{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T05:33:13Z","timestamp":1776835993697,"version":"3.51.2"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.saa.2020.118381","type":"journal-article","created":{"date-parts":[[2020,4,16]],"date-time":"2020-04-16T21:43:30Z","timestamp":1587073410000},"page":"118381","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":39,"special_numbering":"C","title":["RNA-responsive fluorescent carbon dots for fast and wash-free nucleolus imaging"],"prefix":"10.1016","volume":"237","author":[{"given":"Xiaohui","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanqiang","family":"Sun","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lingbo","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaohui","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2020.118381_bb0005","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.tibs.2005.04.002","article-title":"The discovery of split genes and RNA splicing","volume":"30","author":"Sharp","year":"2005","journal-title":"Trends Biochem. Sci."},{"key":"10.1016\/j.saa.2020.118381_bb0010","doi-asserted-by":"crossref","first-page":"R34","DOI":"10.1186\/gb-2014-15-2-r34","article-title":"A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection","volume":"15","author":"Hoffmann","year":"2014","journal-title":"Genome Biol."},{"key":"10.1016\/j.saa.2020.118381_bb0015","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1073\/pnas.69.6.1514","article-title":"Correlation of messenger RNA function with adenylate-rich segments in the genomes of single-stranded RNA viruses","volume":"69","author":"Johnston","year":"1972","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.saa.2020.118381_bb0020","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1038\/nature12734","article-title":"RNA catalyses nuclear pre-mRNA splicing","volume":"503","author":"Fica","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.saa.2020.118381_bb0025","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1002\/jcp.1040900310","article-title":"The relative amounts of the cytoplasmic RNA species in normal, transformed and senescent cultured cell lines","volume":"90","author":"Johnson","year":"1977","journal-title":"J. Cell. Physiol."},{"key":"10.1016\/j.saa.2020.118381_bb0030","doi-asserted-by":"crossref","first-page":"4380","DOI":"10.1039\/C8TB01125G","article-title":"A ratiometric fluorescent composite nanomaterial for RNA detection based on graphene quantum dots and molecular probes","volume":"6","author":"Li","year":"2018","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2020.118381_bb0035","doi-asserted-by":"crossref","first-page":"579","DOI":"10.3390\/cells8060579","article-title":"Genome organization in and around the nucleolus","volume":"8","author":"Bersaglieri","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.saa.2020.118381_bb0040","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1039\/C6TB00319B","article-title":"A photostable AIEgen for nucleolus and mitochondria imaging with organelle-specific emission","volume":"4","author":"Yu","year":"2016","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2020.118381_bb0045","doi-asserted-by":"crossref","first-page":"5930","DOI":"10.1039\/C9CC02162K","article-title":"Phenyleneethynylene trimer-based rigid-flexible [2+2] macrocycles for nucleic acid labelling in live cells","volume":"55","author":"Moon","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118381_bb0050","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1615\/CritRevEukaryotGeneExpr.v13.i1.40","article-title":"The dynamics of the nucleolus","volume":"13","author":"Leung","year":"2003","journal-title":"Crit. Rev. Eukaryot. Gene Expr."},{"key":"10.1016\/j.saa.2020.118381_bb0055","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1101\/gad.11.19.2449","article-title":"Link between aging and the nucleolus","volume":"11","author":"Guarente","year":"1997","journal-title":"Genes Dev."},{"key":"10.1016\/j.saa.2020.118381_bb0060","doi-asserted-by":"crossref","first-page":"11358","DOI":"10.1021\/acs.analchem.8b02301","article-title":"Dynamically long-term imaging of cellular RNA by fluorescent carbon dots with surface Isoquinoline moieties and amines","volume":"90","author":"Cheng","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118381_bb0065","doi-asserted-by":"crossref","first-page":"28529","DOI":"10.1021\/acsami.6b10737","article-title":"Visible and near-infrared dual-emission carbogenic small molecular complex with high RNA selectivity and renal clearance for nucleolus and tumor imaging","volume":"8","author":"He","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2020.118381_bb0070","doi-asserted-by":"crossref","first-page":"10664","DOI":"10.1021\/acsami.7b19549","article-title":"Fluorescent carbon quantum dots with intrinsic nucleolus-targeting capability for nucleolus imaging and enhanced cytosolic and nuclear drug delivery","volume":"10","author":"Hua","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2020.118381_bb0075","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.polymer.2017.11.030","article-title":"AIE-active florescent polymers: the design, synthesis and the cell imaging application","volume":"133","author":"Lei","year":"2017","journal-title":"Polymer"},{"key":"10.1016\/j.saa.2020.118381_bb0080","doi-asserted-by":"crossref","first-page":"9259","DOI":"10.1021\/acs.analchem.9b02147","article-title":"Hydrogen-bond-induced emission of carbon dots for wash-free nucleus imaging","volume":"91","author":"Liu","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118381_bb0085","doi-asserted-by":"crossref","first-page":"3554","DOI":"10.1002\/adma.201306192","article-title":"Integrating oxaliplatin with highly luminescent carbon dots: an unprecedented theranostic agent for personalized medicine","volume":"26","author":"Zheng","year":"2014","journal-title":"Adv. Mater."},{"key":"10.1016\/j.saa.2020.118381_bb0090","doi-asserted-by":"crossref","first-page":"1901517","DOI":"10.1002\/smll.201901517","article-title":"Retrosynthesis of tunable fluorescent carbon dots for precise long-term mitochondrial tracking","volume":"15","author":"Geng","year":"2019","journal-title":"Small (Weinheim an Der Bergstrasse, Germany)"},{"key":"10.1016\/j.saa.2020.118381_bb0095","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/j.cclet.2019.06.012","article-title":"SciFinder-guided rational design of fluorescent carbon dots for ratiometric monitoring intracellular pH fluctuations under heat shock","volume":"30","author":"Liu","year":"2019","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.saa.2020.118381_bb0100","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nrc1430","article-title":"Nuclear structure in cancer cells","volume":"4","author":"Zink","year":"2004","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.saa.2020.118381_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118147","article-title":"Machine learning assisted dual-channel carbon quantum dots-based fluorescence sensor array for detection of tetracyclines","volume":"232","author":"Xu","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2020.118381_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117859","article-title":"Multicolor emissive sulfur, nitrogen co-doped carbon dots and their application in ion detection and solid lighting","volume":"229","author":"Qin","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2020.118381_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2020.118208","article-title":"Bithiophene-based fluorescent sensor for highly sensitive and ultrarapid detection of Hg2+ in water, seafood, urine and live cells","volume":"233","author":"Li","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2020.118381_bb0120","doi-asserted-by":"crossref","first-page":"1902688","DOI":"10.1002\/advs.201902688","article-title":"Gram-scale synthesis of 41% efficient single-component white-light-emissive carbonized polymer dots with hybrid fluorescence\/phosphorescence for white light-emitting diodes","volume":"7","author":"Wang","year":"2020","journal-title":"Adv. Sci."},{"key":"10.1016\/j.saa.2020.118381_bb0125","doi-asserted-by":"crossref","first-page":"1801192","DOI":"10.1002\/advs.201801192","article-title":"Graphitic nitrogen and high-crystalline triggered strong photoluminescence and room-temperature ferromagnetism in carbonized polymer dots","volume":"6","author":"Lu","year":"2019","journal-title":"Adv. Sci. (Weinh)"},{"key":"10.1016\/j.saa.2020.118381_bb0130","doi-asserted-by":"crossref","first-page":"9526","DOI":"10.1039\/C9NR01118H","article-title":"Controllable acidophilic dual-emission fluorescent carbonized polymer dots for selective imaging of bacteria","volume":"11","author":"Zhao","year":"2019","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2020.118381_bb0135","doi-asserted-by":"crossref","first-page":"2659","DOI":"10.1039\/C9QM00556K","article-title":"Carbonized polymer dots TiO2 photonic crystal heterostructures with enhanced light harvesting and charge separation for efficient and stable photocatalysis","volume":"3","author":"Yue Zhao","year":"2019","journal-title":"Mater. Chem. Front."},{"key":"10.1016\/j.saa.2020.118381_bb0140","doi-asserted-by":"crossref","first-page":"1703919","DOI":"10.1002\/smll.201703919","article-title":"One-step hydrothermal synthesis of nitrogen-doped conjugated carbonized polymer dots with 31% efficient red emission for in vivo imaging","volume":"14","author":"Liu","year":"2018","journal-title":"Small"},{"key":"10.1016\/j.saa.2020.118381_bb0145","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s11671-018-2657-4","article-title":"Sulfuric acid assisted preparation of red-emitting carbonized polymer dots and the application of bio-imaging","volume":"13","author":"Tan","year":"2018","journal-title":"Nanoscale Res. Lett."},{"key":"10.1016\/j.saa.2020.118381_bb0150","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1021\/acsomega.8b01169","article-title":"Noninvasive brain tumor imaging using red emissive carbonized polymer dots across the blood\u2013brain barrier","volume":"3","author":"Liu","year":"2018","journal-title":"ACS Omega"},{"key":"10.1016\/j.saa.2020.118381_bb0155","doi-asserted-by":"crossref","DOI":"10.1002\/adbi.201900261","article-title":"Spatiotemporally monitoring cell viability through programmable mitochondrial membrane potential transformation by using fluorescent carbon dots","volume":"4","author":"Yin","year":"2020","journal-title":"Adv. Biosyst."},{"key":"10.1016\/j.saa.2020.118381_bb0160","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1016\/j.talanta.2018.11.079","article-title":"Synthesis of sulfur-rich nitrogen dots from a single source precursor and its application in dual-mode sensing","volume":"195","author":"Tang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2020.118381_bb0165","doi-asserted-by":"crossref","first-page":"12663","DOI":"10.1021\/acsami.6b15746","article-title":"Red emission B, N, S-co-doped carbon dots for colorimetric and fluorescent dual mode detection of Fe3+ ions in complex biological fluids and living cells","volume":"9","author":"Liu","year":"2017","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2020.118381_bb0170","doi-asserted-by":"crossref","first-page":"32647","DOI":"10.1021\/acsami.9b09590","article-title":"Nucleolus-targeted red emissive carbon dots with polarity-sensitive and excitation-independent fluorescence emission: high-resolution cell imaging and in vivo tracking","volume":"11","author":"Hua","year":"2019","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2020.118381_bb0175","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1016\/j.polymer.2005.11.059","article-title":"Analysis of cation\u2013\u03c0 interactions to the structural stability of RNA binding proteins","volume":"47","author":"Chakkaravarthi","year":"2006","journal-title":"Polymer"},{"key":"10.1016\/j.saa.2020.118381_bb0180","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1021\/acs.analchem.8b05305","article-title":"Tracking of mitochondrial endogenous ribonucleic acid in the cancer cells and macrophages using a novel small-molecular fluorescent probe","volume":"91","author":"Liu","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118381_bb0185","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1016\/j.biomaterials.2013.05.020","article-title":"The use of a near-infrared RNA fluorescent probe with a large stokes shift for imaging living cells assisted by the macrocyclic molecule CB7","volume":"34","author":"Li","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.saa.2020.118381_bb0190","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1007\/s00216-018-1500-1","article-title":"Rapid cancer diagnosis by highly fluorescent carbon nanodots-based imaging","volume":"411","author":"Duan","year":"2019","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2020.118381_bb0195","doi-asserted-by":"crossref","first-page":"16956","DOI":"10.1039\/C5CC06304C","article-title":"Nucleus-staining with biomolecule-mimicking nitrogen-doped carbon dots prepared by a fast neutralization heat strategy","volume":"51","author":"Kang","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118381_bb0200","doi-asserted-by":"crossref","first-page":"10948","DOI":"10.1039\/C7NR03658B","article-title":"Carbon quantum dots with intrinsic mitochondrial targeting ability for mitochondria-based theranostics","volume":"9","author":"Hua","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2020.118381_bb0205","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1021\/acs.nanolett.7b04700","article-title":"One-step synthesis of ultrasmall and ultrabright organosilica nanodots with 100% photoluminescence quantum yield: long-term lysosome imaging in living, fixed, and permeabilized cells","volume":"18","author":"Chen","year":"2018","journal-title":"Nano Lett."},{"key":"10.1016\/j.saa.2020.118381_bb0210","doi-asserted-by":"crossref","first-page":"12221","DOI":"10.1021\/acs.langmuir.6b03331","article-title":"Hydrophobic carbon nanodots with rapid cell penetrability and tunable photoluminescence behavior for in vitro and in vivo imaging","volume":"32","author":"Mao","year":"2016","journal-title":"Langmuir"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520303590?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520303590?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:28:07Z","timestamp":1761355687000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142520303590"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":42,"alternative-id":["S1386142520303590"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2020.118381","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"RNA-responsive fluorescent carbon dots for fast and wash-free nucleolus imaging","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2020.118381","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118381"}}