{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:25:38Z","timestamp":1794288338653,"version":"4.9.0"},"reference-count":50,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T00:00:00Z","timestamp":1791763200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005969","name":"University of Bologna","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005969","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023440","name":"Escuela Superior Polit\u00e9cnica de Chimborazo","doi-asserted-by":"publisher","award":["IDIPI-333"],"award-info":[{"award-number":["IDIPI-333"]}],"id":[{"id":"10.13039\/501100023440","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Research in Veterinary Science"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.rvsc.2026.106437","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T15:51:17Z","timestamp":1791820277000},"page":"106437","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Cytoprotective effect of microencapsulated Vaccinium floribundum Kunth on porcine vascular wall mesenchymal stem cells under serum deprivation conditions"],"prefix":"10.1016","volume":"213","author":[{"given":"Giulia","family":"Biondolillo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irvin","family":"Tubon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabiana","family":"Antognoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Melotti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Salaroli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Augusta","family":"Zannoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara","family":"Bernardini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.rvsc.2026.106437_bb0005","doi-asserted-by":"crossref","DOI":"10.3389\/fvets.2026.1834730","article-title":"Microencapsulated Vaccinium floribundum Kunth extract promotes endothelial angiogenesis in vitro and attenuates inflammation in vitro and in vivo","volume":"13","author":"Antognoni","year":"2026","journal-title":"Front. Vet. Sci."},{"key":"10.1016\/j.rvsc.2026.106437_bb0010","doi-asserted-by":"crossref","DOI":"10.3390\/molecules29235504","article-title":"Bioactive properties of microencapsulated anthocyanins from Vaccinium floribundum and Rubus glaucus","volume":"29","author":"Barba-Ostria","year":"2024","journal-title":"Molecules"},{"key":"10.1016\/j.rvsc.2026.106437_bb0015","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1186\/s12917-019-1873-1","article-title":"Constitutive and LPS-stimulated secretome of porcine Vascular Wall-mesenchymal stem cells exerts effects on in vitro endothelial angiogenesis","volume":"15","author":"Bernardini","year":"2019","journal-title":"BMC Vet. Res."},{"key":"10.1016\/j.rvsc.2026.106437_bb0020","doi-asserted-by":"crossref","DOI":"10.3390\/ani13162601","article-title":"Isolation of vascular wall mesenchymal stem cells from the thoracic aorta of adult G\u00f6ttingen minipigs: a new protocol for the simultaneous endothelial cell collection","volume":"13","author":"Bernardini","year":"2023","journal-title":"Animals"},{"key":"10.1016\/j.rvsc.2026.106437_bb0025","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1093\/jpp\/rgac098","article-title":"Different protective capability of chlorogenic acid and quercetin against indomethacin-induced gastrointestinal ulceration","volume":"75","author":"Boonyong","year":"2023","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0030","doi-asserted-by":"crossref","DOI":"10.3390\/nu14235133","article-title":"Behind the scenes of anthocyanins\u2014from the health benefits to potential applications in food, pharmaceutical and cosmetic fields","volume":"14","author":"C\u00e2mara","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.rvsc.2026.106437_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.scienta.2022.111207","article-title":"Reproductive phenology of Vaccinium floribundum Kunth (Ericaceae) and codification according to the BBCH scale based on evidence from the volcano Chimborazo paramo (Ecuador)","volume":"303","author":"Caranqui-Aldaz","year":"2022","journal-title":"Sci. Hortic."},{"key":"10.1016\/j.rvsc.2026.106437_bb0040","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.vetimm.2012.03.015","article-title":"Comparative phenotypic and molecular characterization of porcine mesenchymal stem cells from different sources for translational studies in a large animal model","volume":"147","author":"Casado","year":"2012","journal-title":"Vet. Immunol. Immunopathol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0060","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1002\/ddr.21940","article-title":"Quercetin regulates vascular endothelium function in chronic renal failure via modulation of Eph\/Cav-1 signaling","volume":"83","author":"Chen","year":"2022","journal-title":"Drug Dev. Res."},{"key":"10.1016\/j.rvsc.2026.106437_bb0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.116003","article-title":"Chlorogenic acid attenuates deoxynivalenol-induced apoptosis and pyroptosis in human keratinocytes via activating Nrf2\/HO-1 and inhibiting MAPK\/NF-\u03baB\/NLRP3 pathways","volume":"170","author":"Chen","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.rvsc.2026.106437_bb0045","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s40883-018-0056-0","article-title":"In vitro models of ischemia-reperfusion injury","volume":"4","author":"Chen","year":"2018","journal-title":"Regen. Eng. Transl. Med."},{"key":"10.1016\/j.rvsc.2026.106437_bb0050","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/983059","article-title":"Cellular kinetics of perivascular MSC precursors","volume":"2013","author":"Chen","year":"2013","journal-title":"Stem Cells Int."},{"key":"10.1016\/j.rvsc.2026.106437_bb0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2019.172885","article-title":"Quercetin protects the vascular endothelium against iron overload damages via ROS\/ADMA\/DDAHII\/eNOS\/NO pathway","volume":"868","author":"Chen","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0070","doi-asserted-by":"crossref","DOI":"10.1155\/2024\/5698119","article-title":"Quercetin attenuates oxidative stress and apoptosis in brain tissue of APP\/PS1 double transgenic AD mice by regulating Keap1\/Nrf2\/HO-1 pathway to improve cognitive impairment","volume":"2024","author":"Cheng","year":"2024","journal-title":"Behav. Neurol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0075","doi-asserted-by":"crossref","first-page":"1873","DOI":"10.1016\/j.fct.2007.04.003","article-title":"Cytoprotective effect of anthocyanins against doxorubicin-induced toxicity in H9c2 cardiomyocytes in relation to their antioxidant activities","volume":"45","author":"Choi","year":"2007","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0080","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1093\/stmcls\/sxac066","article-title":"The characteristics and survival potential under sub-lethal stress of mesenchymal stromal\/stem cells isolated from the human Vascular Wall","volume":"40","author":"Ciavarella","year":"2022","journal-title":"Stem Cells"},{"key":"10.1016\/j.rvsc.2026.106437_bb0085","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1016\/j.transproceed.2010.03.080","article-title":"Isolation and ex vivo expansion of bone marrow\u2013derived porcine mesenchymal stromal cells: potential for application in an experimental model of solid organ transplantation in large animals","volume":"42","author":"Comite","year":"2010","journal-title":"Transplant. Proc."},{"key":"10.1016\/j.rvsc.2026.106437_bb0090","doi-asserted-by":"crossref","first-page":"3223","DOI":"10.12659\/MSM.896916","article-title":"Angiotensin II-induced apoptosis of human umbilical vein endothelial cells was inhibited by blueberry anthocyanin through Bax- and caspase 3-dependent pathways","volume":"22","author":"Du","year":"2016","journal-title":"Med. Sci. Monit."},{"key":"10.1016\/j.rvsc.2026.106437_bb0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.jim.2005.06.021","article-title":"Quantitative simultaneous multiplex real-time PCR for the detection of porcine cytokines","volume":"306","author":"Duvigneau","year":"2005","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.rvsc.2026.106437_bb0100","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1080\/13880209.2022.2110599","article-title":"Chlorogenic acid promotes angiogenesis and attenuates apoptosis following cerebral ischaemia-reperfusion injury by regulating the PI3K-Akt signalling","volume":"60","author":"Fan","year":"2022","journal-title":"Pharm. Biol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.tiv.2021.105131","article-title":"PTEN mediates serum deprivation-induced cytotoxicity in H9c2 cells via the PI3K\/AKT signaling pathway","volume":"73","author":"Gong","year":"2021","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.rvsc.2026.106437_bb0110","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1186\/s13287-020-01682-y","article-title":"A novel role of vitronectin in promoting survival of mesenchymal stem cells under serum deprivation stress","volume":"11","author":"Goyal","year":"2020","journal-title":"Stem Cell Res. Ther."},{"key":"10.1016\/j.rvsc.2026.106437_bb0115","doi-asserted-by":"crossref","first-page":"14680","DOI":"10.18632\/oncotarget.14747","article-title":"Cytoprotective effect of chlorogenic acid against hydrogen peroxide-induced oxidative stress in MC3T3-E1 cells through PI3K\/Akt-mediated Nrf2\/HO-1 signaling pathway","volume":"8","author":"Han","year":"2017","journal-title":"Oncotarget"},{"key":"10.1016\/j.rvsc.2026.106437_bb0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.freeradbiomed.2019.04.014","article-title":"Chlorogenic acid promotes the Nrf2\/HO-1 anti-oxidative pathway by activating p21Waf1\/Cip1 to resist dexamethasone-induced apoptosis in osteoblastic cells","volume":"137","author":"Han","year":"2019","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.rvsc.2026.106437_bb0125","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1002\/ame2.12551","article-title":"Targeting signaling pathways in neurodegenerative diseases: quercetin's cellular and molecular mechanisms for neuroprotection","volume":"8","author":"Islam","year":"2025","journal-title":"Anim. Model. Exp. Med."},{"key":"10.1016\/j.rvsc.2026.106437_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112039","article-title":"Cytoprotective effects of the flavonoid quercetin by activating mitochondrial BKCa channels in endothelial cells","volume":"142","author":"Kampa","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.rvsc.2026.106437_bb0135","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1002\/jnr.23204","article-title":"In vitro ischemia suppresses hypoxic induction of hypoxia inducible factor-1\u03b1 by inhibition of synthesis and not enhanced degradation","volume":"91","author":"Karuppagounder","year":"2013","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.rvsc.2026.106437_bb0140","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2014.00169","article-title":"Nestin(+) tissue-resident multipotent stem cells contribute to tumor progression by differentiating into pericytes and smooth muscle cells resulting in blood vessel remodeling","volume":"4","author":"Klein","year":"2014","journal-title":"Front. Oncol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/ani15213095","article-title":"Mammary epithelial cell spheroid: stabilization through vascular-wall mesenchymal stem cells and endothelial cells co-culture","volume":"15","author":"La Mantia","year":"2025","journal-title":"Animals"},{"key":"10.1016\/j.rvsc.2026.106437_bb0150","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1002\/jcb.22731","article-title":"LPA rescues ER stress-associated apoptosis in hypoxia and serum deprivation-stimulated mesenchymal stem cells","volume":"111","author":"Li","year":"2010","journal-title":"J. Cell. Biochem."},{"key":"10.1016\/j.rvsc.2026.106437_bb0155","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1089\/scd.2012.0504","article-title":"Defining vascular stem cells","volume":"22","author":"Lin","year":"2013","journal-title":"Stem Cells Dev."},{"key":"10.1016\/j.rvsc.2026.106437_bb0160","article-title":"Sea buckthorn Proanthocyanidins are the protective agent of mitochondrial function in macrophages under oxidative stress","volume":"13","author":"Liu","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0165","article-title":"In vitro techniques to domesticate Morti\u00f1o (Vaccinium floribundum Kunth) and other Vaccinium species: a review","volume":"14","author":"Montesdeoca","year":"2025","journal-title":"Plants"},{"key":"10.1016\/j.rvsc.2026.106437_bb0170","doi-asserted-by":"crossref","first-page":"275","DOI":"10.3109\/14653241003596679","article-title":"Multidistrict human mesenchymal vascular cells: pluripotency and stemness characteristics","volume":"12","author":"Pasquinelli","year":"2010","journal-title":"Cytotherapy"},{"key":"10.1016\/j.rvsc.2026.106437_bb0175","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1089\/ten.2006.0325","article-title":"Prolonged hypoxia concomitant with serum deprivation induces massive human mesenchymal stem cell death","volume":"13","author":"Potier","year":"2007","journal-title":"Tissue Eng."},{"key":"10.1016\/j.rvsc.2026.106437_bb0180","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1161\/CIRCRESAHA.116.305368","article-title":"Vascular Wall progenitor cells in health and disease","volume":"116","author":"Psaltis","year":"2015","journal-title":"Circ. Res."},{"key":"10.1016\/j.rvsc.2026.106437_bb0185","doi-asserted-by":"crossref","first-page":"144","DOI":"10.5344\/ajev.1965.16.3.144","article-title":"Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents","volume":"16","author":"Singleton","year":"1965","journal-title":"Am. J. Enol. Vitic."},{"key":"10.1016\/j.rvsc.2026.106437_bb0190","first-page":"29","article-title":"MicroRNA-329-3p alleviates high glucose-induced endothelial cell injury via inhibition of the TLR4\/TRAF6\/NF-\u03baB signaling pathway","volume":"21","author":"Song","year":"2021","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.rvsc.2026.106437_bb0195","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/6829173","article-title":"In vitro anti-inflammatory effect of Salvia sagittata ethanolic extract on primary cultures of porcine aortic endothelial cells","volume":"2019","author":"Tubon","year":"2019","journal-title":"Oxidative Med. Cell. Longev."},{"key":"10.1016\/j.rvsc.2026.106437_bb0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2020.110040","article-title":"Kaempferol protects mitochondria and alleviates damages against endotheliotoxicity induced by doxorubicin","volume":"126","author":"Wu","year":"2020","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.rvsc.2026.106437_bb0205","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.atherosclerosis.2006.09.006","article-title":"Inhibitory effect of polyphenol cyanidin on TNF-\u03b1-induced apoptosis through multiple signaling pathways in endothelial cells","volume":"193","author":"Xu","year":"2007","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.rvsc.2026.106437_bb0210","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/fcp.12926","article-title":"Targeting Nrf2 signaling pathway by quercetin in the prevention and treatment of neurological disorders: an overview and update on new developments","volume":"37","author":"Zamanian","year":"2023","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.rvsc.2026.106437_bb0215","doi-asserted-by":"crossref","first-page":"4378","DOI":"10.1111\/1541-4337.13026","article-title":"An updated review on the stability of anthocyanins regarding the interaction with food proteins and polysaccharides","volume":"21","author":"Zang","year":"2022","journal-title":"Compr. Rev. Food Sci. Food Saf."},{"key":"10.1016\/j.rvsc.2026.106437_bb0220","first-page":"C322","article-title":"Cells derived from porcine aorta tunica media show mesenchymal stromal-like cell properties in in vitro culture","volume":"306","author":"Zaniboni","year":"2014","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.rvsc.2026.106437_bb0225","first-page":"C320","article-title":"In vitro differentiation of porcine aortic vascular precursor cells to endothelial and vascular smooth muscle cells","volume":"309","author":"Zaniboni","year":"2015","journal-title":"Am. J. Phys. Cell Phys."},{"key":"10.1016\/j.rvsc.2026.106437_bb0230","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1093\/cvr\/cvt061","article-title":"Blood flow and stem cells in vascular disease","volume":"99","author":"Zhang","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"10.1016\/j.rvsc.2026.106437_bb0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2023.12.020","article-title":"New perspectives on the therapeutic potential of quercetin in non-communicable diseases: targeting Nrf2 to counteract oxidative stress and inflammation","volume":"14","author":"Zhang","year":"2024","journal-title":"J. Pharm. Anal."},{"key":"10.1016\/j.rvsc.2026.106437_bb0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.ecoenv.2021.112586","article-title":"Procyanidins inhibit fine particulate matter-induced vascular smooth muscle cells apoptosis via the activation of the Nrf2 signaling pathway","volume":"223","author":"Zhang","year":"2021","journal-title":"Ecotoxicol. Environ. Saf."},{"key":"10.1016\/j.rvsc.2026.106437_bb0245","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12964-022-00860-0","article-title":"Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-\u03baB signaling pathway","volume":"20","author":"Zheng","year":"2022","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.rvsc.2026.106437_bb0250","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1016\/S0308-8146(98)00102-2","article-title":"The determination of flavonoid contents in mulberry and their scavenging effects on superoxide radicals","volume":"64","author":"Zhishen","year":"1999","journal-title":"Food Chem."}],"container-title":["Research in Veterinary Science"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528826003917?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0034528826003917?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T05:18:07Z","timestamp":1794287887000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0034528826003917"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":50,"alternative-id":["S0034528826003917"],"URL":"https:\/\/doi.org\/10.1016\/j.rvsc.2026.106437","relation":{},"ISSN":["0034-5288"],"issn-type":[{"value":"0034-5288","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cytoprotective effect of microencapsulated Vaccinium floribundum Kunth on porcine vascular wall mesenchymal stem cells under serum deprivation conditions","name":"articletitle","label":"Article Title"},{"value":"Research in Veterinary Science","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.rvsc.2026.106437","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106437"}}