{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T19:54:15Z","timestamp":1786996455350,"version":"build-2736575974"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2022,1]]},"DOI":"10.1016\/j.saa.2021.120334","type":"journal-article","created":{"date-parts":[[2021,8,28]],"date-time":"2021-08-28T15:16:39Z","timestamp":1630163799000},"page":"120334","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":42,"special_numbering":"C","title":["Analysis of the ternary antiretroviral therapy dolutegravir, lamivudine and abacavir using UV spectrophotometry and chemometric tools"],"prefix":"10.1016","volume":"264","author":[{"given":"Ahmed","family":"Serag","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed A.","family":"Hasan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enas H.","family":"Tolba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed M.","family":"Abdelzaher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman Abo","family":"Elmaaty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2021.120334_b0005","unstructured":"UNAIDS, Global HIV & AIDS statistics \u2013 Fact sheet, 2021."},{"issue":"1","key":"10.1016\/j.saa.2021.120334_b0010","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/nrmicro794","article-title":"The role of sexually transmitted diseases in HIV transmission","volume":"2","author":"Galvin","year":"2004","journal-title":"Nat. Rev. Microbiol."},{"issue":"5","key":"10.1016\/j.saa.2021.120334_b0015","doi-asserted-by":"crossref","first-page":"e308","DOI":"10.1016\/S2352-3018(20)30105-3","article-title":"Maintaining HIV care during the COVID-19 pandemic","volume":"7","author":"Jiang","year":"2020","journal-title":"Lancet HIV"},{"issue":"6","key":"10.1016\/j.saa.2021.120334_b0020","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/s41577-020-0311-8","article-title":"The trinity of COVID-19: immunity, inflammation and intervention","volume":"20","author":"Tay","year":"2020","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.saa.2021.120334_b0025","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.coviro.2016.03.004","article-title":"Current status and prospects of HIV treatment","volume":"18","author":"Cihlar","year":"2016","journal-title":"Curr. Opin. Virol."},{"issue":"19","key":"10.1016\/j.saa.2021.120334_b0030","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1056\/NEJMoa1215541","article-title":"Dolutegravir plus abacavir\u2013lamivudine for the treatment of HIV-1 infection","volume":"369","author":"Walmsley","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.saa.2021.120334_b0035","doi-asserted-by":"crossref","first-page":"299","DOI":"10.2147\/PPA.S65199","article-title":"Combination dolutegravir\u2013abacavir\u2013lamivudine in the management of HIV\/AIDS: clinical utility and patient considerations","volume":"9","author":"Cruciani","year":"2015","journal-title":"Patient Preference Adherence"},{"issue":"7","key":"10.1016\/j.saa.2021.120334_b0040","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.1517\/14656566.2014.913023","article-title":"Dolutegravir, abacavir and lamivudine as HIV therapy","volume":"15","author":"Fernandez-Montero","year":"2014","journal-title":"Expert Opin. Pharmacother."},{"issue":"1","key":"10.1016\/j.saa.2021.120334_b0045","doi-asserted-by":"crossref","first-page":"46","DOI":"10.22159\/ijap.2018v10i1.21156","article-title":"Simultaneous estimation of lamivudine, abacavir and dolutegravir by UPLC method","volume":"10","author":"Dubey","year":"2018","journal-title":"Int. J. App. Pharm"},{"key":"10.1016\/j.saa.2021.120334_b0050","first-page":"168","article-title":"RP-HPLC method development and validation for the simultaneous determination of lamivudine, abacavir and dolutegravir in pharmaceutical dosage forms, World","volume":"5","author":"Rajkumar","year":"2017","journal-title":"J. Pharm. Sci."},{"key":"10.1016\/j.saa.2021.120334_b0055","first-page":"2905","article-title":"Simultaneous stability-indicating method for the determination of Abacavir, Dolutegravir and Lamivudine by RP-HPLC","volume":"7","author":"Priya","year":"2016","journal-title":"Int. J. Pharmaceut. Sci. Res."},{"key":"10.1016\/j.saa.2021.120334_b0060","doi-asserted-by":"crossref","first-page":"392","DOI":"10.5740\/jaoacint.16-0246","article-title":"Molecular and quantum mechanical study for the separation of cefprozil in the presence of Its alkaline degradation product Using RP-HPLC with UV detection","volume":"100","author":"Attia","year":"2017","journal-title":"J. AOAC Int."},{"issue":"5","key":"10.1016\/j.saa.2021.120334_b0065","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1080\/22297928.2017.1385418","article-title":"Stability Indicating HPLC-UV vs. UPLC-DAD for Estimation of Atorvastatin Simultaneously with Aspirin, Clopidogrel and their Related Impurities in Bulk and Capsules","volume":"7","author":"Elkady","year":"2017","journal-title":"Analyt. Chem. Lett."},{"issue":"4","key":"10.1016\/j.saa.2021.120334_b0070","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1080\/10826076.2017.1296461","article-title":"A comparative study of HPLC-UV and UPLC-DAD methods for simultaneous estimation of aspirin and cilostazol in the presence of their related impurities in bulk and capsules","volume":"40","author":"Elkady","year":"2017","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"10.1016\/j.saa.2021.120334_b0075","unstructured":"M.W. Dong, The essence of modern HPLC: advantages, limitations, fundamentals, and opportunities (2013) 1\u20137"},{"key":"10.1016\/j.saa.2021.120334_b0080","doi-asserted-by":"crossref","first-page":"159","DOI":"10.4155\/bio-2019-0284","article-title":"Statistical optimization and validation of a novel ultra-performance liquid chromatography method for estimation of nintedanib in rat and human plasma","volume":"12","author":"Shukla","year":"2020","journal-title":"Bioanalysis"},{"key":"10.1016\/j.saa.2021.120334_b0085","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.saa.2017.08.066","article-title":"Different spectrophotometric methods applied for the analysis of simeprevir in the presence of its oxidative degradation product: Acomparative study","volume":"190","author":"Attia","year":"2018","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0090","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/j.saa.2015.10.040","article-title":"Zero order and signal processing spectrophotometric techniques applied for resolving interference of metronidazole with ciprofloxacin in their pharmaceutical dosage form","volume":"154","author":"Attia","year":"2016","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0095","doi-asserted-by":"crossref","first-page":"118853","DOI":"10.1016\/j.saa.2020.118853","article-title":"Smart UV spectrophotometric methods based on simple mathematical filtration for the simultaneous determination of celecoxib and ramipril in their pharmaceutical mixtures with amlodipine: A comparative statistical study","volume":"244","author":"Attala","year":"2021","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0100","doi-asserted-by":"crossref","first-page":"335","DOI":"10.4155\/bio-2019-0293","article-title":"Separation-free spectrophotometric platforms for rapid assessment of combined antiplatelet therapy in complex matrices","volume":"12","author":"Elsonbaty","year":"2020","journal-title":"Bioanalysis"},{"key":"10.1016\/j.saa.2021.120334_b0105","first-page":"280","article-title":"Simultaneous Estimation of Terconazole and Benzoic Acid in Bulk and Creams Using RP-HPLC, Derivative Spectrophotometry and Chemometric Techniques","volume":"9","author":"Elbagary","year":"2017","journal-title":"J. Chem. Pharmaceut. Res."},{"key":"10.1016\/j.saa.2021.120334_b0110","first-page":"462","article-title":"Simultaneous HPLC and derivative spectrophotometry detrmination of tioconazole and benzyl alcohol in bulk and cream with tioconazole forced degradation study","volume":"14","author":"Bagary","year":"2014","journal-title":"Anal. Chem. Ind. J"},{"key":"10.1016\/j.saa.2021.120334_b0115","doi-asserted-by":"crossref","first-page":"119855","DOI":"10.1016\/j.saa.2021.119855","article-title":"Advanced eco-friendly UV spectrophotometric approach for resolving overlapped spectral signals of antihypertensive agents in their binary and tertiary pharmaceutical dosage form","volume":"258","author":"Attala","year":"2021","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0120","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.saa.2016.01.026","article-title":"Stability indicating methods for the analysis of cefprozil in the presence of its alkaline induced degradation product","volume":"159","author":"Attia","year":"2016","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0125","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.saa.2016.07.016","article-title":"Firefly algorithm versus genetic algorithm as powerful variable selection tools and their effect on different multivariate calibration models in spectroscopy: A comparative study","volume":"170","author":"Attia","year":"2017","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0130","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.saa.2015.11.024","article-title":"Effect of genetic algorithm as a variable selection method on different chemometric models applied for the analysis of binary mixture of amoxicillin and flucloxacillin: A comparative study","volume":"156","author":"Attia","year":"2016","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0135","doi-asserted-by":"crossref","first-page":"119042","DOI":"10.1016\/j.saa.2020.119042","article-title":"An evaluation of different bio-inspired feature selection techniques on multivariate calibration models in spectroscopy","volume":"246","author":"El-Zeiny","year":"2021","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0140","doi-asserted-by":"crossref","first-page":"118415","DOI":"10.1016\/j.saa.2020.118415","article-title":"Analysis of quinary therapy targeting multiple cardiovascular diseases using UV spectrophotometry and chemometric tools","volume":"238","author":"Elsonbaty","year":"2020","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2021.120334_b0145","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1021\/ac00162a020","article-title":"Partial least-squares methods for spectral analyses. 1. Relation to other quantitative calibration methods and the extraction of qualitative information","volume":"60","author":"Haaland","year":"1988","journal-title":"Anal. Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142521009112?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142521009112?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:51:32Z","timestamp":1761357092000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142521009112"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1]]},"references-count":29,"alternative-id":["S1386142521009112"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2021.120334","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2022,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Analysis of the ternary antiretroviral therapy dolutegravir, lamivudine and abacavir using UV spectrophotometry and chemometric tools","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2021.120334","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"120334"}}