-title":"Lancet Infect. Dis."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0090","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1292\/jvms.16-0514","article-title":"Capsular serotypes, virulence-associated genes and antimicrobial susceptibility of Streptococcus suis isolates from pigs in Korea","volume":"79","author":"Oh","year":"2017","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0095","doi-asserted-by":"crossref","DOI":"10.1186\/s12879-017-2294-z","article-title":"Case report: two human Streptococcus suis infections in Borneo, Sabah, Malaysia","volume":"17","author":"Rajahram","year":"2017","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0100","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1592\/phco.26.8.1099","article-title":"Tigecycline: first of a new class of antimicrobial agents","volume":"26","author":"Rose","year":"2006","journal-title":"Pharmacotherapy"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0105","doi-asserted-by":"crossref","DOI":"10.3390\/genes8010039","article-title":"The complex relationship between virulence and antibiotic resistance","volume":"8","author":"Schroeder","year":"2017","journal-title":"Genes (Basel)"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0110","doi-asserted-by":"crossref","first-page":"2722","DOI":"10.1093\/jac\/dkx202","article-title":"Inducibility of Tn916 conjugative transfer in Enterococcus faecalis by subinhibitory concentrations of ribosome-targeting antibiotics","volume":"72","author":"Scornec","year":"2017","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0115","first-page":"948","article-title":"Streptococcus suis meningitis with ventriculoperitoneal shunt infection and spondylodiscitis","volume":"104","author":"Tsai","year":"2005","journal-title":"J. Formos. Med. Assoc."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0120","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1574-6968.2010.02189.x","article-title":"Reduced virulence is an important characteristic of biofilm infection of Streptococcus suis","volume":"316","author":"Wang","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0125","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/j.1574-6968.2010.02189.x","article-title":"Reduced virulence is an important characteristic of biofilm infection of Streptococcus suis","volume":"316","author":"Wang","year":"2011","journal-title":"FEMS Microbiol. Lett."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0130","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.vetmic.2011.04.029","article-title":"Functional analysis of luxS in Streptococcus suis reveals a key role in biofilm formation and virulence","volume":"152","author":"Wang","year":"2011","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0135","doi-asserted-by":"crossref","first-page":"924276","DOI":"10.1155\/2013\/924276","article-title":"Overexpression of luxS cannot increase autoinducer-2 production, only affect the growth and biofilm formation in Streptococcus suis","volume":"2013","author":"Wang","year":"2013","journal-title":"ScientificWorldJournal"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0140","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1007\/s00284-013-0509-0","article-title":"Biofilm formation, host-cell adherence, and virulence genes regulation of Streptococcus suis in response to autoinducer-2 signaling","volume":"68","author":"Wang","year":"2014","journal-title":"Curr. Microbiol."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0145","article-title":"A comprehensive analysis on spread and distribution characteristic of antibiotic resistance genes in livestock farms of southeastern China","volume":"11","author":"Wang","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0150","doi-asserted-by":"crossref","first-page":"7231","DOI":"10.1007\/s00253-018-9170-7","article-title":"The LuxS\/AI-2 system of Streptococcus suis","volume":"102","author":"Wang","year":"2018","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0155","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1016\/j.vetmic.2019.05.006","article-title":"LuxS\/AI-2 system is involved in fluoroquinolones susceptibility in Streptococcus suis through overexpression of efflux pump SatAB","volume":"233","author":"Wang","year":"2019","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0160","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.ijantimicag.2012.08.016","article-title":"LuxS\/AI-2 system is involved in antibiotic susceptibility and autolysis in Staphylococcus aureus NCTC 8325","volume":"41","author":"Xue","year":"2013","journal-title":"Int. J. Antimicrob. Agents"},{"key":"10.1016\/j.rvsc.2019.12.007_bb0165","doi-asserted-by":"crossref","first-page":"4693","DOI":"10.3168\/jds.2015-10543","article-title":"Short communication: the role of autoinducer 2 (AI-2) on antibiotic resistance regulation in an Escherichia coli strain isolated from a dairy cow with mastitis","volume":"99","author":"Xue","year":"2016","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0170","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3389\/fcimb.2018.00138","article-title":"The LuxS\/AI-2 quorum-sensing system of Streptococcus pneumoniae is required to cause disease, and to regulate virulence- and metabolism-related genes in a rat model of middle ear infection","volume":"8","author":"Yadav","year":"2018","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0175","first-page":"67","article-title":"Identification of isolates of swine Streptococcus in Jiangsu Province during 1998","volume":"22","author":"Yao","year":"1999","journal-title":"J. Nanjing Agric. Univ."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0180","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.3168\/jds.2017-13761","article-title":"Imidazole decreases the ampicillin resistance of an Escherichia coli strain isolated from a cow with mastitis by inhibiting the function of autoinducer 2","volume":"101","author":"Yu","year":"2018","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2019.12.007_bb0185","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s10646-017-1886-0","article-title":"A study on the role that quorum sensing play in antibiotic-resistant plasmid conjugative transfer in Escherichia coli","volume":"27","author":"Zhang","year":"2018","journal-title":"Ecotoxicology"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528819304886?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528819304886?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:20:36Z","timestamp":1758514836000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528819304886"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":37,"alternative-id":["S0034528819304886"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.12.007","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Autoinducer-2 influences tetracycline resistance in Streptococcus suis by regulating the tet(M) gene via transposon Tn916","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2019.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}