{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T04:29:04Z","timestamp":1791606544200,"version":"4.3.4"},"reference-count":32,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2023,12,1]],"date-time":"2023-12-01T00:00:00Z","timestamp":1701388800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2023,12]]},"DOI":"10.1016\/j.saa.2023.123088","type":"journal-article","created":{"date-parts":[[2023,6,28]],"date-time":"2023-06-28T13:57:42Z","timestamp":1687960662000},"page":"123088","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"special_numbering":"C","title":["PCA-WRKNN-assisted label-free SERS serum analysis platform enabling non-invasive diagnosis of Alzheimer\u2019s disease"],"prefix":"10.1016","volume":"302","author":[{"given":"Wei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaoyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cong","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fushan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2023.123088_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132015","article-title":"A facile and effective immunoassay for sensitive detection of phosphorylated tau: The role of flower-shaped TiO2 in specificity and signal amplification","volume":"366","author":"Zhang","year":"2022","journal-title":"Sensor Actuat. B-Chem."},{"key":"10.1016\/j.saa.2023.123088_b0010","doi-asserted-by":"crossref","first-page":"609","DOI":"10.3233\/JAD-215551","article-title":"Shortening of Saccades as a Possible Easy-to-Use Biomarker to Detect Risk of Alzheimer\u2019s Disease","volume":"88","author":"Hannonen","year":"2022","journal-title":"J. Alzheimers. Dis."},{"key":"10.1016\/j.saa.2023.123088_b0015","doi-asserted-by":"crossref","first-page":"4124","DOI":"10.1007\/s12035-022-02839-x","article-title":"Direct AT2R Stimulation Slows Post-stroke Cognitive Decline in the 5XFAD Alzheimer\u2019s Disease Mice","volume":"59","author":"Ahmed","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.saa.2023.123088_b0020","article-title":"Advances in risk reduction or prevention of dementia and national public health strategies, Alzheimer\u2019s Disease","author":"Gill","year":"2022","journal-title":"International"},{"key":"10.1016\/j.saa.2023.123088_b0025","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer's disease: Recommendations from the National Institute on Aging-Alzheimer's Association workgroups on diagnostic guidelines for Alzheimer's disease","volume":"7","author":"McKhann","year":"2011","journal-title":"Alzheimers. Dement."},{"issue":"48","key":"10.1016\/j.saa.2023.123088_b0030","doi-asserted-by":"crossref","first-page":"2140","DOI":"10.1007\/s00259-021-05253-y","article-title":"The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers","volume":"I","author":"Ashton","year":"2021","journal-title":"Eur. J. Nucl. Med. Mol."},{"key":"10.1016\/j.saa.2023.123088_b0035","doi-asserted-by":"crossref","unstructured":"P.J. Nicholas, A. To, O. Tanglay, I.M. Young, M.E. Sughrue, S. Doyen, Using a ResNet-18 Network to Detect Features of Alzheimer&rsquo;s Disease on Functional Magnetic Resonance Imaging: A Failed Replication. Comment on Odusami et al. Analysis of Features of Alzheimer&rsquo;s Disease: Detection of Early Stage from Functional Brain Changes in Magnetic Resonance Images Using a Finetuned ResNet18 Network. Diagnostics 2021, 11, 1071, Diagnostics 12 (2022) 1094.","DOI":"10.3390\/diagnostics12051094"},{"key":"10.1016\/j.saa.2023.123088_b0040","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1111\/jnc.15571","article-title":"Detection and quantification of A\u03b2\u22123\u201340 (APP669-711) in cerebrospinal fluid","volume":"160","author":"Klafki","year":"2022","journal-title":"J. Neurochem."},{"key":"10.1016\/j.saa.2023.123088_b0045","first-page":"1","article-title":"Accurate Age Estimation of Bloodstains Based on Visible Reflectance Spectroscopy and Chemometrics Methods","volume":"9","author":"Sun","year":"2017","journal-title":"IEEE. Photonics. J."},{"key":"10.1016\/j.saa.2023.123088_b0050","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1109\/TBME.2004.831538","article-title":"Detection of skin cancer by classification of Raman spectra","volume":"51","author":"Sigurdsson","year":"2004","journal-title":"IEEE T. Bio-Med. Eng."},{"key":"10.1016\/j.saa.2023.123088_b0055","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1007\/s00216-019-02349-1","article-title":"Potential of Raman spectroscopy for the analysis of plasma\/serum in the liquid state: recent advances","volume":"412","author":"Parachalil","year":"2020","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2023.123088_b0060","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1080\/10408347.2016.1209104","article-title":"Vibrational Spectroscopy in Body Fluids Analysis","volume":"47","author":"Bunaciu","year":"2017","journal-title":"Crit. Rev. Anal. Chem."},{"key":"10.1016\/j.saa.2023.123088_b0065","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1515\/nanoph-2019-0401","article-title":"Recent advances in nano-photonic techniques for pharmaceutical drug monitoring with emphasis on Raman spectroscopy","volume":"9","author":"Frosch","year":"2020","journal-title":"Nanophotonics"},{"key":"10.1016\/j.saa.2023.123088_b0070","doi-asserted-by":"crossref","unstructured":"J. Moros, S. Garrigues, M.d.l. Guardia, Vibrational spectroscopy provides a green tool for multi-component analysis, Trac-Trend. Anal. Chem. 29 (2010) 578-591.","DOI":"10.1016\/j.trac.2009.12.012"},{"key":"10.1016\/j.saa.2023.123088_b0075","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/S1369-7021(12)70017-2","article-title":"SERS: Materials, applications, and the future","volume":"15","author":"Sharma","year":"2012","journal-title":"Mater. Today"},{"key":"10.1016\/j.saa.2023.123088_b0080","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-022-01327-7","article-title":"Highly sensitive near-infrared SERS nanoprobes for in vivo imaging using gold-assembled silica nanoparticles with controllable nanogaps","volume":"20","author":"Bock","year":"2022","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.saa.2023.123088_b0085","doi-asserted-by":"crossref","DOI":"10.1186\/s12951-015-0106-4","article-title":"Label-free NIR-SERS discrimination and detection of foodborne bacteria by in situ synthesis of Ag colloids","volume":"13","author":"Chen","year":"2015","journal-title":"J. Nanobiotechnol."},{"key":"10.1016\/j.saa.2023.123088_b0090","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.aca.2019.11.049","article-title":"A review on recent advances in the applications of surface-enhanced Raman scattering in analytical chemistry","volume":"1097","author":"Fan","year":"2020","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2023.123088_b0095","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1021\/ac202452t","article-title":"Shell Thickness-Dependent Raman Enhancement for Rapid Identification and Detection of Pesticide Residues at Fruit Peels","volume":"84","author":"Liu","year":"2012","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2023.123088_b0100","doi-asserted-by":"crossref","first-page":"8696","DOI":"10.1021\/jacs.8b02972","article-title":"1T\u2032 Transition Metal Telluride Atomic Layers for Plasmon-Free SERS at Femtomolar Levels","volume":"140","author":"Tao","year":"2018","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2023.123088_b0105","doi-asserted-by":"crossref","first-page":"3114","DOI":"10.1002\/adfm.201303384","article-title":"Highly Intensified Surface Enhanced Raman Scattering by Using Monolayer Graphene as the Nanospacer of Metal Film-Metal Nanoparticle Coupling System","volume":"24","author":"Li","year":"2014","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.saa.2023.123088_b0110","doi-asserted-by":"crossref","first-page":"9578","DOI":"10.1021\/acs.analchem.2c00436","article-title":"Self-Calibration 3D Hybrid SERS Substrate and Its Application in Quantitative Analysis","volume":"94","author":"Fu","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2023.123088_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2019.115796","article-title":"Deep learning and artificial intelligence methods for Raman and surface-enhanced Raman scattering","volume":"124","author":"Lussier","year":"2020","journal-title":"Trac-Trend. Anal. Chem."},{"key":"10.1016\/j.saa.2023.123088_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodchem.2021.131471","article-title":"The application of machine-learning and Raman spectroscopy for the rapid detection of edible oils type and adulteration","volume":"373","author":"Zhao","year":"2022","journal-title":"Food Chem."},{"key":"10.1016\/j.saa.2023.123088_b0125","doi-asserted-by":"crossref","first-page":"42328","DOI":"10.1021\/acsami.0c11322","article-title":"Attomolar Sensing Based on Liquid Interface-Assisted Surface-Enhanced Raman Scattering in Microfluidic Chip by Femtosecond Laser Processing","volume":"12","author":"Bai","year":"2020","journal-title":"ACS Appl. Mater. Inter."},{"key":"10.1016\/j.saa.2023.123088_b0130","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/jrs.882","article-title":"Near-infrared Raman spectroscopy for the classification of epithelial pre-cancers and cancers","volume":"33","author":"Stone","year":"2002","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.saa.2023.123088_b0135","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/jemt.20229","article-title":"Micro-Raman spectroscopy used to identify and grade human skin pilomatrixoma","volume":"68","author":"Cheng","year":"2005","journal-title":"Microsc. Res. Techniq."},{"key":"10.1016\/j.saa.2023.123088_b0140","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1529\/biophysj.105.066761","article-title":"Micro-Raman Spectroscopy Detects Individual Neoplastic and Normal Hematopoietic Cells","volume":"90","author":"Chan","year":"2006","journal-title":"Biophys. J."},{"key":"10.1016\/j.saa.2023.123088_b0145","doi-asserted-by":"crossref","unstructured":"N. Stone, C. Kendall, J. Smith, P. Crow, H. Barr, Raman spectroscopy for identification of epithelial cancers, Faraday Discuss. 126 (2004) 141-57; discussion 169-83.","DOI":"10.1039\/b304992b"},{"key":"10.1016\/j.saa.2023.123088_b0150","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1021\/ac00101a001","article-title":"Raman Spectroscopy of Normal and Diseased Human Breast Tissues","volume":"67","author":"Frank","year":"1995","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2023.123088_b0155","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1002\/chir.20225","article-title":"Raman optical activity of proteins, carbohydrates and glycoproteins","volume":"18","author":"Zhu","year":"2006","journal-title":"Chirality"},{"key":"10.1016\/j.saa.2023.123088_b0160","doi-asserted-by":"crossref","first-page":"5441","DOI":"10.1007\/s00216-013-6946-6","article-title":"Analysis of human blood plasma and hen egg white by chiroptical spectroscopic methods (ECD, VCD, ROA)","volume":"405","author":"Synytsya","year":"2013","journal-title":"Anal. Bioanal. Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142523007734?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142523007734?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T02:33:00Z","timestamp":1761359580000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142523007734"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12]]},"references-count":32,"alternative-id":["S1386142523007734"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2023.123088","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2023,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PCA-WRKNN-assisted label-free SERS serum analysis platform enabling non-invasive diagnosis of Alzheimer\u2019s disease","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2023.123088","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"123088"}}