{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T08:28:50Z","timestamp":1740126530098,"version":"3.37.3"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T00:00:00Z","timestamp":1714953600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008119","name":"Norges Milj\u00f8- og Biovitenskapelige Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008119","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2024,6]]},"DOI":"10.1016\/j.rvsc.2024.105287","type":"journal-article","created":{"date-parts":[[2024,5,6]],"date-time":"2024-05-06T08:40:08Z","timestamp":1714984808000},"page":"105287","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A longitudinal study of the blood and urine metabolome of Vipera berus envenomated dogs"],"prefix":"10.1016","volume":"173","author":[{"given":"Tove V.","family":"Nicolaysen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runa","family":"R\u00f8rtveit","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anja \u00d8.","family":"Vassli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elise S.","family":"Sand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja B.P.","family":"Elgst\u00f8en","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helge","family":"Rootwelt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heidi S.","family":"Lund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bente K.","family":"S\u00e6vik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin E.","family":"Zimmer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2024.105287_bb0005","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/ndt\/gfp457","article-title":"Increased urinary losses of carnitine and decreased intramitochondrial coenzyme a in gentamicin-induced acute renal failure in rats","volume":"25","author":"Al-Shabanah","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.rvsc.2024.105287_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/molecules21101398","article-title":"Proteome and Peptidome of Vipera berus berus venom","volume":"21","author":"Bocian","year":"2016","journal-title":"Molecules"},{"key":"10.1016\/j.rvsc.2024.105287_bb0015","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1111\/j.1939-165X.2003.tb00332.x","article-title":"Creatinine in the dog: a review","volume":"32","author":"Braun","year":"2003","journal-title":"Vet. Clin. Pathol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0020","doi-asserted-by":"crossref","first-page":"600","DOI":"10.3945\/ajcn.116.146639","article-title":"A metabolomic study of biomarkers of meat and fish intake","volume":"105","author":"Cheung","year":"2017","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.rvsc.2024.105287_bb0025","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.phrs.2004.05.002","article-title":"Methadone--metabolism, pharmacokinetics and interactions","volume":"50","author":"Ferrari","year":"2004","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.rvsc.2024.105287_bb0030","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1111\/j.1939-165X.2011.00335.x","article-title":"Clinicopathologic abnormalities associated with snake envenomation in domestic animals","volume":"40","author":"Goddard","year":"2011","journal-title":"Vet. Clin. Pathol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0035","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.rvsc.2020.11.019","article-title":"Urinary clusterin and cystatin B as biomarkers of tubular injury in dogs following envenomation by the European adder","volume":"134","author":"Gordin","year":"2021","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2024.105287_bb0040","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1016\/j.jacc.2010.11.051","article-title":"The outcome of neutrophil gelatinase-associated lipocalin-positive subclinical acute kidney injury: a multicenter pooled analysis of prospective studies","volume":"57","author":"Haase","year":"2011","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0045","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.tem.2022.04.004","article-title":"Diet- and microbiota-related metabolite, 5-aminovaleric acid betaine (5-AVAB), in health and disease","volume":"33","author":"Haikonen","year":"2022","journal-title":"Trends Endocrinol. Metab."},{"key":"10.1016\/j.rvsc.2024.105287_bb0050","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/sj.ki.5002715","article-title":"Urinary biomarkers in the early diagnosis of acute kidney injury","volume":"73","author":"Han","year":"2008","journal-title":"Kidney Int."},{"key":"10.1016\/j.rvsc.2024.105287_bb0055","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1111\/jvim.15817","article-title":"Ambulatory electrocardiography and serum cardiac troponin I measurement in 21 dogs envenomated by the European adder (Vipera berus)","volume":"34","author":"Harjen","year":"2020","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2024.105287_bb0060","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1186\/s12917-021-02851-8","article-title":"Serial serum creatinine, SDMA and urinary acute kidney injury biomarker measurements in dogs envenomated by the European adder (Vipera berus)","volume":"17","author":"Harjen","year":"2021","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2024.105287_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.tcam.2021.100586","article-title":"Evaluation of urinary Clusterin and cystatin B as biomarkers for renal injury in dogs Envenomated by the European adder (Vipera berus)","volume":"46","author":"Harjen","year":"2022","journal-title":"Top. Companion Anim. Med."},{"key":"10.1016\/j.rvsc.2024.105287_bb0070","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0263238","article-title":"Persistent hypercoagulability in dogs envenomated by the European adder (Vipera berus berus)","volume":"17","author":"Harjen","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.rvsc.2024.105287_bb0075","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1093\/ndt\/gfp456","article-title":"Urinary excretion of carnitine as a marker of proximal tubular damage associated with platin-based antineoplastic drugs","volume":"25","author":"Haschke","year":"2010","journal-title":"Nephrol. Dial. Transplant."},{"key":"10.1016\/j.rvsc.2024.105287_bb0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.foodchem.2003.09.023","article-title":"Radioisotopic determination of l-carnitine content in foods commonly eaten in Western countries","volume":"86","author":"Jean Demarquoy","year":"2004","journal-title":"Food Chem."},{"key":"10.1016\/j.rvsc.2024.105287_bb0085","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1080\/15563650500394597","article-title":"A nationwide study of Vipera berus bites during one year-epidemiology and morbidity of 231 cases","volume":"44","author":"Karlson-Stiber","year":"2006","journal-title":"Clin. Toxicol. (Phila.)"},{"key":"10.1016\/j.rvsc.2024.105287_bb0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1681\/ASN.2017030314","article-title":"Kidney proximal tubule Lipoapoptosis is regulated by fatty acid Transporter-2 (FATP2)","volume":"29","author":"Khan","year":"2018","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0095","article-title":"Hund d\u00f8d etter huggormbitt (Dog dead following adderbite)","volume":"126","author":"Kolbj\u00f8rnsen","year":"2014","journal-title":"Norsk Veterin\u00e6rtidsskrift"},{"key":"10.1016\/j.rvsc.2024.105287_bb0100","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1172\/JCI108704","article-title":"Urinary excretion of hydroxylysine and its glycosides as an index of collagen degradation","volume":"59","author":"Krane","year":"1977","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.rvsc.2024.105287_bb0105","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jprot.2016.06.020","article-title":"Venomics of Vipera berus berus to explain differences in pathology elicited by Vipera ammodytes ammodytes envenomation: therapeutic implications","volume":"146","author":"Latinovic","year":"2016","journal-title":"J. Proteome"},{"key":"10.1016\/j.rvsc.2024.105287_bb0110","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1751-0147-52-26","article-title":"Clinical and biochemical changes in 53 Swedish dogs bitten by the European adder--Vipera berus","volume":"52","author":"Lervik","year":"2010","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.rvsc.2024.105287_bb0115","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.metabol.2007.06.001","article-title":"L-arginine metabolism in dog kidney and isolated nephron segments","volume":"57","author":"Levillain","year":"2008","journal-title":"Metabolism"},{"key":"10.1016\/j.rvsc.2024.105287_bb0120","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.21871","article-title":"Potential urinary biomarkers of nephrotoxicity in cyclophosphamide-treated rats investigated by NMR-based metabolic profiling","volume":"31","author":"Lim","year":"2017","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0125","doi-asserted-by":"crossref","first-page":"W201","DOI":"10.1093\/nar\/gkw253","article-title":"MBROLE 2.0-functional enrichment of chemical compounds","volume":"44","author":"Lopez-Ibanez","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.rvsc.2024.105287_bb0130","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1111\/vec.12099","article-title":"Adverse reactions to equine-derived F(ab\u2019)2 -antivenin in 54 dogs envenomated by Vipera berus berus","volume":"23","author":"Lund","year":"2013","journal-title":"J. Vet. Emerg. Crit. Care (San Antonio)"},{"year":"2022","series-title":"Collaborative Effort of multiple institutions","author":"MassBank of North America","key":"10.1016\/j.rvsc.2024.105287_bb0135"},{"key":"10.1016\/j.rvsc.2024.105287_bb0140","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1073\/pnas.78.12.7769","article-title":"Proline and glucose transport by renal membranes from dogs with spontaneous idiopathic Fanconi syndrome","volume":"78","author":"Medow","year":"1981","journal-title":"Proc. Natl. Acad. Sci. USA"},{"year":"2022","series-title":"HighChem LLC, Slovakia","author":"mzCloud","key":"10.1016\/j.rvsc.2024.105287_bb0145"},{"key":"10.1016\/j.rvsc.2024.105287_bb0150","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1177\/1060028021999644","article-title":"Creatinine assessment in non-steady-state conditions: a critical review","volume":"55","author":"Nix","year":"2021","journal-title":"Ann. Pharmacother."},{"key":"10.1016\/j.rvsc.2024.105287_bb0155","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1016\/j.toxicon.2012.08.010","article-title":"Proteomic profiling of dog urine after European adder (Vipera berus berus) envenomation by two-dimensional difference gel electrophoresis","volume":"60","author":"Palviainen","year":"2012","journal-title":"Toxicon"},{"key":"10.1016\/j.rvsc.2024.105287_bb0160","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.tvjl.2013.09.008","article-title":"Evaluation of renal impairment in dogs after envenomation by the common European adder (Vipera berus berus)","volume":"198","author":"Palviainen","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2024.105287_bb0165","doi-asserted-by":"crossref","first-page":"W388","DOI":"10.1093\/nar\/gkab382","article-title":"MetaboAnalyst 5.0: narrowing the gap between raw spectra and functional insights","volume":"49","author":"Pang","year":"2021","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.rvsc.2024.105287_bb0170","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1038\/nrm3314","article-title":"Innovation: metabolomics: the apogee of the omics trilogy","volume":"13","author":"Patti","year":"2012","journal-title":"Nat. Rev. Mol. Cell Biol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0175","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1136\/vr.b4817","article-title":"Myocardial cell damage in 24 dogs bitten by the common European viper (Vipera berus)","volume":"166","author":"Pelander","year":"2010","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2024.105287_bb0180","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1093\/ajcn\/nqy202","article-title":"Serum metabolites associated with dietary protein intake: results from the modification of diet in renal disease (MDRD) randomized clinical trial","volume":"109","author":"Rebholz","year":"2019","journal-title":"Am. J. Clin. Nutr."},{"key":"10.1016\/j.rvsc.2024.105287_bb0185","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1007\/BF03261931","article-title":"Carnitine and acylcarnitines: pharmacokinetic, pharmacological and clinical aspects","volume":"51","author":"Reuter","year":"2012","journal-title":"Clin. Pharmacokinet."},{"key":"10.1016\/j.rvsc.2024.105287_bb0190","doi-asserted-by":"crossref","first-page":"3829","DOI":"10.1007\/s00467-020-04911-x","article-title":"Snake bite associated with acute kidney injury","volume":"36","author":"Sarkar","year":"2021","journal-title":"Pediatr. Nephrol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0195","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/978-3-030-15950-4_37","article-title":"Metabolomics and biomarker discovery","volume":"1140","author":"Sinclair","year":"2019","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.rvsc.2024.105287_bb0200","doi-asserted-by":"crossref","first-page":"4010","DOI":"10.1021\/acs.jproteome.1c00326","article-title":"Bridging the polar and hydrophobic metabolome in single-run untargeted liquid chromatography-mass spectrometry dried blood spot metabolomics for clinical purposes","volume":"20","author":"Skogvold","year":"2021","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.rvsc.2024.105287_bb0205","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1136\/vr.d4695","article-title":"Canine adder bites in the UK: a retrospective study of cases reported to the veterinary poisons information service","volume":"169","author":"Sutton","year":"2011","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2024.105287_bb0210","first-page":"221","article-title":"European adder bites in dogs in southern Germany. A retrospective study over a 6.5-year period","volume":"43","author":"Turkovic","year":"2015","journal-title":"Tierarztl Prax Ausg K Kleintiere Heimtiere"},{"key":"10.1016\/j.rvsc.2024.105287_bb0215","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13028-017-0296-x","article-title":"Twenty-four-hour ambulatory electrocardiography characterization of heart rhythm in Vipera berus-envenomed dogs","volume":"59","author":"Vestberg","year":"2017","journal-title":"Acta Vet. Scand."},{"key":"10.1016\/j.rvsc.2024.105287_bb0220","doi-asserted-by":"crossref","first-page":"8483","DOI":"10.1007\/s00216-016-9974-1","article-title":"Evaluation of dilution and normalization strategies to correct for urinary output in HPLC-HRTOFMS metabolomics","volume":"408","author":"Vogl","year":"2016","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.rvsc.2024.105287_bb0225","doi-asserted-by":"crossref","first-page":"2767","DOI":"10.2174\/1568026617666170713172331","article-title":"Evaluation of temporal changes in urine-based Metabolomic and kidney injury markers to detect compound induced acute kidney tubular toxicity in beagle dogs","volume":"17","author":"Wagoner","year":"2017","journal-title":"Curr. Top. Med. Chem."},{"key":"10.1016\/j.rvsc.2024.105287_bb0230","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1152\/physrev.00035.2018","article-title":"Metabolomics for investigating physiological and pathophysiological processes","volume":"99","author":"Wishart","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.rvsc.2024.105287_bb0235","doi-asserted-by":"crossref","first-page":"D622","DOI":"10.1093\/nar\/gkab1062","article-title":"HMDB 5.0: the human metabolome database for 2022","volume":"50","author":"Wishart","year":"2022","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.rvsc.2024.105287_bb0240","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.chroma.2015.12.007","article-title":"Sample normalization methods in quantitative metabolomics","volume":"1430","author":"Wu","year":"2016","journal-title":"J. Chromatogr. A"},{"issue":"2266\u20132281","key":"10.1016\/j.rvsc.2024.105287_bb0245","article-title":"TMAVA, a metabolite of intestinal microbes, is increased in plasma from patients with liver steatosis, inhibits gamma-Butyrobetaine hydroxylase, and exacerbates fatty liver in mice","volume":"158","author":"Zhao","year":"2020","journal-title":"Gastroenterology"}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003452882400153X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S003452882400153X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,16]],"date-time":"2024-05-16T00:46:24Z","timestamp":1715820384000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S003452882400153X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6]]},"references-count":49,"alternative-id":["S003452882400153X"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2024.105287","relation":{},"ISSN":["0034-5288"],"issn-type":[{"type":"print","value":"0034-5288"}],"subject":[],"published":{"date-parts":[[2024,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A longitudinal study of the blood and urine metabolome of Vipera berus envenomated dogs","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2024.105287","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105287"}}