{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T17:58:33Z","timestamp":1775584713565,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,11,1]],"date-time":"2020-11-01T00:00:00Z","timestamp":1604188800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2020,11]]},"DOI":"10.1016\/j.saa.2020.118602","type":"journal-article","created":{"date-parts":[[2020,6,15]],"date-time":"2020-06-15T11:30:19Z","timestamp":1592220619000},"page":"118602","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["A novel fluorescent probe with dual-sites for simultaneously monitoring metabolisms of cysteine in living cells and zebrafishes"],"prefix":"10.1016","volume":"241","author":[{"given":"Guoxing","family":"Yin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yabing","family":"Gan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Youyu","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Yin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shouzhuo","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2020.118602_bb0005","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1039\/C8CS01006D","article-title":"Functional synthetic probes for selective targeting and multi-analyte detection and imaging","volume":"48","author":"Yue","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0010","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.1002\/anie.201800485","article-title":"A multi-signal fluorescent probe with multiple binding sites for simultaneous sensing of cysteine, homocysteine, and glutathione","volume":"57","author":"Yin","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118602_bb0015","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1002\/anie.201813935","article-title":"Simultaneous visualization of endogenous homocysteine, cysteine, glutathione, and their transformation through different fluorescence channels","volume":"58","author":"Yin","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118602_bb0020","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-018-07882-8","article-title":"Double-slit photoelectron interference in strong-field ionization of the neon dimer","volume":"10","author":"Kunitski","year":"2019","journal-title":"Nat. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0025","doi-asserted-by":"crossref","first-page":"16067","DOI":"10.1002\/anie.201908950","article-title":"Rational design of a dual-reactivity-based fluorescent probe for visualizing intracellular HSNO","volume":"58","author":"Chen","year":"2019","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118602_bb0030","doi-asserted-by":"crossref","first-page":"18301","DOI":"10.1021\/jacs.9b09722","article-title":"Ferroptosis accompanied by \u2022OH generation and cytoplasmic viscosity increase revealed via dual-functional fluorescence probe","volume":"141","author":"Li","year":"2019","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118602_bb0035","doi-asserted-by":"crossref","first-page":"118073","DOI":"10.1016\/j.saa.2020.118073","article-title":"AND logic gate based fluorescence probe for simultaneous detection of peroxynitrite and hypochlorous acid","volume":"230","author":"Li","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2020.118602_bb0040","doi-asserted-by":"crossref","first-page":"118154","DOI":"10.1016\/j.saa.2020.118154","article-title":"A new colorimetric and ratiometric probe for highly selective recognition and bioimaging of ClO\u2212 and Al3+","volume":"232","author":"Li","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2020.118602_bb0045","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1039\/C7CS00528H","article-title":"Fluorescent probes for the simultaneous detection of multiple analytes in biology","volume":"47","author":"Kolanowski","year":"2018","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0050","doi-asserted-by":"crossref","first-page":"1294","DOI":"10.1039\/C4OB02076F","article-title":"\u201cAND\u201d luminescent \u201creactive\u201d molecular logic gates: a gateway to multi-analyte bioimaging and biosensing","volume":"13","author":"Romieu","year":"2015","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.saa.2020.118602_bb0055","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1016\/j.tips.2018.02.007","article-title":"Cysteine metabolism in neuronal redox homeostasis","volume":"39","author":"Paul","year":"2018","journal-title":"Trends Pharmacol. Sci."},{"key":"10.1016\/j.saa.2020.118602_bb0060","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.jbior.2016.01.001","article-title":"Nonessential amino acid metabolism in breast cancer","volume":"62","author":"Geck","year":"2016","journal-title":"Adv. Biol. Regul."},{"key":"10.1016\/j.saa.2020.118602_bb0065","doi-asserted-by":"crossref","first-page":"1652S","DOI":"10.1093\/jn\/136.6.1652S","article-title":"Mammalian cysteine metabolism: new insights into regulation of cysteine metabolism","volume":"136","author":"Stipanuk","year":"2006","journal-title":"J. Nutr."},{"key":"10.1016\/j.saa.2020.118602_bb0070","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1111\/bph.14464","article-title":"Homeostatic impact of sulfite and hydrogen sulfide on cysteine catabolism","volume":"176","author":"Kohl","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.saa.2020.118602_bb0075","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s10545-009-9006-9","article-title":"Dealing with methionine\/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur","volume":"34","author":"Stipanuk","year":"2011","journal-title":"J. Inherit. Metab. Dis."},{"key":"10.1016\/j.saa.2020.118602_bb0080","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/BF00806085","article-title":"l-Cysteine metabolism via 3-mercaptopyruvate pathway and sulfate formation in rat liver mitochondria","volume":"2","author":"Ubuka","year":"1992","journal-title":"Amino Acids"},{"key":"10.1016\/j.saa.2020.118602_bb0085","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1007\/s00726-009-0264-5","article-title":"Amino acids and gaseous signaling","volume":"37","author":"Li","year":"2009","journal-title":"Amino Acids"},{"key":"10.1016\/j.saa.2020.118602_bb0090","doi-asserted-by":"crossref","first-page":"15167","DOI":"10.1002\/chem.201502832","article-title":"A dual-response fluorescent probe reveals the H2O2-induced H2S biogenesis through a cystathionine \u03b2-synthase pathway","volume":"21","author":"Yi","year":"2015","journal-title":"Chem. Eur. J."},{"key":"10.1016\/j.saa.2020.118602_bb0095","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1021\/acs.chemrev.7b00205","article-title":"Chemical biology of H2S signaling through persulfidation","volume":"118","author":"Filipovic","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0100","doi-asserted-by":"crossref","first-page":"4596","DOI":"10.1039\/C4CS00298A","article-title":"Chemical probes for molecular imaging and detection of hydrogen sulfide and reactive sulfur species in biological systems","volume":"44","author":"Lin","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0105","doi-asserted-by":"crossref","first-page":"2120","DOI":"10.1039\/b925092a","article-title":"Fluorescent and colorimetric probes for detection of thiols","volume":"39","author":"Chen","year":"2010","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0110","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1021\/acs.analchem.7b04234","article-title":"Small-molecule fluorescent probes for imaging and detection of reactive oxygen, nitrogen, and sulfur species in biological systems","volume":"90","author":"Jiao","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118602_bb0115","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.cell.2014.11.048","article-title":"Endogenous hydrogen sulfide production is essential for dietary restriction benefits","volume":"160","author":"Hine","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.saa.2020.118602_bb0120","doi-asserted-by":"crossref","first-page":"6257","DOI":"10.1039\/C7SC00423K","article-title":"A multi-signal fluorescent probe for simultaneously distinguishing and sequentially sensing cysteine\/homocysteine, glutathione, and hydrogen sulfide in living cells","volume":"8","author":"He","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118602_bb0125","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.1039\/C5SC03591K","article-title":"Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals","volume":"7","author":"Chen","year":"2016","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118602_bb0130","doi-asserted-by":"crossref","first-page":"368","DOI":"10.2174\/1389200217666151210125918","article-title":"Cysteine network (CYSTEINET) dysregulation in Parkinson\u2019s disease: role of N-acetylcysteine","volume":"17","author":"Marcos","year":"2016","journal-title":"Curr. Drug Metab."},{"key":"10.1016\/j.saa.2020.118602_bb0135","doi-asserted-by":"crossref","first-page":"2760","DOI":"10.1039\/C5CC09092J","article-title":"A mitochondria-targeted fluorescent probe for ratiometric detection of endogenous sulfur dioxide derivatives in cancer cells","volume":"52","author":"Li","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0140","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1039\/C6CC06459K","article-title":"Fluorescence detection of endogenous bisulfite in liver cancer cells using an effective ESIPT enhanced FRET platform","volume":"53","author":"Li","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0145","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1021\/acs.chemrev.7b00425","article-title":"Long-lived emissive probes for time-resolved photoluminescence bioimaging and biosensing","volume":"118","author":"Zhang","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0150","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.ccr.2019.03.001","article-title":"Reaction-based fluorescent probes for SO2 derivatives and their biological applications","volume":"388","author":"Li","year":"2019","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0155","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1039\/C9SC01652J","article-title":"Fluorescent probes for organelle-targeted bioactive species imaging","volume":"10","author":"Gao","year":"2019","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118602_bb0160","doi-asserted-by":"crossref","first-page":"10403","DOI":"10.1021\/acs.chemrev.9b00145","article-title":"Coumarin-based small-molecule fluorescent chemosensors","volume":"119","author":"Cao","year":"2019","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2020.118602_bb0165","doi-asserted-by":"crossref","first-page":"3373","DOI":"10.1039\/c4an00478g","article-title":"A coumarin-based fluorescent probe for differential identification of sulfide and sulfite in CTAB micelle solution","volume":"139","author":"Tian","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2020.118602_bb0170","doi-asserted-by":"crossref","first-page":"5290","DOI":"10.1039\/C4AN01086H","article-title":"Colorimetric and fluorescent determination of sulfide and sulfite with kinetic discrimination","volume":"139","author":"Pei","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2020.118602_bb0175","doi-asserted-by":"crossref","first-page":"85529","DOI":"10.1039\/C6RA15065A","article-title":"A dual functional probe: sensitive fluorescence response to H2S and colorimetric detection for SO32\u2212","volume":"6","author":"Chen","year":"2016","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2020.118602_bb0180","doi-asserted-by":"crossref","first-page":"3181","DOI":"10.1021\/jacs.6b12845","article-title":"Dual-site fluorescent probe for visualizing the metabolism of Cys in living cells","volume":"139","author":"Yue","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118602_bb0185","doi-asserted-by":"crossref","first-page":"2686","DOI":"10.1021\/acs.analchem.7b04493","article-title":"Real-time visualization of cysteine metabolism in living cells with ratiometric fluorescence probes","volume":"90","author":"Xu","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118602_bb0190","doi-asserted-by":"crossref","first-page":"11387","DOI":"10.1039\/C8CC05418E","article-title":"A multi-signal mitochondria-targeted fluorescent probe for real-time visualization of cysteine metabolism in living cells and animals","volume":"54","author":"Yang","year":"2018","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0195","doi-asserted-by":"crossref","first-page":"13712","DOI":"10.1002\/anie.201306688","article-title":"Selective and sensitive chromofluorogenic detection of the sulfite anion in water using hydrophobic hybrid organic\u2013inorganic silica nanoparticles","volume":"52","author":"Santos-Figueroa","year":"2013","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118602_bb0200","doi-asserted-by":"crossref","first-page":"2637","DOI":"10.1039\/c3cc39161b","article-title":"Fluorescent probe for biological gas SO2 derivatives bisulfite and sulfite","volume":"49","author":"Sun","year":"2013","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0205","doi-asserted-by":"crossref","first-page":"6893","DOI":"10.1002\/anie.201102162","article-title":"Catalytic enantioselective addition of sodium bisulfite to chalcones","volume":"50","author":"Moccia","year":"2011","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118602_bb0210","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.talanta.2018.08.059","article-title":"A dual-emission and mitochondria-targeted fluorescent probe for rapid detection of SO2 derivatives and its imaging in living cells","volume":"191","author":"Yin","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2020.118602_bb0215","doi-asserted-by":"crossref","first-page":"7505","DOI":"10.1039\/C5CC01184A","article-title":"A FRET\u2013ICT dual-quenching fluorescent probe with large off\u2013on response for H2S: synthesis, spectra and bioimaging","volume":"51","author":"Zhang","year":"2015","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0220","doi-asserted-by":"crossref","first-page":"7429","DOI":"10.1016\/j.biomaterials.2013.06.013","article-title":"Three-channel fluorescent sensing via organic white light-emitting dyes for detection of hydrogen sulfide in living cells","volume":"34","author":"Wang","year":"2013","journal-title":"Biomaterials"},{"key":"10.1016\/j.saa.2020.118602_bb0225","doi-asserted-by":"crossref","first-page":"10529","DOI":"10.1039\/c2cc34031c","article-title":"A near-infrared fluorescent turn-on probe for fluorescence imaging of hydrogen sulfide in living cells based on thiolysis of dinitrophenyl ether","volume":"48","author":"Cao","year":"2012","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0230","doi-asserted-by":"crossref","first-page":"2310","DOI":"10.1021\/ol400973v","article-title":"A lysosome-targetable fluorescent probe for imaging hydrogen sulfide in living cells","volume":"15","author":"Liu","year":"2013","journal-title":"Org. Lett."},{"key":"10.1016\/j.saa.2020.118602_bb0235","doi-asserted-by":"crossref","first-page":"12234","DOI":"10.1039\/C4CC03312D","article-title":"Fluorescent probes for hydrogen sulfide detection and bioimaging","volume":"50","author":"Yu","year":"2014","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118602_bb0240","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1021\/cb500986w","article-title":"Quantitative imaging of glutathione in live cells using a reversible reaction-based ratiometric fluorescent probe","volume":"10","author":"Jiang","year":"2015","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.saa.2020.118602_bb0245","doi-asserted-by":"crossref","first-page":"5812","DOI":"10.1002\/anie.201702114","article-title":"A reversible fluorescent probe for real-time quantitative monitoring of cellular glutathione","volume":"56","author":"Liu","year":"2017","journal-title":"Angew. Chem. Int. Ed."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520305813?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520305813?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:30:00Z","timestamp":1761355800000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142520305813"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,11]]},"references-count":49,"alternative-id":["S1386142520305813"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2020.118602","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2020,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A novel fluorescent probe with dual-sites for simultaneously monitoring metabolisms of cysteine in living cells and zebrafishes","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2020.118602","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118602"}}