{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T10:44:48Z","timestamp":1784717088769,"version":"3.55.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.rvsc.2025.105822","type":"journal-article","created":{"date-parts":[[2025,7,23]],"date-time":"2025-07-23T23:17:45Z","timestamp":1753312665000},"page":"105822","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Metabolite profile as a prime marker of fertility detection in Egyptian dairy buffaloes (Bubalus bubalis)"],"prefix":"10.1016","volume":"193","author":[{"given":"Seham Samir","family":"Soliman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherif M.","family":"Afifi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Banny Silva Barbosa","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdelaziz M.","family":"Sakr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Mahmoud","family":"Hegazy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naglaa M.","family":"Ammar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.rvsc.2025.105822_bb0005","first-page":"126","article-title":"Seasonal variation in number of ovarian follicles and hormonal levels in Egyptian buffalo and cattle","volume":"9","author":"Abdoon","year":"2016","journal-title":"Int. J. Vet. Sci."},{"issue":"1","key":"10.1016\/j.rvsc.2025.105822_bb0010","first-page":"131","article-title":"Effect of reproductive status and season on blood biochemical, hormonal and antioxidant changes in Egyptian buffaloes","volume":"9","author":"Abdoon","year":"2020","journal-title":"Int. J. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105822_bb0015","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s13048-023-01161-x","article-title":"Lyophilized equine platelet-rich plasma (L-GFequina) antagonize the reproductive toxicity and oxidative stress induced by cyclophosphamide in female rats","volume":"16","author":"Abdoon","year":"2023","journal-title":"J. Ovarian Res."},{"key":"10.1016\/j.rvsc.2025.105822_bb0020","doi-asserted-by":"crossref","DOI":"10.1111\/rda.14665","article-title":"Uterotubal junction of the bovine (Bostaurus) versus the dromedary camel (Camelusdromedarius): histology and histomorphometry","volume":"59","author":"Abdoon","year":"2024","journal-title":"Reprod. Domest. Anim."},{"key":"10.1016\/j.rvsc.2025.105822_bb0025","doi-asserted-by":"crossref","first-page":"8923","DOI":"10.1038\/s41598-025-91710-9","article-title":"Metabolomic profile of dromedary camel follicular fluid during the breeding and non-breeding seasons","volume":"15","author":"Abdoon","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rvsc.2025.105822_bb0030","doi-asserted-by":"crossref","first-page":"203","DOI":"10.4172\/2375-4508.1000203","article-title":"An overview on functional causes of infertility in cows","volume":"5","author":"Abraham","year":"2017","journal-title":"JFIV. Reprod. Med. Genet."},{"key":"10.1016\/j.rvsc.2025.105822_bb0035","first-page":"603","article-title":"Biochemical and hormonal profile in anestrous Nili- Ravi buffaloes","volume":"87","author":"Akhtar","year":"2010","journal-title":"Ind. Vet. J."},{"issue":"5","key":"10.1016\/j.rvsc.2025.105822_bb0040","doi-asserted-by":"crossref","DOI":"10.1002\/fsn3.70314","article-title":"Amaranthus spinosus Linn. Extract as an innovative strategy to regulate biomarkers for ovarian hyperthecosis via circular RNA (hsa-circ-0001577): evidence from biochemical, metabolomics, histological, and phytochemical profiling","volume":"13","author":"Ammar","year":"2025","journal-title":"Food Sci. Nutr."},{"key":"10.1016\/j.rvsc.2025.105822_bb0045","doi-asserted-by":"crossref","first-page":"271","DOI":"10.3923\/ajava.2015.271.280","article-title":"Blood metabolic profile and certain hormones concentrations in Egyptian buffalo during different physiological states","volume":"10","author":"Ashmawy","year":"2015","journal-title":"Asian J. Anim. Vet. Adv."},{"key":"10.1016\/j.rvsc.2025.105822_bb0050","article-title":"Ovarian morphometry and follicular population in non-pregnant and pregnant Camelus dromedaries","volume":"1-7","author":"El-sanea","year":"2025","journal-title":"Egypt. J. Vet. Sci."},{"issue":"9","key":"10.1016\/j.rvsc.2025.105822_bb0055","doi-asserted-by":"crossref","first-page":"1475","DOI":"10.3390\/ani13091475","article-title":"Modulation of apoptosis and autophagy by melatonin in juglone-exposed bovine oocytes","volume":"13","author":"El-Sheikh","year":"2023","journal-title":"Animals"},{"issue":"3\u20134","key":"10.1016\/j.rvsc.2025.105822_bb0060","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.anireprosci.2006.03.003","article-title":"The postpartum buffalo: II. Acyclicity and anestrus","volume":"97","author":"El-Wishy","year":"2007","journal-title":"Anim. Reprod. Sci."},{"issue":"100","key":"10.1016\/j.rvsc.2025.105822_bb0065","doi-asserted-by":"crossref","first-page":"4348","DOI":"10.1210\/jc.2015-2862","article-title":"Maternal early pregnancy serum metabolites and risk of gestational diabetes mellitus","volume":"1","author":"Enquobahrie","year":"2015","journal-title":"Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.rvsc.2025.105822_bb0070","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27092935","article-title":"Comparative metabolite fingerprinting of four different cinnamon species analyzed via UPLC-MS and GC-MS and chemometric tools","volume":"27","author":"Farag","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.rvsc.2025.105822_bb0075","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1007\/978-1-59745-244-1_1","article-title":"Metabolite profiling in blood plasma","author":"Fiehn","year":"2007","journal-title":"Metabolomics"},{"issue":"4","key":"10.1016\/j.rvsc.2025.105822_bb0080","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0193803","article-title":"Metabolic and hormonal adaptation in Bubalus bubalis around calving and early lactation","volume":"13","author":"Fiore","year":"2018","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.rvsc.2025.105822_bb0085","doi-asserted-by":"crossref","first-page":"3465","DOI":"10.3168\/jds.2022-22209","article-title":"Serum metabolomics assessment of etiological processes predisposing ketosis in water buffalo during early lactation","volume":"106","author":"Fiore","year":"2023","journal-title":"J. Dairy Sci."},{"issue":"2","key":"10.1016\/j.rvsc.2025.105822_bb0090","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/1354750X.2022.2157488","article-title":"Metabolomics approach of Symphyotrichum squamatum ethanol extract and its nano-Ag formulation protective effect on gastric ulcer via bio-chemical and pathological analyses","volume":"28","author":"Hassan","year":"2023","journal-title":"Biomarkers"},{"key":"10.1016\/j.rvsc.2025.105822_bb0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11306-018-1396-y","article-title":"Illuminating the dark metabolome to advance the molecular characterization of biological systems","volume":"14","author":"Jones","year":"2018","journal-title":"Metabolomics"},{"issue":"1\u20132","key":"10.1016\/j.rvsc.2025.105822_bb0100","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.anireprosci.2011.07.013","article-title":"Changes in biochemical composition of follicular fluid during reproductive acyclicity in water buffalo (Bubalus bubalis)","volume":"127","author":"Khan","year":"2011","journal-title":"Anim. Reprod. Sci."},{"key":"10.1016\/j.rvsc.2025.105822_bb0105","doi-asserted-by":"crossref","first-page":"510","DOI":"10.20546\/ijcmas.2017.607.061","article-title":"Evaluation of hormonal treatment protocol and improved nutritional therapeutic management practices for inducing heat in anestrus cows","volume":"6","author":"Lawania","year":"2017","journal-title":"Int. JCurr. Micro. App. Sci."},{"issue":"7","key":"10.1016\/j.rvsc.2025.105822_bb0110","doi-asserted-by":"crossref","first-page":"e3058","DOI":"10.1210\/clinem\/dgac141","article-title":"Branched-chain amino acids and their interactions with lipid metabolites for increased risk of gestational diabetes","volume":"107","author":"Li","year":"2022","journal-title":"Clin. Endocrinol. Metab."},{"key":"10.1016\/j.rvsc.2025.105822_bb0115","series-title":"Metabolomic changes in dairy ruminants affected by hyperketonemia","author":"Lisuzzo","year":"2024"},{"issue":"14","key":"10.1016\/j.rvsc.2025.105822_bb0120","doi-asserted-by":"crossref","first-page":"2333","DOI":"10.3390\/ani13142333","article-title":"Metabolic changes associated with different levels of energy deficits in Mediterranean buffaloes during the early lactation stage: type and role of the main lipid fractions involved","volume":"13","author":"Lisuzzo","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.rvsc.2025.105822_bb0125","doi-asserted-by":"crossref","first-page":"7043883","DOI":"10.1155\/2022\/7043883","article-title":"The regulation and characterization of mitochondrial-derived methylmalonic acid in mitochondrial dysfunction and oxidative stress: from basic research to clinical practice","volume":"1","author":"Liu","year":"2022","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.rvsc.2025.105822_bb0130","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.702826","article-title":"Branched-chain amino acids: catabolism in skeletal muscle and implications for muscle and whole-body metabolism","volume":"12","author":"Mann","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.rvsc.2025.105822_bb0135","article-title":"Rational design of new NO and redox sensitivity into connexin26 hemichannels","volume":"1 5(2)","author":"Meigh","year":"2015","journal-title":"Open Biol."},{"key":"10.1016\/j.rvsc.2025.105822_bb0140","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12864-019-6074-6","article-title":"Uncovering sperm metabolome to discover biomarkers for bull fertility","volume":"20","author":"Menezes","year":"2019","journal-title":"BMC Genomics"},{"key":"10.1016\/j.rvsc.2025.105822_bb0145","first-page":"42","article-title":"Seasonal variations in the metabolomic profile of the ovarian follicle components in Italian Mediterranean buffaloes","volume":"2024","author":"Michal","year":"2024","journal-title":"Theriogenology"},{"issue":"4","key":"10.1016\/j.rvsc.2025.105822_bib211","doi-asserted-by":"crossref","first-page":"100948","DOI":"10.1016\/j.repbio.2024.100948","article-title":"Endoplasmic reticulum stress is involved in mycotoxin zearalenone induced inflammatory response, proliferation, and apoptosis in goat endometrial stromal cells","volume":"24","author":"Mohamed","year":"2024","journal-title":"Reprod. Biol"},{"key":"10.1016\/j.rvsc.2025.105822_bb0150","doi-asserted-by":"crossref","first-page":"625","DOI":"10.14202\/vetworld.2015.625-630","article-title":"Serum metabolic and minerals profile in norgestomet primed postpartum anestrous surti buffaloes","volume":"8","author":"Parmar","year":"2015","journal-title":"Vet. World."},{"key":"10.1016\/j.rvsc.2025.105822_bb0155","first-page":"36","article-title":"Estrus induction, fertility and biochemical profile in true anoestrus Surti buffaloes primed with different estrus synchronization protocols","volume":"39","author":"Patel","year":"2018","journal-title":"Indian. J. Anim. Reprod."},{"key":"10.1016\/j.rvsc.2025.105822_bb0160","first-page":"5","article-title":"Influence of estrus synchronization protocols on plasma profile of progesterone, protein and cholesterol in acyclic Holstein Friesian crossbred cows","volume":"13","author":"Prajapati","year":"2018","journal-title":"Indian. J. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105822_bb0165","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1071\/RD03004","article-title":"Consequences of exposure to serum, with or without vitamin E supplementation, in terms of the fatty acid content and viability of bovine blastocysts produced in vitro","volume":"15","author":"Reis","year":"2003","journal-title":"Reprod. Fertil. Dev."},{"key":"10.1016\/j.rvsc.2025.105822_bb0170","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1007\/s11259-024-10620-9","article-title":"Alterations in the uterine echotexture, hemodynamics, and histological findings in relation to metabolomic profiles in goats with different ovarian activities (active versus inactive ovaries)","volume":"49","author":"Samir","year":"2025","journal-title":"Vet. Res. Commun."},{"issue":"1","key":"10.1016\/j.rvsc.2025.105822_bb0175","doi-asserted-by":"crossref","DOI":"10.1002\/edm2.201","article-title":"Metabolic dysfunction in pregnancy: fingerprinting the maternal metabolome using proton nuclear magnetic resonance spectroscopy","volume":"4","author":"Scott","year":"2021","journal-title":"Endocrinol. Diabetes Metab."},{"key":"10.1016\/j.rvsc.2025.105822_bb0180","first-page":"35","article-title":"Role of cholesterol and its fractions in buffalo ovarian follicular atresia","volume":"2","author":"Sesh","year":"2013","journal-title":"Int. J. Adv. Vet. Sci. Tech."},{"issue":"5","key":"10.1016\/j.rvsc.2025.105822_bb0185","first-page":"1387","article-title":"Impact of reproductive status, body condition score, and locality on hormonal, and some blood metabolites in Egyptian buffaloes","volume":"55","author":"Soliman","year":"2024","journal-title":"Egypt. J. Vet. Sci."},{"key":"10.1016\/j.rvsc.2025.105822_bb0190","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s41598-024-82921-7","article-title":"Ovario- protective effect of Moringa oleifera leaf extract against cyclophosphamide-induced oxidative ovarian damage and reproductive dysfunction in female rats","volume":"15","author":"Soliman","year":"2025","journal-title":"Sci. Rep."},{"key":"10.1016\/j.rvsc.2025.105822_bb0195","article-title":"Expression of growth factors in buffalo ovarian tissue across different follicular developmental stages","volume":"1-11","author":"Soliman","year":"2025","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.rvsc.2025.105822_bb0200","doi-asserted-by":"crossref","unstructured":"Usacheva, A.M., Chernikov, A.V., Karmanova, E.E., et al. Pharmacological aspects of the use of lipoic acid (review). Pharm. Chem. J. 55: 1138\u20131146. doi:https:\/\/doi.org\/10.1007\/s11094-022-02549-7.","DOI":"10.1007\/s11094-022-02549-7"},{"key":"10.1016\/j.rvsc.2025.105822_bb0205","article-title":"Myricetin-loaded SBA-15 silica nanoparticles for enhanced management of pyrexia, pain, and inflammation through modulation of MAPK\/NF-\u03baB and COX-2\/PGE-2 pathways: evidence from biochemical, histological, and metabolomic analysis","volume":"666","author":"Zeinab","year":"2024","journal-title":"Int. J. Pharm."},{"issue":"9","key":"10.1016\/j.rvsc.2025.105822_bb0210","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.1007\/s43032-024-01526-7","article-title":"The essential role of PGF2\u03b1\/PTGFR in molding endometrial breakdown and vascular dynamics, regulated by HIF-1\u03b1 in a mouse menstrual-like model","volume":"31","author":"Zhou","year":"2024","journal-title":"Reprod. Sci."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528825002966?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528825002966?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T23:36:23Z","timestamp":1768692983000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528825002966"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":43,"alternative-id":["S0034528825002966"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2025.105822","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Metabolite profile as a prime marker of fertility detection in Egyptian dairy buffaloes (Bubalus bubalis)","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2025.105822","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"105822"}}