{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:56:53Z","timestamp":1768816613650,"version":"3.49.0"},"reference-count":28,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2019,8]]},"DOI":"10.1016\/j.saa.2019.04.064","type":"journal-article","created":{"date-parts":[[2019,5,1]],"date-time":"2019-05-01T17:00:18Z","timestamp":1556730018000},"page":"444-449","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"special_numbering":"C","title":["Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products"],"prefix":"10.1016","volume":"219","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9130-9083","authenticated-orcid":false,"given":"Ahmed S.","family":"Saad","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eman S.","family":"Elzanfaly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael K.","family":"Halim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khadiga M.","family":"Kelani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2019.04.064_bb0005","series-title":"Martindale: The Complete Drug Reference","year":"2007"},{"key":"10.1016\/j.saa.2019.04.064_bb0010","series-title":"The Clarke's Analysis of Drugs and Poisons","year":"2005"},{"key":"10.1016\/j.saa.2019.04.064_bb0015","series-title":"The Merck Index","year":"2006"},{"key":"10.1016\/j.saa.2019.04.064_bb0020","series-title":"The British Pharmacopoeia","year":"2009"},{"key":"10.1016\/j.saa.2019.04.064_bb0025","unstructured":"The United States Pharmacopoeia (USP32), National Formulary (NF27), Asian ed., The United State Pharmacopoeia Convention, 2009."},{"key":"10.1016\/j.saa.2019.04.064_bb0030","series-title":"Physical and Technical Pharmacy","author":"Henry","year":"1963"},{"key":"10.1016\/j.saa.2019.04.064_bb0035","series-title":"Physicochemical Principles of Pharmacy","author":"Florence","year":"1988"},{"key":"10.1016\/j.saa.2019.04.064_bb0040","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1002\/dta.320","article-title":"Improved partial least squares models for stability-indicating analysis of mebeverine and sulpiride mixtures in pharmaceutical preparation: a comparative study","volume":"5","author":"Darwish","year":"2013","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.saa.2019.04.064_bb0045","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1080\/02626669809492102","article-title":"An artificial neural network approach to rainfall-runoff modelling","volume":"43","author":"Dawson","year":"1998","journal-title":"Hydrol. Sci. J."},{"key":"10.1016\/j.saa.2019.04.064_bb0050","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.saa.2016.06.001","article-title":"Full spectrum and selected spectrum based multivariate calibration methods for simultaneous determination of betamethasone dipropionate, clotrimazole and benzyl alcohol: development, validation and application on commercial dosage form","volume":"169","author":"Darwish","year":"2016","journal-title":"Spectrochim. Acta - Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2019.04.064_bb0055","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1016\/j.saa.2018.07.046","article-title":"Traditional versus advanced chemometric models for the impurity profiling of paracetamol and chlorzoxazone: application to pure and pharmaceutical dosage forms","volume":"205","author":"Saad","year":"2018","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2019.04.064_bb0060","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1002\/jps.2600681018","article-title":"High-performance liquid chromatography of two peripheral vasodilators, nylidrin hydrochloride and isoxsuprine hydrochloride, in pharmaceutical dosage forms","volume":"68","author":"Volpe","year":"1979","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.saa.2019.04.064_bb0065","series-title":"65 \u2014 Analytical Profile of Isoxsuprine Hydrochloride","author":"Facu","year":"2015"},{"key":"10.1016\/j.saa.2019.04.064_bb0070","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/S0731-7085(03)00521-1","article-title":"Chemometric determination of amiloride hydrochloride, atenolol, hydrochlorothiazide and timolol maleate in synthetic mixtures and pharmaceutical formulations","volume":"34","author":"Ferraro","year":"2004","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2019.04.064_bb0075","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1248\/cpb.54.415","article-title":"Chemometric determination of naproxen sodium and pseudoephedrine hydrochloride in tablets by HPLC","volume":"54","author":"Din\u00e7","year":"2006","journal-title":"Chem. Pharm. Bull. (Tokyo)."},{"key":"10.1016\/j.saa.2019.04.064_bb0080","first-page":"117","article-title":"Determination of enantiomeric composition of ofloxacin in tablets by chemometric techniques applied to overlapped chromatograms","volume":"7","author":"Kamal","year":"2015","journal-title":"Der Pharma Chem."},{"key":"10.1016\/j.saa.2019.04.064_bb0085","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1016\/j.saa.2013.11.045","article-title":"Different approaches in Partial Least Squares and Artificial Neural Network models applied for the analysis of a ternary mixture of Amlodipine, Valsartan and Hydrochlorothiazide","volume":"122","author":"Darwish","year":"2014","journal-title":"Spectrochim. Acta - Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2019.04.064_bb0090","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1039\/a703654j","article-title":"Multilevel multifactor designs for multivariate calibration","volume":"122","author":"Brereton","year":"1997","journal-title":"Analyst."},{"key":"10.1016\/j.saa.2019.04.064_bb0095","series-title":"Practical Handbook of Genetic Algorithms","author":"Chambers","year":"1995"},{"key":"10.1016\/j.saa.2019.04.064_bb0100","series-title":"Genetic Algorithms and Data Structures \u2014 Evolution Programs","author":"Michalewicz","year":"1996"},{"key":"10.1016\/j.saa.2019.04.064_bb0105","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0003-2670(96)00543-0","article-title":"Simultaneous spectrophotometric determination of ethinylestradiol and levonorgestrel by partial least squares and principal component regression multivariate calibration","volume":"340","author":"Berzas Nevado","year":"1997","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2019.04.064_bb0110","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/0003-2670(92)85255-5","article-title":"Optimization of calibration data with the dynamic genetic algorithm","volume":"268","author":"Li","year":"1992","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2019.04.064_bb0115","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1002\/jps.2600820816","article-title":"Spectrophotometric analysis of a pharmaceutical preparation by principal component regression","volume":"82","author":"Blanco","year":"1993","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.saa.2019.04.064_bb0120","series-title":"Chemometric Techniques for Quantitative Analysis","author":"Bayne","year":"1999"},{"key":"10.1016\/j.saa.2019.04.064_bb0125","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1021\/ac00209a024","article-title":"Comparison of multivariate calibration methods for quantitative spectral analysis","volume":"62","author":"Thomas","year":"1990","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2019.04.064_bb0130","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1080\/22297928.2018.1438312","article-title":"Application of genetic algorithm as a variable selection in partial least square and artificial neural network for the simultaneous analysis of sacubitril and valsartan in their recently approved pharmaceutical preparation","volume":"8","author":"Attia","year":"2018","journal-title":"Anal. Chem. Lett."},{"key":"10.1016\/j.saa.2019.04.064_bb0135","unstructured":"Artificial Neural Networks (ANN) Definition | Investopedia, (n.d.). https:\/\/www.investopedia.com\/terms\/a\/artificial-neural-networks-ann.asp (accessed July 23, 2018)."},{"key":"10.1016\/j.saa.2019.04.064_bb0140","series-title":"Handbook of Chemometrics and Qualimetrics","author":"Massart","year":"1997"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519304457?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519304457?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:12:02Z","timestamp":1761354722000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142519304457"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8]]},"references-count":28,"alternative-id":["S1386142519304457"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2019.04.064","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2019,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2019.04.064","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}