{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T03:36:11Z","timestamp":1788406571936,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,3,1]],"date-time":"2022-03-01T00:00:00Z","timestamp":1646092800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2022,3]]},"DOI":"10.1016\/j.rvsc.2021.12.014","type":"journal-article","created":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T01:22:10Z","timestamp":1640222530000},"page":"41-49","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["Identification of a novel broad-spectrum endolysin, Ply0643, with high antibacterial activity in mouse models of streptococcal bacteriaemia and mastitis"],"prefix":"10.1016","volume":"143","author":[{"given":"Guangjin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Mao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zihao","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changming","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huochun","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2021.12.014_bb0005","doi-asserted-by":"crossref","first-page":"7847","DOI":"10.1128\/JB.186.23.7847-7857.2004","article-title":"Transcriptional activation of sclA by Mga requires a distal binding site in Streptococcus pyogenes","volume":"186","author":"Almengor","year":"2004","journal-title":"J. Bacteriol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0010","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1007\/s00253-006-0771-1","article-title":"Mutagenesis of a bacteriophage lytic enzyme PlyGBS significantly increases its antibacterial activity against group B streptococci","volume":"74","author":"Cheng","year":"2007","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0015","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1128\/AAC.49.1.111-117.2005","article-title":"Removal of group B streptococci colonizing the vagina and oropharynx of mice with a bacteriophage lytic enzyme","volume":"49","author":"Cheng","year":"2005","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0020","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.tim.2005.08.007","article-title":"Bacteriophage lytic enzymes: novel anti-infectives","volume":"13","author":"Fischetti","year":"2005","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0025","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.ijmm.2010.04.002","article-title":"Bacteriophage endolysins: a novel anti-infective to control Gram-positive pathogens","volume":"300","author":"Fischetti","year":"2010","journal-title":"Int. J. Med. Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0030","doi-asserted-by":"crossref","first-page":"100086","DOI":"10.1016\/j.onehlt.2019.100086","article-title":"A one health perspective on dairy production and dairy food safety","volume":"7","author":"Garcia","year":"2019","journal-title":"One Health"},{"key":"10.1016\/j.rvsc.2021.12.014_bb0035","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/AAC.02526-12","article-title":"Novel bacteriophage lysin with broad lytic activity protects against mixed infection by Streptococcus pyogenes and methicillin-resistant Staphylococcus aureus","volume":"57","author":"Gilmer","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0040","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00071-17","article-title":"Recombinant endolysins as potential therapeutics against antibiotic-resistant staphylococcus aureus: current status of research and novel delivery strategies","volume":"31","author":"Haddad Kashani","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0045","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1128\/AEM.01831-08","article-title":"Phage lysin LysK can be truncated to its CHAP domain and retain lytic activity against live antibiotic-resistant staphylococci","volume":"75","author":"Horgan","year":"2009","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0050","doi-asserted-by":"crossref","first-page":"118","DOI":"10.3389\/fcimb.2016.00118","article-title":"Evolution and diversity of the antimicrobial resistance associated mobilome in streptococcus suis: A probable mobile genetic elements reservoir for other streptococci","volume":"6","author":"Huang","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0055","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1186\/1471-2164-14-775","article-title":"Comparative genomics analysis of Streptococcus agalactiae reveals that isolates from cultured tilapia in China are closely related to the human strain A909","volume":"14","author":"Liu","year":"2013","journal-title":"BMC Genomics"},{"key":"10.1016\/j.rvsc.2021.12.014_bb0060","doi-asserted-by":"crossref","first-page":"2170","DOI":"10.1126\/science.1066869","article-title":"Rapid killing of Streptococcus pneumoniae with a bacteriophage cell wall hydrolase","volume":"294","author":"Loeffler","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.rvsc.2021.12.014_bb0065","doi-asserted-by":"crossref","first-page":"6199","DOI":"10.1128\/IAI.71.11.6199-6204.2003","article-title":"Phage lytic enzyme Cpl-1 as a novel antimicrobial for pneumococcal bacteremia","volume":"71","author":"Loeffler","year":"2003","journal-title":"Infect. Immun."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0070","doi-asserted-by":"crossref","first-page":"4107","DOI":"10.1073\/pnas.061038398","article-title":"Prevention and elimination of upper respiratory colonization of mice by group A streptococci by using a bacteriophage lytic enzyme","volume":"98","author":"Nelson","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0075","doi-asserted-by":"crossref","first-page":"6276","DOI":"10.1128\/AAC.01701-13","article-title":"In vitro characterization of PlySK1249, a novel phage lysin, and assessment of its antibacterial activity in a mouse model of Streptococcus agalactiae bacteremia","volume":"57","author":"Oechslin","year":"2013","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0080","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fmicb.2011.00235","article-title":"Streptococcus suis, an Emerging Drug-Resistant Animal and Human Pathogen","volume":"2","author":"Palmieri","year":"2011","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0085","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1099\/mic.0.27063-0","article-title":"The bifunctional peptidoglycan lysin of Streptococcus agalactiae bacteriophage B30","volume":"150","author":"Pritchard","year":"2004","journal-title":"Microbiology"},{"key":"10.1016\/j.rvsc.2021.12.014_bb0090","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.2217\/fmb.12.97","article-title":"Bacteriophage endolysins as novel antimicrobials","volume":"7","author":"Schmelcher","year":"2012","journal-title":"Future Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0095","doi-asserted-by":"crossref","first-page":"8475","DOI":"10.1007\/s00253-015-6579-0","article-title":"Synergistic streptococcal phage lambda SA2 and B30 endolysins kill streptococci in cow milk and in a mouse model of mastitis","volume":"99","author":"Schmelcher","year":"2015","journal-title":"Appl. Microbiol. Biotechnol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0100","doi-asserted-by":"crossref","first-page":"7377","DOI":"10.1128\/AEM.02300-15","article-title":"Prophage lysin Ply30 protects mice from Streptococcus suis and Streptococcus equi subsp. zooepidemicus infections","volume":"81","author":"Tang","year":"2015","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0105","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.micpath.2019.03.035","article-title":"Antimicrobial resistance and virulence genes of Streptococcus isolated from dairy cows with mastitis in China","volume":"131","author":"Tian","year":"2019","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0110","doi-asserted-by":"crossref","DOI":"10.3390\/antibiotics9090621","article-title":"Characterization of the bacteriophage-derived endolysins PlySs2 and PlySs9 with In vitro lytic activity against bovine mastitis streptococcus uberis","volume":"9","author":"Vander Elst","year":"2020","journal-title":"Antibiotics"},{"key":"10.1016\/j.rvsc.2021.12.014_bb0115","doi-asserted-by":"crossref","first-page":"40182","DOI":"10.1038\/srep40182","article-title":"A novel chimeric lysin with robust antibacterial activity against planktonic and biofilm methicillin-resistant Staphylococcus aureus","volume":"7","author":"Yang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0120","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s12917-018-1732-5","article-title":"Antimicrobial susceptibility of Streptococcus suis isolated from diseased pigs, asymptomatic pigs, and human patients in Thailand","volume":"15","author":"Yongkiettrakul","year":"2019","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0125","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/S0966-842X(00)01705-4","article-title":"Phages will out: strategies of host cell lysis","volume":"8","author":"Young","year":"2000","journal-title":"Trends Microbiol."},{"key":"10.1016\/j.rvsc.2021.12.014_bb0130","doi-asserted-by":"crossref","DOI":"10.1128\/IAI.00377-19","article-title":"Identification of an Autorepressing Two-Component Signaling System That Modulates Virulence in Streptococcus suis Serotype 2","volume":"87","author":"Zhong","year":"2019","journal-title":"Infect. Immun."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528821003581?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528821003581?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:25:23Z","timestamp":1758515123000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528821003581"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,3]]},"references-count":26,"alternative-id":["S0034528821003581"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2021.12.014","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2022,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of a novel broad-spectrum endolysin, Ply0643, with high antibacterial activity in mouse models of streptococcal bacteriaemia and mastitis","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2021.12.014","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}