{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T00:15:46Z","timestamp":1781223346915,"version":"3.54.1"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,3,1]],"date-time":"2021-03-01T00:00:00Z","timestamp":1614556800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["4588\/2014-2020"],"award-info":[{"award-number":["4588\/2014-2020"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["p 308142\/2014-4"],"award-info":[{"award-number":["p 308142\/2014-4"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004612","name":"Funda\u00e7\u00e3o Arauc\u00e1ria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004612","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2021,3]]},"DOI":"10.1016\/j.saa.2020.119173","type":"journal-article","created":{"date-parts":[[2020,11,20]],"date-time":"2020-11-20T21:39:14Z","timestamp":1605908354000},"page":"119173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["Photophysical characterization of Hypericin-loaded in micellar, liposomal and copolymer-lipid nanostructures based F127 and DPPC liposomes"],"prefix":"10.1016","volume":"248","author":[{"given":"Fl\u00e1via","family":"Amanda Pedroso de Morais","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato","family":"Sonchini Gon\u00e7alves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katieli","family":"Souza Campanholi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruna","family":"Martins de Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ot\u00e1vio","family":"Augusto Capeloto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Lazarin-Bidoia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodolfo","family":"Bento Balbinot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celso","family":"Vataru Nakamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis","family":"Carlos Malacarne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilker","family":"Caetano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noboru","family":"Hioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2020.119173_b0005","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.pdpdt.2011.08.003","article-title":"Photodiagnosis and photodynamic therapy of peritoneal metastasis of ovarian cancer","volume":"9","author":"Guyon","year":"2012","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S1040-8428(84)80016-5","article-title":"Photodynamic therapy (PDT) of malignant tumors","volume":"2","author":"Dougherty","year":"1984","journal-title":"Crit. Rev. Oncol. Hematol."},{"key":"10.1016\/j.saa.2020.119173_b0015","doi-asserted-by":"crossref","first-page":"2319","DOI":"10.1021\/acsami.7b16455","article-title":"meso -Tetrahydroxyphenylchlorin-Conjugated Gold Nanoparticles as a Tool To Improve Photodynamic Therapy","volume":"10","author":"Haimov","year":"2018","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2020.119173_b0020","doi-asserted-by":"crossref","first-page":"15426","DOI":"10.1021\/acsami.9b04488","article-title":"Nitroreductase-Activatable Theranostic Molecules with High PDT Efficiency under Mild Hypoxia Based on a TADF Fluorescein Derivative","volume":"11","author":"Liu","year":"2019","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2020.119173_b0025","doi-asserted-by":"crossref","first-page":"17573","DOI":"10.1021\/acsami.5b05038","article-title":"Self-Assembled Nanoparticles Based on Amphiphilic Anticancer Drug-Phospholipid Complex for Targeted Drug Delivery and Intracellular Dual-Controlled Release","volume":"7","author":"Li","year":"2015","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2020.119173_b0030","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1021\/acsabm.8b00507","article-title":"DNA Targeting Long-Chain Alkoxy Appended Tin(IV) Porphyrin Scaffolds: Photophysical and Antimicrobial PDT Investigations","volume":"1","author":"Ravikumar","year":"2018","journal-title":"ACS Appl. Bio Mater."},{"key":"10.1016\/j.saa.2020.119173_b0035","doi-asserted-by":"crossref","first-page":"26711","DOI":"10.1021\/acsami.9b09020","article-title":"Photodynamic Chitosan Nano-Assembly as a Potent Alternative Candidate for Combating Antibiotic-Resistant Bacteria","volume":"11","author":"Zhang","year":"2019","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2020.119173_b0040","doi-asserted-by":"crossref","first-page":"25037","DOI":"10.1021\/acsami.8b05546","article-title":"Aggregation-Induced Emission Nanoparticles Encapsulated with PEGylated Nano Graphene Oxide and Their Applications in Two-Photon Fluorescence Bioimaging and Photodynamic Therapy in Vitro and in Vivo","volume":"10","author":"Sun","year":"2018","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2020.119173_b0045","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.jconrel.2011.12.012","article-title":"Polymeric micelles drug delivery system in oncology","volume":"159","author":"Gong","year":"2012","journal-title":"J. Control. Release."},{"key":"10.1016\/j.saa.2020.119173_b0050","doi-asserted-by":"crossref","first-page":"12","DOI":"10.3390\/pharmaceutics9020012","article-title":"Liposomal Formulations in Clinical Use: An Updated Review","volume":"9","author":"Bulbake","year":"2017","journal-title":"Pharmaceutics."},{"key":"10.1016\/j.saa.2020.119173_b0055","doi-asserted-by":"crossref","unstructured":"M. Manconi, F. Marongiu, I. Castangia, M.L. Manca, C. Caddeo, C.I.G. Tuberoso, G. Dhallewin, G. Bacchetta, A.M. Fadda, Polymer-associated liposomes for the oral delivery of grape pomace extract, Colloids Surfaces B Biointerfaces. 146 (2016) 910\u2013917. doi:10.1016\/j.colsurfb.2016.07.043.","DOI":"10.1016\/j.colsurfb.2016.07.043"},{"key":"10.1016\/j.saa.2020.119173_b0060","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1039\/c2pp25249j","article-title":"The influence of Pluronics\u00ae on dark cytotoxicity, photocytotoxicity, localization and uptake of curcumin in cancer cells: studies of curcumin and curcuminoids XLIX","author":"Singh","year":"2013","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.saa.2020.119173_b0065","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.jphotobiol.2017.04.008","article-title":"Response surface method optimization of a novel Hypericin formulation in P123 micelles for colorectal cancer and antimicrobial photodynamic therapy","volume":"170","author":"Montanha","year":"2017","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2020.119173_b0070","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1039\/c8pp00444g","article-title":"Hypericin photodynamic activity. Part III: in vitro evaluation in different nanocarriers against trypomastigotes of Trypanosoma cruzi","volume":"18","author":"de Morais","year":"2019","journal-title":"Photochem. Photobiol. Sci."},{"key":"10.1016\/j.saa.2020.119173_b0075","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jphotobiol.2018.11.019","article-title":"Hypericin photodynamic activity in DPPC liposome. PART I: biomimetism of loading, location, interactions and thermodynamic properties","volume":"190","author":"de Morais","year":"2019","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2020.119173_b0080","doi-asserted-by":"crossref","unstructured":"F.A.P. de Morais, R.S. Gon\u00e7alves, B.H. Vilsinski, D. Lazarin-Bid\u00f3ia, R.B. Balbinot, T.M. Tsubone, K. Brunaldi, C. Vataru Nakamura, N. Hioka, W. Caetano, Hypericin Photodynamic Activity in DPPC liposome. PART II: Stability and application in melanoma B16-F10 cancer cells, Photochem. Photobiol. Sci. 51 (2020) 51-2070-51\u20132070. doi:10.1039\/C9PP00284G.","DOI":"10.1039\/c9pp00284g"},{"key":"10.1016\/j.saa.2020.119173_b0085","doi-asserted-by":"crossref","first-page":"4530","DOI":"10.1021\/acsanm.0c00386","article-title":"Stable Dipalmitoylphosphatidylcholine Liposomes Coated with an F127 Copolymer for Hypericin Loading and Delivery","volume":"3","author":"de Morais","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.saa.2020.119173_b0090","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1080\/10717544.2018.1531954","article-title":"Photodynamic therapy - hypericin tetraether liposome conjugates and their antitumor and antiangiogenic activity","volume":"26","author":"Plenagl","year":"2019","journal-title":"Drug Deliv."},{"key":"10.1016\/j.saa.2020.119173_b0095","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.pdpdt.2019.08.016","article-title":"Importance of Hypericin-Bcl2 interactions for biological effects at subcellular levels","volume":"28","author":"Stroffekova","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0100","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/S1011-1344(99)00135-9","article-title":"Skin photosensitization with topical hypericin in hairless mice","volume":"53","author":"Kamuhabwa","year":"1999","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2020.119173_b0105","doi-asserted-by":"crossref","unstructured":"P. Agostinis, A. Vantieghem, W. Merlevede, P. a M. De Witte, Hypericin in cancer treatment: More light on the way, Int. J. Biochem. Cell Biol. 34 (2002) 221\u2013241. doi:10.1016\/S1357-2725(01)00126-1.","DOI":"10.1016\/S1357-2725(01)00126-1"},{"key":"10.1016\/j.saa.2020.119173_b0110","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.7150\/thno.4924","article-title":"Exploring Theranostic Potentials of Radioiodinated Hypericin in Rodent Necrosis Models","volume":"2","author":"Li","year":"2012","journal-title":"Theranostics."},{"key":"10.1016\/j.saa.2020.119173_b0115","doi-asserted-by":"crossref","first-page":"667","DOI":"10.7150\/thno.6650","article-title":"Necrosis Avidity: A Newly Discovered Feature of Hypericin and its Preclinical Applications in Necrosis Imaging","volume":"3","author":"Jiang","year":"2013","journal-title":"Theranostics."},{"key":"10.1016\/j.saa.2020.119173_b0120","doi-asserted-by":"crossref","first-page":"17874","DOI":"10.1039\/c3ra42609b","article-title":"A self-assembled nanostructured material with photosensitising properties","volume":"3","author":"Comas-Barcel\u00f3","year":"2013","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2020.119173_b0125","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.pdpdt.2013.06.001","article-title":"Microendoscopy for hypericin fluorescence tumor diagnosis in a subcutaneous glioma mouse model","volume":"10","author":"Noell","year":"2013","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2019.101588","article-title":"Hypericin and its radio iodinated derivatives \u2013 A novel combined approach for the treatment of pediatric alveolar rhabdomyosarcoma cells in vitro","volume":"29","author":"Ocker","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0135","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1016\/j.ejso.2011.12.021","article-title":"Hypericin for visualization of high grade gliomas: First clinical experience","volume":"38","author":"Ritz","year":"2012","journal-title":"Eur. J. Surg. Oncol."},{"key":"10.1016\/j.saa.2020.119173_b0140","doi-asserted-by":"crossref","unstructured":"M. Van De Putte, T. Roskams, G. Bormans, A. Verbruggen, P. a M. De Witte, The impact of aggregation on the biodistribution of hypericin, Int. J. Oncol. 28 (2006) 655\u2013660.","DOI":"10.3892\/ijo.28.3.655"},{"key":"10.1016\/j.saa.2020.119173_b0145","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1080\/14786419.2017.1356836","article-title":"An optimized protocol for anthraquinones isolation from Rhamnus frangula L","volume":"32","author":"Gon\u00e7alves","year":"2018","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.saa.2020.119173_b0150","doi-asserted-by":"crossref","first-page":"1196","DOI":"10.1080\/14786419.2018.1457661","article-title":"Optimized protocol for multigram preparation of emodin anthrone, a precursor in the hypericin synthesis","volume":"33","author":"Gon\u00e7alves","year":"2019","journal-title":"Nat. Prod. Res."},{"key":"10.1016\/j.saa.2020.119173_b0155","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.colsurfb.2018.10.068","article-title":"Preparation, microstructure and function of liposome with light responsive switch","volume":"178","author":"Liu","year":"2019","journal-title":"Colloids Surfaces B Biointerfaces."},{"key":"10.1016\/j.saa.2020.119173_b0160","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1002\/jps.2600600902","article-title":"Pharmaceutical Applications of Solid Dispersion Systems","volume":"60","author":"Chiou","year":"1971","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.saa.2020.119173_b0165","doi-asserted-by":"crossref","first-page":"7870","DOI":"10.1021\/j100132a013","article-title":"Excited-state properties of hypericin: Electronic spectra and fluorescence decay kinetics","volume":"97","author":"Yamazaki","year":"1993","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.saa.2020.119173_b0170","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.jlumin.2018.01.027","article-title":"Fluorescence quantum yield determination of molecules in liquids by thermally driven conical diffraction","volume":"197","author":"De Lima","year":"2018","journal-title":"J. Lumin."},{"key":"10.1016\/j.saa.2020.119173_b0175","doi-asserted-by":"crossref","first-page":"1685","DOI":"10.1021\/cr010371d","article-title":"Physical Mechanisms of Generation and Deactivation of Singlet Oxygen","volume":"103","author":"Schweitzer","year":"2003","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2020.119173_b0180","doi-asserted-by":"crossref","first-page":"1535","DOI":"10.1038\/nprot.2013.087","article-title":"Relative and absolute determination of fluorescence quantum yields of transparent samples","volume":"8","author":"W\u00fcrth","year":"2013","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.saa.2020.119173_b0185","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/0022-1759(83)90303-4","article-title":"Rapid colorimetric assay for cellular growth and survival: Application to proliferation and cytotoxicity assays","volume":"65","author":"Mosmann","year":"1983","journal-title":"J. Immunol. Methods."},{"key":"10.1016\/j.saa.2020.119173_b0190","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1751-1097.1995.tb05259.x","article-title":"Spectroscopic and photoacoustic studies of hypericin embedded in liposomes as a photoreceptor model","volume":"62","author":"Lenci","year":"1995","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.saa.2020.119173_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2020.101737","article-title":"Hypericin-mediated photoinactivation of polymeric nanoparticles against Staphylococcus aureus","volume":"30","author":"Malacrida","year":"2020","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0200","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.saa.2017.12.004","article-title":"Excitation of triplet states of hypericin in water mediated by hydrotropic cromolyn sodium salt, Spectrochim","volume":"193","author":"Ke\u0161a","year":"2018","journal-title":"Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2020.119173_b0205","doi-asserted-by":"crossref","unstructured":"R.S. Gon\u00e7alves, G. Braga, A.C. V. de Oliveira, G.B. C\u00e9sar, T.T. Tominaga, E.H. Zampiere, I.R. Calori, F.A.P. de Morais, E.A. Basso, R.M. Pontes, N. Hioka, W. Caetano, Hypericin Delivery System Based on P84 Copolymeric Micelles Linked with N -(3-Aminopropyl)-2-pyrrolidone for Melanoma-Targeted Photodynamic Therapy, ACS Appl. Polym. Mater. (2020) acsapm.0c00114. doi:10.1021\/acsapm.0c00114.","DOI":"10.1021\/acsapm.0c00114"},{"key":"10.1016\/j.saa.2020.119173_b0210","doi-asserted-by":"crossref","unstructured":"K. da S.S. Campanholi, A.P. Gerola, B.H. Vilsinski, \u00c9.L. de Oliveira, F.A.P. de Morais, B.R. Rabello, G. Braga, I.R. Calori, E.L. Silva, N. Hioka, W. Caetano, Development of Pluronic\u00ae nanocarriers comprising Pheophorbide, Zn-Pheophorbide, Lapachol and \u03b2-lapachone combined drugs: Photophysical and spectroscopic studies, Dye. Pigment. 157 (2018) 238\u2013250. doi:10.1016\/j.dyepig.2018.04.057.","DOI":"10.1016\/j.dyepig.2018.04.057"},{"key":"10.1016\/j.saa.2020.119173_b0215","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1021\/ct400466m","article-title":"Molecular Dynamics Studies of Liposomes as Carriers for Photosensitizing Drugs: Development, Validation, and Simulations with a Coarse-Grained Model","volume":"10","author":"J\u00e4mbeck","year":"2014","journal-title":"J. Chem. Theory Comput."},{"key":"10.1016\/j.saa.2020.119173_b0220","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1111\/j.1751-1097.1997.tb01926.x","article-title":"Fluorescence and Time-Resolved Photoacoustics of Hypericin Inserted in Liposomes: Dependence on Pigment Concentration and Bilayer Phase","volume":"65","author":"Losi","year":"1997","journal-title":"Photochem. Photobiol."},{"key":"10.1016\/j.saa.2020.119173_b0225","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molliq.2018.02.027","article-title":"Determination of the fluorescence labels location in lipid bilayer based on fluorescence quenching","volume":"256","author":"Pentak","year":"2018","journal-title":"J. Mol. Liq."},{"key":"10.1016\/j.saa.2020.119173_b0230","doi-asserted-by":"crossref","unstructured":"P.C. de S. Pereira, R.S. Gon\u00e7alves, M.A. Zampar, M.C. Montanha, F.A.P. de Morais, E. Kimura, C. V. Nakamura, M.L. Bruschi, N. Hioka, W. Caetano, Photosynthesis of hypericin in aqueous medium: A greener approach to prodrug strategy design in photodynamic therapy, J. Mol. Liq. 304 (2020) 112746. doi:10.1016\/j.molliq.2020.112746.","DOI":"10.1016\/j.molliq.2020.112746"},{"key":"10.1016\/j.saa.2020.119173_b0235","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.jconrel.2009.10.024","article-title":"An overview of liposome lyophilization and its future potential","volume":"142","author":"Chen","year":"2010","journal-title":"J. Control. Release."},{"key":"10.1016\/j.saa.2020.119173_b0240","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jcis.2004.11.042","article-title":"Effect of chain lengths of PEO-PPO-PEO on small unilamellar liposome morphology and stability: An AFM investigation","volume":"285","author":"Liang","year":"2005","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.saa.2020.119173_b0245","doi-asserted-by":"crossref","first-page":"4317","DOI":"10.1021\/j100012a063","article-title":"Spectroscopic properties of hypericin in solution and at surfaces","volume":"99","author":"Wynn","year":"1995","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.saa.2020.119173_b0250","doi-asserted-by":"crossref","first-page":"9154","DOI":"10.1021\/j100138a015","article-title":"Triplet-state reactions of hypericin. Time-resolved laser photolysis and electron paramagnetic resonance spectroscopy","volume":"97","author":"Michaeli","year":"1993","journal-title":"J. Phys. Chem."},{"key":"10.1016\/j.saa.2020.119173_b0255","doi-asserted-by":"crossref","first-page":"5528","DOI":"10.2174\/0929867325666180104153848","article-title":"Generation of Reactive Oxygen Species by Photosensitizers and their Modes of Action on Proteins","volume":"25","author":"Bilkis","year":"2018","journal-title":"Curr. Med. Chem."},{"key":"10.1016\/j.saa.2020.119173_b0260","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1063\/1.555934","article-title":"Quantum Yields for the Photosensitized Formation of the Lowest Electronically Excited Singlet State of Molecular Oxygen in Solution","volume":"22","author":"Wilkinson","year":"1993","journal-title":"J. Phys. Chem. Ref. Data."},{"key":"10.1016\/j.saa.2020.119173_b0265","doi-asserted-by":"crossref","first-page":"5154","DOI":"10.1021\/acs.jpcb.8b00659","article-title":"Phosphorescence Kinetics of Singlet Oxygen Produced by Photosensitization in Spherical Nanoparticles. Part II. the Case of Hypericin-Loaded Low-Density Lipoprotein Particles","volume":"122","author":"Datta","year":"2018","journal-title":"J. Phys. Chem. B."},{"key":"10.1016\/j.saa.2020.119173_b0270","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.ejpb.2014.06.013","article-title":"Assessment of drug entrapment within liposomes using photophysical probes","volume":"88","author":"Oliverio","year":"2014","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"10.1016\/j.saa.2020.119173_b0275","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jphotobiol.2015.06.009","article-title":"Differential susceptibility of primary cultured human skin cells to hypericin PDT in an in vitro model","volume":"149","author":"Popovic","year":"2015","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2020.119173_b0280","doi-asserted-by":"crossref","unstructured":"N.J. Wills, J. Park, J. Wen, S. Kesavan, G. a Kraus, J.W. Petrich, S. Carpenter, Tumor cell toxicity of hypericin and related analogs., Photochem. Photobiol. 74 (2001) 216\u2013220. doi:10.1562\/0031-8655(2001)074<0216:TCTOHA>2.0.CO;2.","DOI":"10.1562\/0031-8655(2001)074<0216:TCTOHA>2.0.CO;2"},{"key":"10.1016\/j.saa.2020.119173_b0285","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1021\/jp3119296","article-title":"Investigation of the Photobleaching Process of Eosin Y in Aqueous Solution by Thermal Lens Spectroscopy","volume":"117","author":"Herculano","year":"2013","journal-title":"J. Phys. Chem. B."},{"key":"10.1016\/j.saa.2020.119173_b0290","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.pdpdt.2018.12.013","article-title":"Benefits of hypericin transport and delivery by low- and high-density lipoproteins to cancer cells: From in vitro to ex ovo","volume":"25","author":"Lenkavska","year":"2019","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0295","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.pdpdt.2018.08.008","article-title":"Hypericin-assisted photodynamic therapy against anaplastic thyroid cancer","volume":"24","author":"Kim","year":"2018","journal-title":"Photodiagnosis Photodyn. Ther."},{"key":"10.1016\/j.saa.2020.119173_b0300","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.jcis.2007.02.072","article-title":"Effect of polymer characteristics on structure of polymer-liposome complexes","volume":"311","author":"Cho","year":"2007","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.saa.2020.119173_b0305","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.foodcont.2018.07.027","article-title":"Serum albumins are efficient delivery systems for the photosensitizer hypericin in photosensitization-based treatments against Staphylococcus aureus","volume":"94","author":"Pezzuoli","year":"2018","journal-title":"Food Control."},{"key":"10.1016\/j.saa.2020.119173_b0310","first-page":"81","article-title":"A review on phospholipids and their main applications in drug delivery systems","volume":"10","author":"Li","year":"2015","journal-title":"Asian J. Pharm. Sci."},{"key":"10.1016\/j.saa.2020.119173_b0315","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jcis.2010.12.005","article-title":"Interaction of cationic liposomes with cell membrane models","volume":"355","author":"Bonicelli","year":"2011","journal-title":"J. Colloid Interface Sci."},{"key":"10.1016\/j.saa.2020.119173_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2019.118666","article-title":"Hypericin inclusion complexes encapsulated in liposomes for antimicrobial photodynamic therapy","volume":"570","author":"Plenagl","year":"2019","journal-title":"Int. J. Pharm."},{"key":"10.1016\/j.saa.2020.119173_b0325","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biocel.2015.12.003","article-title":"Enhancement of oxaliplatin sensitivity in human colorectal cancer by hypericin mediated photodynamic therapy via ROS-related mechanism","volume":"71","author":"Lin","year":"2016","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.saa.2020.119173_b0330","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1021\/js970004a","article-title":"Binding, Uptake, and Transport of Hypericin by Caco-2 Cell Monolayers","volume":"86","author":"Sattler","year":"1997","journal-title":"J. Pharm. Sci."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520311525?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142520311525?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T18:59:17Z","timestamp":1778612357000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142520311525"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3]]},"references-count":66,"alternative-id":["S1386142520311525"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2020.119173","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2021,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Photophysical characterization of Hypericin-loaded in micellar, liposomal and copolymer-lipid nanostructures based F127 and DPPC liposomes","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2020.119173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"119173"}}