{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,31]],"date-time":"2026-03-31T19:30:19Z","timestamp":1774985419032,"version":"3.50.1"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T00:00:00Z","timestamp":1775779200000},"content-version":"am","delay-in-days":313,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.rvsc.2025.105649","type":"journal-article","created":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T02:17:03Z","timestamp":1744165023000},"page":"105649","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Prognostic value of circulating cardiac and renal biomarkers in dogs with myxomatous mitral valve disease"],"prefix":"10.1016","volume":"189","author":[{"given":"Naoki","family":"Iwasa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rie","family":"Kumazawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamu","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Okamoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mifumi","family":"Kawabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Munetaka","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuhiro","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yui","family":"Kobatake","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Naohito","family":"Nishii","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2025.105649_bb0005","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1016\/S0735-1097(00)00804-4","article-title":"Myocardial infarction redefined\u2014a consensus document of the Joint European Society of Cardiology\/American College of Cardiology Committee for the redefinition of myocardial infarction","volume":"36","author":"Alpert","year":"2000","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.esmoop.2023.101831","article-title":"Prognostic value of comorbidities in older patients with cancer: the ELCAPA cohort study","volume":"8","author":"Benderra","year":"2023","journal-title":"ESMO Open."},{"key":"10.1016\/j.rvsc.2025.105649_bb0015","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/j.cvsm.2010.03.008","article-title":"Canine degenerative myxomatous mitral valve disease: natural history, clinical presentation and therapy","volume":"40","author":"Borgarelli","year":"2010","journal-title":"Vet. Clin. North Am. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2025.105649_bb0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.jvc.2021.04.009","article-title":"The predictive value of clinical, radiographic, echocardiographic variables and cardiac biomarkers for assessing risk of the onset of heart failure or cardiac death in dogs with preclinical myxomatous mitral valve disease enrolled in the DELAY study","volume":"36","author":"Borgarelli","year":"2021","journal-title":"J. Vet. Cardiol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0025","doi-asserted-by":"crossref","first-page":"194","DOI":"10.2460\/javma.1995.206.02.194","article-title":"Vertebral scale system to measure canine heart size in radiographs","volume":"206","author":"Buchanan","year":"1995","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2025.105649_bb0030","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1136\/vr.105265","article-title":"Serial measurements of cardiac troponin I in heart failure secondary to canine mitral valve disease","volume":"185","author":"Chan","year":"2019","journal-title":"Vet. Rec."},{"key":"10.1016\/j.rvsc.2025.105649_bb0035","doi-asserted-by":"crossref","first-page":"743","DOI":"10.2460\/javma.2005.227.743","article-title":"Effects of animal position and number of repeated measurements on selected two-dimensional and M-mode echocardiographic variables in healthy dogs","volume":"227","author":"Chetboul","year":"2005","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2025.105649_bb0040","first-page":"3113","article-title":"Allometric scaling of M-mode cardiac measurements in normal adult dogs","volume":"18","author":"Cornell","year":"2004","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0045","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.rvsc.2012.12.007","article-title":"Plasma atrial natriuretic peptide is an early diagnosis and disease severity marker of myxomatous mitral valve disease in dogs","volume":"94","author":"Ebisawa","year":"2013","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105649_bb0050","doi-asserted-by":"crossref","first-page":"171","DOI":"10.2460\/javma.240.2.171","article-title":"Evaluation of plasma N-terminal pro-B-type natriuretic peptide concentrations in dogs with and without cardiac disease","volume":"240","author":"Ettinger","year":"2012","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2025.105649_bb0055","author":"EZR (eazy R)"},{"key":"10.1016\/j.rvsc.2025.105649_bb0060","author":"EZR (eazy R)"},{"key":"10.1016\/j.rvsc.2025.105649_bb0065","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.tvjl.2009.04.004","article-title":"Cardiac troponin I as a marker for severity and prognosis of cardiac disease in dogs","volume":"184","author":"Fonfara","year":"2010","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2025.105649_bb0070","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1007\/s11259-023-10154-6","article-title":"A study of the inter- and intraoperator variability on selected echocardiographic measurements in dogs","volume":"47","author":"Ghilardi","year":"2023","journal-title":"Vet. Res. Commun."},{"key":"10.1016\/j.rvsc.2025.105649_bb0075","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1111\/jsap.13136","article-title":"Long-term biological variability and the generation of a new reference interval for plasma N-terminal pro-B-type natriuretic peptide in Labrador retrievers","volume":"61","author":"Gomart","year":"2020","journal-title":"J. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2025.105649_bb0080","first-page":"293","article-title":"Measurement of plasma atrial natriuretic peptide as an indicator of prognosis in dogs with cardiac disease","volume":"44","author":"Greco","year":"2003","journal-title":"Can. Vet. J."},{"key":"10.1016\/j.rvsc.2025.105649_bb0085","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1740-8261.2002.tb01051.x","article-title":"Left atrial to aortic root indices using two-dimensional and M-mode echocardiography in cavalier king charles spaniels with and without left atrial enlargement","volume":"43","author":"Hansson","year":"2002","journal-title":"Vet. Radiol. Ultrasound"},{"key":"10.1016\/j.rvsc.2025.105649_bb0090","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1097\/EDE.0b013e3181c1ea43","article-title":"The hazards of hazard ratios","volume":"21","author":"Hern\u00e1n","year":"2010","journal-title":"Epidemiology"},{"key":"10.1016\/j.rvsc.2025.105649_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.tvjl.2019.105420","article-title":"Measurements of echocardiographic indices and biomarkers of kidney injury in dogs with chronic kidney disease","volume":"255","author":"Hezzell","year":"2020","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2025.105649_bb0100","doi-asserted-by":"crossref","first-page":"340","DOI":"10.2460\/javma.256.3.340","article-title":"Evaluation of atrial natriuretic peptide and cardiac troponin I concentrations for assessment of disease severity in dogs with naturally occurring mitral valve disease","volume":"256","author":"Hori","year":"2020","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2025.105649_bb0105","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.rvsc.2018.06.014","article-title":"Serum cystatin C concentration measured routinely is a prognostic marker for renal disease in dogs","volume":"119","author":"Iwasa","year":"2018","journal-title":"Res. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105649_bb0110","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1111\/jvim.16669","article-title":"Prognostic value of serum cystatin C concentration in dogs with myxomatous mitral valve disease","volume":"37","author":"Iwasa","year":"2023","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0115","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1740-8261.2012.01976.x","article-title":"Vertebral heart scores in eight dog breeds","volume":"54","author":"Jepsen-Grant","year":"2013","journal-title":"Vet. Radiol. Ultrasound"},{"key":"10.1016\/j.rvsc.2025.105649_bb0120","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software \u201cEZR\u201d for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transplant."},{"key":"10.1016\/j.rvsc.2025.105649_bb0125","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1161\/01.CIR.83.3.902","article-title":"Diagnostic efficiency of troponin T measurements in acute myocardial infarction","volume":"83","author":"Katus","year":"1991","journal-title":"Circulation"},{"key":"10.1016\/j.rvsc.2025.105649_bb0130","doi-asserted-by":"crossref","first-page":"1127","DOI":"10.1111\/jvim.15488","article-title":"ACVIM consensus guidelines for the diagnosis and treatment of myxomatous mitral valve disease in dogs","volume":"33","author":"Keene","year":"2019","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0135","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1001\/jamacardio.2017.2922","article-title":"Restricted mean survival time as a measure to interpret clinical trial results","volume":"2","author":"Kim","year":"2017","journal-title":"JAMA Cardiol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0140","first-page":"H1684","article-title":"Differential atrial and ventricular expression of myocardial BNP during evolution of heart failure","volume":"274","author":"Luchner","year":"1998","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0145","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S0002-9149(99)80428-7","article-title":"Rapid bedside whole blood cardiospecific troponin T immunoassay for the diagnosis of acute myocardial infarction","volume":"75","author":"Mach","year":"1995","journal-title":"Am. J. Cardiol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0150","doi-asserted-by":"crossref","first-page":"694","DOI":"10.1161\/01.RES.81.5.694","article-title":"Involvement of transcriptional and posttranscriptional mechanisms in cardiac overload-induced increase of B-type natriuretic peptide gene expression","volume":"81","author":"Magga","year":"1997","journal-title":"Circ. Res."},{"key":"10.1016\/j.rvsc.2025.105649_bb0155","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.2460\/javma.253.8.1038","article-title":"Diagnostic value of vertebral left atrial size as determined from thoracic radiographs for assessment of left atrial size in dogs with myxomatous mitral valve disease","volume":"253","author":"Malcolm","year":"2018","journal-title":"J. Am. Vet. Med. Assoc."},{"key":"10.1016\/j.rvsc.2025.105649_bb0160","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1111\/jvim.14524","article-title":"Preliminary investigation of cardiovascular-renal disorders in dogs with chronic mitral valve disease","volume":"30","author":"Martinelli","year":"2016","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0165","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1111\/jvim.15390","article-title":"Factors associated with disease progression in dogs with presumed preclinical degenerative mitral valve disease attending primary care veterinary practices in the United Kingdom","volume":"33","author":"Mattin","year":"2019","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0170","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.tvjl.2013.02.016","article-title":"Relationship between glomerular filtration rate and plasma N-terminal pro B-type natriuretic peptide concentrations in dogs with chronic kidney disease","volume":"197","author":"Miyagawa","year":"2013","journal-title":"Vet. J."},{"key":"10.1016\/j.rvsc.2025.105649_bb0175","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1292\/jvms.20-0201","article-title":"Serum cystatin C concentration can be used to evaluate glomerular filtration rate in small dogs","volume":"82","author":"Miyagawa","year":"2021","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.rvsc.2025.105649_bb0180","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/0735-1097(95)00504-8","article-title":"Plasma and cardiac tissue atrial and brain natriuretic peptides in experimental heart failure","volume":"27","author":"Moe","year":"1996","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0185","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1748-5827.2009.00889.x","article-title":"N-terminal pro B-type natriuretic peptide and left ventricular diameter independently predict mortality in dogs with mitral valve disease","volume":"51","author":"Moonarmart","year":"2010","journal-title":"J. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2025.105649_bb0190","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1111\/jvim.14820","article-title":"Effects of oral prednisone administration on serum cystatin C in dogs","volume":"31","author":"Mu\u00f1oz","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0195","doi-asserted-by":"crossref","first-page":"11785","DOI":"10.1038\/s41598-022-16018-4","article-title":"Comparison of the efficacies of 1.0 and 1.5 mm silicone tubes for the treatment of nasolacrimal duct obstruction","volume":"12","author":"Nakamura","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rvsc.2025.105649_bb0200","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1111\/jvim.14703","article-title":"Cardiac troponin I and amino-terminal pro B-type natriuretic peptide in dogs with stable chronic kidney disease","volume":"31","author":"Palander","year":"2017","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0205","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1111\/jsap.12387","article-title":"Cardiovascular-renal axis disorders in the domestic dog and cat: a veterinary consensus statement","volume":"56","author":"Pouchelon","year":"2015","journal-title":"J. Small Anim. Pract."},{"key":"10.1016\/j.rvsc.2025.105649_bb0210","first-page":"429","article-title":"Evaluation of four 2-dimensional echocardiographic methods of assessing left atrial size in dogs","volume":"14","author":"Rishniw","year":"2000","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0215","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1186\/1471-2288-13-152","article-title":"Restricted mean survival time: an alternative to the hazard ratio for the design and analysis of randomized trials with a time-to-event outcome","volume":"13","author":"Royston","year":"2013","journal-title":"BMC Med. Res. Methodol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0220","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1210\/er.2003-0006","article-title":"Cardiac hormones as diagnostic tools in heart failure","volume":"24","author":"Ruskoaho","year":"2003","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.rvsc.2025.105649_bb0225","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/jvim.12310","article-title":"Breed differences in natriuretic peptides in healthy dogs","volume":"28","author":"Sj\u00f6strand","year":"2014","journal-title":"J. Vet. Intern. Med."},{"key":"10.1016\/j.rvsc.2025.105649_bb0230","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1292\/jvms.71.925","article-title":"Evaluation of plasma N-terminal probrain natriuretic peptide (NT-proBNP) concentrations in dogs with mitral valve insufficiency","volume":"71","author":"Takemura","year":"2009","journal-title":"J. Vet. Med. Sci."},{"key":"10.1016\/j.rvsc.2025.105649_bb0235","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1200\/JCO.2014.55.2208","article-title":"Moving beyond the hazard ratio in quantifying the between-group difference in survival analysis","volume":"32","author":"Uno","year":"2014","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.rvsc.2025.105649_bb0240","article-title":"Prognostic value of the serum osteoprotegerin level in patients with hepatocellular carcinoma following surgical resection","volume":"11","author":"Zhang","year":"2021","journal-title":"Front. Oncol."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528825001237?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528825001237?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,8,10]],"date-time":"2025-08-10T11:58:01Z","timestamp":1754827081000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528825001237"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":48,"alternative-id":["S0034528825001237"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2025.105649","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Prognostic value of circulating cardiac and renal biomarkers in dogs with myxomatous mitral valve disease","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2025.105649","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105649"}}