{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T01:34:52Z","timestamp":1772847292730,"version":"3.50.1"},"reference-count":36,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,5,1]],"date-time":"2022-05-01T00:00:00Z","timestamp":1651363200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2022,5]]},"DOI":"10.1016\/j.saa.2022.121029","type":"journal-article","created":{"date-parts":[[2022,2,18]],"date-time":"2022-02-18T11:53:28Z","timestamp":1645185208000},"page":"121029","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Identification of polycystic ovary syndrome from blood serum using hormone levels via Raman spectroscopy and multivariate analysis"],"prefix":"10.1016","volume":"273","author":[{"given":"Zozan","family":"Guleken","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huri","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Berk","family":"Bulut","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wies\u0142aw","family":"Paja","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Orzechowska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magdalena","family":"Parlinska-Wojtan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"Depciuch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.saa.2022.121029_b0005","article-title":"Polycystic ovary syndrome","volume":"2","author":"Azziz","year":"2016","journal-title":"Nat. Rev. Dis. Prim."},{"issue":"11","key":"10.1016\/j.saa.2022.121029_b0010","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.4158\/EP15748.DSC","article-title":"American association of clinical endocrinologists, American college of endocrinology, and androgen excess and pcos society disease state clinical review: Guide to the best practices in the evaluation and treatment of polycystic ovary syndrome - Part 1","volume":"21","author":"Goodman","year":"2015","journal-title":"Endocr. Pract."},{"key":"10.1016\/j.saa.2022.121029_b0015","series-title":"Diagnosis And Management Of Polycystic Ovary Syndrome","first-page":"135","author":"Farid","year":"2009"},{"issue":"3","key":"10.1016\/j.saa.2022.121029_b0020","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.fertnstert.2018.05.004","article-title":"Recommendations from the international evidence-based guideline for the assessment and management of polycystic ovary syndrome","volume":"110","author":"Teede","year":"2018","journal-title":"Fertil. Steril."},{"issue":"7","key":"10.1016\/j.saa.2022.121029_b0025","doi-asserted-by":"crossref","first-page":"846","DOI":"10.1016\/j.bbamem.2006.04.010","article-title":"Chemical imaging of biological tissue with synchrotron infrared light","volume":"1758","author":"Miller","year":"2006","journal-title":"Biochim. Biophys. Acta - Biomembr."},{"key":"10.1016\/j.saa.2022.121029_b0030","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.addr.2015.03.009","article-title":"Raman spectroscopy for medical diagnostics - From in-vitro biofluid assays to in-vivo cancer detection","volume":"89","author":"Kong","year":"2015","journal-title":"Adv. Drug Deliv. Rev."},{"key":"10.1016\/j.saa.2022.121029_b0035","doi-asserted-by":"crossref","first-page":"120246","DOI":"10.1016\/j.saa.2021.120246","article-title":"Diagnosis of endometriosis using endometrioma volume and vibrational spectroscopy with multivariate methods as a noninvasive method","volume":"264","author":"Guleken","year":"2022","journal-title":"Spectrochim. Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2022.121029_b0040","doi-asserted-by":"crossref","first-page":"114250","DOI":"10.1016\/j.jpba.2021.114250","article-title":"Assessment of the effect of endocrine abnormalities on biomacromolecules and lipids by FT-IR and biochemical assays as biomarker of metabolites in early Polycystic ovary syndrome women","volume":"204","author":"Guleken","year":"2021","journal-title":"J. Pharm. Biomed. Anal."},{"issue":"2","key":"10.1016\/j.saa.2022.121029_b0045","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1364\/BOE.9.000801","article-title":"Surface-enhanced Raman scattering for the detection of polycystic ovary syndrome","volume":"9","author":"Momenpour","year":"2018","journal-title":"Biomed. Opt. Express."},{"key":"10.1016\/j.saa.2022.121029_b0050","doi-asserted-by":"crossref","first-page":"111139","DOI":"10.1016\/j.mce.2020.111139","article-title":"Raman spectroscopy of follicular fluid and plasma with machine-learning algorithms for polycystic ovary syndrome screening","volume":"523","author":"Zhang","year":"2021","journal-title":"Mol. Cell. Endocrinol."},{"key":"10.1016\/j.saa.2022.121029_b0055","series-title":"Polycystic ovary syndrome","first-page":"377","article-title":"Diagnostic criteria for polycystic ovary syndrome: towards a rational approach","author":"Zawadzki","year":"1992"},{"key":"10.1016\/j.saa.2022.121029_b0060","first-page":"2248","article-title":"Determinants of Abnormal Gonadotropin Secretion in Clinically Defined Women with Polycystic Ovary Syndrome1","volume":"82","author":"Taylor","year":"1997","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"1-2","key":"10.1016\/j.saa.2022.121029_b0065","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1016\/0003-2697(76)90527-3","article-title":"A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding","volume":"72","author":"Bradford","year":"1976","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.saa.2022.121029_b0070","first-page":"50","article-title":"Quantitation of protein","volume":"182","author":"Stoscheck","year":"1990","journal-title":"MethodsEnzymol."},{"key":"10.1016\/j.saa.2022.121029_b0075","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1210\/er.2015-1104","article-title":"The Pathogenesis of Polycystic Ovary Syndrome (PCOS): The hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.saa.2022.121029_b0080","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1017\/S1462399408000598","article-title":"Polycystic ovarian syndrome: Pathophysiology, molecular aspects and clinical implications","volume":"10","author":"Diamanti-Kandarakis","year":"2008","journal-title":"Expert Rev. Mol. Med."},{"key":"10.1016\/j.saa.2022.121029_b0085","article-title":"Elevated Serum Level of DHEAS as a Hormone and IL-6 as a Proinflammatory Cytokine May Better Indicate Metabolic Syndrome in PCOS Women","volume":"71","author":"Guleken","year":"2021","journal-title":"J. Med. Physiol. Biophys."},{"key":"10.1016\/j.saa.2022.121029_b0090","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1039\/b304992b","article-title":"Raman spectroscopy for identification of epithelial cancers","volume":"126","author":"Stone","year":"2004","journal-title":"Faraday Discuss."},{"issue":"3","key":"10.1016\/j.saa.2022.121029_b0095","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1002\/bip.20398","article-title":"Discrimination of normal, inflammatory, premalignant, and malignant oral tissue: A Raman spectroscopy study","volume":"81","author":"Malini","year":"2006","journal-title":"Biopolymers"},{"issue":"7","key":"10.1016\/j.saa.2022.121029_b0100","doi-asserted-by":"crossref","first-page":"1529","DOI":"10.1016\/j.saa.2004.11.017","article-title":"Near infrared Raman spectra of human brain lipids","volume":"61","author":"Krafft","year":"2005","journal-title":"Spectrochim. Acta - Part A Mol. Biomol. Spectrosc."},{"issue":"1","key":"10.1016\/j.saa.2022.121029_b0105","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1098\/rsif.2004.0008","article-title":"Discrimination between ricin and sulphur mustard toxicity in vitro using Raman spectroscopy","volume":"1","author":"Notingher","year":"2004","journal-title":"J. R. Soc. Interface."},{"key":"10.1016\/j.saa.2022.121029_b0110","first-page":"847","article-title":"The effect of estrogen receptor agonists on pancreaticobiliary duct ligation induced experimental acute pancreatitis","volume":"68","author":"Guleken","year":"2017","journal-title":"J. Physiol. Pharmacol."},{"issue":"5","key":"10.1016\/j.saa.2022.121029_b0115","doi-asserted-by":"crossref","first-page":"E849","DOI":"10.1152\/ajpendo.1999.276.5.E849","article-title":"TNF-\u03b1 impairs insulin signaling and insulin stimulation of glucose uptake in C2C12 muscle cells","volume":"276","author":"del Aguila","year":"1999","journal-title":"Am. J. Physiol. - Endocrinol. Metab."},{"key":"10.1016\/j.saa.2022.121029_b0120","first-page":"17","article-title":"Polycystic ovary syndrome (PCOS), diagnostic criteria, and AMH, Asian Pacific","volume":"18","author":"Mohammad","year":"2017","journal-title":"J. Cancer Prev."},{"issue":"3","key":"10.1016\/j.saa.2022.121029_b0125","first-page":"270","article-title":"Assessment the Correlations of Hormones, Lipid Profiles, Oxidative Stress, and Zinc Concentration in Iraqi Women with Polycystic Ovary Syndrome, Reports Biochem","volume":"9","author":"Shenta","year":"2020","journal-title":"Mol. Biol."},{"issue":"1","key":"10.1016\/j.saa.2022.121029_b0130","doi-asserted-by":"crossref","DOI":"10.1186\/s12958-017-0230-0","article-title":"The effect of estradiol on granulosa cell responses to FSH in women with polycystic ovary syndrome","volume":"15","author":"Homer","year":"2017","journal-title":"Reprod. Biol. Endocrinol."},{"issue":"1","key":"10.1016\/j.saa.2022.121029_b0135","doi-asserted-by":"crossref","DOI":"10.1186\/s43042-019-0031-4","article-title":"Hyperandrogenism in polycystic ovarian syndrome and role of CYP gene variants: a review","volume":"20","author":"Ashraf","year":"2019","journal-title":"Egypt. J. Med. Hum. Genet."},{"key":"10.1016\/j.saa.2022.121029_b0140","series-title":"Chemical history: reviews of the recent literature","author":"Roberts","year":"2005"},{"issue":"1","key":"10.1016\/j.saa.2022.121029_b0145","first-page":"165","article-title":"Prevalence and Predictors of Risk for Type 2 Diabetes Mellitus and Impaired Glucose Tolerance in Polycystic Ovary Syndrome: A Prospective, Controlled Study in 254 Affected Women 1","volume":"84","author":"Legro","year":"1999","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"9","key":"10.1016\/j.saa.2022.121029_b0150","doi-asserted-by":"crossref","first-page":"2167","DOI":"10.3390\/ijms20092167","article-title":"Membrane lipid composition: Effect on membrane and organelle structure, function and compartmentalization and therapeutic avenues","volume":"20","author":"Casares","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2022.121029_b0155","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1136\/jcp.2003.015271","article-title":"Cardiovascular risk in women with polycystic ovarian syndrome (PCOS)","volume":"58","author":"Bickerton","year":"2005","journal-title":"J. Clin. Pathol."},{"issue":"3","key":"10.1016\/j.saa.2022.121029_b0160","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.1016\/j.fertnstert.2010.12.027","article-title":"Lipid levels in polycystic ovary syndrome: Systematic review and meta-analysis","volume":"95","author":"Wild","year":"2011","journal-title":"Fertil. Steril."},{"key":"10.1016\/j.saa.2022.121029_b0165","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-52263-w","article-title":"Metformin induces lipid changes on sphingolipid species and oxidized lipids in polycystic ovary syndrome women","volume":"9","author":"Pradas","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.saa.2022.121029_b0170","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1210\/jc.2014-2086","article-title":"Proteomics of follicular fluid from women with polycystic ovary syndrome suggests molecular defects in follicular development","volume":"100","author":"Ambekar","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.saa.2022.121029_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-54067-4","article-title":"Thromboinflammatory changes in plasma proteome of pregnant women with PCOS detected by quantitative label-free proteomics","volume":"9","author":"Arffman","year":"2019","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.saa.2022.121029_b0180","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/0003702815620127","article-title":"Application of Raman Spectroscopy and Infrared Spectroscopy in the Identification of Breast Cancer","volume":"70","author":"Depciuch","year":"2016","journal-title":"Appl. Spectrosc."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522001779?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522001779?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:59:32Z","timestamp":1761357572000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142522001779"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5]]},"references-count":36,"alternative-id":["S1386142522001779"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2022.121029","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2022,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of polycystic ovary syndrome from blood serum using hormone levels via Raman spectroscopy and multivariate analysis","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2022.121029","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121029"}}