{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T14:00:12Z","timestamp":1785074412511,"version":"3.55.0"},"reference-count":41,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32373070"],"award-info":[{"award-number":["32373070"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.rvsc.2026.106165","type":"journal-article","created":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T03:43:30Z","timestamp":1774583010000},"page":"106165","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dihydromyricetin attenuates LPS-induced liver injury in chicks through the JNK signaling pathway"],"prefix":"10.1016","volume":"205","author":[{"given":"Lina","family":"Jia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarui","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenghua","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingchao","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinru","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianan","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changwen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2026.106165_bb0005","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/35106036","article-title":"The promise of retinoids to fight against cancer","volume":"1","author":"Altucci","year":"2001","journal-title":"Nat. Rev. Cancer."},{"key":"10.1016\/j.rvsc.2026.106165_bb0010","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1016\/j.jhep.2013.03.033","article-title":"Decoding cell death signals in liver inflammation","volume":"59","author":"Brenner","year":"2013","journal-title":"J. Hepatol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1111\/bph.12432","article-title":"JNK signalling in cancer: in need of new, smarter therapeutic targets","volume":"171","author":"Bubici","year":"2014","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0020","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.jep.2014.12.013","article-title":"Protective effects of Penthorum chinense Pursh against chronic ethanol-induced liver injury in mice","volume":"161","author":"Cao","year":"2015","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0025","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s13567-020-00796-8","article-title":"Dihydromyricetin attenuates Escherichia coli lipopolysaccharide-induced ileum injury in chickens by inhibiting NLRP3 inflammasome and TLR4\/NF-\u03baB signalling pathway","volume":"51","author":"Chang","year":"2020","journal-title":"Vet. Res."},{"key":"10.1016\/j.rvsc.2026.106165_bb0030","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6692579","article-title":"Dihydromyricetin acts as a potential redox balance mediator in cancer chemoprevention","volume":"2021","author":"Chen","year":"2021","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.rvsc.2026.106165_bb0035","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2015.05.009","article-title":"Dihydromyricetin improves glucose and lipid metabolism and exerts anti-inflammatory effects in nonalcoholic fatty liver disease: a randomized controlled trial","volume":"99","author":"Chen","year":"2015","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.rvsc.2026.106165_bb0040","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13567-023-01184-8","article-title":"Dihydromyricetin inhibits African swine fever virus replication by downregulating toll-like receptor 4-dependent pyroptosis in vitro","volume":"54","author":"Chen","year":"2023","journal-title":"Vet. Res."},{"key":"10.1016\/j.rvsc.2026.106165_bb0045","doi-asserted-by":"crossref","first-page":"8534","DOI":"10.3390\/molecules27238534","article-title":"Paeoniflorin protects against acetaminophen-induced liver injury in mice via JNK signaling pathway","volume":"27","author":"Deng","year":"2022","journal-title":"Molecules."},{"key":"10.1016\/j.rvsc.2026.106165_bb0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2021.105767","article-title":"Dihydromyricetin improves DSS-induced colitis in mice via modulation of fecal-bacteria-related bile acid metabolism","volume":"171","author":"Dong","year":"2021","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.rvsc.2026.106165_bb0055","first-page":"1531","article-title":"Phosphorylation-dependent targeting of c-Jun ubiquitination by Jun N-kinase","volume":"13","author":"Fuchs","year":"1996","journal-title":"Oncogene."},{"key":"10.1016\/j.rvsc.2026.106165_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.174079","article-title":"JNK signaling pathway in metabolic disorders: an emerging therapeutic target","volume":"901","author":"Garg","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0065","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.scitotenv.2019.01.360","article-title":"H2S inhalation-induced energy metabolism disturbance is involved in LPS mediated hepatocyte apoptosis through mitochondrial pathway","volume":"663","author":"Guo","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.rvsc.2026.106165_bb0070","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.jphotobiol.2016.05.002","article-title":"Apoptosis inhibition effect of Dihydromyricetin against UVA-exposed human keratinocyte cell line","volume":"161","author":"He","year":"2016","journal-title":"J. Photochem. Photobiol. B."},{"key":"10.1016\/j.rvsc.2026.106165_bb0075","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1021\/acs.jnatprod.5b00275","article-title":"Suppression of inflammatory responses by Dihydromyricetin, a flavonoid from Ampelopsis grossedentata, via inhibiting the activation of NF-\u03baB and MAPK signaling pathways","volume":"78","author":"Hou","year":"2015","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.rvsc.2026.106165_bb0080","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s13238-010-0019-9","article-title":"MAPK signaling in inflammation-associated cancer development","volume":"1","author":"Huang","year":"2010","journal-title":"Protein Cell."},{"key":"10.1016\/j.rvsc.2026.106165_bb0085","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12865-017-0199-7","article-title":"Lipopolysaccharide mediates immuno-pathological alterations in young chicken liver through TLR4 signaling","volume":"18","author":"Huang","year":"2017","journal-title":"BMC Immunol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0090","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1097\/01.CCM.0000259462.97164.A0","article-title":"Incidence and prognosis of early hepatic dysfunction in critically ill patients--a prospective multicenter study","volume":"35","author":"Kramer","year":"2007","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.rvsc.2026.106165_bb0095","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1152\/physrev.2001.81.2.807","article-title":"Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation","volume":"81","author":"Kyriakis","year":"2001","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.rvsc.2026.106165_bb0100","doi-asserted-by":"crossref","first-page":"7112","DOI":"10.1021\/acs.jafc.0c01722","article-title":"Nobiletin protects against acute liver injury via targeting c-Jun N-terminal kinase (JNK)-induced apoptosis of hepatocytes","volume":"68","author":"Li","year":"2020","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.rvsc.2026.106165_bb0105","doi-asserted-by":"crossref","first-page":"31805","DOI":"10.18632\/oncotarget.5567","article-title":"Mutation of cysteine 46 in IKK-beta increases inflammatory responses","volume":"6","author":"Li","year":"2015","journal-title":"Oncotarget."},{"key":"10.1016\/j.rvsc.2026.106165_bb0110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1007\/s12011-018-1629-y","article-title":"Association between cortisol, insulin resistance and zinc in obesity: a mini-review","volume":"191","author":"Morais","year":"2019","journal-title":"Biol. Trace Elem. Res."},{"issue":"3","key":"10.1016\/j.rvsc.2026.106165_bb0115","first-page":"221","article-title":"Study on the hypolipidemic effect of flavones and dihydromyricetin from Tengcha","volume":"27","author":"Mou-cheng","year":"2007","journal-title":"J. Tea Sci. 2007"},{"key":"10.1016\/j.rvsc.2026.106165_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2020.110266","article-title":"Selenium ameliorates cadmium-induced mouse leydig TM3 cell apoptosis via inhibiting the ROS\/JNK \/c-Jun signaling pathway","volume":"192","author":"Ren","year":"2020","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.rvsc.2026.106165_bb0125","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/B978-0-12-396456-4.00013-4","article-title":"Role of the JNK pathway in human diseases","volume":"106","author":"Sabapathy","year":"2012","journal-title":"Prog. Mol. Biol. Transl. Sci."},{"key":"10.1016\/j.rvsc.2026.106165_bb0130","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1021\/acs.jnatprod.2c00324","article-title":"Platanosides, a potential botanical drug combination, decrease liver injury caused by acetaminophen overdose in mice","volume":"85","author":"Samuvel","year":"2022","journal-title":"J. Nat. Prod."},{"key":"10.1016\/j.rvsc.2026.106165_bb0135","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1186\/s13567-022-01024-1","article-title":"Dihydromyricetin alleviates Escherichia coli lipopolysaccharide-induced hepatic injury in chickens by inhibiting the NLRP3 inflammasome","volume":"53","author":"Shi","year":"2022","journal-title":"Vet. Res."},{"key":"10.1016\/j.rvsc.2026.106165_bb0140","doi-asserted-by":"crossref","DOI":"10.1042\/BSR20180902","article-title":"Protective role of Dihydromyricetin in Alzheimer\u2019s disease rat model associated with activating AMPK\/SIRT1 signaling pathway","volume":"39","author":"Sun","year":"2019","journal-title":"Biosci. Rep."},{"key":"10.1016\/j.rvsc.2026.106165_bb0145","article-title":"Mechanism of Dihydromyricetin on inflammatory diseases","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0150","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s12967-019-1900-9","article-title":"Apolipoprotein A5 alleviates LPS\/D-GalN-induced fulminant liver failure in mice by inhibiting TLR4-mediated NF-\u03baB pathway","volume":"17","author":"Tao","year":"2019","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.rvsc.2026.106165_bb0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172888","article-title":"Multitarget and promising role of dihydromyricetin in the treatment of metabolic diseases","volume":"870","author":"Tong","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.neulet.2023.137404","article-title":"Dihydromyricetin alleviates hippocampal ferroptosis in type 2 diabetic cognitive impairment rats via inhibiting the JNK-inflammatory factor pathway","volume":"812","author":"Wang","year":"2023","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.rvsc.2026.106165_bb0165","article-title":"Dihydromyricetin protects against diabetic cardiomyopathy in Streptozotocin-induced diabetic mice","volume":"2017","author":"Wu","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"10.1016\/j.rvsc.2026.106165_bb0170","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.3390\/cancers14143487","article-title":"Present status, challenges, and prospects of Dihydromyricetin in the Battle against Cancer","volume":"14","author":"Wu","year":"2022","journal-title":"Cancers (Basel)."},{"key":"10.1016\/j.rvsc.2026.106165_bb0175","doi-asserted-by":"crossref","first-page":"3071","DOI":"10.2147\/DDDT.S378786","article-title":"Dihydromyricetin attenuates cerebral ischemia reperfusion injury by inhibiting SPHK1\/mTOR signaling and targeting Ferroptosis","volume":"16","author":"Xie","year":"2022","journal-title":"Drug Des. Devel. Ther."},{"key":"10.1016\/j.rvsc.2026.106165_bb0180","doi-asserted-by":"crossref","first-page":"498","DOI":"10.3109\/08830185.2014.889129","article-title":"The role of the liver in sepsis","volume":"33","author":"Yan","year":"2014","journal-title":"Int. Rev. Immunol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0185","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/taap.2000.8968","article-title":"Synergistic hepatotoxicity from coexposure to bacterial endotoxin and the pyrrolizidine alkaloid monocrotaline","volume":"166","author":"Yee","year":"2000","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2022.154437","article-title":"Study on the mechanism of Tong-Qiao-Huo-Xue decoction regulating apoptosis via ASK1\/MKK4\/JNK pathway in MCAO\/R rats","volume":"106","author":"Yuan","year":"2022","journal-title":"Phytomedicine."},{"key":"10.1016\/j.rvsc.2026.106165_bb0195","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.3389\/fphar.2018.01204","article-title":"Recent update on the pharmacological effects and mechanisms of dihydromyricetin","volume":"9","author":"Zhang","year":"2018","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106165_bb0200","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.biopha.2016.06.036","article-title":"Curcumin alleviates lipopolysaccharide induced sepsis and liver failure by suppression of oxidative stress-related inflammation via PI3K\/AKT and NF-\u03baB related signaling","volume":"83","author":"Zhong","year":"2016","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.rvsc.2026.106165_bb0205","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.202101093","article-title":"Dihydromyricetin improves high-fat diet-induced hyperglycemia through ILC3 activation via a SIRT3-dependent mechanism","volume":"66","author":"Zhou","year":"2022","journal-title":"Mol. Nutr. Food Res."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528826001189?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528826001189?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T13:12:40Z","timestamp":1785071560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528826001189"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":41,"alternative-id":["S0034528826001189"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2026.106165","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dihydromyricetin attenuates LPS-induced liver injury in chicks through the JNK signaling pathway","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2026.106165","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106165"}}