{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T09:28:52Z","timestamp":1762507732273},"reference-count":22,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2019,9,1]],"date-time":"2019-09-01T00:00:00Z","timestamp":1567296000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2019,9]]},"DOI":"10.1016\/j.saa.2019.05.026","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T22:58:55Z","timestamp":1557615535000},"page":"117121","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures"],"prefix":"10.1016","volume":"220","author":[{"given":"Ramzia I.","family":"El-Bagary","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marianne A.","family":"Mahrouse","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maha M.","family":"El-Hakeem","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amal B.","family":"Megally","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amira A.","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2019.05.026_bb0010","series-title":"Clinical Immunology","article-title":"Mechanism of action for leflunomide in rheumatoid arthritis","author":"Fox","year":"2018"},{"key":"10.1016\/j.saa.2019.05.026_bb0015","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1177\/1759720X09359104","article-title":"Effects of diacerein at the molecular level in the osteoarthritis disease process","volume":"2","author":"Martel-Pelletier","year":"2010","journal-title":"Ther Adv Musculoskelet Dis."},{"key":"10.1016\/j.saa.2019.05.026_bb0020","doi-asserted-by":"crossref","first-page":"1524","DOI":"10.1093\/jaoac\/89.6.1524","article-title":"Spectrophotometric stability-indicating methods for the determination of leflunomide in the presence of its degradates","volume":"89","author":"Abbas","year":"2006","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.saa.2019.05.026_bb0025","doi-asserted-by":"crossref","first-page":"414","DOI":"10.4103\/0975-1483.71631","article-title":"Visible spectrophotometric estimation of Diacerein in bulk and pharmaceutical dosage forms","volume":"2","author":"Sivakumar","year":"2010","journal-title":"J. Young Pharm."},{"key":"10.1016\/j.saa.2019.05.026_bb0030","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1016\/j.jchromb.2010.06.028","article-title":"Chromatographic separation and sensitive determination of teriflunomide, an active metabolite of leflunomide in human plasma by liquid chromatography-tandem mass spectrometry","volume":"878","author":"Parekh","year":"2010","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.saa.2019.05.026_bb0035","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1365\/s10337-006-0739-4","article-title":"HPLC with diode-array detection for determination of leflunomide in tablets","volume":"63","author":"Miron","year":"2006","journal-title":"Chromatographia"},{"key":"10.1016\/j.saa.2019.05.026_bb0040","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpba.2005.06.030","article-title":"Determination of leflunomide in tablets by high performance liquid chromatography","volume":"40","author":"Yeniceli","year":"2006","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2019.05.026_bb0045","first-page":"785","article-title":"HPLC determination of active metabolite of leflunomide in plasma","volume":"50","author":"Pawinski","year":"2005","journal-title":"Chem Analityczna"},{"key":"10.1016\/j.saa.2019.05.026_bb0050","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.jchromb.2004.01.016","article-title":"Rapid determination of the active leflunomide metabolite A77 1726 in human plasma by high-performance liquid chromatography","volume":"803","author":"Chan","year":"2004","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.saa.2019.05.026_bb0055","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/bmc.244","article-title":"Simultaneous determination of leflunomide and its active metabolite, A77 1726, in human plasma by high-performance liquid chromatography","volume":"17","author":"Schmidt","year":"2003","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.saa.2019.05.026_bb0060","first-page":"113","article-title":"Determination of leflunomide and related compounds by reversed phase high performance liquid chromatography","volume":"29","author":"Jiang","year":"2001","journal-title":"Fenxihuaxue"},{"key":"10.1016\/j.saa.2019.05.026_bb0070","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1093\/chromsci\/bmu031","article-title":"Stability-indicating HPLC method for quantification of celecoxib and diacerein along with its impurities in capsule dosage form","volume":"53","author":"Bapatu","year":"2015","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.saa.2019.05.026_bb0075","doi-asserted-by":"crossref","first-page":"498","DOI":"10.1080\/10826076.2012.745152","article-title":"Development and validation of a stability-indicating RP-HPLC method for the estimation of diacerin impurities in API and pharmaceutical formulation","volume":"37","author":"Raghava Raju","year":"2014","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.saa.2019.05.026_bb0080","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/chromsci\/bms197","article-title":"Validated stability indicating TLC-densitometric method for the determination of diacerein","volume":"52","author":"Ali","year":"2014","journal-title":"J. Chromatogr. Sci."},{"key":"10.1016\/j.saa.2019.05.026_bb0085","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.saa.2013.04.064","article-title":"Simaltaneous determination of some cholesterol-lowering drugs in their binary mixture by novel spectrophotometric methods","volume":"113","author":"Lotfy","year":"2013","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.saa.2019.05.026_bb0090","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.saa.2018.06.072","article-title":"Different resolution techniques for management of overlapped spectra: application for the determination of novel co-formulated hypogycemic drugs in their combined pharmaceutical dosage form","volume":"205","author":"Moussa","year":"2018","journal-title":"Spectrochim. Acta"},{"key":"10.1016\/j.saa.2019.05.026_bb0095","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1093\/jaoac\/91.2.299","article-title":"Smart stability-indicating spectrophotometric methods for determination of binary mixtures without prior separation","volume":"91","author":"El Bardicy","year":"2008","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.saa.2019.05.026_bb0100","first-page":"735","article-title":"Absorbance subtraction and amplitude modulation as novel spectrophotometric methods for the analysis of binary mixtures","volume":"6","author":"Lotfy","year":"2014","journal-title":"Int. J. Pharma. Pharm. Sci."},{"key":"10.1016\/j.saa.2019.05.026_bb0105","doi-asserted-by":"crossref","first-page":"761","DOI":"10.4236\/ajac.2012.311101","article-title":"A comparative study of the novel ratio difference method versus conventional spectrophotometric techniques for the analysis of binary mixture with overlapped spectra","volume":"3","author":"Lotfy","year":"2012","journal-title":"Am. J. Anal. Chem."},{"key":"10.1016\/j.saa.2019.05.026_bb0110","series-title":"Q2B: Validation of Analytical Procedures: Methodology","first-page":"62","author":"International Conference on Harmonization (ICH)","year":"2005"},{"key":"10.1016\/j.saa.2019.05.026_bb0115","series-title":"Assay of Leflunomide Tablets","author":"The United States Pharmacopoeia (USP 42)","year":"2019"},{"key":"10.1016\/j.saa.2019.05.026_bb0120","article-title":"Development and validation of RP-HPLC method for simultaneous estimation of diacerein and aceclofenac in pharmaceutical dosage form","volume":"4","author":"Nimila","year":"2010","journal-title":"International J. of Pharm tech Research."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519305025?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519305025?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,12,12]],"date-time":"2020-12-12T12:49:50Z","timestamp":1607777390000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142519305025"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9]]},"references-count":22,"alternative-id":["S1386142519305025"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2019.05.026","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2019,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Novel spectrophotometric methods for the determination of Leflunomide and Diacerein in binary mixtures","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2019.05.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117121"}}