{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,8]],"date-time":"2025-07-08T11:34:08Z","timestamp":1751974448400,"version":"3.37.3"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007433","name":"China West Normal University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007433","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018542","name":"Natural Science Foundation of Sichuan Province","doi-asserted-by":"publisher","award":["2023NSFSC0354","15E006"],"award-info":[{"award-number":["2023NSFSC0354","15E006"]}],"id":[{"id":"10.13039\/501100018542","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.saa.2024.125008","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T01:20:29Z","timestamp":1724376029000},"page":"125008","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Developing an off-on fluorescence sensor based on red copper nanoclusters wrapped by sulfhydryl and polymer double ligands for sensitive detection of N-acetyl-L-cysteine"],"prefix":"10.1016","volume":"324","author":[{"given":"Yao","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jingxue","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue","family":"Ma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengjun","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2024.125008_b0005","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1007\/s10895-017-2036-z","article-title":"Determination of diclofenac and N-acetylcysteine by an optimized luminescence method using CdS quantum dots as sensitizers","volume":"27","author":"Samadi-Maybodi","year":"2017","journal-title":"J Fluoresc."},{"key":"10.1016\/j.saa.2024.125008_b0010","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1080\/00032719.2019.1609491","article-title":"Poly(adenine) DNA-templated gold nanocluster-based fluorescent strategy for the determination of thiol-containing pharmaceuticals","volume":"52","author":"Wang","year":"2019","journal-title":"Anal Lett."},{"key":"10.1016\/j.saa.2024.125008_b0015","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/j.dyepig.2012.10.014","article-title":"Highly selective and sensitive fluorescent sensing of N-acetylcysteine: Effective discrimination of N-acetylcysteine from cysteine","volume":"96","author":"Dong","year":"2013","journal-title":"Dyes Pigments."},{"key":"10.1016\/j.saa.2024.125008_b0020","doi-asserted-by":"crossref","first-page":"6512","DOI":"10.1039\/C6AY01493C","article-title":"A quantum dot-based dual fluorescent probe for recognition of mercuric ions and N-acetylcysteine: \u201cOn-Off-On\u201d approach","volume":"8","author":"Pawar","year":"2016","journal-title":"Anal. Methods."},{"key":"10.1016\/j.saa.2024.125008_b0025","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.aca.2013.07.037","article-title":"N-acetylcysteine induced quenching of red fluorescent oligonucleotide-stabilized silver nanoclusters and the application in pharmaceutical detection","volume":"793","author":"Wang","year":"2013","journal-title":"Anal Chim Acta."},{"key":"10.1016\/j.saa.2024.125008_b0030","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1002\/bio.4292","article-title":"Metal ion-mediated carbon dot nanoprobe for fluorescent turn-on sensing of N-acetyl-l-cysteine","volume":"37","author":"Wang","year":"2022","journal-title":"Luminescence."},{"key":"10.1016\/j.saa.2024.125008_b0035","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1002\/bmc.583","article-title":"Separation and quantification of N-acetyl-l-cysteine and N-acetyl-cysteine-amide by HPLC with fluorescence detection","volume":"20","author":"Wu","year":"2006","journal-title":"Biomedical Chromatography."},{"key":"10.1016\/j.saa.2024.125008_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132028","article-title":"Conductive 2D phthalocyanine-based metal-organic framework as a photoelectrochemical sensor for N-acetyl-L-cysteine detection","volume":"367","author":"Zhuge","year":"2022","journal-title":"Sensor Actuat B-Chem."},{"key":"10.1016\/j.saa.2024.125008_b0045","doi-asserted-by":"crossref","DOI":"10.1155\/2011\/140756","article-title":"Spectrophotometric determination of N-Acetyl-L-cysteine and N-(2-Mercaptopropionyl)-glycine in pharmaceutical preparations","volume":"2011","author":"Kukoc-Modun","year":"2011","journal-title":"Int J Anal Chem."},{"key":"10.1016\/j.saa.2024.125008_b0050","doi-asserted-by":"crossref","first-page":"4221","DOI":"10.1039\/C7AN01136A","article-title":"Branched polyethylenimine-functionalized carbon dots as sensitive and selective fluorescent probes for N-acetylcysteine via an off\u2013on mechanism","volume":"142","author":"Liu","year":"2017","journal-title":"Analyst."},{"key":"10.1016\/j.saa.2024.125008_b0055","doi-asserted-by":"crossref","first-page":"4173","DOI":"10.1021\/acsanm.3c05697","article-title":"Folic acid detection using \u03b2-cyclodextrin-functionalized copper nanoclusters and vitamin B6 cofactor pyridoxal","volume":"7","author":"Vegad","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.saa.2024.125008_b0060","doi-asserted-by":"crossref","first-page":"5678","DOI":"10.1021\/acsanm.4c00828","article-title":"Polyacrylic Acid-Ca2+(Ce3+) nanoclusters as fluorescent \u201cOff\u2013On\u2013Off\u201d probes for quantitative detection of pyrophosphate and alkaline phosphatase","volume":"7","author":"Fan","year":"2024","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.saa.2024.125008_b0065","doi-asserted-by":"crossref","DOI":"10.1021\/acsami.4c00560","article-title":"Bifunctional MOF-encapsulated cobalt-doped carbon dots nanozyme-powered chemiluminescence\/fluorescence dual-mode detection of aflatoxin B1","author":"Yi","year":"2024","journal-title":"ACS Appl. Mater Interfaces"},{"key":"10.1016\/j.saa.2024.125008_b0070","article-title":"A dual-functional BSA-MnO2 quantum dots-based ratiometric sensor for the detection of acid phosphatase","author":"Xu","year":"2024","journal-title":"ACS. Appl Nano Mater"},{"key":"10.1016\/j.saa.2024.125008_b0075","doi-asserted-by":"crossref","DOI":"10.1039\/D4TC00107A","article-title":"A fluorescence probe based on blue luminescent carbon dots for sensing Fe3+ in plants","author":"Lin","year":"2024","journal-title":"J Mater Chem C."},{"key":"10.1016\/j.saa.2024.125008_b0080","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00604-024-06265-9","article-title":"Dual-emission ciprofloxacin-gold nanoclusters enable ratiometric sensing of Cu2+, Al3+, and Hg2+","volume":"191","author":"Saleh","year":"2024","journal-title":"Microchim Acta."},{"key":"10.1016\/j.saa.2024.125008_b0085","article-title":"Multicolor fluorescent probe based on copper nanoclusters and organometallic frameworks for selective detection of aluminum ions","volume":"687","author":"Li","year":"2024","journal-title":"A Colloid Surface A."},{"key":"10.1016\/j.saa.2024.125008_b0090","article-title":"Chameleon-like response mechanism of gold-silver bimetallic nanoclusters stimulated by sulfur ions and their application in visual fluorescence sensing","author":"Zhang","year":"2024","journal-title":"Anal. Chem"},{"key":"10.1016\/j.saa.2024.125008_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.132333","article-title":"Thunnus albacares protein-mediated synthesis of water-soluble Copper nanoclusters as sensitive fluorescent probe for Ferric ion detection","volume":"1254","author":"Sabarinathan","year":"2022","journal-title":"J Mol Struct."},{"key":"10.1016\/j.saa.2024.125008_b0100","doi-asserted-by":"crossref","first-page":"24754","DOI":"10.1039\/D3TA04477G","article-title":"Venkatesh, Atomically precise copper nanoclusters as a potential catalyst for the electrochemical oxygen evolution reaction","volume":"11","author":"Saini","year":"2023","journal-title":"J Mater Chem A."},{"key":"10.1016\/j.saa.2024.125008_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molliq.2023.122296","article-title":"Colloidal synthesis of phospholipid-copper nanoclusters as active catalysts for the oxidative degradation of water tracer fluorescent molecule","volume":"385","author":"Kalidhasan","year":"2023","journal-title":"J Mol Liq."},{"key":"10.1016\/j.saa.2024.125008_b0110","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1021\/acs.analchem.3c04644","article-title":"Copper nanosheet-based wash-free fluorescence imaging of cancer cells","volume":"96","author":"Li","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2024.125008_b0115","doi-asserted-by":"crossref","first-page":"25862","DOI":"10.1039\/D3RA03606E","article-title":"Potential impact of various surface ligands on the cellular uptake and biodistribution characteristics of red, green, and blue emitting Cu nanoclusters","volume":"13","author":"Busi","year":"2023","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2024.125008_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134712","article-title":"Preparation of co-enhanced gold nanoclusters and its application in the detections of 4-hexylresorcinol and Cr6+","volume":"1275","author":"Cheng","year":"2023","journal-title":"J Mol Struct."},{"key":"10.1016\/j.saa.2024.125008_b0125","doi-asserted-by":"crossref","first-page":"21371","DOI":"10.1021\/acsanm.3c04868","article-title":"Therapeutic targeting of lung adenocarcinoma with mannose-coated chitosan\/copper nanocluster-levocetirizine nanocomposite","volume":"6","author":"Choudhury","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"10.1016\/j.saa.2024.125008_b0130","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1039\/D3TB02618C","article-title":"Porphyrin and doxorubicin mediated nanoarchitectonics of copper clusters: a bimodal theranostics for cancer diagnosis and treatment in vitro","volume":"12","author":"Joseph","year":"2024","journal-title":"J Mater Chem B."},{"key":"10.1016\/j.saa.2024.125008_b0135","doi-asserted-by":"crossref","first-page":"11980","DOI":"10.1039\/C5CC00901D","article-title":"Nanohybrids from nanotubular J-aggregates and transparent silica nanoshells","volume":"51","author":"Qiao","year":"2015","journal-title":"Chem Commun."},{"key":"10.1016\/j.saa.2024.125008_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.optmat.2023.114580","article-title":"4-Mercaptobenzoic acid coated self-assembled aggregative luminescent copper nanoclusters for the detection of ethyl vanillin","volume":"146","author":"Feng","year":"2023","journal-title":"Opt Mater."},{"key":"10.1016\/j.saa.2024.125008_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2022.108086","article-title":"CuNCs modified with dual-ligand to achieve fluorescence visualization detection of Tin (\u2163)","volume":"183","author":"Pu","year":"2022","journal-title":"Microchem J."},{"key":"10.1016\/j.saa.2024.125008_b0150","doi-asserted-by":"crossref","first-page":"1130","DOI":"10.1021\/acs.langmuir.3c03497","article-title":"Intramolecular charge transfer of gold nanoclusters for pH indicating","volume":"40","author":"Zhu","year":"2024","journal-title":"Langmuir"},{"key":"10.1016\/j.saa.2024.125008_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121783","article-title":"Ratiometric fluorescent detection of sulfide ions in Radix Codonopsis and living cells based on PVP-supported gold\/copper nanoclusters with tunable dual emission","volume":"284","author":"Chen","year":"2023","journal-title":"Spectrochimica Acta A."},{"key":"10.1016\/j.saa.2024.125008_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.122697","article-title":"Development of low-cost copper nanoclusters for highly selective \u201cturn-on\u201d sensing of Hg2+ ions","volume":"297","author":"Sharma","year":"2023","journal-title":"Spectrochim Acta A."},{"key":"10.1016\/j.saa.2024.125008_b0165","doi-asserted-by":"crossref","first-page":"6533","DOI":"10.1021\/acsami.3c13321","article-title":"Assembly-induced emission of copper nanoclusters: Revealing the sensing mechanism for detection of volatile basic nitrogen in seafood freshness on-site monitoring","volume":"16","author":"Zhou","year":"2024","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2024.125008_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2022.121408","article-title":"One-step synthesis of blue emission copper nanoclusters for the detection of furaltadone and temperature","volume":"279","author":"Cai","year":"2022","journal-title":"Spectrochim Acta A."},{"key":"10.1016\/j.saa.2024.125008_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.124259","article-title":"Single gold nanocluster probe-based fluorescent sensor array for heavy metal ion discrimination","volume":"405","author":"Zhang","year":"2021","journal-title":"J Hazard Mater."},{"key":"10.1016\/j.saa.2024.125008_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochem.2023.114896","article-title":"Multifunctional fluorogenic probes from hydrazide schiff base-modified polyvinylpyrrolidone to detect Al3+ in aqueous environment and living cells","volume":"444","author":"Le","year":"2023","journal-title":"J Photoch Photobio A."},{"key":"10.1016\/j.saa.2024.125008_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124573","article-title":"The synthesis of gold nanoclusters with high stability and their application in fluorometric detection for Hg2+ and cell imaging","volume":"260","author":"Xie","year":"2023","journal-title":"Talanta."},{"key":"10.1016\/j.saa.2024.125008_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2020.105253","article-title":"Glutathione functionalized copper nanoclusters as a fluorescence platform for specific biosensing of cysteine and application in cellular imaging","volume":"158","author":"Rajamanikandan","year":"2020","journal-title":"Microchem J."},{"key":"10.1016\/j.saa.2024.125008_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.342182","article-title":"A dual-emitting fluoroprobe fabricated by aloe leaf-based N-doped carbon quantum dots and copper nanoclusters for nitenpyram detection in waters by virtue of inner filter effect and static quenching principles","volume":"1289","author":"Wang","year":"2024","journal-title":"Analytica Chimica Acta."},{"key":"10.1016\/j.saa.2024.125008_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.colsurfb.2022.112698","article-title":"2-Mercaptobenzothiazole-supported ratiometric fluorescent copper nanoclusters for activatable GSH sensing to drive tumor recognition","volume":"217","author":"Li","year":"2022","journal-title":"Colloid Surface B."},{"key":"10.1016\/j.saa.2024.125008_b0205","doi-asserted-by":"crossref","DOI":"10.1590\/S0103-50532007000500023","article-title":"Flow injection turbidimetric determination of acetylcysteine in pharmaceutical formulations using silver nitrate as precipitant reagent","volume":"18","author":"Suarez","year":"2007","journal-title":"J Brazil Chem Soc."},{"key":"10.1016\/j.saa.2024.125008_b0210","doi-asserted-by":"crossref","first-page":"3932","DOI":"10.1016\/j.jchromb.2011.10.042","article-title":"Simple and rapid determination of thiol compounds by HPLC and fluorescence detection with 1,3,5,7-tetramethyl-8-phenyl-(2-maleimide) difluoroboradiaza-s-indacene","volume":"879","author":"Guo","year":"2011","journal-title":"J Chromatogr B."},{"key":"10.1016\/j.saa.2024.125008_b0215","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.talanta.2007.05.035","article-title":"Electrochemical determination of homocysteine at a gold nanoparticle-modified electrode","volume":"74","author":"Ag\u00fc\u00ed","year":"2007","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2024.125008_b0220","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1021\/bc9002019","article-title":"Antibody\u2212drug conjugates: Linking cytotoxic payloads to monoclonal antibodies","volume":"21","author":"Ducry","year":"2010","journal-title":"Bioconjugate Chem."},{"key":"10.1016\/j.saa.2024.125008_b0225","doi-asserted-by":"crossref","first-page":"8682737","DOI":"10.1155\/2016\/8682737","article-title":"N-acetyl-cysteine as effective and safe chelating agent in metal-on-metal hip-implanted patients: Two cases","volume":"2016","author":"Giampreti","year":"2016","journal-title":"Case Reports in Orthopedics"},{"key":"10.1016\/j.saa.2024.125008_b0230","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1002\/bio.3891","article-title":"A turn-on fluorescence strategy for biothiols determination by blocking Hg(II)-mediated fluorescence quenching of adenine-rich DNA-templated gold nanoclusters","volume":"35","author":"Wang","year":"2020","journal-title":"Luminescence"},{"key":"10.1016\/j.saa.2024.125008_b0235","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.snb.2016.08.147","article-title":"Multi-talented applications for cell imaging, tumor cells recognition, patterning, staining and temperature sensing by using egg white-encapsulated gold nanoclusters","volume":"240","author":"Tian","year":"2017","journal-title":"Sensor Actua B-Chem."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524011740?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524011740?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,9,10]],"date-time":"2024-09-10T16:29:59Z","timestamp":1725985799000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142524011740"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":47,"alternative-id":["S1386142524011740"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2024.125008","relation":{},"ISSN":["1386-1425"],"issn-type":[{"type":"print","value":"1386-1425"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developing an off-on fluorescence sensor based on red copper nanoclusters wrapped by sulfhydryl and polymer double ligands for sensitive detection of N-acetyl-L-cysteine","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2024.125008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125008"}}