{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T17:39:43Z","timestamp":1791653983205,"version":"4.3.4"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100015638","name":"Beijing Key Laboratory of Work Safety Intelligent Monitoring, Beijing University of Posts and Telecommunications","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100015638","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["62,071,059"],"award-info":[{"award-number":["62,071,059"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["11971072"],"award-info":[{"award-number":["11971072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.saa.2024.124402","type":"journal-article","created":{"date-parts":[[2024,5,1]],"date-time":"2024-05-01T15:46:03Z","timestamp":1714578363000},"page":"124402","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"special_numbering":"C","title":["Cervical cancer biomarker screening based on Raman spectroscopy and multivariate statistical analysis"],"prefix":"10.1016","volume":"317","author":[{"given":"Qiwen","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongli","family":"Ding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huixia","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yishu","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guohua","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longfei","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.saa.2024.124402_b0005","doi-asserted-by":"crossref","first-page":"209","DOI":"10.3322\/caac.21660","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries","volume":"71","author":"Sung","year":"2021","journal-title":"CA Cancer J Clin."},{"key":"10.1016\/j.saa.2024.124402_b0010","doi-asserted-by":"crossref","unstructured":"C. Murali Krishna G.D. Sockalingum M.S. Vidyasagar M. Manfait D.J. Fernanades B.M. Vadhiraja K. Maheedhar An overview on applications of optical spectroscopy in cervical cancers J Cancer Res Ther. 2008 Jan-Mar;4(1):26\u201336.","DOI":"10.4103\/0973-1482.39602"},{"issue":"17","key":"10.1016\/j.saa.2024.124402_b0015","doi-asserted-by":"crossref","first-page":"3449","DOI":"10.1007\/s00216-023-04730-7","article-title":"Rapid and precise detection of cancers via label-free SERS and deep learning","volume":"415","author":"Xiong","year":"2023","journal-title":"Anal Bioanal Chem."},{"key":"10.1016\/j.saa.2024.124402_b0020","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1038\/s41536-017-0014-3","article-title":"Raman Spectroscopy and Regenerative Medicine: A Review","volume":"2","author":"Ember","year":"2017","journal-title":"NPJ Regen Med"},{"issue":"189","key":"10.1016\/j.saa.2024.124402_b0025","article-title":"Establishment of a reliable scheme for obtaining highly stable SERS signal of biological serum","volume":"1","author":"Li","year":"2021","journal-title":"Biosens Bioelectron."},{"issue":"4","key":"10.1016\/j.saa.2024.124402_b0030","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1364\/BOE.448121","article-title":"Rapid detection of hysteromyoma and cervical cancer based on serum surface-enhanced Raman spectroscopy and a support vector machine","volume":"13","author":"Zheng","year":"2022","journal-title":"Biomed Opt Express."},{"key":"10.1016\/j.saa.2024.124402_b0035","first-page":"1","article-title":"Metal-organic frameworks based surface-enhanced Raman spectroscopy technique for ultra-sensitive biomedical trace detection","volume":"3","author":"Zhang","year":"2022","journal-title":"Nano Res."},{"issue":"7","key":"10.1016\/j.saa.2024.124402_b0040","doi-asserted-by":"crossref","first-page":"423","DOI":"10.3389\/fchem.2019.00423","article-title":"Theoretical approaches for modeling the effect of the electrode potential in the SERS vibrational wavenumbers of pyridine adsorbed on a charged silver surface","volume":"5","author":"Aranda","year":"2019","journal-title":"Front Chem."},{"issue":"2","key":"10.1016\/j.saa.2024.124402_b0045","doi-asserted-by":"crossref","first-page":"e202100198","DOI":"10.1002\/jbio.202100198","article-title":"Multispectral label-free Raman spectroscopy can detect ovarian and endometrial cancer with high accuracy","volume":"15","author":"David","year":"2022","journal-title":"J Biophotonics."},{"issue":"27","key":"10.1016\/j.saa.2024.124402_b0050","doi-asserted-by":"crossref","first-page":"8279","DOI":"10.1007\/s00216-015-8946-1","article-title":"Raman spectroscopy for screening and diagnosis of cervical cancer","volume":"407","author":"Lyng","year":"2015","journal-title":"Anal Bioanal Chem."},{"issue":"14","key":"10.1016\/j.saa.2024.124402_b0055","doi-asserted-by":"crossref","first-page":"4828","DOI":"10.3390\/ijms21144828","article-title":"Simultaneous FTIR and Raman Spectroscopy in Endometrial Atypical Hyperplasia and Cancer","volume":"21","author":"Barnas","year":"2020","journal-title":"Int J Mol Sci."},{"issue":"1","key":"10.1016\/j.saa.2024.124402_b0060","doi-asserted-by":"crossref","first-page":"9079","DOI":"10.1038\/s41598-021-88640-7","article-title":"Spectroscopic evaluation of carcinogenesis in endometrial cancer","volume":"11","author":"Depciuch","year":"2021","journal-title":"Sci Rep."},{"issue":"23","key":"10.1016\/j.saa.2024.124402_b0070","doi-asserted-by":"crossref","first-page":"41580","DOI":"10.1364\/OE.472726","article-title":"Single-model multi-tasks deep learning network for recognition and quantitation of surface-enhanced Raman spectroscopy","volume":"30","author":"Xie","year":"2022","journal-title":"Opt Express."},{"issue":"292","key":"10.1016\/j.saa.2024.124402_b0085","article-title":"A novel detection technology for early gastric cancer based on Raman spectroscopy","volume":"5","author":"Yin","year":"2023","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc."},{"issue":"242","key":"10.1016\/j.saa.2024.124402_b0090","article-title":"Surface Enhanced Raman Spectroscopy of the serum samples for the diagnosis of Hepatitis C and prediction of the viral loads","volume":"5","author":"Kashif","year":"2020","journal-title":"Spectrochim Acta A Mol Biomol Spectrosc."},{"issue":"12","key":"10.1016\/j.saa.2024.124402_b0095","article-title":"Vibrational spectroscopy of liquid biopsies for prostate cancer diagnosis","volume":"30","author":"Medipally","year":"2020","journal-title":"Ther Adv Med Oncol."},{"issue":"2022","key":"10.1016\/j.saa.2024.124402_b0100","first-page":"4777434","article-title":"ATR-IR Spectroscopy Application to Diagnostic Screening of Advanced Endometriosis","volume":"6","author":"Kokot","year":"2022","journal-title":"Oxid Med Cell Longev."},{"issue":"190","key":"10.1016\/j.saa.2024.124402_b0105","article-title":"Raman spectroscopy-based biomarker screening by studying the fingerprint characteristics of chronic lymphocytic leukemia and diffuse large B-cell lymphoma","volume":"25","author":"Bai","year":"2020","journal-title":"J Pharm Biomed Anal."},{"issue":"11","key":"10.1016\/j.saa.2024.124402_b0110","article-title":"An Immune Model to Predict Prognosis of Breast Cancer Patients Receiving Neoadjuvant Chemotherapy Based on Support Vector Machine","volume":"27","author":"Wang","year":"2021","journal-title":"Front Oncol."},{"key":"10.1016\/j.saa.2024.124402_b0115","first-page":"2580","article-title":"Feature Selection Algorithm based on Random Forest applied to Sleep Apnea Detection","volume":"2019","author":"Deviaene","year":"2019","journal-title":"Annu Int Conf IEEE Eng Med Biol Soc."},{"issue":"2019","key":"10.1016\/j.saa.2024.124402_b0120","first-page":"3491852","article-title":"Metabolomics Analysis in Serum from Patients with Colorectal Polyp and Colorectal Cancer by 1H-NMR Spectrometry","volume":"7","author":"Gu","year":"2019","journal-title":"Dis Markers."},{"issue":"14","key":"10.1016\/j.saa.2024.124402_b0125","doi-asserted-by":"crossref","first-page":"3967","DOI":"10.1039\/c3an36890d","article-title":"Blood plasma surface-enhanced Raman spectroscopy for non-invasive optical detection of cervical cancer","volume":"138","author":"Feng","year":"2013","journal-title":"Analyst"},{"issue":"8","key":"10.1016\/j.saa.2024.124402_b0130","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1364\/BOE.465295","article-title":"Prediction of the postoperative prognosis in patients with non-muscle-invasive bladder cancer based on preoperative serum surface-enhanced Raman spectroscopy","volume":"13","author":"Zhu","year":"2022","journal-title":"Biomed Opt Express."},{"issue":"9","key":"10.1016\/j.saa.2024.124402_b0135","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.3390\/cancers13092008","article-title":"Raman spectroscopy of liquid-based cervical smear samples as a triage to Stratify Women Who Are HPV-positive on screening","volume":"13","author":"Traynor","year":"2021","journal-title":"Cancers (basel)."},{"issue":"2","key":"10.1016\/j.saa.2024.124402_b0140","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/s23020657","article-title":"Mutual information-driven feature reduction for hyperspectral image classification","volume":"23","author":"Islam","year":"2023","journal-title":"Sensors (basel)."},{"issue":"13","key":"10.1016\/j.saa.2024.124402_b0145","doi-asserted-by":"crossref","first-page":"3227","DOI":"10.3390\/cancers14133227","article-title":"New Insights into the Multivariate Analysis of SER Spectra collected on blood samples for prostate cancer detection: towards a better understanding of the role played by different biomolecules on cancer screening: a preliminary study","volume":"14","author":"Munteanu","year":"2022","journal-title":"Cancers (basel)."},{"issue":"15","key":"10.1016\/j.saa.2024.124402_b0150","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.3390\/plants11151936","article-title":"Oil Palm Fruits Ripeness Classification Based on the Characteristics of Protein, Lipid, Carotene, and Guanine\/Cytosine from the Raman Spectra","volume":"11","author":"Tzuan","year":"2022","journal-title":"Plants (basel)."},{"key":"10.1016\/j.saa.2024.124402_b0155","doi-asserted-by":"crossref","unstructured":"R. Zhang Y. Yang W. Dong M. Lin J. He X. Zhang T. Tian Y. Yang K. Chen Q.Y. Lei S. Zhang Y. Xu L. Lv D-mannose facilitates immunotherapy and radiotherapy of triple-negative breast cancer via degradation of PD-L1 Proc Natl Acad Sci U S A. 119 8 2022 e2114851119.","DOI":"10.1073\/pnas.2114851119"},{"key":"10.1016\/j.saa.2024.124402_b0160","doi-asserted-by":"crossref","unstructured":"Hybrid variable selectionTraynor D, Duraipandian S, Bhatia R, Cuschieri K, Tewari P, Kearney P, D'Arcy T, O'Leary JJ, Martin CM, Lyng FM. Development and Validation of a Raman Spectroscopic Classification Model for Cervical Intraepithelial Neoplasia (CIN) Cancers (Basel) 2022 Apr 6;14(7):1836.","DOI":"10.3390\/cancers14071836"},{"issue":"3","key":"10.1016\/j.saa.2024.124402_b0165","doi-asserted-by":"crossref","first-page":"e278","DOI":"10.5301\/jbm.5000244","article-title":"Mannose receptor as a potential biomarker for gastric cancer: a pilot study","volume":"32","author":"Liu","year":"2017","journal-title":"Int J Biol Markers."},{"issue":"24","key":"10.1016\/j.saa.2024.124402_b0170","doi-asserted-by":"crossref","first-page":"e146945","DOI":"10.1172\/jci.insight.146945","article-title":"Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis","volume":"6","author":"\u0160\u010dup\u00e1kov\u00e1","year":"2021","journal-title":"JCI Insight."},{"issue":"2","key":"10.1016\/j.saa.2024.124402_b0065","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1039\/C5AN01786F","article-title":"Raman technologies in cancer diagnostics","volume":"141","author":"Austin","year":"2016","journal-title":"Analyst"},{"issue":"1138","key":"10.1016\/j.saa.2024.124402_b0075","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.aca.2020.09.019","article-title":"Anti-fouling SERS-based immunosensor for point-of-care detection of the B7\u2013H6 tumor biomarker in cervical cancer patient serum","volume":"22","author":"Panikar","year":"2020","journal-title":"Anal Chim Acta."},{"issue":"26","key":"10.1016\/j.saa.2024.124402_b0080","doi-asserted-by":"crossref","first-page":"7099","DOI":"10.1007\/s00216-020-02843-x","article-title":"SERS spectroscopy using Au-Ag nanoshuttles and hydrophobic paper-based Au nanoflower substrate for simultaneous detection of dual cervical cancer-associated serum biomarkers","volume":"412","author":"Lu","year":"2020","journal-title":"Anal Bioanal Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524005687?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524005687?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,5,27]],"date-time":"2024-05-27T06:44:44Z","timestamp":1716792284000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142524005687"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":34,"alternative-id":["S1386142524005687"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2024.124402","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cervical cancer biomarker screening based on Raman spectroscopy and multivariate statistical analysis","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2024.124402","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}],"article-number":"124402"}}