{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:36:38Z","timestamp":1781915798850,"version":"3.54.5"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.saa.2022.122048","type":"journal-article","created":{"date-parts":[[2022,10,29]],"date-time":"2022-10-29T22:25:29Z","timestamp":1667082329000},"page":"122048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"special_numbering":"P2","title":["O-phthalaldehyde assisted surface enhanced Raman spectroscopy selective determination of trace homocysteine in serum"],"prefix":"10.1016","volume":"287","author":[{"given":"Zhishun","family":"Jie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ye","family":"Ying","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.saa.2022.122048_b0005","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1007\/s00404-017-4457-y","article-title":"Maternal serum homocysteine and uterine artery Doppler as predictors of preeclampsia and poor placentation","volume":"296","author":"Maged","year":"2017","journal-title":"Arch. Gynecol. Obstet."},{"key":"10.1016\/j.saa.2022.122048_b0010","doi-asserted-by":"crossref","DOI":"10.1038\/s12276-019-0216-4","article-title":"Disturbed homocysteine metabolism is associated with cancer","volume":"51","author":"Hasan","year":"2019","journal-title":"Exp. Mol. Med."},{"key":"10.1016\/j.saa.2022.122048_b0015","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s10847-015-0486-y","article-title":"Real time OFF\u2013ON monitoring of gluthathione (GSH) in living cell","volume":"82","author":"Lee","year":"2015","journal-title":"J. Incl. Phenom. Macrocycl. Chem."},{"key":"10.1016\/j.saa.2022.122048_b0020","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bios.2015.02.012","article-title":"A label-free method for detecting biothiols based on poly(thymine)-templated copper nanoparticles","volume":"69","author":"Zhang","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2022.122048_b0025","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1016\/j.snb.2015.01.117","article-title":"Photostable red turn-on fluorescent diketopyrrolopyrrole chemodosimeters for the detection of cysteine in living cells","volume":"211","author":"Qu","year":"2015","journal-title":"Sens. Actuators, B"},{"key":"10.1016\/j.saa.2022.122048_b0030","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/j.talanta.2018.11.066","article-title":"A series of BODIPY-based probes for the detection of cysteine and homocysteine in living cells","volume":"195","author":"Wang","year":"2019","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2022.122048_b0035","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1111\/bjh.16618","article-title":"Homocysteine is associated with severity of microvasculopathy in sickle cell disease patients","author":"Samarron","year":"2020","journal-title":"Brit. J. Haematol."},{"issue":"3","key":"10.1016\/j.saa.2022.122048_b0040","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1080\/09637486.2019.1648387","article-title":"Relationship between folate, vitamin B-12, homocysteine, transaminase and mild cognitive impairment in China: a case-control study","volume":"71","author":"Zhou","year":"2020","journal-title":"Int. J. Food. Sci. Nutr."},{"issue":"13","key":"10.1016\/j.saa.2022.122048_b0045","first-page":"1635","article-title":"Hyperhomocysteinemia Accelerates Acute Kidney Injury to Chronic Kidney Disease Progression by Downregulating Heme Oxygenase-1 Expression","volume":"30","author":"Li","year":"2019","journal-title":"Redox Sign."},{"key":"10.1016\/j.saa.2022.122048_b0050","first-page":"1","article-title":"Homocysteine directly interacts and activates the angiotensin II type I receptor to aggravate vascular injury","volume":"9","author":"Li","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.saa.2022.122048_b0055","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.mam.2016.11.003","article-title":"Homocysteine and disease: Causal associations or epiphenomenons?","volume":"53","author":"Hannibal","year":"2017","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.saa.2022.122048_b0060","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1039\/C5CC07886E","article-title":"A fluorescent probe for relay recognition of homocysteine and Group IIIA ions including Ga(III)","volume":"52","author":"Wang","year":"2016","journal-title":"Chem. Commun. (Camb)"},{"key":"10.1016\/j.saa.2022.122048_b0065","unstructured":"https:\/\/www.biomart.cn\/infosupply\/29974764.htm.2022.03."},{"key":"10.1016\/j.saa.2022.122048_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2021.131755","article-title":"Simpler fluorescent probe for homocysteine selective detection","volume":"1250","author":"Nehra","year":"2022","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2022.122048_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.apsusc.2021.149735","article-title":"Facile preparation of an electrochemical aptasensor based on Au NPs\/graphene sponge for detection of homocysteine","volume":"556","author":"Wen","year":"2021","journal-title":"Appl. Surf. Sci."},{"key":"10.1016\/j.saa.2022.122048_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.123091","article-title":"A novel turn-on type AIE fluorescent probe for highly selective detection of cysteine\/homocysteine and its application in living cells","volume":"239","author":"Wang","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2022.122048_b0085","doi-asserted-by":"crossref","first-page":"7582","DOI":"10.1039\/C7SC03218H","article-title":"Simultaneous quantification of multiple endogenous biothiols in single living cells by plasmonic Raman probes","volume":"8","author":"Li","year":"2017","journal-title":"Chem. Sci."},{"key":"10.1016\/j.saa.2022.122048_b0090","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.bios.2015.04.013","article-title":"SERS-active Au@Ag nanorod dimers for ultrasensitive dopamine detection","volume":"71","author":"Tang","year":"2015","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2022.122048_b0095","doi-asserted-by":"crossref","first-page":"8153","DOI":"10.1021\/ja502472x","article-title":"Galvanic replacement-free deposition of Au on Ag for core-shell nanocubes with enhanced chemical stability and SERS activity","volume":"136","author":"Yang","year":"2014","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2022.122048_b0100","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.talanta.2017.04.052","article-title":"A recyclable silver ions-specific surface-enhanced Raman scattering (SERS) sensor","volume":"171","author":"Sun","year":"2017","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2022.122048_b0105","doi-asserted-by":"crossref","first-page":"6788","DOI":"10.1039\/C7CC03020G","article-title":"Observing the dynamic \u201chot spots\u201d on two-dimensional Au nanoparticles monolayer film","volume":"53","author":"Zhang","year":"2017","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.saa.2022.122048_b0110","doi-asserted-by":"crossref","DOI":"10.1038\/natrevmats.2016.21","article-title":"Nanostructure-based plasmon-enhanced Raman spectroscopy for surface analysis of materials","volume":"1","author":"Ding","year":"2016","journal-title":"Nat. Rev. Mater."},{"key":"10.1016\/j.saa.2022.122048_b0115","doi-asserted-by":"crossref","first-page":"9213","DOI":"10.1021\/ac4019439","article-title":"Surface-enhanced Raman spectroscopy-based, homogeneous, multiplexed immunoassay with antibody-fragments-decorated gold nanoparticles","volume":"85","author":"Wang","year":"2013","journal-title":"Anal. Chem."},{"issue":"3","key":"10.1016\/j.saa.2022.122048_b0120","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1039\/C7CS00786H","article-title":"Designing surface-enhanced Raman scattering (SERS) platforms beyond hotspot engineering: emerging opportunities in analyte manipulations and hybrid materials [J]","volume":"48","author":"Lee","year":"2019","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2022.122048_b0125","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1016\/j.saa.2017.04.066","article-title":"Large-volume constant-concentration sampling technique coupling with surface-enhanced Raman spectroscopy for rapid on-site gas analysis","volume":"183","author":"Zhang","year":"2017","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2022.122048_b0130","doi-asserted-by":"crossref","DOI":"10.3390\/s17112689","article-title":"Selectivity\/Specificity Improvement Strategies in Surface-Enhanced Raman Spectroscopy Analysis","volume":"17","author":"Wang","year":"2017","journal-title":"Sensors (Basel)"},{"key":"10.1016\/j.saa.2022.122048_b0135","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.snb.2018.10.078","article-title":"Gold nanoparticle enriched by Q sepharose spheres for chemical reaction tandem SERS detection of malondialdehyde","volume":"281","author":"Yan","year":"2019","journal-title":"Sens. Actuators, B"},{"key":"10.1016\/j.saa.2022.122048_b0140","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.talanta.2016.04.024","article-title":"Derivatization reaction-based surface-enhanced Raman scattering (SERS) for detection of trace acetone","volume":"155","author":"Zheng","year":"2016","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2022.122048_b0145","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.talanta.2012.01.026","article-title":"Gold nanoparticle extraction followed by o-phthaldialdehyde derivatization for fluorescence sensing of different forms of homocysteine in plasma","volume":"91","author":"Lai","year":"2012","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2022.122048_b0150","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1039\/B916511H","article-title":"Fluorescent sensing of homocysteine in urine: using fluorosurfactant-capped gold nanoparticles and o-Phthaldialdehyde","volume":"135","author":"Lin","year":"2010","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2022.122048_b0155","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.1002\/bio.3904","article-title":"Selective reaction of homocysteine with o-phthalaldehyde under flow conditions in highly alkaline medium: fluorimetric determination using zone fluidics","volume":"35","author":"Tsiasioti","year":"2020","journal-title":"Luminescence"},{"key":"10.1016\/j.saa.2022.122048_b0160","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/S0378-4347(01)00554-0","article-title":"Determination of homocysteine thiolactone and homocysteine in cell cultures using high-performance liquid chromatography with fluorescence detection","volume":"767","author":"Mukai","year":"2002","journal-title":"J. Chromatogr. B"},{"key":"10.1016\/j.saa.2022.122048_b0165","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.tet.2017.11.035","article-title":"Assessment of the regioselectivity in the condensation reaction of unsymmetrical o -phthaldialdehydes with alanine","volume":"74","author":"D'Hollander","year":"2018","journal-title":"Tetrahedron"},{"key":"10.1016\/j.saa.2022.122048_b0170","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1021\/acs.orglett.6b00983","article-title":"Traceless and Chemoselective Amine Bioconjugation via Phthalimidine Formation in Native Protein Modification","volume":"18","author":"Tung","year":"2016","journal-title":"Org. Lett."},{"key":"10.1016\/j.saa.2022.122048_b0175","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/physci241020a0","article-title":"Controlled Nucleation for the Regulation of the Particle Size in Monodisperse Gold Suspensions","volume":"241","author":"Frens","year":"1973","journal-title":"Nat. Phys. Sci."},{"key":"10.1016\/j.saa.2022.122048_b0180","doi-asserted-by":"crossref","first-page":"107497","DOI":"10.1016\/j.bioelechem.2020.107497","article-title":"A label-free aptasensor for highly sensitive detection of homocysteine based on gold nanoparticles","volume":"134","author":"Beitollahi","year":"2020","journal-title":"Bioelectrochemistry"},{"key":"10.1016\/j.saa.2022.122048_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.synthmet.2020.116432","article-title":"Selective homocysteine detection of nitrogen-doped graphene quantum dots: Synergistic effect of surface catalysis and photoluminescence sensing","volume":"267","author":"Zou","year":"2020","journal-title":"Synth. Met."},{"key":"10.1016\/j.saa.2022.122048_b0190","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.talanta.2018.05.010","article-title":"A turn-on fluorescent probe for simultaneous sensing of cysteine\/homocysteine and hydrogen sulfide and its bioimaging applications","volume":"187","author":"Chen","year":"2018","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2022.122048_b0195","doi-asserted-by":"crossref","first-page":"9176","DOI":"10.1039\/c3cc45519j","article-title":"A highly sensitive near-infrared fluorescent probe for cysteine and homocysteine in living cells","volume":"49","author":"Kong","year":"2013","journal-title":"Chem. Commun. (Camb)"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522011969?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142522011969?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T02:17:20Z","timestamp":1761358640000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142522011969"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":39,"alternative-id":["S1386142522011969"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2022.122048","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"O-phthalaldehyde assisted surface enhanced Raman spectroscopy selective determination of trace homocysteine in serum","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2022.122048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"122048"}}