{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T15:48:40Z","timestamp":1771256920532,"version":"3.50.1"},"reference-count":49,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,6,1]],"date-time":"2022-06-01T00:00:00Z","timestamp":1654041600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,3,7]],"date-time":"2022-03-07T00:00:00Z","timestamp":1646611200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2022,6]]},"DOI":"10.1016\/j.saa.2022.121092","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T11:49:14Z","timestamp":1646048954000},"page":"121092","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Visible and Near-Infrared hyperspectral imaging (HSI) can reliably quantify CD3 and CD45 positive inflammatory cells in myocarditis: Pilot study on formalin-fixed paraffin-embedded specimens from myocard obtained during autopsy"],"prefix":"10.1016","volume":"274","author":[{"given":"A.","family":"Brunner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.M.","family":"Schmidt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Zelger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Woess","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Arora","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P.","family":"Zelger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6272-3242","authenticated-orcid":false,"given":"C.W.","family":"Huck","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0203-213X","authenticated-orcid":false,"given":"J.","family":"Pallua","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2022.121092_b0005","series-title":"Hyperspectral imaging: techniques for spectral detection and classification","author":"Chang","year":"2003"},{"key":"10.1016\/j.saa.2022.121092_b0010","doi-asserted-by":"crossref","first-page":"6283","DOI":"10.1364\/BOE.9.006283","article-title":"On the spectral signature of melanoma: a non-parametric classification framework for cancer detection in hyperspectral imaging of melanocytic lesions, Biomed","volume":"9","author":"Pardo","year":"2018","journal-title":"Opt. Express"},{"key":"10.1016\/j.saa.2022.121092_b0015","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1515\/teme-2014-0018","article-title":"Gewinnung und Verarbeitung hyperspektraler Fluoreszenzbilder zur optischen Mineralklassifikation, tm -","volume":"82","author":"Bauer","year":"2015","journal-title":"Tech. Mess."},{"key":"10.1016\/j.saa.2022.121092_b0020","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1515\/teme-2015-0039","article-title":"Spectral and geometric aspects of mineral identification by means of hyperspectral fluorescence imaging, tm -","volume":"82","author":"Bauer","year":"2015","journal-title":"Tech. Mess."},{"key":"10.1016\/j.saa.2022.121092_b0025","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1515\/teme-2014-0005","article-title":"Hyperspectral image unmixing involving spatial information by extending the alternating least-squares algorithm, tm -","volume":"82","author":"Bauer","year":"2015","journal-title":"Tech. Mess."},{"key":"10.1016\/j.saa.2022.121092_b0030","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1109\/JSTARS.2012.2194696","article-title":"Hyperspectral Unmixing Overview: Geometrical, Statistical, and Sparse Regression-Based Approaches","volume":"5","author":"Bioucas-Dias","year":"2012","journal-title":"IEEE J. Sel. Top. Appl. Earth Obs. Remote Sens."},{"issue":"2-3","key":"10.1016\/j.saa.2022.121092_b0035","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0168-1699(02)00100-X","article-title":"Machine vision technology for agricultural applications","volume":"36","author":"Chen","year":"2002","journal-title":"Comput. Electron. Agric."},{"issue":"3-4","key":"10.1016\/j.saa.2022.121092_b0040","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1177\/09603360211024971","article-title":"New perspectives of hyperspectral imaging for clinical research","volume":"32","author":"Pallua","year":"2021","journal-title":"NIR News"},{"key":"10.1016\/j.saa.2022.121092_b0045","series-title":"Hyperspectral remote sensing of vegetation","author":"Thenkabail","year":"2011"},{"issue":"3-4","key":"10.1016\/j.saa.2022.121092_b0050","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0169-1368(99)00007-4","article-title":"Remote sensing for mineral exploration","volume":"14","author":"Sabins","year":"1999","journal-title":"Ore Geol. Rev."},{"issue":"1-3","key":"10.1016\/j.saa.2022.121092_b0055","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.forsciint.2012.09.012","article-title":"Hyperspectral imaging for non-contact analysis of forensic traces","volume":"223","author":"Edelman","year":"2012","journal-title":"Forensic Sci. Int."},{"issue":"20","key":"10.1016\/j.saa.2022.121092_b0060","doi-asserted-by":"crossref","first-page":"5176","DOI":"10.1039\/C4AN00961D","article-title":"Near infrared hyperspectral imaging for forensic analysis of document forgery","volume":"139","author":"Silva","year":"2014","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2022.121092_b0065","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.forsciint.2014.06.023","article-title":"Detection of residues from explosive manipulation by near infrared hyperspectral imaging: a promising forensic tool","volume":"242","author":"Fernandez de la Ossa","year":"2014","journal-title":"Forensic Sci. Int."},{"issue":"9","key":"10.1016\/j.saa.2022.121092_b0070","doi-asserted-by":"crossref","first-page":"3045","DOI":"10.3390\/s21093045","article-title":"Hyperspectral Imaging for Bloodstain Identification","volume":"21","author":"Zulfiqar","year":"2021","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.saa.2022.121092_b0075","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1038\/s41598-021-85737-x","article-title":"Forensic analysis of beverage stains using hyperspectral imaging","volume":"11","author":"Melit Devassy","year":"2021","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.saa.2022.121092_b0080","doi-asserted-by":"crossref","first-page":"1039","DOI":"10.1080\/10408398.2011.651542","article-title":"Application of hyperspectral imaging in food safety inspection and control: a review","volume":"52","author":"Feng","year":"2012","journal-title":"Crit. Rev. Food Sci. Nutr."},{"key":"10.1016\/j.saa.2022.121092_b0085","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.1080\/10408398.2013.871693","article-title":"Applications of near-infrared spectroscopy in food safety evaluation and control: a review of recent research advances","volume":"55","author":"Qu","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"9","key":"10.1016\/j.saa.2022.121092_b0090","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1080\/10408398.2013.834875","article-title":"Applications of hyperspectral imaging in chicken meat safety and quality detection and evaluation: a review","volume":"55","author":"Xiong","year":"2015","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"2","key":"10.1016\/j.saa.2022.121092_b0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1007\/s00339-011-6689-1","article-title":"Advances in multispectral and hyperspectral imaging for archaeology and art conservation","volume":"106","author":"Liang","year":"2012","journal-title":"Appl. Phys. A"},{"key":"10.1016\/j.saa.2022.121092_b0100","doi-asserted-by":"crossref","first-page":"343","DOI":"10.5194\/isprs-archives-XLI-B5-343-2016","article-title":"Adaptation of industrial hyperspectral line scanner for archaeological applications","volume":"5","author":"Miljkovi\u0107","year":"2016","journal-title":"Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci"},{"key":"10.1016\/j.saa.2022.121092_b0105","doi-asserted-by":"crossref","unstructured":"C. Cucci, A. Casini, Chapter 3.8 - Hyperspectral imaging for artworks investigation, in: J.M. Amigo (Ed.), Data Handling in Science and Technology, Elsevier 2020, pp. 583-604.","DOI":"10.1016\/B978-0-444-63977-6.00023-7"},{"issue":"09","key":"10.1016\/j.saa.2022.121092_b0110","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1117\/1.JBO.23.9.091409","article-title":"Intraoperative hyperspectral determination of human tissue properties","volume":"23","author":"Wisotzky","year":"2018","journal-title":"J. Biomed. Opt."},{"issue":"2","key":"10.1016\/j.saa.2022.121092_b0115","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3390\/s18020430","article-title":"An Intraoperative Visualization System Using Hyperspectral Imaging to Aid in Brain Tumor Delineation","volume":"18","author":"Fabelo","year":"2018","journal-title":"Sensors (Basel)"},{"issue":"3","key":"10.1016\/j.saa.2022.121092_b0120","doi-asserted-by":"crossref","first-page":"e0193721","DOI":"10.1371\/journal.pone.0193721","article-title":"Spatio-spectral classification of hyperspectral images for brain cancer detection during surgical operations","volume":"13","author":"Fabelo","year":"2018","journal-title":"PLoS ONE"},{"key":"10.1016\/j.saa.2022.121092_b0125","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.exphem.2020.09.191","article-title":"Visible and near-infrared hyperspectral imaging techniques allow the reliable quantification of prognostic markers in lymphomas: A pilot study using the Ki67 proliferation index as an example","volume":"91","author":"Willenbacher","year":"2020","journal-title":"Exp. Hematol."},{"issue":"2","key":"10.1016\/j.saa.2022.121092_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202000424","article-title":"Hyperspectral imaging as a diagnostic tool to differentiate between amalgam tattoos and other dark pigmented intraoral lesions","volume":"14","author":"Laimer","year":"2021","journal-title":"J. Biophotonics"},{"issue":"1","key":"10.1016\/j.saa.2022.121092_b0135","doi-asserted-by":"crossref","first-page":"010901","DOI":"10.1117\/1.JBO.19.1.010901","article-title":"Medical hyperspectral imaging: a review","volume":"19","author":"Lu","year":"2014","journal-title":"J. Biomed. Opt."},{"issue":"6","key":"10.1016\/j.saa.2022.121092_b0140","doi-asserted-by":"crossref","first-page":"756","DOI":"10.3390\/cancers11060756","article-title":"In-Vivo and Ex-Vivo Tissue Analysis through Hyperspectral Imaging Techniques: Revealing the Invisible Features of Cancer","volume":"11","author":"Halicek","year":"2019","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.saa.2022.121092_b0145","doi-asserted-by":"crossref","first-page":"36","DOI":"10.3390\/jcm8010036","article-title":"Use of Hyperspectral\/Multispectral Imaging in Gastroenterology. Shedding Some(-)Different(-)Light into the Dark","volume":"8","author":"Ortega","year":"2019","journal-title":"J. Clin. Med."},{"issue":"6","key":"10.1016\/j.saa.2022.121092_b0150","doi-asserted-by":"crossref","first-page":"3195","DOI":"10.1364\/BOE.386338","article-title":"Hyperspectral and multispectral imaging in digital and computational pathology: a systematic review [Invited], Biomed","volume":"11","author":"Ortega","year":"2020","journal-title":"Opt. Express"},{"key":"10.1016\/j.saa.2022.121092_b0155","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.ijcard.2015.05.008","article-title":"Diagnosis of myocarditis: Current state and future perspectives","volume":"191","author":"Biesbroek","year":"2015","journal-title":"Int. J. Cardiol."},{"issue":"4","key":"10.1016\/j.saa.2022.121092_b0160","doi-asserted-by":"crossref","first-page":"603","DOI":"10.3390\/jcm10040603","article-title":"Epidemiological Impact of Myocarditis","volume":"10","author":"Golpour","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.saa.2022.121092_b0165","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/s000590050007","article-title":"Definition of inflammatory cardiomyopathy (myocarditis): on the way to consensus. A status report","volume":"25","author":"Maisch","year":"2000","journal-title":"Herz"},{"key":"10.1016\/j.saa.2022.121092_b0170","first-page":"3","article-title":"Myocarditis. A histopathologic definition and classification","volume":"1","author":"Aretz","year":"1987","journal-title":"Am. J. Cardiovasc. Pathol."},{"key":"10.1016\/j.saa.2022.121092_b0175","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.forsciint.2018.01.027","article-title":"When is myocarditis indeed the cause of death?","volume":"285","author":"Bonsignore","year":"2018","journal-title":"Forensic. Sci. Int."},{"issue":"9","key":"10.1016\/j.saa.2022.121092_b0180","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1016\/j.humpath.2005.07.009","article-title":"Diagnosis and presentation of fatal myocarditis","volume":"36","author":"Kyto","year":"2005","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.saa.2022.121092_b0185","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.forsciint.2014.02.012","article-title":"Quantitative diagnosis of lymphocytic myocarditis in forensic medicine","volume":"238","author":"Nielsen","year":"2014","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.saa.2022.121092_b0190","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/jcp.53.2.147","article-title":"Necropsy diagnosis of myocarditis: a retrospective study using CD45RO immunohistochemistry","volume":"53","author":"Feeley","year":"2000","journal-title":"J. Clin. Pathol."},{"key":"10.1016\/j.saa.2022.121092_b0195","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.forsciint.2012.08.004","article-title":"Forensic grading of myocarditis: an experimental contribution to the distinction between lethal myocarditis and incidental myocarditis","volume":"223","author":"Casali","year":"2012","journal-title":"Forensic Sci. Int."},{"key":"10.1016\/j.saa.2022.121092_b0200","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4172\/2157-7145.1000325","article-title":"Niessen HWM Diagnosing Lymphocytic Myocarditis in AdultAutopsies Combining the Dallas Criteria with Immunohistochemical Stainings","volume":"7","author":"Fronczek","year":"2016","journal-title":"J. Forensic Res."},{"issue":"9","key":"10.1016\/j.saa.2022.121092_b0205","doi-asserted-by":"crossref","first-page":"153040","DOI":"10.1016\/j.prp.2020.153040","article-title":"The future of pathology is digital","volume":"216","author":"Pallua","year":"2020","journal-title":"Pathol. Res. Pract."},{"issue":"1","key":"10.1016\/j.saa.2022.121092_b0210","doi-asserted-by":"crossref","first-page":"159","DOI":"10.2307\/2529310","article-title":"The measurement of observer agreement for categorical data","volume":"33","author":"Landis","year":"1977","journal-title":"Biometrics"},{"key":"10.1016\/j.saa.2022.121092_b0215","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.humpath.2016.11.006","article-title":"CD45 is a more sensitive marker than CD3 to diagnose lymphocytic myocarditis in the endomyocardium","volume":"62","author":"Woudstra","year":"2017","journal-title":"Hum. Pathol."},{"key":"10.1016\/j.saa.2022.121092_b0220","first-page":"917","article-title":"Immunohistochemical characterization of lymphocytes in uninflamed ventricular myocardium. Implications for myocarditis","volume":"109","author":"Linder","year":"1985","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"1","key":"10.1016\/j.saa.2022.121092_b0225","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1007\/s00414-011-0634-x","article-title":"The role of focal myocardial inflammation in sudden unexpected cardiac and noncardiac deaths\u2013a clinicopathological study","volume":"127","author":"Zhang","year":"2013","journal-title":"Int. J. Legal Med."},{"key":"10.1016\/j.saa.2022.121092_b0230","first-page":"764","article-title":"Hypersensitivity myocarditis","volume":"115","author":"Burke","year":"1991","journal-title":"Arch. Pathol. Lab. Med."},{"issue":"4","key":"10.1016\/j.saa.2022.121092_b0235","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1007\/s004140050066","article-title":"Myocardial necrosis and cocaine. A quantitative morphologic study in 26 cocaine-associated deaths","volume":"110","author":"Fineschi","year":"1997","journal-title":"Int. J. Legal Med."},{"key":"10.1016\/j.saa.2022.121092_b0240","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1136\/bmj.322.7296.1207","article-title":"Antipsychotic drugs and heart muscle disorder in international pharmacovigilance: data mining study","volume":"322","author":"Coulter","year":"2001","journal-title":"BMJ"},{"key":"10.1016\/j.saa.2022.121092_b0245","doi-asserted-by":"crossref","first-page":"263","DOI":"10.2165\/00002018-200022040-00002","article-title":"Cardiotoxicity of chemotherapeutic agents: incidence, treatment and prevention","volume":"22","author":"Pai","year":"2000","journal-title":"Drug Saf."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522002402?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522002402?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T01:59:10Z","timestamp":1761357550000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142522002402"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6]]},"references-count":49,"alternative-id":["S1386142522002402"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2022.121092","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2022,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Visible and Near-Infrared hyperspectral imaging (HSI) can reliably quantify CD3 and CD45 positive inflammatory cells in myocarditis: Pilot study on formalin-fixed paraffin-embedded specimens from myocard obtained during autopsy","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2022.121092","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"121092"}}