{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T13:27:27Z","timestamp":1777642047256,"version":"3.51.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.saa.2022.121695","type":"journal-article","created":{"date-parts":[[2022,8,2]],"date-time":"2022-08-02T12:31:18Z","timestamp":1659443478000},"page":"121695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Simultaneous spectrophotometric determination of fluphenazine HCl and nortriptyline HCl in presence of their potential impurities perphenazine and dibenzosuberone in bulk and pharmaceutical formulation"],"prefix":"10.1016","volume":"282","author":[{"given":"Maimana A.","family":"Magdy","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nessreen S.","family":"Abdelhamid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Basma H.","family":"Anwar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nehal F.","family":"Farid","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2022.121695_b0005","unstructured":"The British Pharmacopoeia, Medicines and Healthcare products Regulatory Agency, London, UK, 2013."},{"issue":"1","key":"10.1016\/j.saa.2022.121695_b0010","first-page":"64","article-title":"Spectrophotometric determination of diltiazern, fluphenazine and dothiepin hydrochlorides using chromotrope 2R and rose Bengal","volume":"20","author":"Hosny","year":"2004","journal-title":"Mansou. J. Pharmaceut. Sci."},{"issue":"3","key":"10.1016\/j.saa.2022.121695_b0015","first-page":"503","article-title":"Simultaneous determination of fluphenazine, trifluoperazine, and prochloroperazine in pharmaceutical preparations by HPLC method","volume":"7","author":"Dhabab","year":"2012","journal-title":"J. Int. Environ. Appl. Sci."},{"key":"10.1016\/j.saa.2022.121695_b0020","unstructured":"J.I. Javaid, H. Dekirmenjian, U. Liskevych, R.L. Lin, J.M. Davis, Fluphenazine determination in human plasma by a sensitive gas chromatographic method using nitrogen."},{"issue":"3","key":"10.1016\/j.saa.2022.121695_b0025","doi-asserted-by":"crossref","first-page":"241","DOI":"10.2174\/1573412912666160524144945","article-title":"Concurrent estimation of gabapentin and nortriptyline hydrochloride in their combined dosage form using OPA-\u03b2-mercaptoethanol derivatization by spectrophotometric and spectrofluorimetric methods","volume":"13","author":"Shah","year":"2017","journal-title":"Curr. Pharmaceut. Anal."},{"issue":"9","key":"10.1016\/j.saa.2022.121695_b0030","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1016\/j.jchromb.2010.01.033","article-title":"Quantification of nortriptyline in plasma by HPLC and fluorescence detection","volume":"878","author":"Almudever","year":"2010","journal-title":"J. Chromatogr. B"},{"issue":"1","key":"10.1016\/j.saa.2022.121695_b0035","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/S0021-9673(00)93769-5","article-title":"Assay of human plasma for nortriptyline by radioacetylation and thin-layer chromatography","volume":"132","author":"Zuleski","year":"1977","journal-title":"J. Chromatogr. A"},{"issue":"7","key":"10.1016\/j.saa.2022.121695_b0040","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1365\/s10337-007-0373-9","article-title":"Directly suspended droplet microextraction and analysis of amitriptyline and nortriptyline by GC","volume":"66","author":"Sarafraz-Yazdi","year":"2007","journal-title":"Chromatographia"},{"key":"10.1016\/j.saa.2022.121695_b0045","unstructured":"TabletWise, Motival tablet. https:\/\/www.tabletwise.net\/egypt\/motival-tablet [Accessed in 31-10-2021 at 01:13 AM]."},{"issue":"10","key":"10.1016\/j.saa.2022.121695_b0050","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1080\/00032719108053013","article-title":"Spectrophotometric assay of fluphenazine HCL-nortriptyline HCL mixture in tablets using Fourier function method","volume":"24","author":"Mahgoub","year":"1991","journal-title":"Anal. Lett."},{"issue":"11","key":"10.1016\/j.saa.2022.121695_b0055","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1080\/00032719.2016.1251448","article-title":"Simultaneous spectrophotometric determination of imipramine hydrochloride with chlordiazepoxide and nortriptyline hydrochloride with fluphenazine hydrochloride","volume":"50","author":"Mansour","year":"2017","journal-title":"Anal. Lett."},{"issue":"5","key":"10.1016\/j.saa.2022.121695_b0060","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1007\/s10895-009-0488-5","article-title":"Second-derivative synchronous fluorescence spectroscopy for the simultaneous determination of fluphenazine hydrochloride and nortriptyline hydrochloride in pharmaceutical preparations","volume":"19","author":"Walash","year":"2009","journal-title":"J. Fluoresc."},{"issue":"12","key":"10.1016\/j.saa.2022.121695_b0065","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1134\/S1061934814120041","article-title":"Chromatographic methods for the determination of fluphenazine, nortriptyline and its impurity amitriptyline in bulk and pharmaceutical formulations","volume":"69","author":"El-Houssini","year":"2014","journal-title":"J. Anal. Chem."},{"issue":"7","key":"10.1016\/j.saa.2022.121695_b0070","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1081\/AL-120005971","article-title":"Spectrophotometric and stability indicating high performance liquid chromatographic determination of nortriptyline hydrochloride and fluphenazine hydrochloride","volume":"35","author":"El-Ragehy","year":"2002","journal-title":"Anal. Lett."},{"issue":"2","key":"10.1016\/j.saa.2022.121695_b0075","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/0026-265X(88)90019-7","article-title":"Determination of nortriptyline hydrochloride and fluphenazine hydrochloride in commercial tablets by reverse phase high-performance liquid chromatography","volume":"38","author":"Sa'sa","year":"1988","journal-title":"Microchem. J."},{"issue":"6","key":"10.1016\/j.saa.2022.121695_b0080","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/j.jpha.2012.05.004","article-title":"Simultaneous determination of nortriptyline hydrochloride and fluphenazine hydrochloride in microgram quantities from low dosage forms by liquid chromatography-UV detection","volume":"2","author":"Ashour","year":"2012","journal-title":"J. Pharmaceut. Anal."},{"issue":"6","key":"10.1016\/j.saa.2022.121695_b0085","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1080\/10826076.2012.673213","article-title":"Simultaneous HPLC-determination of nortriptyline and fluphenazine in one minute using monolithic stationary phase","volume":"36","author":"Hashem","year":"2013","journal-title":"J. Liquid Chromatogr. Related Technol."},{"issue":"2","key":"10.1016\/j.saa.2022.121695_b0090","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1002\/cpt196782249","article-title":"Specific therapeutic actions of acetophenazine, perphenazine, and benzquinamide in newly admitted schizophrenic patients","volume":"8","author":"Hollister","year":"1967","journal-title":"Clin. Pharmacol. Therapeut."},{"issue":"10","key":"10.1016\/j.saa.2022.121695_b0095","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1001\/archpsyc.63.10.1069","article-title":"Comparative effectiveness of antipsychotic drugs: a commentary on cost utility of the latest antipsychotic drugs in schizophrenia study (CUtLASS 1) and clinical antipsychotic trials of intervention effectiveness (CATIE)","volume":"63","author":"Lieberman","year":"2006","journal-title":"Arch. Gen. Psychia."},{"issue":"12","key":"10.1016\/j.saa.2022.121695_b0100","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.3390\/10121429","article-title":"Synthesis of novel, potentially biologically active dibenzosuberone derivatives","volume":"10","author":"Merkas","year":"2005","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2022.121695_b0105","series-title":"PLS-Toolbox 2.0 for use With Matlab 6.5","author":"Wise","year":"1998"},{"key":"10.1016\/j.saa.2022.121695_b0110","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1039\/a703654j","article-title":"Multilevel multifactor designs for multivariate calibration","volume":"122","author":"Brereton","year":"1997","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2022.121695_b0115","unstructured":"R.G. Brereton, J. Wiley, Chemometrics: Data Analysis for the Laboratory and Chemical Plant, Chichester, United Kingdom, 1997."},{"key":"10.1016\/j.saa.2022.121695_b0120","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1093\/jaoacint\/qsab059","article-title":"Three different approaches based on derivative ratio spectra for spectrophotometric resolution of a quaternary mixture in semisolid dosage form","volume":"104","author":"Fahmy","year":"2021","journal-title":"J. AOAC Int."},{"key":"10.1016\/j.saa.2022.121695_b0125","doi-asserted-by":"crossref","first-page":"118213","DOI":"10.1016\/j.saa.2020.118213","article-title":"A comparative study of two novel validated spectrophotometric techniques for resolution of four-component mixtures with severely overlapping spectra","volume":"233","author":"Abdelhamid","year":"2020","journal-title":"Spectrochim. Acta Part A: Mole. Biomole. Spectrosc."},{"issue":"2","key":"10.1016\/j.saa.2022.121695_b0130","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1016\/j.jpha.2011.11.004","article-title":"Validated stability indicating methods for determination of nitazoxanide in presence of its degradation products","volume":"2","author":"Ali","year":"2012","journal-title":"J. Pharmaceut. Anal."},{"issue":"12","key":"10.1016\/j.saa.2022.121695_b0135","doi-asserted-by":"crossref","first-page":"1956","DOI":"10.1080\/00032719.2020.1725541","article-title":"Simultaneous spectrophotometric quantification of metamizole sodium, pitofenone hydrochloride, and fenpiverinium bromide in a pharmaceutical product using multivariate calibration methods","volume":"53","author":"Savic","year":"2020","journal-title":"Anal. Lett."},{"issue":"4","key":"10.1016\/j.saa.2022.121695_b0140","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/dta.113","article-title":"Spectrophotometric determination of isopropamide Iodide and trifluoperazine hydrochloride in presence of trifluoperazine oxidative degradate","volume":"2","author":"Abbas","year":"2010","journal-title":"Drug Test. Anal."},{"key":"10.1016\/j.saa.2022.121695_b0145","unstructured":"ICH Harmonised Tripartite Guideline: Validation Of Analytical Procedures: Text And Methodology Q2(R1), 2005."},{"key":"10.1016\/j.saa.2022.121695_b0150","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.trac.2012.03.013","article-title":"Analytical Eco-Scale for assessing the greenness of analytical procedures","volume":"37","author":"Ga\u0142uszka","year":"2012","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.saa.2022.121695_b0155","unstructured":"D. Raynie, J. Driver, Green assessment of chemical method, in: 13th Annual Green Chemistry & Engineering Conference, ASC, Maryland, USA, 2009, pp. 34."},{"key":"10.1016\/j.saa.2022.121695_b0160","doi-asserted-by":"crossref","first-page":"105557","DOI":"10.1016\/j.microc.2020.105557","article-title":"Analytical tools for greenness assessment of chromatographic approaches: application to pharmaceutical combinations of Indapamide, perindopril and amlodipine","volume":"159","author":"Saleh","year":"2020","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2022.121695_b0165","doi-asserted-by":"crossref","first-page":"10076","DOI":"10.1021\/acs.analchem.0c01887","article-title":"AGREE\u2014analytical greenness METRIC approach and software","volume":"92","author":"Pena-Pereira","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2022.121695_b0170","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/j.talanta.2018.01.013","article-title":"A new tool for the evaluation of the analytical procedure: green analytical procedure index","volume":"181","author":"P\u0142otka-Wasylka","year":"2018","journal-title":"Talanta"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522008447?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522008447?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T02:09:01Z","timestamp":1761358141000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142522008447"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":34,"alternative-id":["S1386142522008447"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2022.121695","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Simultaneous spectrophotometric determination of fluphenazine HCl and nortriptyline HCl in presence of their potential impurities perphenazine and dibenzosuberone in bulk and pharmaceutical formulation","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2022.121695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"121695"}}