{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T17:03:39Z","timestamp":1770138219270,"version":"3.49.0"},"reference-count":57,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100001843","name":"Science and Engineering Research Board","doi-asserted-by":"publisher","award":["SB\/FT\/LS-277\/2012"],"award-info":[{"award-number":["SB\/FT\/LS-277\/2012"]}],"id":[{"id":"10.13039\/501100001843","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2019,7]]},"DOI":"10.1016\/j.saa.2019.04.013","type":"journal-article","created":{"date-parts":[[2019,4,10]],"date-time":"2019-04-10T11:27:10Z","timestamp":1554895630000},"page":"229-236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Inhibition of copper-induced aggregation of human \u03b3D-crystallin by rutin and studies on its role in molecular level for enhancing the chaperone activity of human \u03b1A-crystallin by using multi-spectroscopic techniques"],"prefix":"10.1016","volume":"218","author":[{"given":"Priyanka","family":"Chauhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kalyan S.","family":"Ghosh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2019.04.013_bb0005","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.jmb.2010.05.067","article-title":"Partially folded aggregation intermediates of human \u03b3D-, \u03b3C-, and \u03b3S-crystallin are recognized and bound by human \u03b1B-crystallin chaperone","volume":"401","author":"Sampson","year":"2010","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.saa.2019.04.013_bb0010","doi-asserted-by":"crossref","first-page":"10449","DOI":"10.1073\/pnas.89.21.10449","article-title":"\u03b1-Crystallin can function as a molecular chaperone","volume":"89","author":"Horwitz","year":"1992","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.saa.2019.04.013_bb0015","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1016\/0014-4835(90)90113-9","article-title":"Role of site-specific, metal-catalyzed oxidation in lens aging and cataract: a hypothesis","volume":"50","author":"Garland","year":"1990","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0020","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0300-9084(98)80068-0","article-title":"Vitamin C induced oxidation of eye lens gamma crystallins","volume":"80","author":"Atalay","year":"1998","journal-title":"Biochimie"},{"key":"10.1016\/j.saa.2019.04.013_bb0025","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1179\/135100099101535007","article-title":"Redox availability of lens iron and copper: implications for HO\u00b7 generation in cataract","volume":"4","author":"Garner","year":"1999","journal-title":"Redox Rep."},{"key":"10.1016\/j.saa.2019.04.013_bb0030","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1006\/exer.2000.0887","article-title":"The effects of hyperbaric oxygen on the crystallins of cultured rabbit lenses: a possible catalytic role for copper","volume":"71","author":"Padgaonkar","year":"2000","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0035","doi-asserted-by":"crossref","first-page":"263\u2212272","DOI":"10.1021\/acschembio.5b00919","article-title":"Copper and zinc ions specifically promote nonamyloid aggregation of the highly stable human \u03b3-D crystallin","volume":"11","author":"Quintanar","year":"2016","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.saa.2019.04.013_bb0040","doi-asserted-by":"crossref","first-page":"1995","DOI":"10.1021\/cr040410w","article-title":"Copper homeostasis and neurodegenerative disorders (Alzheimer's, prion, and Parkinson's diseases and amyotrophic lateral sclerosis)","volume":"106","author":"Gaggelli","year":"2006","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2019.04.013_bb0045","doi-asserted-by":"crossref","first-page":"858","DOI":"10.1016\/j.neurobiolaging.2013.09.034","article-title":"Copper pathology in vulnerable brain regions in Parkinson's disease","volume":"35","author":"Davies","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.saa.2019.04.013_bb0050","unstructured":"M.F. Ahmad, D. Singh, A. Taiyab, T. Ramakrishna, B. Raman, C.M. Rao, Selective Cu2+ binding, redox silencing, and cytoprotective effects of the small heat shock proteins \u03b1A- and \u03b1B-crystallin, J. Mol. Biol. 38 (2008) 2812\u20132824."},{"key":"10.1016\/j.saa.2019.04.013_bb0055","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1016\/j.jinorgbio.2004.03.013","article-title":"Effects of divalent metal ions on the alphaB-crystallin chaperone-like activity: spectroscopic evidence for a complex between copper (II) and protein","volume":"98","author":"Ganadu","year":"2004","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.saa.2019.04.013_bb0060","doi-asserted-by":"crossref","unstructured":"A. Biswas and K.P. Das, Zn2+ enhances the molecular chaperone function and stability of alpha-crystallin, Biochemistry 47 (2008) 804\u2013816.","DOI":"10.1021\/bi7011965"},{"key":"10.1016\/j.saa.2019.04.013_bb0065","doi-asserted-by":"crossref","first-page":"3279","DOI":"10.1021\/bi200091q","article-title":"Binding of \u03b3-crystallin substrate prevents the binding of copper and zinc ions to the molecular chaperone \u03b1-crystallin","volume":"50","author":"Ghosh","year":"2011","journal-title":"Biochemistry"},{"key":"10.1016\/j.saa.2019.04.013_bb0070","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1007\/s00775-016-1433-0","article-title":"Inhibition of copper-mediated aggregation of human \u03b3D-crystallin by Schiff bases","volume":"22","author":"Chauhan","year":"2017","journal-title":"J. Biol. Inorg. Chem."},{"key":"10.1016\/j.saa.2019.04.013_bb0075","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.1021\/jf903038r","article-title":"Recent research on polyphenolics in vision and eye health","volume":"58","author":"Kalt","year":"2010","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.saa.2019.04.013_bb0080","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1211\/jpp.62.08.0001","article-title":"Potential of the bioflavonoids in the prevention\/treatment of ocular disorders","volume":"62","author":"Majumdar","year":"2010","journal-title":"J. Pharm. Pharmacol."},{"key":"10.1016\/j.saa.2019.04.013_bb0085","doi-asserted-by":"crossref","first-page":"69","DOI":"10.2478\/v10102-011-0013-y","article-title":"Natural flavonoids as potential multifunctional agents in prevention of diabetic cataract","volume":"4","author":"Stefek","year":"2011","journal-title":"Interdiscip. Toxicol."},{"key":"10.1016\/j.saa.2019.04.013_bb0090","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/exer.2001.1049","article-title":"Antioxidant properties of green and black tea, and their potential ability to retard the progression of eye lens cataract","volume":"73","author":"Thiagarajan","year":"2001","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0095","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1159\/000063881","article-title":"Green tea (Camellia sinensis) protects against selenite-induced oxidative stress in experimental cataractogenesis","volume":"34","author":"Gupta","year":"2002","journal-title":"Ophthalmic Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0100","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.jcrs.2006.02.041","article-title":"Ingestion of IH636 grape seed proanthocyanidin extract to prevent selenite-induced oxidative stress in experimental cataract","volume":"32","author":"Durukan","year":"2006","journal-title":"J Cataract Refract Surg"},{"key":"10.1016\/j.saa.2019.04.013_bb0105","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1007\/s00417-010-1598-0","article-title":"Amelioration of selenite toxicity and cataractogenesis in cultured rat lenses by Vitex negundo","volume":"249","author":"Rooban","year":"2011","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"10.1016\/j.saa.2019.04.013_bb0110","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1002\/ptr.2005","article-title":"Modulation of selenite cataract by the flavonoid fraction of Emilia sonchifolia in experimental animal models","volume":"20","author":"Lija","year":"2006","journal-title":"Phytother. Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0115","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/02713680903428991","article-title":"Broccoli regulates protein alterations and cataractogenesis in selenite models","volume":"35","author":"Vibin","year":"2010","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0120","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1006\/exer.2002.2035","article-title":"Molecular and cellular assessment of Ginkgo biloba extract as a possible ophthalmic drug","volume":"75","author":"Thiagarajan","year":"2002","journal-title":"Exp. Eye Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0125","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.tiv.2010.05.021","article-title":"Isorhamnetin-3-glucoside alleviates oxidative stress and opacification in selenite cataract in vitro","volume":"24","author":"Devi","year":"2010","journal-title":"Toxicol. in Vitro"},{"key":"10.1016\/j.saa.2019.04.013_bb0130","doi-asserted-by":"crossref","first-page":"122","DOI":"10.3109\/02713680903447884","article-title":"Effect of curcumin on selenite-induced cataractogenesis in Wistar rat pups","volume":"35","author":"Manikandan","year":"2010","journal-title":"Curr. Eye Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0135","doi-asserted-by":"crossref","first-page":"185","DOI":"10.4103\/0301-4738.49391","article-title":"Preventive effect of onion juice on selenite-induced experimental cataract","volume":"57","author":"Javadzadeh","year":"2009","journal-title":"Indian J. Ophthalmol."},{"key":"10.1016\/j.saa.2019.04.013_bb0140","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.saa.2017.11.036","article-title":"Probing the inhibitory potency of epigallocatechin gallate against human \u03b3B-crystallin aggregation: spectroscopic, microscopic and simulation studies","volume":"192","author":"Chaudhury","year":"2017","journal-title":"Spectrochim. Acta A"},{"key":"10.1016\/j.saa.2019.04.013_bb0145","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.biochi.2017.02.016","article-title":"Green tea flavanols protect human \u03b3B-crystallin from oxidative photodamage","volume":"137","author":"Chaudhury","year":"2017","journal-title":"Biochimie"},{"key":"10.1016\/j.saa.2019.04.013_bb0150","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/S0891-5849(98)00262-7","article-title":"Quercetin inhibits hydrogen peroxide-induced oxidation of the rat lens","volume":"26","author":"Sanderson","year":"1999","journal-title":"Free. Rad. Biol. Med."},{"key":"10.1016\/j.saa.2019.04.013_bb0155","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/S0891-5849(02)00843-2","article-title":"Quercetin metabolism in the lens: role in inhibition of hydrogen peroxide induced cataract","volume":"33","author":"Cornish","year":"2002","journal-title":"Free Rad. Biol. Med."},{"key":"10.1016\/j.saa.2019.04.013_bb0160","first-page":"685","article-title":"Anticataract action of topical quercetin and myricetin in galactosemic rats","volume":"6","author":"Mohan","year":"1988","journal-title":"Med. Sci. Res."},{"key":"10.1016\/j.saa.2019.04.013_bb0165","first-page":"2570","article-title":"Prevention of selenite-induced cataractogenesis by rutin in Wistar rats","volume":"15","author":"Isai","year":"2009","journal-title":"Mol. Vis."},{"key":"10.1016\/j.saa.2019.04.013_bb0170","doi-asserted-by":"crossref","first-page":"101","DOI":"10.3341\/kjo.2010.24.2.101","article-title":"Protective effect of catechin on apoptosis of the lens epithelium in rats with N-methyl-N-nitrosoureainduced cataracts","volume":"24","author":"Lee","year":"2010","journal-title":"Korean J. Ophthalmol."},{"key":"10.1016\/j.saa.2019.04.013_bb0175","first-page":"210","article-title":"Grape seed proanthocyanidin extract protects human lens epithelial cells from oxidative stress via reducing NF-\u043aB and MAPK protein expression","volume":"17","author":"Jia","year":"2011","journal-title":"Mol. Vis."},{"key":"10.1016\/j.saa.2019.04.013_bb0180","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1110\/ps.0225503","article-title":"In vitro unfolding, refolding, and polymerization of human \u03b3D crystallin, a protein involved in cataract formation","volume":"12","author":"Kosinski-collins","year":"2003","journal-title":"Prot. Sci."},{"key":"10.1016\/j.saa.2019.04.013_bb0185","series-title":"Principles of Fluorescence Spectroscopy","author":"Lakowicz","year":"2006"},{"key":"10.1016\/j.saa.2019.04.013_bb0190","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1111\/j.1749-6632.1949.tb27297.x","article-title":"The attraction of proteins for small molecules and ions","volume":"51","author":"Scatchard","year":"1949","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.saa.2019.04.013_bb0195","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.jlumin.2017.06.032","article-title":"Studies on molecular interactions between Schiff bases and eye lens chaperone human \u03b1\u0391-crystallin","volume":"192","author":"Chauhan","year":"2017","journal-title":"J. Lumin."},{"key":"10.1016\/j.saa.2019.04.013_bb0200","doi-asserted-by":"crossref","DOI":"10.1039\/C4RA04575K","article-title":"In vitro evaluation of copper-chelating properties of flavonoids","volume":"4","author":"\u0158\u00edha","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2019.04.013_bb0205","doi-asserted-by":"crossref","unstructured":"G. Escandar and. L. Sala, Complexing behavior of rutin and quercetin, Can. J. Chem. 69 (1991) 1994\u20132001.","DOI":"10.1139\/v91-288"},{"key":"10.1016\/j.saa.2019.04.013_bb0210","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.3390\/12071352","article-title":"Synthesis and characterization of a metal complex containing naringin and Cu, and its antioxidant, antimicrobial, antiinflammatory and tumor cell cytotoxicity","volume":"12","author":"Pereira","year":"2007","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2019.04.013_bb0215","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/347872","article-title":"Synthesis, cytotoxic activity, and DNA binding properties of copper (II) complexes with hesperetin, naringenin, and apigenin","author":"Tan","year":"2009","journal-title":"Bioinorg. Chem. Appl."},{"key":"10.1016\/j.saa.2019.04.013_bb0220","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1016\/j.jinorgbio.2010.06.007","article-title":"The characterisation of structural and antioxidant properties of isoflavone metal chelates","volume":"104","author":"Dowling","year":"2010","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.saa.2019.04.013_bb0225","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.molstruc.2009.12.037","article-title":"Synthesis, characterization, spectroscopic and antioxidation studies of Cu(II)\u2013morin complex","volume":"967","author":"Panhwar","year":"2010","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2019.04.013_bb0230","doi-asserted-by":"crossref","first-page":"3270","DOI":"10.1016\/j.febslet.2011.09.005","article-title":"Complex formation of rutin and quercetin with copper alters the mode of inhibition of Ribonuclease A","volume":"585","author":"Tripathy","year":"2011","journal-title":"FEBS Lett."},{"key":"10.1016\/j.saa.2019.04.013_bb0235","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jinorgbio.2017.12.006","article-title":"Physicochemical, antioxidant, DNA cleaving properties and antimicrobial activity of fisetin-copper chelates","volume":"180","author":"\u0141odyga-Chrusci\u0144ska","year":"2018","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.saa.2019.04.013_bb0240","first-page":"6","article-title":"Spectroscopic analysis on the binding interaction of biologically active pyrimidine derivative with bovine serum albumin","volume":"65","author":"Suryawanshi","year":"2016","journal-title":"J. Pharma. Anal."},{"key":"10.1016\/j.saa.2019.04.013_bb0245","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1002\/bio.2546","article-title":"Comparison of the binding behavior of FCCP with HSA and HTF as determined by spectroscopic and molecular modeling techniques","volume":"29","author":"Moghaddam","year":"2014","journal-title":"Luminescence"},{"key":"10.1016\/j.saa.2019.04.013_bb0250","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1080\/07391102.2015.1009946","article-title":"Study of the interaction between DNP and DIDS with human hemoglobin as binary and ternary systems: spectroscopic and molecular modeling investigation","volume":"34","author":"Rashidipour","year":"2016","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2019.04.013_bb0255","doi-asserted-by":"crossref","first-page":"3096","DOI":"10.1021\/bi00514a017","article-title":"Thermodynamics of protein association reactions: forces contributing to stability","volume":"20","author":"Ross","year":"1981","journal-title":"Biochemistry"},{"key":"10.1016\/j.saa.2019.04.013_bb0260","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1110\/ps.062216006","article-title":"Fluorescence resonance energy transfer study of subunit exchange in human lens crystallins and congenital cataract crystallin mutants","volume":"15","author":"Liang","year":"2006","journal-title":"Prot. Sci."},{"key":"10.1016\/j.saa.2019.04.013_bb0265","series-title":"New Trends in Fluorescence Spectroscopy","author":"Valeur","year":"1999"},{"key":"10.1016\/j.saa.2019.04.013_bb0270","series-title":"Biophysical and Biochemical Aspects of Fluorescence Spectroscopy","first-page":"1","article-title":"Fluorescence quenching reactions: probing biological macromolecular structures","author":"Eftink","year":"1991"},{"key":"10.1016\/j.saa.2019.04.013_bb0275","doi-asserted-by":"crossref","first-page":"9792","DOI":"10.3390\/molecules16129792","article-title":"Probing the interaction of human serum albumin with norfloxacin in the presence of high-frequency electromagnetic fields: fluorescence spectroscopy and circular dichroism investigations","volume":"16","author":"Azimi","year":"2011","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2019.04.013_bb0280","doi-asserted-by":"crossref","first-page":"1880","DOI":"10.1080\/07391102.2014.977351","article-title":"A comparison study of the interaction between \u03b2-lactoglobulin and retinol at two different conditions: spectroscopic and molecular modeling approaches","volume":"33","author":"Ahmadi","year":"2015","journal-title":"J. Biomol. Struct. Dyn."},{"key":"10.1016\/j.saa.2019.04.013_bb0285","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1074\/jbc.275.6.3767","article-title":"Synthesis and characterization of a peptide identified as a functional element in alphaA-crystallin","volume":"275","author":"Sharma","year":"2000","journal-title":"J. Biol. Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519303889?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519303889?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,8,7]],"date-time":"2019-08-07T01:41:04Z","timestamp":1565142064000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142519303889"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,7]]},"references-count":57,"alternative-id":["S1386142519303889"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2019.04.013","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2019,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inhibition of copper-induced aggregation of human \u03b3D-crystallin by rutin and studies on its role in molecular level for enhancing the chaperone activity of human \u03b1A-crystallin by using multi-spectroscopic techniques","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2019.04.013","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}