{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T18:03:44Z","timestamp":1784657024707,"version":"3.55.0"},"reference-count":44,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001804","name":"Canada Research Chairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001804","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012236","name":"Alberta Agriculture and Forestry","doi-asserted-by":"publisher","award":["2018F009R"],"award-info":[{"award-number":["2018F009R"]}],"id":[{"id":"10.13039\/100012236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009192","name":"Alberta Innovates","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009410","name":"Universitat de Lleida","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008920","name":"University of Saskatchewan","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008920","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000190","name":"University of Alberta","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.rvsc.2020.10.012","type":"journal-article","created":{"date-parts":[[2020,10,17]],"date-time":"2020-10-17T19:26:36Z","timestamp":1602962796000},"page":"335-342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"special_numbering":"C","title":["Common and specific mineral and metabolic features in dairy cows with clinical metritis, hypocalcaemia or ketosis"],"prefix":"10.1016","volume":"135","author":[{"given":"Elda","family":"Dervishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graham","family":"Plastow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brent","family":"Hoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos","family":"Colazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2020.10.012_bb0005","doi-asserted-by":"crossref","first-page":"2939","DOI":"10.3168\/jds.S0022-0302(84)81657-4","article-title":"Manipulating dietary anions and cations for prepartum dairy cows to reduce incidence of milk fever","volume":"67","author":"Block","year":"1984","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0010","series-title":"Canadian Council on Animal Care CCAC Guidelines on: The Care and Use of Farm Animals in Research, Teaching and Testing","author":"Canadian Council on Animal Care","year":"2009"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0015","doi-asserted-by":"crossref","first-page":"3895","DOI":"10.3168\/jds.2010-3687","article-title":"Short communication: reference values for blood parameters in Holstein dairy cows: effects of parity, stage of lactation, and season of production","volume":"94","author":"Cozzi","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0020","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1016\/j.tvjl.2007.12.029","article-title":"Milk fever in dairy cows: a review of pathophysiology and control principles","volume":"176","author":"DeGaris","year":"2008","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0025","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.rvsc.2015.11.004","article-title":"Alterations in innate immunity reactants and carbohydrate and lipid metabolism precede occurrence of metritis in transition dairy cows","volume":"104","author":"Dervishi","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0030","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s11306-018-1379-z","article-title":"Urine metabolic fingerprinting can be used to predict the risk of metritis and highlight the pathobiology of the disease in dairy cows","volume":"14","author":"Dervishi","year":"2018","journal-title":"Metabolomics"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0035","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1159\/000480529","article-title":"Elevate apoptosis in the liver of dairy cows with ketosis","volume":"43","author":"Du","year":"2017","journal-title":"Cell. Physiol. Biochem."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0040","doi-asserted-by":"crossref","first-page":"5764","DOI":"10.3168\/jds.2010-3429","article-title":"Risk factors for postpartum uterine diseases in dairy cows","volume":"93","author":"Dubuc","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0045","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.3168\/jds.2010-3758","article-title":"Effects of postpartum uterine diseases on milk production and culling in dairy cows","volume":"94","author":"Dubuc","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0050","doi-asserted-by":"crossref","unstructured":"Duffield, T.F., Lissemore, K.D, McBride, B.W., and Leslie, K.E., 2009. Impact of hyperketonemia in early lactation dairy cows on health and production. J. Dairy Sci. 92, 571\u2013580.","DOI":"10.3168\/jds.2008-1507"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0055","doi-asserted-by":"crossref","first-page":"68","DOI":"10.3168\/jds.S0022-0302(89)79081-0","article-title":"A body condition scoring chart for Holstein dairy cows","volume":"72","author":"Edmonson","year":"1989","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0060","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1111\/j.1439-0396.1971.tb01573.x","article-title":"Calcium balance studies in dairy cows under experimental induction and prevention of hypocalcaemic paresis puerperalis. The solution of the aetiology and the prevention of milk fever by dietary means","volume":"28","author":"Ender","year":"1971","journal-title":"Z. Z. Tierphysiol. Tierernahr. Futtermittelkd"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0065","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.livsci.2019.05.016","article-title":"The factors associated with postpartum body condition score change and its relationship with serum analytes, milk production and reproductive performance in dairy cows","volume":"228","author":"Gobikrushanth","year":"2019","journal-title":"Livest. Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0070","doi-asserted-by":"crossref","first-page":"1292","DOI":"10.3168\/jds.S0022-0302(06)72197-X","article-title":"Major advances in our understanding of nutritional influences on bovine health","volume":"89","author":"Goff","year":"2006","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0075","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.tvjl.2007.12.020","article-title":"The monitoring, prevention, and treatment of milk fever and subclinical hypocalcemia in dairy cows","volume":"176","author":"Goff","year":"2008","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0080","doi-asserted-by":"crossref","first-page":"1520","DOI":"10.3168\/jds.2013-7467","article-title":"Diet-induced pseudohypoparathyroidism: a hypocalcemia and milk fever risk factor","volume":"97","author":"Goff","year":"2014","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0085","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1051\/vetres:2004063","article-title":"Haptoglobin and serum amyloid a in milk from dairy cows with chronic sub-clinical mastitis","volume":"36","author":"Gr\u00f6nlund","year":"2005","journal-title":"Vet. Res."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0090","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.3168\/jds.S0022-0302(97)76056-9","article-title":"Strategies for preventing milk fever in dairy cattle","volume":"80","author":"Horst","year":"1997","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0095","doi-asserted-by":"crossref","first-page":"3220","DOI":"10.3168\/jds.2006-807","article-title":"Prepartum behaviour and dry matter intake identify dairy cows at risk for metritis","volume":"90","author":"Huzzey","year":"2007","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0100","doi-asserted-by":"crossref","unstructured":"Huzzey, J.M., Duffield, T.F, LeBlanc, S.J, Veira, D.M, Weary, D.M., and von Keyserlingk M.A.G., 2009. Haptoglobin as an early indicator of metritis. J. Dairy Sci. 92, 621\u2013625.","DOI":"10.3168\/jds.2008-1526"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0105","doi-asserted-by":"crossref","first-page":"5878","DOI":"10.3168\/jds.2010-3391","article-title":"Associations of prepartum plasma cortisol, haptoglobin, fecal cortisol metabolites, and nonesterified fatty acids with postpartum health status in Holstein dairy cows","volume":"94","author":"Huzzey","year":"2011","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0110","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.prevetmed.2015.04.011","article-title":"Associations of peripartum markers of stress and inflammation with milk yield and reproductive performance in Holstein dairy cows","volume":"120","author":"Huzzey","year":"2015","journal-title":"Prev. Vet. Med."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0115","doi-asserted-by":"crossref","first-page":"S29","DOI":"10.1262\/jrd.1056S29","article-title":"Monitoring metabolic health of dairy cattle in the transition period","volume":"56","author":"LeBlanc","year":"2010","journal-title":"J Reprod Dev."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0120","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.rvsc.2017.06.019","article-title":"Accuracy of a cow-side test for the diagnosis of hyperketonemia and hypoglycemia in lactating dairy cows","volume":"115","author":"Macmillan","year":"2017","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0125","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.rvsc.2020.03.011","article-title":"The association of circulating pre partum metabolites, minerals, cytokines and hormones with postpartum health status in dairy cattle","volume":"130","author":"Macmillan","year":"2020","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0130","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.theriogenology.2020.03.034","article-title":"Relationships between early postpartum nutritional and metabolic profiles and subsequent reproductive performance of lactating dairy cows","volume":"151","author":"Macmillan","year":"2020","journal-title":"Theriogenology."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0135","doi-asserted-by":"crossref","first-page":"7158","DOI":"10.3168\/jds.2012-5812","article-title":"Evaluation of peripartal calcium status, energetic profile, and neutrophil function in dairy cows at low or high risk of developing uterine disease","volume":"95","author":"Martinez","year":"2012","journal-title":"J.Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0140","series-title":"National Research Council Nutrient Requirements of Dairy Cattle","author":"National Research Council","year":"2001"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0145","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cvfa.2004.06.006","article-title":"Monitoring and testing dairy herds for metabolic disease","volume":"20","author":"Oetzel","year":"2004","journal-title":"Vet. Clin. North Am. Food Anim. Pract."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0150","series-title":"American Association of Bovine Practitioners. 40th Annual Conference. Vancouver, BC, Canada","article-title":"Herd-level ketosis\u2013diagnosis and risk factors","author":"Oetzel","year":"2007"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0155","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.3168\/jds.2009-2852","article-title":"Associations of elevated nonesterified fatty acids and beta-hydroxybutyrate concentrations with early lactation reproductive performance and milk production in transition dairy cattle in the northeastern United States","volume":"93","author":"Ospina","year":"2010","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0160","doi-asserted-by":"crossref","first-page":"10398","DOI":"10.3168\/jds.2017-13054","article-title":"A 100-year review: metabolic health indicators and management of dairy cattle","volume":"100","author":"Overton","year":"2017","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0165","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.2215\/CJN.05910809","article-title":"Calcium metabolism in health and disease","volume":"5","author":"Peacock","year":"2010","journal-title":"Clin. J. Am. Soc. Nephrol."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0170","doi-asserted-by":"crossref","unstructured":"Pinedo, P, Velez, J., Solano, G., Rodriguez, N., Naves, J., Schuenemann, G.M, and Risco, C., 2017. Effect of oral calcium administration on the cure and reproductive performance of Holstein cows diagnosed with puerperal metritis. J. Dairy Sci. 100, 2917\u20132927.","DOI":"10.3168\/jds.2016-11577"},{"key":"10.1016\/j.rvsc.2020.10.012_bb5000","series-title":"RStudio: Integrated Development for R","author":"RStudio Team","year":"2019"},{"key":"10.1016\/j.rvsc.2020.10.012_bb0180","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.tvjl.2010.03.025","article-title":"Prevalence of subclinical hypocalcemia in dairy herds","volume":"188","author":"Reinhardt","year":"2011","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0185","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1016\/j.theriogenology.2005.08.021","article-title":"Defining postpartum uterine disease in cattle","volume":"65","author":"Sheldon","year":"2006","journal-title":"Theriogenology."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0190","doi-asserted-by":"crossref","first-page":"W251","DOI":"10.1093\/nar\/gkv380","article-title":"MetaboAnalyst 3.0\u2013\u2013making metabolomics more meaningful","volume":"43","author":"Xia","year":"2015","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0195","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.3168\/jds.2013-6846","article-title":"Effects of seasonal change and parity on raw milk composition and related indices in Chinese Holstein cows in northern China","volume":"96","author":"Yang","year":"2013","journal-title":"J. Dairy Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0200","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1385\/BTER:109:3:255","article-title":"Seasonal and physiological variations in serum chemistry and mineral concentrations in cattle","volume":"109","author":"Yokus","year":"2006","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0205","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s12011-011-9131-9","article-title":"Concentrations of sodium, potassium, magnesium, and iron in the serum of dairy cows with subclinical ketosis","volume":"144","author":"Zhang","year":"2011","journal-title":"Biol. Trace Elem. Res."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0210","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.rvsc.2016.06.012","article-title":"Dairy cows affected by ketosis show alterations in innate immunity and lipid and carbohydrate metabolism during the dry off period and postpartum","volume":"107","author":"Zhang","year":"2016","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0215","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s11306-017-1180-4","article-title":"Metabotyping reveals distinct metabolic alterations in ketotic cows and identifies early predictive serum biomarkers for the risk of disease","volume":"13","author":"Zhang","year":"2017","journal-title":"Metabolomics."},{"key":"10.1016\/j.rvsc.2020.10.012_bb0220","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.rvsc.2017.12.008","article-title":"Milk fever in dairy cows is preceded by activation of innate immunity and alterations in carbohydrate metabolism prior to disease occurrence","volume":"117","author":"Zhang","year":"2018","journal-title":"Res. Vet. Sci."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003452882031050X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003452882031050X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:26:39Z","timestamp":1758515199000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003452882031050X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":44,"alternative-id":["S003452882031050X"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2020.10.012","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Common and specific mineral and metabolic features in dairy cows with clinical metritis, hypocalcaemia or ketosis","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2020.10.012","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}