{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:41:29Z","timestamp":1765546889535,"version":"3.44.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003046","name":"Empresa Brasileira de Pesquisa Agropecuaria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003046","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2022,10]]},"DOI":"10.1016\/j.rvsc.2022.04.006","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T04:41:26Z","timestamp":1650861686000},"page":"92-95","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Upregulated genes in articular cartilage may help to counteract femoral head separation in broilers with 21\u00a0days of age"],"prefix":"10.1016","volume":"147","author":[{"given":"Carlos Eduardo","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane de Oliveira","family":"Peixoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lana Teixeira","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u00e9bora Ester Petry","family":"Marcelino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vicky Lilge","family":"Kawski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Tonello","family":"Neis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00f4nica Corr\u00eaa","family":"Ledur","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adriana M\u00e9rcia Guaratini","family":"Ibelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2022.04.006_bb0005","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s11302-006-9033-z","article-title":"P1 receptors and cytokine secretion","volume":"3","author":"Abbracchio","year":"2007","journal-title":"Purinergic Signal"},{"issue":"11","key":"10.1016\/j.rvsc.2022.04.006_bb0010","first-page":"1","article-title":"Adenosine deaminase modulates metabolic remodeling and orchestrates joint destruction in rheumatoid arthritis","volume":"111","author":"Bhagavatham","year":"2021","journal-title":"Sci. Report."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0015","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.micpath.2016.02.008","article-title":"Ectonucleotidases and adenosine deaminase activity in laying hens naturally infected by Salmonella Gallinarum and their effects on the pathogenesis of the disease","volume":"93","author":"Boiago","year":"2016","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0020","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3184\/147020602783698421","article-title":"A review of the aetiology and pathology of leg weakness in broilers in relation to welfare","volume":"13","author":"Bradshaw","year":"2002","journal-title":"Avian Poult. Biol. Rev."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0025","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/j.1365-2443.2010.01483.x","article-title":"Evidence for a role of angiopoietin-like 7 (ANGPTL7) in extracellular matrix formation of the human trabecular meshwork: implications for glaucoma","volume":"16","author":"Comes","year":"2011","journal-title":"Genes Cells"},{"key":"10.1016\/j.rvsc.2022.04.006_bb0030","article-title":"Association of Apolipoprotein B and Adiponectin Receptor 1 genes with carcass, bone integrity and performance traits in a paternal broiler line","volume":"10","author":"da Cruz","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2022.04.006_bb0035","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1080\/00071660902942783","article-title":"Clinical and morphological investigations on the prevalence of lameness associated with femoral head necrosis in broilers","volume":"50","author":"Dinev","year":"2009","journal-title":"Br. Poult. Sci."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0040","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1096\/fj.07-9097com","article-title":"RhAG protein of the Rhesus complex is a CO2 channel in the human red cell membrane","volume":"22","author":"Endeward","year":"2008","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.rvsc.2022.04.006_bb0045","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1038\/nri1180","article-title":"Defensins: antimicrobial peptides of innate immunity","volume":"39","author":"Ganz","year":"2003","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0050","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1152\/ajpcell.00092.2011","article-title":"Human RhAG ammonia channel is impaired by the Phe65Ser mutation in overhydrated stomatocytic red cells","volume":"302","author":"Genetet","year":"2012","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0055","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.3382\/ps.2011-01948","article-title":"Differential gene expression profiles of \u03b2-defensins in the crop, intestine, and spleen using a necrotic enteritis model in 2 commercial broiler chicken lines","volume":"91","author":"Hong","year":"2012","journal-title":"Poult. Sci."},{"issue":"8","key":"10.1016\/j.rvsc.2022.04.006_bb0060","doi-asserted-by":"crossref","first-page":"e0238189","DOI":"10.1371\/journal.pone.0238189","article-title":"Reference genes for proximal femoral epiphysiolysis expression studies in broilers cartilage","volume":"15","author":"Hul","year":"2020","journal-title":"PLoS One"},{"issue":"111","key":"10.1016\/j.rvsc.2022.04.006_bb0065","doi-asserted-by":"crossref","first-page":"17965","DOI":"10.1038\/s41598-021-97306-3","article-title":"Differentially expressed genes in the femur cartilage transcriptome clarify the understanding of femoral head separation in chickens","volume":"2021","author":"Hul","year":"2021","journal-title":"Sci. Report."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0070","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.3382\/ps.2012-02156","article-title":"Footpad dermatitis in Dutch broiler flocks: prevalence and factors of influence","volume":"91","author":"de Jong","year":"2012","journal-title":"Poult. Sci."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0075","doi-asserted-by":"crossref","first-page":"1773","DOI":"10.1093\/ps\/77.12.1773","article-title":"Rapid growth problems: ascites and skeletal deformities in broilers","volume":"77","author":"Julian","year":"1998","journal-title":"Poult. Sci."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0080","doi-asserted-by":"crossref","DOI":"10.1111\/febs.15776","article-title":"A guide to the composition and functions of the extracellular matrix","author":"Karamanos","year":"2021","journal-title":"FEBS J."},{"issue":"12","key":"10.1016\/j.rvsc.2022.04.006_bb0085","first-page":"1","article-title":"Tissue expression and antibacterial activity of host defense peptides in chicken","volume":"121","author":"Lee","year":"2016","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0090","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.3382\/ps\/pev071","article-title":"Downregulation of basic fibroblast growth factor is associated with femoral head necrosis in broilers","volume":"94","author":"Li","year":"2015","journal-title":"Poult. Sci."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0095","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/j.imlet.2007.03.007","article-title":"Avian beta-defensin nomenclature: a community proposed update","volume":"110","author":"Lynn","year":"2007","journal-title":"Immunol. Lett."},{"issue":"6","key":"10.1016\/j.rvsc.2022.04.006_bb0100","first-page":"1","article-title":"An investigation into blood microbiota and its potential association with bacterial Chondronecrosis with osteomyelitis (BCO) in broilers","volume":"61","author":"Mandal","year":"2016","journal-title":"Sci. Report."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0105","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1637\/11082-040715-Review.1","article-title":"Poultry femoral head separation and necrosis: a review","volume":"59","author":"Packialakshmi","year":"2015","journal-title":"Avian Dis."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0110","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1017\/S1751731116002433","article-title":"The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers","volume":"11","author":"Paludo","year":"2017","journal-title":"Animal"},{"issue":"17","key":"10.1016\/j.rvsc.2022.04.006_bb0115","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1007\/s10456-014-9435-4","article-title":"Angiopoietin-like 7, a novel pro-angiogenetic factor over-expressed in cancer","volume":"174","author":"Parri","year":"2014","journal-title":"Angiogenes"},{"key":"10.1016\/j.rvsc.2022.04.006_bb0120","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1074\/jbc.M105746200","article-title":"The angiopoietin-like factor cornea-derived transcript 6 is a putative morphogen for human cornea","volume":"277","author":"Peek","year":"2002","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0125","article-title":"Proximal femoral head transcriptome reveals novel candidate genes related to epiphysiolysis in broiler chickens","volume":"20","author":"Peixoto","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.rvsc.2022.04.006_bb0130","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.livsci.2017.12.003","article-title":"New genes involved in the bacterial chondronecrosis with osteomyelitis in commercial broilers","volume":"208","author":"Petry","year":"2018","journal-title":"Livest. Sci."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0135","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative CT method","volume":"3","author":"Schmittgen","year":"2008","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0140","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.3382\/ps\/pew468","article-title":"Expression of host defense peptides in the intestine of Eimeria-challenged chickens","volume":"96","author":"Su","year":"2017","journal-title":"Poult. Sci."},{"issue":"36","key":"10.1016\/j.rvsc.2022.04.006_bb0150","first-page":"1","article-title":"Breeding for efficiency in the broiler chicken: a review","volume":"364","author":"Tallentire","year":"2016","journal-title":"Agron. Sustain. Dev."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0155","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.joca.2004.01.002","article-title":"Endogenously produced adenosine regulates articular cartilage matrix homeostasis: enzymatic depletion of adenosine stimulates matrix degradation","volume":"12","author":"Tesch","year":"2004","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0160","first-page":"183","article-title":"Bone circulatory disturbances in the development of spontaneous bacterial chondronecrosis with osteomyelitis: a translational model for the pathogenesis of femoral head necrosis","author":"Wideman","year":"2013","journal-title":"Front. Endocrinol. (Lausanne)"},{"key":"10.1016\/j.rvsc.2022.04.006_bb0165","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1080\/03079457.2017.1349872","article-title":"Pathological and microbiological investigations into cases of bacterial chondronecrosis and osteomyelitis in broiler poultry","volume":"46","author":"Wijesurendra","year":"2017","journal-title":"Avian Pathol."},{"issue":"22","key":"10.1016\/j.rvsc.2022.04.006_bb0170","first-page":"1","article-title":"HEMGN and SLC2A1 might be potential diagnostic biomarkers of steroid-induced osteonecrosis of femoral head: study based on WGCNA and DEGs screening","volume":"221","author":"Wu","year":"2021","journal-title":"BMC Musculoskelet. Disord."},{"key":"10.1016\/j.rvsc.2022.04.006_bb0175","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1186\/1471-2105-13-134","article-title":"Primer-BLAST: a tool to design target-specific primers for polymerase chain reaction","volume":"13","author":"Ye","year":"2012","journal-title":"BMC Bioinform."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528822001151?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528822001151?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:26:49Z","timestamp":1758515209000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528822001151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,10]]},"references-count":34,"alternative-id":["S0034528822001151"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2022.04.006","relation":{},"ISSN":["0034-5288"],"issn-type":[{"type":"print","value":"0034-5288"}],"subject":[],"published":{"date-parts":[[2022,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Upregulated genes in articular cartilage may help to counteract femoral head separation in broilers with 21\u00a0days of age","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2022.04.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}