{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T15:07:13Z","timestamp":1780412833967,"version":"3.54.1"},"reference-count":56,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100006606","name":"Natural Science Foundation of Tianjin City","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006606","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.saa.2020.118949","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T02:04:31Z","timestamp":1600308271000},"page":"118949","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["A lysosome-targeted fluorescent probe for the specific detection and imaging of formaldehyde in living cells"],"prefix":"10.1016","volume":"245","author":[{"given":"Songtao","family":"Cai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Song","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liancheng","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianshun","family":"Zeng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2020.118949_bb0005","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1021\/ba-1985-0210.ch015","article-title":"History and status of formaldehyde in the cosmetics industry","volume":"210","author":"Jass","year":"1985","journal-title":"Adv. Chem. Ser."},{"key":"10.1016\/j.saa.2020.118949_bb0010","unstructured":"American Conference of Governmental Industrial Hygienists, Cincinnati, OH, 1996."},{"key":"10.1016\/j.saa.2020.118949_bb0015","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1093\/jnci\/djp416","article-title":"Mortality from lymphohematopoietic malignancies and brain cancer among embalmers exposed to formaldehyde","volume":"101","author":"Hauptmann","year":"2009","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.saa.2020.118949_bb0020","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1021\/ba-1985-0210.ch014","article-title":"Toxicology of formaldehyde","volume":"210","author":"Goode","year":"1985","journal-title":"Adv. Chem. Ser."},{"key":"10.1016\/j.saa.2020.118949_bb0025","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1038\/nature04433","article-title":"Histone demethylation by a family of JmjC domain-containing proteins","volume":"439","author":"Tsukada","year":"2006","journal-title":"Nature"},{"key":"10.1016\/j.saa.2020.118949_bb0030","doi-asserted-by":"crossref","first-page":"175","DOI":"10.2174\/1389557033488187","article-title":"Biological role of formaldehyde, and cycles related to methylation, demethylation, and formaldehyde production","volume":"3","author":"Kalsz","year":"2003","journal-title":"Mini-Rev. Med. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0035","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1111\/jnc.12170","article-title":"Formaldehyde metabolism and formaldehyde-induced stimulation of lactate production and glutathione export in cultured neurons","volume":"125","author":"Tulpule","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.saa.2020.118949_bb0040","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0021-9150(95)05701-3","article-title":"Formaldehyde produced endogenously via deamination of methylamine. A potential risk factor for initiation of endothelial injury","volume":"120","author":"Yu","year":"1996","journal-title":"Atherosclerosis"},{"key":"10.1016\/j.saa.2020.118949_bb0045","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.yrtph.2004.05.001","article-title":"The implausibility of leukemia induction by formaldehyde: a critical review of the biological evidence on distant-site toxicity","volume":"40","author":"Heck","year":"2004","journal-title":"Regul. Toxicol. Pharmacol."},{"key":"10.1016\/j.saa.2020.118949_bb0050","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1007\/s11357-012-9388-8","article-title":"Accumulated hippocampal formaldehyde induces age-dependent memory decline","volume":"35","author":"Tong","year":"2013","journal-title":"Age"},{"key":"10.1016\/j.saa.2020.118949_bb0055","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1038\/srep01807","article-title":"Aging-associated excess formaldehyde leads to spatial memory deficits","volume":"3","author":"Tong","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2020.118949_bb0060","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/jnc.12356","article-title":"Formaldehyde in brain: an overlooked player in neurodegeneration?","volume":"127","author":"Tulpule","year":"2013","journal-title":"J. Neurochem."},{"key":"10.1016\/j.saa.2020.118949_bb0065","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1016\/S1470-2045(09)70358-4","article-title":"A review of human carcinogens-part F: chemical agents and related occupations","volume":"10","author":"Baan","year":"2009","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.saa.2020.118949_bb0070","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.neurobiolaging.2009.07.013","article-title":"Urine formaldehyde level is inversely correlated to mini mental state examination scores in senile dementia","volume":"32","author":"Tong","year":"2011","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.saa.2020.118949_bb0075","doi-asserted-by":"crossref","first-page":"9359","DOI":"10.1021\/acs.analchem.6b02879","article-title":"Lysosome-targeted turn-on fluorescent probe for endogenous formaldehyde in living cells","volume":"88","author":"Tang","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0080","doi-asserted-by":"crossref","first-page":"10886","DOI":"10.1021\/jacs.5b05340","article-title":"An aza-cope reactivity-based fluorescent probe for imaging formaldehyde in living cells","volume":"137","author":"Brewer","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0085","doi-asserted-by":"crossref","first-page":"10890","DOI":"10.1021\/jacs.5b05339","article-title":"A reaction-based fluorescent probe for imaging of formaldehyde in living cells","volume":"137","author":"Roth","year":"2015","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0090","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1002\/anie.201510373","article-title":"Development of a two-photon fluorescent probe for imaging of endogenous formaldehyde in living tissues","volume":"55","author":"Tang","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118949_bb0095","doi-asserted-by":"crossref","first-page":"6520","DOI":"10.1039\/C7CC03050A","article-title":"Two-photon imaging of formaldehyde in live cells and animals utilizing a lysosome-targetable and acidic pH-activatable fluorescent probe","volume":"53","author":"Xie","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118949_bb0100","doi-asserted-by":"crossref","first-page":"16408","DOI":"10.1021\/jacs.8b09794","article-title":"Analyte regeneration fluorescent probes for formaldehyde enabled by regiospecific formaldehyde-induced intramolecularity","volume":"140","author":"Xu","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0105","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1002\/tox.21910","article-title":"Formaldehyde exposure induces autophagy in testicular tissues of adult male rats","volume":"30","author":"Han","year":"2015","journal-title":"Environ. Toxicol."},{"key":"10.1016\/j.saa.2020.118949_bb0110","doi-asserted-by":"crossref","first-page":"11253","DOI":"10.1021\/acs.analchem.6b04087","article-title":"Novel fluorescein-based fluorescent probe for detecting H2S and its real applications in blood plasma and biological imaging","volume":"88","author":"Jin","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0115","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1016\/j.dyepig.2018.07.001","article-title":"A ratiometric fluorescent probe for hypochlorous acid and its biological applications","volume":"160","author":"Liu","year":"2019","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2020.118949_bb0120","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.snb.2017.12.073","article-title":"An ESIPT based fluorescence probe for ratiometric monitoring of nitric oxide","volume":"259","author":"Chen","year":"2018","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0125","doi-asserted-by":"crossref","first-page":"6991","DOI":"10.1039\/C7SC02888A","article-title":"A ratiometric fluorescent probe for imaging and quantifying anti-apoptotic effects of GSH under temperature stress","volume":"8","author":"Han","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118949_bb0130","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1021\/acs.analchem.8b05326","article-title":"Imaging of endogenous hydrogen peroxide during the process of cell mitosis and mouse brain development with a near-infrared ratiometric fluorescent probe","volume":"91","author":"Guo","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0135","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.snb.2019.03.141","article-title":"BODIPY-based naked-eye fluorescent on-off probe with high selectivity for H2S based on thiolysis of dinitrophenyl ether","volume":"290","author":"Fang","year":"2019","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0140","doi-asserted-by":"crossref","first-page":"4185","DOI":"10.1039\/C4CS00280F","article-title":"Small molecule-based ratiometric fluorescence probes for cations, anions, and biomolecules","volume":"44","author":"Lee","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2020.118949_bb0145","doi-asserted-by":"crossref","first-page":"4029","DOI":"10.1039\/C5CC09796G","article-title":"A ratiometric fluorescent formaldehyde probe for bioimaging applications","volume":"52","author":"He","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118949_bb0150","doi-asserted-by":"crossref","first-page":"4073","DOI":"10.1039\/C7SC00748E","article-title":"A 2-aza-cope reactivity-based platform for ratiometric fluorescence imaging of formaldehyde in living cells","volume":"8","author":"Brewer","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118949_bb0155","doi-asserted-by":"crossref","first-page":"3724","DOI":"10.1021\/acs.analchem.7b00044","article-title":"Ratiometric imaging of tissue by two-photon microscopy: observation of a high level of formaldehyde around mouse intestinal crypts","volume":"89","author":"Singha","year":"2017","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0160","doi-asserted-by":"crossref","first-page":"5338","DOI":"10.1021\/jacs.6b12460","article-title":"Development of a general aza-cope reaction trigger applied to fluorescence imaging of formaldehyde in living cells","volume":"139","author":"Bruemmer","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0165","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1016\/j.snb.2016.10.039","article-title":"A highly selective two-photon fluorogenic probe for formaldehyde and its bioimaging application in cells and zebrafish","volume":"241","author":"Xie","year":"2017","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0170","doi-asserted-by":"crossref","first-page":"11247","DOI":"10.1039\/C6CC06158C","article-title":"A biotin-guided formaldehyde sensor selectively detecting endogenous concentrations in cancerous cells and tissues","volume":"52","author":"Lee","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118949_bb0175","doi-asserted-by":"crossref","first-page":"4913","DOI":"10.1016\/j.tetlet.2012.06.117","article-title":"A tailor designed fluorescent \u2018turn-on\u2019 sensor of formaldehyde based on the BODIPY motif","volume":"53","author":"Song","year":"2012","journal-title":"Tetrahedron Lett."},{"key":"10.1016\/j.saa.2020.118949_bb0180","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/j.snb.2015.07.039","article-title":"A rapid and facile fluorimetric method for detecting formaldehyde","volume":"222","author":"Dong","year":"2016","journal-title":"Sensors Actuators B Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0185","doi-asserted-by":"crossref","first-page":"7652","DOI":"10.1039\/c1ob06448g","article-title":"Chromo-fluorogenic detection of aldehydes with a rhodamine based sensor featuring an intramolecular deoxylactam","volume":"9","author":"Li","year":"2011","journal-title":"Org. Biomol. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0190","doi-asserted-by":"crossref","first-page":"9582","DOI":"10.1039\/C6CC04254F","article-title":"An ultra-fast illuminating fluorescent probe for monitoring formaldehyde in living cells, shiitake mushrooms, and indoors","volume":"52","author":"He","year":"2016","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118949_bb0195","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.dyepig.2016.11.020","article-title":"A reaction-based fluorescent probe for the selective detection of formaldehyde and methylglyoxal via distinct emission patterns","volume":"138","author":"Liu","year":"2017","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2020.118949_bb0200","doi-asserted-by":"crossref","first-page":"25790","DOI":"10.1039\/C4RA03725A","article-title":"A turn-on fluorescent probe for imaging lysosomal hydrogen sulfide in living cells","volume":"4","author":"Qiao","year":"2014","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2020.118949_bb0205","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.saa.2020.118949_bb0210","doi-asserted-by":"crossref","first-page":"6758","DOI":"10.1039\/C8SC02578A","article-title":"Visualization of methylglyoxal in living cells and diabetic mice model with a 1,8-naphthalimide-based two-photon fluorescent probe","volume":"9","author":"Yang","year":"2018","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118949_bb0215","doi-asserted-by":"crossref","first-page":"5187","DOI":"10.1021\/acs.analchem.7b05337","article-title":"Celecoxib conjugated fluorescent probe for identification and discrimination of cyclooxygenase-2 enzyme in cancer cells","volume":"90","author":"Gurram","year":"2018","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0220","doi-asserted-by":"crossref","first-page":"5535","DOI":"10.1039\/C7CC02450A","article-title":"A dynamic invertible intramolecular charge-transfer fluorescence probe: real-time monitoring of mitochondrial ATPase activity","volume":"53","author":"Zhang","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2020.118949_bb0225","doi-asserted-by":"crossref","first-page":"6209","DOI":"10.1039\/D0SC00574F","article-title":"A molecular-logic gate for COX-2 and NAT based on conformational and structural changes: visualizing the progression of liver disease","volume":"11","author":"Chen","year":"2020","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2020.118949_bb0230","doi-asserted-by":"crossref","first-page":"12429","DOI":"10.1021\/ja406077j","article-title":"A \u201cturn-on\u201d fluorescent sensor for methylglyoxal","volume":"135","author":"Wang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0235","doi-asserted-by":"crossref","first-page":"1554","DOI":"10.1016\/j.cclet.2016.06.016","article-title":"A 1,8-naphthalimide-derived turn-on fluorescent probe for imaging lysosomal nitric oxide in living cells","volume":"27","author":"Feng","year":"2016","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.saa.2020.118949_bb0240","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.dyepig.2012.08.024","article-title":"A fluorescent and colorimetric chemosensor for nitric oxide basedon 1,8-naphthalimide","volume":"96","author":"Wang","year":"2013","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2020.118949_bb0245","doi-asserted-by":"crossref","first-page":"2903","DOI":"10.1021\/ja311688g","article-title":"Activatable rotor for quantifying lysosomal viscosity in living cells","volume":"135","author":"Wang","year":"2013","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0250","doi-asserted-by":"crossref","first-page":"4557","DOI":"10.1021\/acs.analchem.6b00742","article-title":"Detection of misdistribution of tyrosinase from melanosomes to lysosomes and its upregulation under psoralen\/ultraviolet a with a melanosome-targeting tyrosinase fluorescent probe","volume":"88","author":"Zhou","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0255","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1039\/C4TB00345D","article-title":"A fluorescent light-up probe with \u201cAIE + ESIPT\u201d characteristics for specific detection of lysosomal esterase","volume":"2","author":"Gao","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2020.118949_bb0260","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1021\/ac001498q","article-title":"Formaldehyde in human cancer cells: detection by preconcentration-chemical ionization mass spectrometry","volume":"73","author":"Kato","year":"2001","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2020.118949_bb0265","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1021\/ja808611d","article-title":"Coumarin-derived Cu2+-selective fluorescence sensor: synthesis, mechanisms, and applications in living cells","volume":"131","author":"Jung","year":"2009","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2020.118949_bb0270","doi-asserted-by":"crossref","first-page":"3061","DOI":"10.1002\/(SICI)1521-3773(19991018)38:20<3061::AID-ANIE3061>3.0.CO;2-A","article-title":"Exploiting the self-assembly strategy for the design of selective Cu II ion chemosensors","volume":"38","author":"Grandini","year":"1999","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2020.118949_bb0275","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1126\/science.284.5415.805","article-title":"Undetectable intracellular free copper: the requirement of a copper chaperone for superoxide dismutase","volume":"284","author":"Rae","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.saa.2020.118949_bb0280","doi-asserted-by":"crossref","first-page":"4315","DOI":"10.1016\/j.tetlet.2005.04.101","article-title":"A simple and efficient procedure for the synthesis of benzimidazoles using air as the oxidant","volume":"46","author":"Lin","year":"2005","journal-title":"Tetrahedron Lett."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520309288?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520309288?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:30:02Z","timestamp":1761355802000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142520309288"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":56,"alternative-id":["S1386142520309288"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2020.118949","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A lysosome-targeted fluorescent probe for the specific detection and imaging of formaldehyde in living cells","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2020.118949","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"118949"}}