{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:54:09Z","timestamp":1786996449337,"version":"build-2736575974"},"reference-count":54,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,3,1]],"date-time":"2018-03-01T00:00:00Z","timestamp":1519862400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2018,3]]},"DOI":"10.1016\/j.saa.2017.11.034","type":"journal-article","created":{"date-parts":[[2017,12,2]],"date-time":"2017-12-02T05:40:45Z","timestamp":1512193245000},"page":"427-436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Successive ratio subtraction as a novel manipulation of ratio spectra for quantitative determination of a mixture of furosemide, spironolactone and canrenone"],"prefix":"10.1016","volume":"192","author":[{"given":"Aml A.","family":"Emam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eglal A.","family":"Abdelaleem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim A.","family":"Naguib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7032-9149","authenticated-orcid":false,"given":"Fatma F.","family":"Abdallah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nouruddin W.","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2017.11.034_bb0005","series-title":"National Formulary 29","author":"The United States Pharmacopeia","year":"2011"},{"key":"10.1016\/j.saa.2017.11.034_bb0010","series-title":"Martindale, The Complete Drug Reference","author":"Annon","year":"2002"},{"key":"10.1016\/j.saa.2017.11.034_bb0015","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1016\/j.jacc.2010.06.034","volume":"56","author":"Jentzer","year":"2010","journal-title":"J. Am. Coll. Cardiol."},{"key":"10.1016\/j.saa.2017.11.034_bb0020","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1016\/S0090-9556(25)08434-X","article-title":"Hepatic metabolism of spironolactone. Production of 3-hydroxy-thiomethyl metabolites","volume":"22","author":"Los","year":"2017","journal-title":"Drug Metab. Dispos."},{"key":"10.1016\/j.saa.2017.11.034_bb0025","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1080\/00032719708002293","volume":"30","author":"Sevillano-Cabeza","year":"1997","journal-title":"Anal. Lett."},{"key":"10.1016\/j.saa.2017.11.034_bb0030","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1016\/0731-7085(90)80155-I","volume":"8","author":"Agatonovi\u0107-Ku\u0161trin","year":"1990","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0035","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1134\/S1061934806080053","volume":"61","author":"G\u00f6lc\u00fc","year":"2006","journal-title":"J. Anal. Chem."},{"key":"10.1016\/j.saa.2017.11.034_bb0040","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1007\/BF01244497","volume":"100","author":"\u017divanovi\u0107","year":"1990","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.saa.2017.11.034_bb0045","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1081\/AL-200057227","volume":"38","author":"Tescarollo Dias","year":"2005","journal-title":"Anal. Lett."},{"key":"10.1016\/j.saa.2017.11.034_bb0050","doi-asserted-by":"crossref","first-page":"2557","DOI":"10.1080\/00032710600824698","volume":"39","author":"Silva Semaan","year":"2006","journal-title":"Anal. Lett."},{"key":"10.1016\/j.saa.2017.11.034_bb0055","first-page":"34","volume":"22","author":"Semaan","year":"2005","journal-title":"J. Flow Injection Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0060","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S0378-4347(00)84285-1","volume":"229","author":"Wesley-Hadzija","year":"1982","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0065","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/j.1600-0773.1977.tb02146.x","volume":"41","author":"Mikkelsen","year":"1977","journal-title":"Acta Pharmacol. Toxicol."},{"key":"10.1016\/j.saa.2017.11.034_bb0070","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0378-4347(00)81194-9","volume":"164","author":"Steiness","year":"1979","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0075","doi-asserted-by":"crossref","first-page":"2839","DOI":"10.1039\/a806093b","volume":"123","author":"Ioannou","year":"1988","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2017.11.034_bb0080","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1007\/s10895-009-0479-6","volume":"19","author":"El-Wasseef","year":"2009","journal-title":"J. Fluoresc."},{"key":"10.1016\/j.saa.2017.11.034_bb0085","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1016\/j.aca.2009.12.015","volume":"661","author":"Peralta","year":"2010","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2017.11.034_bb0090","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1016\/S0731-7085(03)00422-9","volume":"33","author":"Guzm\u00e1n","year":"2003","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0095","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.1080\/01483918508074082","volume":"8","author":"Lovett","year":"1985","journal-title":"J. Liq. Chromatogr."},{"key":"10.1016\/j.saa.2017.11.034_bb0100","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/S0378-4347(98)00058-9","volume":"710","author":"Abou-Auda","year":"1998","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0105","first-page":"223","volume":"49","author":"Andreasen","year":"1981","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.saa.2017.11.034_bb0110","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0378-4347(00)86044-2","volume":"229","author":"Kerremans","year":"1982","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0115","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jps.2600810621","volume":"81","author":"Farthing","year":"1992","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.saa.2017.11.034_bb0120","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/0378-4347(94)00093-X","volume":"655","author":"Vree","year":"1994","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0125","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0731-7085(85)80061-3","volume":"3","author":"Bauza","year":"1985","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0130","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/0378-4347(84)80213-3","volume":"308","author":"Uchino","year":"1984","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0135","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1016\/0731-7085(85)80061-3","volume":"3","author":"Bauza","year":"1985","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0140","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.chroma.2004.11.055","volume":"1087","author":"Huclov\u00e1","year":"2005","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.saa.2017.11.034_bb0145","doi-asserted-by":"crossref","first-page":"2117","DOI":"10.1021\/jf00056a029","volume":"43","author":"Shaikh","year":"1995","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.saa.2017.11.034_bb0150","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0378-4347(89)80045-3","volume":"497","author":"Radeck","year":"1989","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0155","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1081\/AL-200065813","volume":"38","author":"Semaan","year":"2005","journal-title":"Anal. Lett."},{"key":"10.1016\/j.saa.2017.11.034_bb0160","doi-asserted-by":"crossref","first-page":"1126","DOI":"10.1002\/jps.2600610719","volume":"61","author":"Sadee","year":"1972","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.saa.2017.11.034_bb0165","doi-asserted-by":"crossref","first-page":"168","DOI":"10.5958\/2394-2797.2016.00024.1","volume":"3","author":"Prajapati","year":"2016","journal-title":"Int. J. Pharm. Chem. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0170","doi-asserted-by":"crossref","first-page":"1371","DOI":"10.1080\/00032719908542904","volume":"32","author":"Erk","year":"1999","journal-title":"Anal. Lett."},{"key":"10.1016\/j.saa.2017.11.034_bb0175","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1016\/j.farmac.2003.07.005","volume":"58","author":"Din\u00e7","year":"2003","journal-title":"Il Farmaco"},{"key":"10.1016\/j.saa.2017.11.034_bb0180","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1093\/chrsci\/49.2.129","volume":"49","author":"Hegazy","year":"2011","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.saa.2017.11.034_bb0185","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0378-4347(00)84041-4","volume":"341","author":"Overdiek","year":"1985","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0190","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/S0021-9673(01)81950-6","volume":"329","author":"De Croo","year":"1985","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.saa.2017.11.034_bb0195","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1093\/chromsci\/28.3.123","volume":"28","author":"Bachman","year":"1990","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.saa.2017.11.034_bb0200","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.farmac.2005.02.001","volume":"60","author":"Millership","year":"2005","journal-title":"Il Farmaco"},{"key":"10.1016\/j.saa.2017.11.034_bb0205","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1080\/00387019108020669","volume":"24","author":"Salem","year":"1991","journal-title":"Spectrosc. Lett."},{"key":"10.1016\/j.saa.2017.11.034_bb0210","first-page":"bms062","author":"Ram","year":"2012","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.saa.2017.11.034_bb0215","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1111\/j.1365-2125.1976.tb04883.x","volume":"3","author":"Ramsay","year":"1976","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.saa.2017.11.034_bb0220","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/s10973-010-0936-0","volume":"102","author":"Patyi","year":"2010","journal-title":"J. Therm. Anal. Calorim."},{"key":"10.1016\/j.saa.2017.11.034_bb0225","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0021-9673(97)01167-9","volume":"797","author":"Kaukonen","year":"1998","journal-title":"J. Chromatogr. A"},{"key":"10.1016\/j.saa.2017.11.034_bb0230","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/0378-4347(92)80097-A","volume":"574","author":"Varin","year":"1992","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0235","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/0378-4347(94)00241-X","volume":"658","author":"Herr\u00e1ez-Hern\u00e1ndez","year":"1994","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"10.1016\/j.saa.2017.11.034_bb0240","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/S0731-7085(96)01767-0","volume":"14","author":"Jankowski","year":"1996","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0245","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1002\/jms.1006","volume":"41","author":"Dong","year":"2006","journal-title":"J. Mass Spectrom."},{"key":"10.1016\/j.saa.2017.11.034_bb0250","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0039-9140(98)00357-9","volume":"49","author":"Mart\u00edn","year":"1999","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2017.11.034_bb0255","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/j.jpba.2010.03.004","volume":"52","author":"Sora","year":"2010","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2017.11.034_bb0260","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/jaoac\/91.2.299","volume":"91","author":"El-Bardicy","year":"2008","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.saa.2017.11.034_bb0265","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.saa.2012.04.095","volume":"96","author":"Lotfy","year":"2012","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2017.11.034_bb0270","series-title":"Q2B: Validation of Analytical Procedures: Methodology","volume":"62","author":"International Conference on Harmonization (ICH)","year":"1997"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142517309423?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142517309423?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,6,27]],"date-time":"2025-06-27T19:56:30Z","timestamp":1751054190000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142517309423"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3]]},"references-count":54,"alternative-id":["S1386142517309423"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2017.11.034","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2018,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Successive ratio subtraction as a novel manipulation of ratio spectra for quantitative determination of a mixture of furosemide, spironolactone and canrenone","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2017.11.034","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2017 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}