{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T23:23:32Z","timestamp":1767914612671,"version":"3.49.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,6,1]],"date-time":"2023-06-01T00:00:00Z","timestamp":1685577600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2023,6]]},"DOI":"10.1016\/j.rvsc.2023.04.022","type":"journal-article","created":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T11:27:35Z","timestamp":1682681255000},"page":"252-256","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Efficacy of a single dose of nitazoxanide in dogs naturally infected with Giardia duodenalis"],"prefix":"10.1016","volume":"159","author":[{"given":"Felipe","family":"Romano","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3578-3087","authenticated-orcid":false,"given":"Maria Anete","family":"Lallo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2023.04.022_bb0005","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1007\/s40475-021-00248-z","article-title":"Giardia duodenalis virulence - \u201cto be, or not to be\u201d","volume":"8","author":"Arg\u00fcello-Garc\u00eda","year":"2021","journal-title":"Curr. Trop. Med. Rep."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0010","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.pt.2010.02.005","article-title":"Giardiasis in dogs and cats: update on epidemiology and public health significance","volume":"26","author":"Ballweber","year":"2010","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0015","doi-asserted-by":"crossref","first-page":"988","DOI":"10.2460\/ajvr.1994.55.07.988","article-title":"Efficacy of fenbendazole against giardiasis in dogs","volume":"55","author":"Barr","year":"1994","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1007250","article-title":"Five facts about Giardia lamblia","volume":"14","author":"Cernikova","year":"2018","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0025","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/j.pt.2017.02.006","article-title":"Pathogenic mechanisms of Cryptosporidium and Giardia","volume":"33","author":"Certad","year":"2017","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.vetpar.2019.08.005","article-title":"Successful use of secnidazole to manage a giardiosis outbreak in a shelter","volume":"274","author":"Cheung","year":"2019","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bib156","doi-asserted-by":"crossref","first-page":"626424","DOI":"10.3389\/fvets.2021.626424","article-title":"Effectiveness of fenbendazole and metronidazole against Giardia infection in dogs monitored for 50-days in home-conditions","volume":"8","author":"Ciuca","year":"2021","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0035","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.parint.2011.06.024","article-title":"Secnidazole for the treatment of giardiasis in naturally infected cats","volume":"60","author":"Da Silva","year":"2011","journal-title":"Parasitol. Int."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0040","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.ijpddr.2021.05.003","article-title":"In vitro selection of Giardia duodenalis for albendazole resistance identifies a \u03b2-tubulin mutation at amino acid E198K","volume":"16","author":"Emery-Corbin","year":"2021","journal-title":"Int. J. Parasitol. Drugs Drug Resist."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0045","first-page":"110","article-title":"A field clinical study to confirm the efficacy and safety of a metronidazole-based oral suspension in dogs naturally infested by giardiasis: comparison to fenbendazole","volume":"16","author":"Faure","year":"2018","journal-title":"Int. J. Appl. Res. Vet. Med."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0050","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1128\/CMR.00033-10","article-title":"Zoonotic potential and molecular epidemiology of Giardia species and giardiasis","volume":"24","author":"Feng","year":"2011","journal-title":"Clin. Microbiol. Rev."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0055","doi-asserted-by":"crossref","first-page":"100","DOI":"10.1053\/j.tcam.2017.11.001","article-title":"Evaluation of metronidazole with and without Enterococcus Faecium SF68 in shelter dogs with diarrhea","volume":"32","author":"Fenimore","year":"2017","journal-title":"Top. Companion. Anim. Med."},{"issue":"187","key":"10.1016\/j.rvsc.2023.04.022_bb0060","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.vetpar.2011.12.023","article-title":"Control of Giardia infections with ronidazole and intensive hygiene management in a dog kennel","volume":"8","author":"Fiechter","year":"2012","journal-title":"Vet. Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0065","series-title":"The Predominance of Giardia Duodenalis aII Sub-Assemblage in Young Children from Salvador, Bahia, Brazil","first-page":"557","volume":"vol. 40","author":"Figueiredo Pacheco","year":"2020"},{"key":"10.1016\/j.rvsc.2023.04.022_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0228145","article-title":"Evaluation of the effects of anthelmintic administration on the fecal microbiome of healthy dogs with and without subclinical Giardia spp. and Cryptosporidium canis infections","volume":"15","author":"Fujishiro","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2023.04.022_bb0075","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1051\/parasite\/2016013","article-title":"Giardia duodenalis genetic assemblages and hosts","volume":"23","author":"Heyworth","year":"2016","journal-title":"Parasite."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0080","first-page":"621","article-title":"Single dose secnidazol treatment efficacy against naturally occurring Giardia duodenalis infection in dogs","volume":"139","author":"Karahall\u0130","year":"2017","journal-title":"Magyar \u00c1llatorvosok Lapja."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0085","first-page":"16","article-title":"Retrospective and comparative study of Giardia sp. prevalence in dogs, cats, and small ruminants in endemic areas in different brazilian states","volume":"47","author":"Moraes","year":"2019","journal-title":"Acta Sci. Vet."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0090","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1186\/s13071-017-1998-7","article-title":"Efficay of nitazoxanide to treat natural Giardia infections in dogs","volume":"10","author":"Moron-Soto","year":"2017","journal-title":"Parasit.Vectors."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0095","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1093\/jac\/dkm205","article-title":"Characterization of Giardia lamblia WB C6 clones resistant to nitazoxanide and to metronidazole","volume":"60","author":"M\u00fcller","year":"2007","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0100","doi-asserted-by":"crossref","first-page":"74","DOI":"10.4314\/ovj.v10i1.12","article-title":"Giardia duodenalis infection in dogs affected by primary chronic enteropathy","volume":"10","author":"Perrucci","year":"2020","journal-title":"Open Vet. J."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0110","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1111\/jvim.15871","article-title":"Effects of metronidazole on the fecal microbiome and metabolome in healthy dogs","volume":"34","author":"Pilla","year":"2020","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0115","doi-asserted-by":"crossref","first-page":"7072","DOI":"10.1128\/AAC.02900-14","article-title":"Giardial triosephosphate isomerase as possible target of the cytotoxic effect of omeprazole in Giardia lamblia","volume":"58","author":"Reyes-Vivas","year":"2014","journal-title":"Antimicrob. Agents Chemother."},{"issue":"S3","key":"10.1016\/j.rvsc.2023.04.022_bb0120","doi-asserted-by":"crossref","first-page":"23","DOI":"10.2460\/javma.22.08.0349","article-title":"Randomized controlled trial demonstrates nutritional management is superior to metronidazole for treatment of acute colitis in dogs","volume":"260","author":"Rudinsky","year":"2022","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0125","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/j.ijpara.2013.06.001","article-title":"Zoonotic potential of Giardia","volume":"43","author":"Ryan","year":"2013","journal-title":"Inter.J. Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0130","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/bs.apar.2019.07.002","article-title":"Molecular epidemiology of giardiasis from a veterinary perspective","volume":"106","author":"Ryan","year":"2019","journal-title":"Adv. Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0135","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.pt.2006.02.015","article-title":"Giardia and Cryptosporidium join the \u2018Neglected diseases Initiative\u2019","volume":"22","author":"Savioli","year":"2006","journal-title":"Trends Parasitol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0140","doi-asserted-by":"crossref","first-page":"201","DOI":"10.2174\/1570163814666170727130003","article-title":"Update on nitazoxanide: a multifunctional chemotherapeutic agent","volume":"15","author":"Shakya","year":"2018","journal-title":"Curr. Drug. Discov. Technol."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0145","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.tvjl.2016.04.011","article-title":"Diagnosis and interpretation of intestinal dysbiosis in dogs and cats \u2013 review","volume":"215","author":"Suchodolski","year":"2016","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2023.04.022_bb0155","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.3855\/jidc.13095","article-title":"Frequency of Giardia duodenalis infection and its genetic variability in dogs in Cuiab\u00e1, Midwest Brazil","volume":"14","author":"Trevisan","year":"2020","journal-title":"J. Infect Dev. Ctries."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528823001248?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528823001248?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T04:32:19Z","timestamp":1758515539000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528823001248"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6]]},"references-count":30,"alternative-id":["S0034528823001248"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2023.04.022","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2023,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Efficacy of a single dose of nitazoxanide in dogs naturally infected with Giardia duodenalis","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2023.04.022","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}