{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:44:51Z","timestamp":1780091091610,"version":"3.54.0"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T00:00:00Z","timestamp":1633046400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2662021DKQD003"],"award-info":[{"award-number":["2662021DKQD003"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["31772784"],"award-info":[{"award-number":["31772784"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["2662021DKQD003"],"award-info":[{"award-number":["2662021DKQD003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["31772784"],"award-info":[{"award-number":["31772784"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["2662021DKQD003"],"award-info":[{"award-number":["2662021DKQD003"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","award":["31772784"],"award-info":[{"award-number":["31772784"]}],"id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2021,10]]},"DOI":"10.1016\/j.rvsc.2021.07.014","type":"journal-article","created":{"date-parts":[[2021,7,16]],"date-time":"2021-07-16T12:02:09Z","timestamp":1626436929000},"page":"133-139","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Icariin and its phosphorylated derivatives reduce duck hepatitis A virus serotype 1-induced oxidative stress and inflammatory damage in duck embryonic hepatocytes through mitochondrial regulation"],"prefix":"10.1016","volume":"139","author":[{"given":"Wen","family":"Xiong","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wensai","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyun","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanliang","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaguo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2021.07.014_bb0005","doi-asserted-by":"crossref","first-page":"853175","DOI":"10.1155\/2012\/853175","article-title":"Oxidative stress and inflammation: essential partners in alcoholic liver disease","volume":"2012","author":"Ambade","year":"2012","journal-title":"Int. J. Hepatol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0010","series-title":"Annual Review of Physiology","first-page":"533","article-title":"Supramolecular Organization of Respiratory Complexes","volume":"vol. 78","author":"Antonio Enriquez","year":"2016"},{"key":"10.1016\/j.rvsc.2021.07.014_bb0015","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/5698931","article-title":"Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?","volume":"2016","author":"Biswas","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0020","first-page":"69","article-title":"The NF-kappa B-mediated control of ROS and JNK signaling","volume":"21","author":"Bubici","year":"2006","journal-title":"Histol. Histopathol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0025","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/j.cell.2006.06.010","article-title":"Mitochondria: dynamic organelles in disease, aging, and development","volume":"125","author":"Chan","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.rvsc.2021.07.014_bb0030","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.carbpol.2018.06.039","article-title":"Effects of bush Sophora root polysaccharide and its sulfate on DHAV-1 replication","volume":"197","author":"Chen","year":"2018","journal-title":"Carbohydr. Polym."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0035","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.3382\/ps\/pey255","article-title":"Inhibition mechanisms of baicalin and its phospholipid complex against DHAV-1 replication","volume":"97","author":"Chen","year":"2018","journal-title":"Poult. Sci."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0040","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.neulet.2011.08.045","article-title":"Prevention of extracellular ADP-induced ATP accumulation of the cultured rat spinal astrocytes via P2Y(1)-mediated inhibition of AMPK","volume":"503","author":"Cui","year":"2011","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0045","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.pnpbp.2017.06.036","article-title":"The interplay between inflammation, oxidative stress, DNA damage, DNA repair and mitochondrial dysfunction in depression","volume":"80","author":"Czarny","year":"2018","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.rvsc.2021.07.014_bb0050","doi-asserted-by":"crossref","first-page":"30269","DOI":"10.3390\/ijms161226225","article-title":"Oxidative stress and inflammation in hepatic diseases: therapeutic possibilities of N-Acetylcysteine","volume":"16","author":"de Andrade","year":"2015","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2015.00179","article-title":"The complex myeloid network of the liver with diverse functional capacity at steady state and in inflammation","volume":"6","author":"Eckert","year":"2015","journal-title":"Front. Immunol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0060","doi-asserted-by":"crossref","first-page":"4434","DOI":"10.1074\/jbc.R111.271999","article-title":"Signal transduction by mitochondrial oxidants","volume":"287","author":"Finkel","year":"2012","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0065","doi-asserted-by":"crossref","DOI":"10.1161\/CIRCRESAHA.117.311401","article-title":"Reactive oxygen species in metabolic and inflammatory signaling","volume":"122","author":"Forrester","year":"2018","journal-title":"Circ. Res."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0070","doi-asserted-by":"crossref","first-page":"1704","DOI":"10.1053\/j.gastro.2016.01.025","article-title":"Inflammation in alcoholic and nonalcoholic fatty liver disease: friend or foe?","volume":"150","author":"Gao","year":"2016","journal-title":"Gastroenterology"},{"key":"10.1016\/j.rvsc.2021.07.014_bb0075","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1038\/nrm.2017.95","article-title":"AMPK: guardian of metabolism and mitochondrial homeostasis","volume":"19","author":"Herzig","year":"2018","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0080","doi-asserted-by":"crossref","first-page":"1327","DOI":"10.1007\/s10495-016-1295-5","article-title":"Mitochondrial dynamics during cell cycling","volume":"21","author":"Horbay","year":"2016","journal-title":"Apoptosis"},{"key":"10.1016\/j.rvsc.2021.07.014_bb0085","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbrc.2008.01.055","article-title":"Interplay between bax, reactive oxygen species production, and cardiolipin oxidation during apoptosis","volume":"368","author":"Jiang","year":"2008","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0090","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/j.bbrc.2010.06.088","article-title":"Silencing stromal interaction molecule 1 by RNA interference inhibits the proliferation and migration of endothelial progenitor cells","volume":"398","author":"Kuang","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0095","doi-asserted-by":"crossref","DOI":"10.3390\/ijms17040465","article-title":"Hepatoprotective effects of Chinese medicinal herbs: a focus on anti-inflammatory and anti-oxidative activities","volume":"17","author":"Lam","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0100","first-page":"139","article-title":"An important role of Nrf2-ARE pathway in the cellular defense mechanism","volume":"37","author":"Lee","year":"2004","journal-title":"J. Biochem. Mol. Biol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0105","doi-asserted-by":"crossref","DOI":"10.1155\/2016\/4234061","article-title":"Insights into the role and interdependence of oxidative stress and inflammation in liver diseases","volume":"2016","author":"Li","year":"2016","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0110","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1136\/ard.2004.022152","article-title":"Effect of nitric oxide on mitochondrial respiratory activity of human articular chondrocytes","volume":"64","author":"Maneiro","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0115","doi-asserted-by":"crossref","first-page":"R551","DOI":"10.1016\/j.cub.2006.06.054","article-title":"Mitochondria: more than just a powerhouse","volume":"16","author":"McBride","year":"2006","journal-title":"Curr. Biol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0120","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.taap.2009.06.009","article-title":"Nrf2 signaling and cell survival","volume":"244","author":"Niture","year":"2010","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0125","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1080\/03602530701468516","article-title":"Reactive oxygen species in mitochondria-mediated cell death","volume":"39","author":"Orrenius","year":"2007","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0130","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/hep.27332","article-title":"Hepatic inflammation and fibrosis: functional links and key pathways","volume":"61","author":"Seki","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.rvsc.2021.07.014_bb0135","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1007\/s00204-013-1034-4","article-title":"Oxidative stress: the mitochondria-dependent and mitochondria-independent pathways of apoptosis","volume":"87","author":"Sinha","year":"2013","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0140","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.mad.2016.07.007","article-title":"ER fatalities-the role of ER-mitochondrial contact sites in yeast life and death decisions","volume":"161","author":"Smethurst","year":"2017","journal-title":"Mech. Ageing Dev."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0145","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1146\/annurev.immunol.21.120601.141126","article-title":"Toll-like receptors","volume":"21","author":"Takeda","year":"2003","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0150","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8167","article-title":"Stk38 protein kinase preferentially inhibits TLR9-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages","volume":"6","author":"Wen","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0155","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-014-0226-3","article-title":"Roles of the antioxidant properties of icariin and its phosphorylated derivative in the protection against duck virus hepatitis","volume":"10","author":"Xiong","year":"2014","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0160","doi-asserted-by":"crossref","DOI":"10.1186\/s12917-015-0459-9","article-title":"Determine the structure of phosphorylated modification of icariin and its antiviral activity against duck hepatitis virus A","volume":"11","author":"Xiong","year":"2015","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0165","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2017.01850","article-title":"Phosphorylation of Icariin Can Alleviate the Oxidative stress caused by the duck hepatitis virus A through mitogen-activated protein kinases signaling pathways","volume":"8","author":"Xiong","year":"2017","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0170","doi-asserted-by":"crossref","first-page":"1783","DOI":"10.1096\/fj.201902265R","article-title":"Icariin and its phosphorylated derivatives alleviate intestinal epithelial barrier disruption caused by enterotoxigenic Escherichia coli through modulate p38 MAPK in vivo and in vitro","volume":"34","author":"Xiong","year":"2020","journal-title":"FASEB J."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0175","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/j.freeradbiomed.2017.10.382","article-title":"White light emitting diode suppresses proliferation and induces apoptosis in hippocampal neuron cells through mitochondrial cytochrome c oxydase-mediated IGF-1 and TNF-alpha pathways","volume":"113","author":"Yang","year":"2017","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.rvsc.2021.07.014_bb0180","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2013.367","article-title":"Drugs to cure avian influenza infection - multiple ways to prevent cell death","volume":"4","author":"Yuan","year":"2013","journal-title":"Cell Death Dis."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528821002307?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528821002307?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:23:49Z","timestamp":1758515029000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528821002307"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10]]},"references-count":36,"alternative-id":["S0034528821002307"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2021.07.014","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2021,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Icariin and its phosphorylated derivatives reduce duck hepatitis A virus serotype 1-induced oxidative stress and inflammatory damage in duck embryonic hepatocytes through mitochondrial regulation","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2021.07.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}