{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:53:56Z","timestamp":1786996436917,"version":"build-2736575974"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,5,1]],"date-time":"2021-05-01T00:00:00Z","timestamp":1619827200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31502035"],"award-info":[{"award-number":["31502035"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2021,5]]},"DOI":"10.1016\/j.rvsc.2021.03.002","type":"journal-article","created":{"date-parts":[[2021,3,5]],"date-time":"2021-03-05T12:12:31Z","timestamp":1614946351000},"page":"230-238","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["The pathologic lesions of liver caused by melamine alone or in combination with cyanuric acid in mice"],"prefix":"10.1016","volume":"136","author":[{"given":"Lingling","family":"Chang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiaoxing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruiping","family":"She","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10(11)","key":"10.1016\/j.rvsc.2021.03.002_bb0005","doi-asserted-by":"crossref","first-page":"e0142564","DOI":"10.1371\/journal.pone.0142564","article-title":"Melamine induces oxidative stress in mouse ovary","volume":"6","author":"Dai","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2021.03.002_bb0010","author":"Organisation for Economic Co-operation (OECD)"},{"issue":"2\u20133","key":"10.1016\/j.rvsc.2021.03.002_bb0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.jcpa.2011.12.008","article-title":"The pathological effects of melamine and cyanuric acid in the diet of walking catfish (Clarius batrachus)","volume":"147","author":"Pirarat","year":"2012","journal-title":"J Comp Pathol"},{"key":"10.1016\/j.rvsc.2021.03.002_bb0020","first-page":"379","article-title":"Protective effects of diallyl sulfide and curcumin separately against thallium-induced toxicity in rats","volume":"17","author":"Abdel-Daim","year":"2015","journal-title":"Cell J."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0025","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1007\/s12640-017-9731-z","article-title":"A brief review of neurotoxicity induced by melamine","volume":"32","author":"An","year":"2017","journal-title":"Neurotox Res"},{"key":"10.1016\/j.rvsc.2021.03.002_bb0030","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.pbb.2012.04.009","article-title":"Melamine induced cognitive impairment associated with oxidative damage in rat\u2019s hippocampus","volume":"102","author":"An","year":"2012","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0035","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1177\/104063870701900510","article-title":"Outbreaks of renal failure associated with melamine and cyanuric acid in dogs and cats in 2004 and 2007","volume":"19","author":"Brown","year":"2007","journal-title":"J. Vet. Diagn. Investig."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0040","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.rvsc.2015.08.018","article-title":"The toxic effect of a mixture of melamine and cyanuric acid on the gastrointestinal tract and liver in mice","volume":"102","author":"Chang","year":"2015","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0045","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.toxlet.2018.07.019","article-title":"Melamine causes testicular toxicity by destroying blood-testis barrier in piglets","volume":"296","author":"Chang","year":"2018","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0050","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3760\/cma.j.issn.0366-6999.2009.03.001","article-title":"A worldwide food safety concern in 2008--melamine-contaminated infant formula in China caused urinary tract stone in 290,000 children in China","volume":"122","author":"Chen","year":"2009","journal-title":"Chin. Med. J."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0055","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/toxsci\/kfn160","article-title":"Identification and characterization of toxicity of contaminants in pet food leading to an outbreak of renal toxicity in cats and dogs","volume":"106","author":"Dobson","year":"2008","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0060","doi-asserted-by":"crossref","first-page":"786051","DOI":"10.1155\/2013\/786051","article-title":"Bees\u2019 honey protects the liver of male rats against melamine toxicity","volume":"2013","author":"El Rabey","year":"2013","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0065","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/01926230701320337","article-title":"Apoptosis: a review of programmed cell death","volume":"35","author":"Elmore","year":"2007","journal-title":"Toxicol. Pathol."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0070","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1046\/j.1471-4159.2003.01821.x","article-title":"Differential effect of nitric oxide on glutathione metabolism and mitochondrial function in astrocytes and neurones: implications for neuroprotection\/neurodegeneration?","volume":"86","author":"Gegg","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0075","first-page":"1","article-title":"Gemcitabine induced cytotoxicity, DNA damage and hepatic injury in laboratory mice","author":"Hailan","year":"2018","journal-title":"Drug Chem Toxicol"},{"issue":"4","key":"10.1016\/j.rvsc.2021.03.002_bb0080","first-page":"247","article-title":"Liver involvement in melamine-associated nephrolithiasis","volume":"15","author":"Hu","year":"2012","journal-title":"Arch Iran Med"},{"key":"10.1016\/j.rvsc.2021.03.002_bb0085","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00240-010-0254-9","article-title":"The mechanism of renal stone formation and renal failure induced by administration of melamine and cyanuric acid","volume":"38","author":"Kobayashi","year":"2010","journal-title":"Urol. Res."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0090","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/S0895-3988(09)60030-1","article-title":"Study on migration of melamine from food packaging materials on markets","volume":"22","author":"Lu","year":"2009","journal-title":"Biomed. Environ. Sci."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0095","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.yrtph.2012.11.011","article-title":"Effect on morphology, oxidative stress and energy metabolism enzymes in the testes of mice after a 13-week oral administration of melamine and cyanuric acid combination","volume":"65","author":"Lv","year":"2013","journal-title":"Regul. Toxicol. Pharmacol."},{"issue":"2","key":"10.1016\/j.rvsc.2021.03.002_bb0100","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/0041-008X(84)90314-4","article-title":"Urolithiasis and bladder carcinogenicity of melamine in rodents","volume":"72","author":"Melnick","year":"1984","journal-title":"Toxicol. Appl.Pharmacol."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0105","doi-asserted-by":"crossref","first-page":"1609","DOI":"10.1007\/s10695-014-9952-5","article-title":"Melamine-cyanurate complexes and oxidative stress markers in trout kidney following melamine and cyanuric acid long-term co-exposure and withdrawal","volume":"40","author":"Pacini","year":"2014","journal-title":"Fish Physiol. Biochem."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0110","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1111\/jfd.12219","article-title":"Pathophysiological changes associated with dietary melamine and cyanuric acid toxicity in red tilapia","volume":"38","author":"Phromkunthong","year":"2015","journal-title":"J. Fish Dis."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0115","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.envpol.2004.06.015","article-title":"Evaluation of photolysis and hydrolysis of atrazine and its first degradation products in the presence of humic acids","volume":"133","author":"Prosen","year":"2005","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0120","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.cll.2010.10.003","article-title":"Toxicosis caused by melamine and cyanuric acid in dogs and cats: uncovering the mystery and subsequent global implications","volume":"31","author":"Puschner","year":"2011","journal-title":"Clin. Lab. Med."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0125","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1177\/104063870701900602","article-title":"Assessment of melamine and cyanuric acid toxicity in cats","volume":"19","author":"Puschner","year":"2007","journal-title":"J. Vet. Diagn. Investig."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0130","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.aquatox.2012.03.018","article-title":"The interplay between thiol-compounds against chromium (VI) in the freshwater green alga Monoraphidium convolutum: toxicology, photosynthesis, and oxidative stress at a glance","volume":"118-119","author":"Takami","year":"2012","journal-title":"Aquat. Toxicol."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0135","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00216-009-3009-0","article-title":"Melamine contamination","volume":"395","author":"Tyan","year":"2009","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0140","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1834-7819.2009.01123.x","article-title":"Lipid peroxidation levels, total oxidant status and superoxide dismutase in serum, saliva and gingival crevicular fluid in chronic periodontitis patients before and after periodontal therapy","volume":"55","author":"Wei","year":"2010","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0145","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0895-3988(09)60028-3","article-title":"A survey on occurrence of melamine and its analogues in tainted infant formula in China","volume":"22","author":"Wu","year":"2009","journal-title":"Biomed. Environ. Sci."},{"issue":"3","key":"10.1016\/j.rvsc.2021.03.002_bb0150","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1016\/j.rvsc.2014.10.001","article-title":"The toxic effects of melamine on spleen lymphocytes with or without cyanuric acid in mice","volume":"97","author":"Yin","year":"2014","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2021.03.002_bb0155","doi-asserted-by":"crossref","first-page":"2690","DOI":"10.1111\/febs.13527","article-title":"Discoveries and controversies in BCL-2 protein-mediated apoptosis","volume":"283","author":"Zheng","year":"2016","journal-title":"FEBS J."},{"issue":"172","key":"10.1016\/j.rvsc.2021.03.002_bb0160","doi-asserted-by":"crossref","first-page":"172ra22","DOI":"10.1126\/scitranslmed.3005114","article-title":"Melamine-induced renal toxicity is mediated by the gut microbiota","volume":"5","author":"Zheng","year":"2013","journal-title":"Sci Transl Med."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528821000643?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528821000643?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:24:55Z","timestamp":1758515095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528821000643"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5]]},"references-count":32,"alternative-id":["S0034528821000643"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2021.03.002","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2021,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The pathologic lesions of liver caused by melamine alone or in combination with cyanuric acid in mice","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2021.03.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}