{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,18]],"date-time":"2026-01-18T13:50:29Z","timestamp":1768744229295,"version":"3.49.0"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,27]],"date-time":"2024-09-27T00:00:00Z","timestamp":1727395200000},"content-version":"am","delay-in-days":270,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,1,1]],"date-time":"2024-01-01T00:00:00Z","timestamp":1704067200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100019920","name":"Soci\u00e9t\u00e9 d'Acc\u00e9l\u00e9ration du Transfert de Technologies","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100019920","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2024,1]]},"DOI":"10.1016\/j.saa.2023.123433","type":"journal-article","created":{"date-parts":[[2023,9,25]],"date-time":"2023-09-25T05:54:22Z","timestamp":1695621262000},"page":"123433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Serum infrared spectral profile is predictive of the degree of hepatic fibrosis in chronic hepatitis C patients"],"prefix":"10.1016","volume":"305","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8626-8352","authenticated-orcid":false,"given":"G\u00e9rard","family":"Thi\u00e9fin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dominique","family":"Bertrand","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Untereiner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roselyne","family":"Garnotel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jean-Pierre","family":"Bronowicki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ganesh D.","family":"Sockalingum","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2023.123433_b0005","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1136\/gutjnl-2018-317593","article-title":"Advances in non-invasive assessment of hepatic fibrosis","volume":"69","author":"Loomba","year":"2020","journal-title":"Gut"},{"key":"10.1016\/j.saa.2023.123433_b0010","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.jhep.2021.05.025","article-title":"EASL Clinical Practice Guidelines on non-invasive tests for evaluation of liver disease severity and prognosis - 2021 update","volume":"75","author":"European Association for the Study of the Liver","year":"2021","journal-title":"J. Hepatol."},{"key":"10.1016\/j.saa.2023.123433_b0015","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/j.hep.2003.09.022","article-title":"Sampling variability of liver fibrosis in chronic hepatitis C","volume":"38","author":"Bedossa","year":"2003","journal-title":"Hepatology"},{"key":"10.1016\/j.saa.2023.123433_b0020","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.cgh.2012.01.023","article-title":"Liver biopsy analysis has a low level of performance for diagnosis of intermediate stages of fibrosis","volume":"10","author":"Poynard","year":"2012","journal-title":"Clin. Gastroenterol. Hepatol."},{"key":"10.1016\/j.saa.2023.123433_b0025","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1111\/j.1572-0241.2002.06038.x","article-title":"Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection","volume":"97","author":"Regev","year":"2002","journal-title":"Am. J. Gastroenterol."},{"key":"10.1016\/j.saa.2023.123433_b0030","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/hep.1840010511","article-title":"Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis","volume":"1","author":"Knodell","year":"1981","journal-title":"Hepatology"},{"key":"10.1016\/j.saa.2023.123433_b0035","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1016\/0168-8278(95)80226-6","article-title":"Histological grading and staging of chronic hepatitis","volume":"22","author":"Ishak","year":"1995","journal-title":"J. Hepatol."},{"key":"10.1016\/j.saa.2023.123433_b0040","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1002\/hep.510240201","article-title":"An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group","volume":"24","author":"Bedossa","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.saa.2023.123433_b0045","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1002\/hep.22742","article-title":"Liver Biopsy","volume":"49","author":"Rockey","year":"2009","journal-title":"Hepatology"},{"key":"10.1016\/j.saa.2023.123433_b0050","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0065-2423(08)00404-6","article-title":"Biomarkers of liver fibrosis","volume":"46","author":"Poynard","year":"2008","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.saa.2023.123433_b0055","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1053\/j.gastro.2007.11.053","article-title":"Non-invasive assessment of liver fibrosis and portal hypertension with transient elastography","volume":"134","author":"Rockey","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.saa.2023.123433_b0060","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1016\/j.jhep.2008.02.008","article-title":"Non-invasive evaluation of liver fibrosis using transient elastography","volume":"48","author":"Castera","year":"2008","journal-title":"J. Hepatol."},{"key":"10.1016\/j.saa.2023.123433_b0065","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1039\/C5CS00585J","article-title":"Developing and understanding biofluid vibrational spectroscopy: a critical review","volume":"45","author":"Baker","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2023.123433_b0070","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.canlet.2020.02.020","article-title":"Biofluid diagnostics by FTIR spectroscopy: A platform technology for cancer detection","volume":"477","author":"Sala","year":"2020","journal-title":"Cancer Lett."},{"key":"10.1016\/j.saa.2023.123433_b0075","doi-asserted-by":"crossref","first-page":"2919","DOI":"10.1007\/s00216-011-5402-8","article-title":"Noninvasive assessment of hepatic fibrosis in patients with chronic hepatitis C using serum Fourier transform infrared spectroscopy","volume":"401","author":"Scaglia","year":"2011","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2023.123433_b0080","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1016\/S0140-6736(00)04258-6","article-title":"MULTIVIRC Group Biochemical markers of liver fibrosis in patients with hepatitis C virus infection: a prospective study","volume":"357","author":"Imbert-Bismut","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.saa.2023.123433_b0085","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/j.trsl.2013.07.007","article-title":"Profiling serologic biomarkers in cirrhotic patients via high-throughput Fourier transform infrared spectroscopy: toward a new diagnostic tool of hepatocellular carcinoma","volume":"162","author":"Zhang","year":"2013","journal-title":"Transl. Res."},{"key":"10.1016\/j.saa.2023.123433_b0090","doi-asserted-by":"crossref","first-page":"7140","DOI":"10.1039\/C5AY00502G","article-title":"Investigating optimum sample preparation for infrared spectroscopic serum diagnostics","volume":"7","author":"Lovergne","year":"2015","journal-title":"Anal. Methods"},{"key":"10.1016\/j.saa.2023.123433_b0095","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/0167-7012(91)90042-O","article-title":"Elaboration of a procedure for identification of bacteria using Fourier-Transform IR spectral libraries: a stepwise correlation approach","volume":"14","author":"Helm","year":"1991","journal-title":"J. Microbiol. Methods"},{"key":"10.1016\/j.saa.2023.123433_b0100","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1366\/0003702894202201","article-title":"Standard normal variate transformation and de-trending of near-infrared diffuse reflectance spectra","volume":"43","author":"Barnes","year":"1989","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.saa.2023.123433_b0105","unstructured":"D.E. Goldberg, Algorithmes g\u00e9n\u00e9tiques, In: Addison-Wesley France (Eds), 1994, 417 pages."},{"key":"10.1016\/j.saa.2023.123433_b0110","first-page":"581","article-title":"Partial Least Squares","volume":"vol. 6","author":"Wold","year":"1985"},{"key":"10.1016\/j.saa.2023.123433_b0115","doi-asserted-by":"crossref","first-page":"7347","DOI":"10.1007\/s00216-013-7163-z","article-title":"Investigating the rapid diagnosis of gliomas from serum samples using infrared spectroscopy and cytokine and angiogenesis factors","volume":"405","author":"Hands","year":"2013","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2023.123433_b0120","first-page":"1","article-title":"Infrared spectroscopy and microscopy in cancer research and diagnosis","volume":"2","author":"Bellisola","year":"2012","journal-title":"Am. J. Cancer Res. Doi."},{"key":"10.1016\/j.saa.2023.123433_b0125","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1007\/s00216-006-0876-5","article-title":"Growth substrate induced functional changes elucidated by FTIR and Raman spectroscopy in in-vitro cultured human keratinocytes","volume":"387","author":"Meade","year":"2007","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2023.123433_b0130","doi-asserted-by":"crossref","DOI":"10.1117\/1.1911847","article-title":"Comparison of mid-infrared and Raman spectroscopy in the quantitative analysis of serum","volume":"10","author":"Rohleder","year":"2005","journal-title":"J. Biomed. Opt."},{"key":"10.1016\/j.saa.2023.123433_b0135","doi-asserted-by":"crossref","first-page":"e7408","DOI":"10.1371\/journal.pone.0007408","article-title":"Chemical imaging on liver steatosis using synchrotron infrared and ToF-SIMS microspectroscopies","volume":"4","author":"Le Naour","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.saa.2023.123433_b0140","series-title":"Biochemistry","article-title":"Applications of infrared, Raman, and Resonance Raman Spectroscopy","author":"Parker","year":"1983"},{"key":"10.1016\/j.saa.2023.123433_b0145","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.jpba.2018.12.011","article-title":"A novel experimental approach for liver analysis in rats exposed to Bisphenol A by means of LC-mass spectrometry and infrared spectroscopy","volume":"165","author":"Errico","year":"2019","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2023.123433_b0150","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1038\/sj.bjc.6604753","article-title":"FTIR-based spectroscopic analysis in the identification of clinically aggressive prostate cancer","volume":"99","author":"Baker","year":"2008","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.saa.2023.123433_b0155","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1081\/ASR-100106157","article-title":"FT-infrared and FT-Raman spectroscopy in biomedical research","volume":"36","author":"Naumann","year":"2001","journal-title":"App. Spectrosc. Rev."},{"key":"10.1016\/j.saa.2023.123433_b0160","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0924-2031(01)00134-5","article-title":"Characteristic infrared spectroscopic patterns in the protein bands of human breast cancer tissue","volume":"27","author":"Eckel","year":"2001","journal-title":"Vib. Spectrosc"},{"key":"10.1016\/j.saa.2023.123433_b0165","doi-asserted-by":"crossref","first-page":"1670","DOI":"10.1053\/j.gastro.2008.03.001","article-title":"Diagnosis and quantitation of fibrosis","volume":"134","author":"Manning","year":"2008","journal-title":"Gastroenterology"},{"key":"10.1016\/j.saa.2023.123433_b0170","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.3390\/cells8111423","article-title":"Metabolic signature of hepatic fibrosis: from individual pathways to systems biology","volume":"8","author":"Chang","year":"2019","journal-title":"Cells"},{"key":"10.1016\/j.saa.2023.123433_b0175","doi-asserted-by":"crossref","first-page":"11433","DOI":"10.1038\/s41598-017-11759-z","article-title":"Identification of key metabolic changes during liver fibrosis progression in rats using a urine and serum metabolomics approach","volume":"7","author":"Chang","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2023.123433_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/bmc.3899","article-title":"Metabolic characterization of the early stage of hepatic fibrosis in rat using GC-TOF\/MS and multivariate data analyses","volume":"31","author":"Jiang","year":"2017","journal-title":"Biomed. Chromatogr."},{"key":"10.1016\/j.saa.2023.123433_b0185","doi-asserted-by":"crossref","first-page":"941","DOI":"10.3748\/wjg.v25.i8.941","article-title":"Dynamic changes of key metabolites during liver fibrosis in rats","volume":"28","author":"Yu","year":"2019","journal-title":"World J. Gastroenterol."},{"key":"10.1016\/j.saa.2023.123433_b0190","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1002\/hep.27587","article-title":"Variations in serum sphingolipid levels associate with liver fibrosis progression and poor treatment outcome in hepatitis C virus but not hepatitis B virus infection","volume":"61","author":"Grammatikos","year":"2015","journal-title":"Hepatology"},{"key":"10.1016\/j.saa.2023.123433_b0195","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1365-2893.2005.00655.x","article-title":"Serum lipid pattern in chronic hepatitis C: histological and virological correlations","volume":"13","author":"Siagris","year":"2006","journal-title":"J. Viral Hepat."},{"key":"10.1016\/j.saa.2023.123433_b0200","doi-asserted-by":"crossref","first-page":"30853","DOI":"10.1038\/srep30853","article-title":"Serum metabolomic signatures discriminate early liver inflammation and fibrosis stages in patients with chronic hepatitis B","volume":"6","author":"Huang","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2023.123433_b0205","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1007\/BF00807325","article-title":"Plasma amino acids in four models of experimental liver injury in rats","volume":"10","author":"Hole\u010dek","year":"1996","journal-title":"Amino Acids"},{"key":"10.1016\/j.saa.2023.123433_b0210","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/j.1872-034X.2009.00614.x","article-title":"Amino acid imbalance in patients with chronic liver diseases","volume":"40","author":"Michitaka","year":"2010","journal-title":"Hepatol. Res."},{"key":"10.1016\/j.saa.2023.123433_b0215","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1530\/JOE-15-0409","article-title":"Metformin improves hepatic IRS2\/PI3K\/Akt signaling in insulin-resistant rats of NASH and cirrhosis","volume":"229","author":"Xu","year":"2016","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.saa.2023.123433_b0220","first-page":"E529","article-title":"Contributions of net hepatic glycogenolysis and gluconeogenesis to glucose production in cirrhosis","volume":"276","author":"Petersen","year":"1999","journal-title":"Am. J. Phys. Anthropol."},{"key":"10.1016\/j.saa.2023.123433_b0225","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.jhep.2009.11.008","article-title":"Prospective comparison of two algorithms combining non-invasive methods for staging liver fibrosis in chronic hepatitis C","volume":"52","author":"Castera","year":"2010","journal-title":"J. Hepatol."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142523011186?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142523011186?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,19]],"date-time":"2025-01-19T22:49:05Z","timestamp":1737326945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142523011186"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,1]]},"references-count":45,"alternative-id":["S1386142523011186"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2023.123433","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2024,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Serum infrared spectral profile is predictive of the degree of hepatic fibrosis in chronic hepatitis C patients","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2023.123433","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"123433"}}