{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,3]],"date-time":"2026-08-03T02:20:36Z","timestamp":1785723636816,"version":"3.56.0"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2020,2]]},"DOI":"10.1016\/j.saa.2019.117610","type":"journal-article","created":{"date-parts":[[2019,10,8]],"date-time":"2019-10-08T01:39:32Z","timestamp":1570498772000},"page":"117610","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":52,"special_numbering":"C","title":["A fluorescent lateral flow biosensor for the quantitative detection of Vaspin using upconverting nanoparticles"],"prefix":"10.1016","volume":"226","author":[{"given":"Muhsin","family":"Ali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Memoon","family":"Sajid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammad Asad Ullah","family":"Khalid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soo Wan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jong Hwan","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongeun","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyung Hyun","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2019.117610_bib1","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bios.2017.07.047","article-title":"Recent advances in biosensor technology in assessment of early diabetes biomarkers","volume":"99","author":"Salek-Maghsoudi","year":"2018","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib2","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1055\/s-2008-1081499","article-title":"Vaspin (SERPINA12) genotypes and risk of type 2 diabetes: results from the MONICA\/KORA studies","volume":"118","author":"Kempf","year":"2010","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"10.1016\/j.saa.2019.117610_bib3","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.metabol.2010.04.008","article-title":"Vaspin and visfatin\/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus","volume":"60","author":"El-Mesallamy","year":"2011","journal-title":"Metab. Clin. Exp."},{"key":"10.1016\/j.saa.2019.117610_bib4","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.metabol.2010.04.008","article-title":"Vaspin and visfatin\/Nampt are interesting interrelated adipokines playing a role in the pathogenesis of type 2 diabetes mellitus","volume":"60","author":"El-Mesallamy","year":"2011","journal-title":"Metabolism"},{"key":"10.1016\/j.saa.2019.117610_bib5","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.diabres.2015.12.001","article-title":"Association between vaspin level and coronary artery disease in patients with type 2 diabetes","volume":"113","author":"Hao","year":"2016","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.saa.2019.117610_bib6","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1016\/j.diabres.2014.07.026","article-title":"Higher vaspin levels in subjects with obesity and type 2 diabetes mellitus: a meta-analysis","volume":"106","author":"Feng","year":"2014","journal-title":"Diabetes Res. Clin. Pract."},{"key":"10.1016\/j.saa.2019.117610_bib7","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1177\/2211068215581349","article-title":"Development and applications of portable biosensors","volume":"20","author":"Srinivasan","year":"2015","journal-title":"J.\u00a0Lab. Autom."},{"key":"10.1016\/j.saa.2019.117610_bib8","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.snb.2017.02.060","article-title":"Aptamer-based point-of-care diagnostic platforms","volume":"246","author":"Dhiman","year":"2017","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2019.117610_bib9","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s00604-012-0772-y","article-title":"Enzyme-linked immunosorbent assay and immunochromatographic strip for rapid detection of atrazine in water samples","volume":"177","author":"Na","year":"2012","journal-title":"Microchimica Acta"},{"key":"10.1016\/j.saa.2019.117610_bib10","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/jf062523h","article-title":"Development of an immunochromatographic lateral-flow test strip for rapid detection of sulfonamides in eggs and chicken muscles","volume":"55","author":"Wang","year":"2007","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.saa.2019.117610_bib11","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.trac.2015.03.006","article-title":"Recent developments in recognition elements for chemical sensors and biosensors","volume":"68","author":"Justino","year":"2015","journal-title":"Trac. Trends Anal. Chem."},{"key":"10.1016\/j.saa.2019.117610_bib12","doi-asserted-by":"crossref","first-page":"888","DOI":"10.1016\/0002-9343(56)90103-6","article-title":"The latex fixation test: I. Application to the serologic diagnosis of rheumatoid arthritis","volume":"21","author":"Singer","year":"1956","journal-title":"Am. J. Med."},{"key":"10.1016\/j.saa.2019.117610_bib13","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s00216-016-0166-9","article-title":"Using fluorescence immunochromatographic test strips based on quantum dots for the rapid and sensitive determination of microcystin-LR","volume":"409","author":"Sun","year":"2017","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2019.117610_bib14","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bios.2015.03.032","article-title":"Immobilization of Fab\u2019fragments onto substrate surfaces: a survey of methods and applications","volume":"70","author":"Crivianu-Gaita","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib15","doi-asserted-by":"crossref","first-page":"3059","DOI":"10.1016\/j.bios.2010.11.040","article-title":"An aptamer-based chromatographic strip assay for sensitive toxin semi-quantitative detection","volume":"26","author":"Wang","year":"2011","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib16","first-page":"689","article-title":"Designs, formats and applications of lateral flow assay: a literature review","volume":"19","author":"Sajid","year":"2015","journal-title":"J.\u00a0Saudi Chem. Soc."},{"key":"10.1016\/j.saa.2019.117610_bib17","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1021\/ac8020592","article-title":"Aptamer-functionalized gold nanoparticles as probes in a dry-reagent strip biosensor for protein analysis","volume":"81","author":"Xu","year":"2008","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2019.117610_bib18","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.bios.2016.06.064","article-title":"Highly sensitive sandwich-type SPR based detection of whole H5Nx viruses using a pair of aptamers","volume":"86","author":"Nguyen","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib19","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bios.2013.07.052","article-title":"An ultra-sensitive detection of a whole virus using dual aptamers developed by immobilization-free screening","volume":"51","author":"Park","year":"2014","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib20","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.bios.2015.03.042","article-title":"Highly amplified detection of visceral adipose tissue-derived serpin (vaspin) using a cognate aptamer duo","volume":"70","author":"Raston","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib21","doi-asserted-by":"crossref","first-page":"2663","DOI":"10.1016\/j.bios.2010.04.034","article-title":"Development of a dual-aptamer-based multiplex protein biosensor","volume":"25","author":"Xie","year":"2010","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib22","doi-asserted-by":"crossref","first-page":"13425","DOI":"10.3390\/s131013425","article-title":"Development of a multiplex sandwich aptamer microarray for the detection of VEGF165 and thrombin","volume":"13","author":"Sosic","year":"2013","journal-title":"Sensors"},{"key":"10.1016\/j.saa.2019.117610_bib23","doi-asserted-by":"crossref","first-page":"997","DOI":"10.4155\/bio.13.38","article-title":"Bioanalysis of antibody\u2013drug conjugates: american association of pharmaceutical scientists antibody\u2013drug conjugate working group position paper","volume":"5","author":"Gorovits","year":"2013","journal-title":"Bioanalysis"},{"key":"10.1016\/j.saa.2019.117610_bib24","article-title":"Recent Advances and Progress of Fluorescent Bio-\/chemosensors Based on Aggregation-Induced Emission Molecules","author":"Mao","year":"2018","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2019.117610_bib25","doi-asserted-by":"crossref","first-page":"11486","DOI":"10.1039\/C5NR01444A","article-title":"Polymeric AIE-based nanoprobes for biomedical applications: recent advances and perspectives","volume":"7","author":"Zhang","year":"2015","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2019.117610_bib26","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1016\/j.msec.2017.07.006","article-title":"Microwave-assisted multicomponent reactions for rapid synthesis of AIE-active fluorescent polymeric nanoparticles by post-polymerization method","volume":"80","author":"Cao","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.saa.2019.117610_bib27","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1016\/j.msec.2017.08.048","article-title":"A\u00a0facile one-pot Mannich reaction for the construction of fluorescent polymeric nanoparticles with aggregation-induced emission feature and their biological imaging","volume":"81","author":"Jiang","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.saa.2019.117610_bib28","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1016\/j.msec.2017.04.080","article-title":"Direct encapsulation of AIE-active dye with \u03b2 cyclodextrin terminated polymers: self-assembly and biological imaging","volume":"78","author":"Huang","year":"2017","journal-title":"Mater. Sci. Eng. C"},{"key":"10.1016\/j.saa.2019.117610_bib29","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.cej.2017.12.085","article-title":"Facile preparation of fluorescent nanodiamond-based polymer composites through a metal-free photo-initiated RAFT process and their cellular imaging","volume":"337","author":"Chen","year":"2018","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.saa.2019.117610_bib30","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.saa.2019.01.011","article-title":"Poly (azomethine-urethane) and zeolite-based composite: fluorescent biosensor for DNA detection","volume":"212","author":"Kamaci","year":"2019","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2019.117610_bib31","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.saa.2019.04.068","article-title":"Highly sensitive analysis of tetrodotoxin based on free-label fluorescence aptamer sensing system","volume":"219","author":"Lan","year":"2019","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2019.117610_bib32","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.saa.2018.06.058","article-title":"Label-free fluorescent aptasensor berberine-based strategy for ultrasensitive detection of Hg2+ ion","volume":"204","author":"Song","year":"2018","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2019.117610_bib33","series-title":"Evolving Point-Of-Care Diagnostics Using Up-Converting Phosphor Bioanalytical Systems","author":"Ouellette","year":"2009"},{"key":"10.1016\/j.saa.2019.117610_bib34","doi-asserted-by":"crossref","first-page":"7622","DOI":"10.1039\/C5AN01634G","article-title":"An upconversion fluorescent resonant energy transfer biosensor for hepatitis B virus (HBV) DNA hybridization detection","volume":"140","author":"Zhu","year":"2015","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2019.117610_bib35","article-title":"Rapid multiplex detection of 10 foodborne pathogens with an up-converting phosphor technology-based 10-channel lateral flow assay","volume":"6","author":"Zhao","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2019.117610_bib36","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1021\/acs.analchem.5b04147","article-title":"Highly sensitive laser scanning of photon-upconverting nanoparticles on a macroscopic scale","volume":"88","author":"Sedlmeier","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2019.117610_bib37","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.bios.2016.09.110","article-title":"Upconversion nanoparticles grafted molybdenum disulfide nanosheets platform for microcystin-LR sensing","volume":"90","author":"Lv","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib38","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/19\/34\/345606","article-title":"An efficient and user-friendly method for the synthesis of hexagonal-phase NaYF4: Yb, Er\/Tm nanocrystals with controllable shape and upconversion fluorescence","volume":"19","author":"Li","year":"2008","journal-title":"Nanotechnology"},{"key":"10.1016\/j.saa.2019.117610_bib39","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1021\/cm031124o","article-title":"Hexagonal sodium yttrium fluoride based green and blue emitting upconversion phosphors","volume":"16","author":"Kr\u00e4mer","year":"2004","journal-title":"Chem. Mater."},{"key":"10.1016\/j.saa.2019.117610_bib40","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1196\/annals.1430.027","article-title":"Photon upconversion in homogeneous fluorescence-based bioanalytical assays","volume":"1130","author":"Soukka","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.saa.2019.117610_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.bios.2016.11.061","article-title":"A\u00a0new lateral flow strip assay (LFSA) using a pair of aptamers for the detection of Vaspin","volume":"93","author":"Raston","year":"2017","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib42","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1039\/C1CS15187H","article-title":"Upconversion nanophosphors for small-animal imaging","volume":"41","author":"Zhou","year":"2012","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2019.117610_bib43","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.cbpa.2010.08.014","article-title":"Upconverting luminescent nanoparticles for use in bioconjugation and bioimaging","volume":"14","author":"Mader","year":"2010","journal-title":"Curr. Opin. Chem. Biol."},{"key":"10.1016\/j.saa.2019.117610_bib44","doi-asserted-by":"crossref","DOI":"10.1088\/0957-4484\/23\/48\/485103","article-title":"Maleimide activation of photon upconverting nanoparticles for bioconjugation","volume":"23","author":"Liebherr","year":"2012","journal-title":"Nanotechnology"},{"key":"10.1016\/j.saa.2019.117610_bib45","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/j.bios.2015.03.037","article-title":"Diagnostics on acute myocardial infarction: cardiac troponin biomarkers","volume":"70","author":"Fathil","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2019.117610_bib46","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1039\/c0nr00253d","article-title":"Absolute quantum yield measurements of colloidal NaYF 4: Er3+, Yb3+ upconverting nanoparticles","volume":"2","author":"Boyer","year":"2010","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2019.117610_bib47","series-title":"Luminescence Applied in Sensor Science","first-page":"29","article-title":"Luminescent chemical sensing, biosensing, and screening using upconverting nanoparticles","author":"Achatz","year":"2010"},{"key":"10.1016\/j.saa.2019.117610_bib48","doi-asserted-by":"crossref","first-page":"239","DOI":"10.7150\/thno.5113","article-title":"Multicolor upconversion nanoparticles for protein conjugation","volume":"3","author":"Wilhelm","year":"2013","journal-title":"Theranostics"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519310005?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142519310005?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:15:42Z","timestamp":1761354942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142519310005"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":48,"alternative-id":["S1386142519310005"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2019.117610","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2020,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A fluorescent lateral flow biosensor for the quantitative detection of Vaspin using upconverting nanoparticles","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2019.117610","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"117610"}}