{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T19:28:39Z","timestamp":1769714919355,"version":"3.49.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,28]],"date-time":"2025-02-28T00:00:00Z","timestamp":1740700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000199","name":"U.S. Department of Agriculture","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000199","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.rvsc.2025.105591","type":"journal-article","created":{"date-parts":[[2025,3,14]],"date-time":"2025-03-14T12:08:16Z","timestamp":1741954096000},"page":"105591","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mucosal and systemic humoral responses after experimental Brucella abortus challenge in non-vaccinated or RB51-vaccinated elk"],"prefix":"10.1016","volume":"187","author":[{"given":"S.C.","family":"Olsen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.","family":"Putz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.M.","family":"Boggiatto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2025.105591_bb0005","series-title":"Techniques for the Brucellosis Laboratory","author":"Alton","year":"1988"},{"key":"10.1016\/j.rvsc.2025.105591_bb0010","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0034-5288(18)33920-1","article-title":"The use of the antiglovulin test in the diagnosis of bovine brucellosis","volume":"14","author":"Beh","year":"1973","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105591_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2019.e02370","article-title":"Sustained antigen release polyanhydride-based vaccine platform for immunization against bovine brucellosis","volume":"5","author":"Boggiatto","year":"2019","journal-title":"Heliyon"},{"key":"10.1016\/j.rvsc.2025.105591_bb0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178780","article-title":"Shifting brucellosis risk in livestock coincides with spreading seroprevalence in elk","volume":"12","author":"Brennan","year":"2017","journal-title":"PLoS ONE"},{"key":"10.1016\/j.rvsc.2025.105591_bb0025","doi-asserted-by":"crossref","first-page":"451","DOI":"10.2460\/ajvr.1996.57.08.1153","article-title":"Effects of age at vaccination on efficacy of Brucella abortus strain RB51 to protect cattle against brucellosis","volume":"57","author":"Cheville","year":"1996","journal-title":"Am. J. Vet. Res."},{"key":"10.1016\/j.rvsc.2025.105591_bb0030","doi-asserted-by":"crossref","first-page":"18","DOI":"10.7589\/0090-3558-38.1.18","article-title":"Brucella abortus strain RB51 vaccination in elk. I. Efficacy of reduced dosage","volume":"38","author":"Cook","year":"2002","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.rvsc.2025.105591_bb0035","doi-asserted-by":"crossref","first-page":"3674","DOI":"10.1128\/AEM.00045-12","article-title":"Molecular epidemiology of Brucella abortus isolates from cattle, elk, and bison in teh United States, 1998 to 2011","volume":"78","author":"Higgins","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"10.1016\/j.rvsc.2025.105591_bb0040","doi-asserted-by":"crossref","first-page":"27","DOI":"10.7589\/0090-3558-38.1.27","article-title":"Brucella abortus strain RB51 vaccination in elk. II. FAilure of high dosage to prevent abortion","volume":"38","author":"Kreeger","year":"2002","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.rvsc.2025.105591_bb0045","first-page":"223","article-title":"Effects of exogenous recombinant interleukin-12 on immune responses and protection against Brucella abortus in a murine model","volume":"65","author":"Lee","year":"2001","journal-title":"Can. J. Vet. Res."},{"key":"10.1016\/j.rvsc.2025.105591_bb0050","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1751-0813.1976.tb00103.x","article-title":"The use of supplementary tests in the serological diagnosis of bovine brucellosis","volume":"52","author":"Mylrea","year":"1976","journal-title":"Austr. Vet. J."},{"key":"10.1016\/j.rvsc.2025.105591_bb0055","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1081\/IAS-100104705","article-title":"Fluorescence polarization assay for the diagnosis of brucellosis: a review","volume":"22","author":"Nielsen","year":"2001","journal-title":"J. Immunoass. Immunochem."},{"key":"10.1016\/j.rvsc.2025.105591_bb0060","doi-asserted-by":"crossref","first-page":"10","DOI":"10.3389\/fcimb.2016.00010","article-title":"Vaccination of elk (Cervus canadensis) with Brucella abortus strain RB51 overexpressing superoxide dismutase and glycosyltransferase genes does not induce adequate protection against experimental Brucella abortus challenge","volume":"6","author":"Nol","year":"2016","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.rvsc.2025.105591_bb0065","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1053\/rvsc.2000.0405","article-title":"Responses of adult cattle to vaccination with a reduced dose of Brucella abortus strain RB51","volume":"69","author":"Olsen","year":"2000","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105591_bb0070","doi-asserted-by":"crossref","first-page":"746","DOI":"10.7589\/0090-3558-38.4.746","article-title":"Immune responses of elk to vaccination with Brucella abortus strain RB51","volume":"38","author":"Olsen","year":"2002","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.rvsc.2025.105591_bb0075","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1128\/CVI.00213-06","article-title":"Immune responses of elk to initial and booster vaccinations with Brucella abortus strain RB51 or 19","volume":"13","author":"Olsen","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.rvsc.2025.105591_bb0080","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1128\/CVI.00419-08","article-title":"Immune responses and protection against experimetnal challenge after vaccination of bison with Brucella abortus strain RB51 or RB51 overexpressing superoxide dismutase and glycosyltransferase genes","volume":"16","author":"Olsen","year":"2009","journal-title":"Clin. Vaccine Immunol."},{"key":"10.1016\/j.rvsc.2025.105591_bb0085","series-title":"Brucellosis in Elk and bison in the Greater Yellowstone Area","first-page":"7","article-title":"The brucellosis eradication program in the United States","author":"Ragan","year":"2002"},{"key":"10.1016\/j.rvsc.2025.105591_bb0090","doi-asserted-by":"crossref","first-page":"269","DOI":"10.7589\/0090-3558-44.2.269","article-title":"Foot-and-mouth disease in north American bison (Bison bison) and elk (Cervus Elaphus nelsoni): susceptibility, intra- and interspecies transmission, clinical signs and lesions","volume":"44","author":"Rhyan","year":"2008","journal-title":"J. Wildl. Dis."},{"key":"10.1016\/j.rvsc.2025.105591_bb0095","doi-asserted-by":"crossref","first-page":"1992","DOI":"10.3201\/eid1912.130167","article-title":"Transmission of brucellosis from elk to cattle and bison, greater Yellowstone area, U.S.A., 2002-2012","volume":"19","author":"Rhyan","year":"2013","journal-title":"Emerg. Infect. Dis."},{"key":"10.1016\/j.rvsc.2025.105591_bb0100","doi-asserted-by":"crossref","first-page":"71","DOI":"10.20506\/rst.32.1.2185","article-title":"Risks of Brucella abortus spillover in the greater Yellowstone area","volume":"32","author":"Schumaker","year":"2013","journal-title":"Rev. Sci. Techn."},{"key":"10.1016\/j.rvsc.2025.105591_bb0105","doi-asserted-by":"crossref","first-page":"344","DOI":"10.7589\/0090-3558-38.2.344","article-title":"Analysis of mitogen-stimulated lymphocyte subset proliferation and nitric oxide production by periopheral blood mononuclear cells of captive elk (Cervus elaphus)","volume":"38","author":"Waters","year":"2002","journal-title":"J. Wildl. Dis."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528825000657?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528825000657?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T08:57:42Z","timestamp":1769677062000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528825000657"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":21,"alternative-id":["S0034528825000657"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2025.105591","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mucosal and systemic humoral responses after experimental Brucella abortus challenge in non-vaccinated or RB51-vaccinated elk","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2025.105591","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"105591"}}