{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T16:27:45Z","timestamp":1787243265485,"version":"build-2736575974"},"reference-count":20,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"name":"National Science Foundation of the People's Republic of China","award":["81502852"],"award-info":[{"award-number":["81502852"]}]},{"name":"National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases in China","award":["2018ZX10711001"],"award-info":[{"award-number":["2018ZX10711001"]}]},{"name":"National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases in China","award":["2018ZX10102001"],"award-info":[{"award-number":["2018ZX10102001"]}]},{"name":"National Science and Technology Major Project for the Control and Prevention of Major Infectious Diseases in China","award":["2020ZX09001016-004-002"],"award-info":[{"award-number":["2020ZX09001016-004-002"]}]},{"name":"Zhejiang Provincial Natural Science Foundation of China","award":["LY19H260006"],"award-info":[{"award-number":["LY19H260006"]}]},{"name":"Independent Task of State Key Laboratory for Diagnosis and Treatment of Infectious Diseases","award":["2019ZZ17"],"award-info":[{"award-number":["2019ZZ17"]}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2020,6]]},"DOI":"10.1016\/j.rvsc.2020.03.017","type":"journal-article","created":{"date-parts":[[2020,3,10]],"date-time":"2020-03-10T22:20:22Z","timestamp":1583878822000},"page":"203-206","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice"],"prefix":"10.1016","volume":"130","author":[{"given":"Haibo","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fumin","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hangping","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanping","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2020.03.017_bb0005","doi-asserted-by":"crossref","first-page":"39505","DOI":"10.1038\/srep39505","article-title":"Composition of the hemagglutinin polybasic proteolytic cleavage motif mediates variable virulence of H7N7 avian influenza viruses","volume":"6","author":"Abdelwhab","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0010","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1016\/S0140-6736(13)60903-4","article-title":"Human infections with the emerging avian influenza a H7N9 virus from wet market poultry: clinical analysis and characterisation of viral genome","volume":"381","author":"Chen","year":"2013","journal-title":"Lancet"},{"key":"10.1016\/j.rvsc.2020.03.017_bb0015","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.vetmic.2015.02.016","article-title":"Adaptive amino acid substitutions enhance the virulence of an H7N7 avian influenza virus isolated from wild waterfowl in mice","volume":"177","author":"Chen","year":"2015","journal-title":"Vet. Microbiol."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0020","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1186\/1743-422X-10-276","article-title":"Rapid emergence of a virulent PB2 E627K variant during adaptation of highly pathogenic avian influenza H7N7 virus to mice","volume":"10","author":"de Jong","year":"2013","journal-title":"Virol. J."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0025","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1637\/7088","article-title":"Molecular characterization of low pathogenicity H7N3 avian influenza viruses isolated in Italy","volume":"48","author":"Di Trani","year":"2004","journal-title":"Avian Dis."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0030","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1126\/science.1093155","article-title":"The structure and receptor binding properties of the 1918 influenza hemagglutinin","volume":"303","author":"Gamblin","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.rvsc.2020.03.017_bb0040","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1007\/s007050170002","article-title":"Universal primer set for the full-length amplification of all influenza a viruses","volume":"146","author":"Hoffmann","year":"2001","journal-title":"Arch. Virol."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0045","doi-asserted-by":"crossref","first-page":"37800","DOI":"10.1038\/srep37800","article-title":"Amino acid substitutions V63I or A37S\/I61T\/V63I\/V100A in the PA N-terminal domain increase the virulence of H7N7 influenza A virus","volume":"6","author":"Hu","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0050","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.3389\/fmicb.2016.01066","article-title":"Pathogenesis and phylogenetic analyses of two avian influenza H7N1 viruses isolated from wild birds","volume":"7","author":"Jin","year":"2016","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0055","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0140-6736(04)15589-X","article-title":"Transmission of H7N7 avian influenza a virus to human beings during a large outbreak in commercial poultry farms in the Netherlands","volume":"363","author":"Koopmans","year":"2004","journal-title":"Lancet"},{"key":"10.1016\/j.rvsc.2020.03.017_bb0060","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1128\/JVI.00894-14","article-title":"Analysis of recombinant H7N9 wild-type and mutant viruses in pigs shows that the Q226L mutation in HA is important for transmission","volume":"88","author":"Liu","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0065","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1637\/11540-112516-Case.1","article-title":"H7N7 highly pathogenic avian influenza in poultry farms in Italy in 2016","volume":"61","author":"Mulatti","year":"2017","journal-title":"Avian Dis."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0070","doi-asserted-by":"crossref","first-page":"1745","DOI":"10.3201\/eid2010.140512","article-title":"Human infection with highly pathogenic a(H7N7) avian influenza virus, Italy, 2013","volume":"20","author":"Puzelli","year":"2014","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0075","first-page":"493","article-title":"A simple method for estimating fifty percent endpoints","volume":"27","author":"Reed","year":"1938","journal-title":"Am. J. Hyg."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0080","doi-asserted-by":"crossref","first-page":"899","DOI":"10.1086\/500219","article-title":"Human illness and isolation of low-pathogenicity avian influenza virus of the H7N3 subtype in British Columbia, Canada","volume":"193","author":"Skowronski","year":"2006","journal-title":"J. Infect. Dis."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0085","doi-asserted-by":"crossref","first-page":"13399","DOI":"10.1128\/JVI.77.24.13399-13402.2003","article-title":"Sequence analysis of recent H7 avian influenza viruses associated with three different outbreaks in commercial poultry in the United States","volume":"77","author":"Spackman","year":"2003","journal-title":"J. Virol."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0090","doi-asserted-by":"crossref","first-page":"9197","DOI":"10.1128\/JVI.00805-14","article-title":"Structure of influenza virus N7: the last piece of the neuraminidase \"jigsaw\" puzzle","volume":"88","author":"Sun","year":"2014","journal-title":"J. Virol."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0095","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001081","article-title":"Structures of receptor complexes of a North American H7N2 influenza hemagglutinin with a loop deletion in the receptor binding site","volume":"6","author":"Yang","year":"2010","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.rvsc.2020.03.017_bb0100","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1038\/nature05379","article-title":"The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA","volume":"444","author":"Ye","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.rvsc.2020.03.017_bb0105","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1099\/jgv.0.000770","article-title":"Enhanced pathogenicity and neurotropism of mouse-adapted H10N7 influenza virus are mediated by novel PB2 and NA mutations","volume":"98","author":"Zhang","year":"2017","journal-title":"J. Gen. Virol."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528819313773?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528819313773?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:19:43Z","timestamp":1758514783000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528819313773"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,6]]},"references-count":20,"alternative-id":["S0034528819313773"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2020.03.017","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2020,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Amino acid substitutions involved in the adaptation of a novel H7N7 avian influenza virus in mice","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2020.03.017","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}