{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T16:10:28Z","timestamp":1792858228731,"version":"4.5.0"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.saa.2024.125049","type":"journal-article","created":{"date-parts":[[2024,8,30]],"date-time":"2024-08-30T15:39:55Z","timestamp":1725032395000},"page":"125049","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Near-infrared hemicyanine photosensitizer for targeted mitochondrial viscosity imaging and efficient photodynamic therapy"],"prefix":"10.1016","volume":"325","author":[{"given":"Wei","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiarao","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoyang","family":"Xiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zongfa","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Shen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2024.125049_b0005","doi-asserted-by":"crossref","first-page":"6712","DOI":"10.1002\/anie.201610819","article-title":"From Composition to Cure: A Systems Engineering Approach to Anticancer Drug Carrier","volume":"56","author":"Chilkoti","year":"2017","journal-title":"AngewChem Int Ed"},{"key":"10.1016\/j.saa.2024.125049_b0010","first-page":"2875","article-title":"The Mycobiome: Cancer Pathogenesis","volume":"14","author":"Gamal","year":"2022","journal-title":"Diagnosis, and Therapy, Cancers"},{"key":"10.1016\/j.saa.2024.125049_b0015","doi-asserted-by":"crossref","first-page":"20230116","DOI":"10.1515\/ntrev-2023-0116","article-title":"Application of nanomaterials in early diagnosis of cancer","volume":"12","author":"Guo","year":"2023","journal-title":"Nanotechnol Rev"},{"key":"10.1016\/j.saa.2024.125049_b0020","doi-asserted-by":"crossref","first-page":"4415","DOI":"10.1002\/anie.201911859","article-title":"A Renal-Clearable Macromolecular Reporter for Near-Infrared Fluorescence Imaging of Bladder Cancer","volume":"59","author":"Huang","year":"2020","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.saa.2024.125049_b0025","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.7150\/thno.80529","article-title":"Wenjuan Lu, Yongchun Wei, Lingxiu Kong, Wei Chen, Xintian Shao, and Yanfeng Wang, Recent advances in fluorescent probes of peroxynitrite: Structural, strategies and biological applications","volume":"13","author":"Jiarao Sun","year":"2023","journal-title":"Theranostics"},{"key":"10.1016\/j.saa.2024.125049_b0030","doi-asserted-by":"crossref","first-page":"7924","DOI":"10.1039\/D2TB01210C","article-title":"The design strategies and biological applications of probes for the gaseous signaling molecule hydrogen sulfide","volume":"10","author":"Kong","year":"2022","journal-title":"J Mater Chem B"},{"key":"10.1016\/j.saa.2024.125049_b0035","doi-asserted-by":"crossref","first-page":"3581","DOI":"10.1021\/acsbiomaterials.3c00307","article-title":"Multifunctional Mitochondria-Targeting Near-Infrared Fluorescent Probe for Viscosity, ONOO\u2013","volume":"9","author":"Lei","year":"2023","journal-title":"Mitophagy, and Bioimaging, ACS Biomater Sci Eng"},{"key":"10.1016\/j.saa.2024.125049_b0040","doi-asserted-by":"crossref","first-page":"2149","DOI":"10.1007\/s12274-020-2822-9","article-title":"Super-resolution quantification of nanoscale damage to mitochondria in live cells","volume":"13","author":"Shao","year":"2020","journal-title":"Nano Res"},{"key":"10.1016\/j.saa.2024.125049_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120089","article-title":"An APN-activated NIR photosensitizer for cancer photodynamic therapy and fluorescence imaging","volume":"253","author":"Zhou","year":"2020","journal-title":"BIOMATERIALS"},{"key":"10.1016\/j.saa.2024.125049_b0050","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1002\/cac2.12416","article-title":"Tumor microenvironment signaling and therapeutics in cancer progression","volume":"43","author":"Goenka","year":"2023","journal-title":"Cancer Commun"},{"key":"10.1016\/j.saa.2024.125049_b0055","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.biomaterials.2019.01.002","article-title":"Oxygenated theranostic nanoplatforms with intracellular agglomeration behavior for improving the treatment efficacy of hypoxic tumors","volume":"197","author":"Zhou","year":"2019","journal-title":"BIOMATERIALS"},{"key":"10.1016\/j.saa.2024.125049_b0060","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/acs.analchem.0c03803","article-title":"Noninvasive Cancer Diagnosis In Vivo Based on a Viscosity-Activated Near-Infrared Fluorescent Probe","volume":"93","author":"Yin","year":"2021","journal-title":"Anal Chem"},{"key":"10.1016\/j.saa.2024.125049_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2022.137762","article-title":"A mitochondria-targeted and viscosity-sensitive near-infrared fluorescent probe for visualization of fatty liver, inflammation and photodynamic cancer therapy","volume":"449","author":"Fan","year":"2022","journal-title":"Chem Eng J"},{"key":"10.1016\/j.saa.2024.125049_b0070","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202301230","article-title":"Dual Key-Activated Nir-I\/II Fluorescence Probe for Monitoring Photodynamic and Photothermal Synergistic Therapy Efficacy","volume":"12","author":"Wang","year":"2023","journal-title":"ADV HEALTHC MATER"},{"key":"10.1016\/j.saa.2024.125049_b0075","doi-asserted-by":"crossref","first-page":"2115","DOI":"10.1039\/D0BM01863E","article-title":"The self-assembly of a hybrid photosensitizer for the synergistically enhanced photodynamic\/photothermal therapy","volume":"9","author":"Chen","year":"2021","journal-title":"Biomater Sci"},{"key":"10.1016\/j.saa.2024.125049_b0080","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jconrel.2023.08.056","article-title":"Recent advances in fluorescence imaging-guided photothermal therapy and photodynamic therapy for cancer: From near-infrared-I to near-infrared-II","volume":"362","author":"Luo","year":"2023","journal-title":"J Control Release"},{"key":"10.1016\/j.saa.2024.125049_b0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1186\/s40824-023-00450-2","article-title":"Precise visualization and ROS-dependent photodynamic therapy of colorectal cancer with a novel mitochondrial viscosity photosensitive fluorescent probe","volume":"27","author":"Xiao","year":"2023","journal-title":"Biomater"},{"key":"10.1016\/j.saa.2024.125049_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.biomaterials.2020.120532","article-title":"Smart J-aggregate of cyanine photosensitizer with the ability to target tumor and enhance photodynamic therapy efficacy","volume":"269","author":"Li","year":"2021","journal-title":"BIOMATERIALS"},{"key":"10.1016\/j.saa.2024.125049_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.nantod.2023.102030","article-title":"Near-infrared photosensitizers adaptive to tumor hypoxic microenvironment for synergistic photothermal-photodynamic and immunotherapy","volume":"53","author":"Meng","year":"2023","journal-title":"Nano Today"},{"key":"10.1016\/j.saa.2024.125049_b0100","doi-asserted-by":"crossref","unstructured":"B.K. Stanis\u0142aw Kwiatkowski, Dawid Przystupski, Jolanta Saczko, Ewa K\u0119dzierska, Karolina Knap-Czop, Jolanta Kotli\u0144ska, Olga Michel, Krzysztof Kotowski, Julita Kulbacka, Photodynamic therapy -mechanisms,photosensitizers and combinations, Biomed Pharmacother, 106 (2018) 1098-1107.","DOI":"10.1016\/j.biopha.2018.07.049"},{"key":"10.1016\/j.saa.2024.125049_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134287","article-title":"A tumor-targeting fluorescent probe for ratiometric imaging of pH and improving PDT\/PTT synergistic therapy","volume":"393","author":"Gu","year":"2023","journal-title":"SENSOR ACTUAT B-CHEM"},{"key":"10.1016\/j.saa.2024.125049_b0110","doi-asserted-by":"crossref","DOI":"10.3389\/fchem.2021.707876","article-title":"Recent Advances in Cyanine-Based Phototherapy Agents","volume":"9","author":"Bilici","year":"2021","journal-title":"FRONT CHEM"},{"key":"10.1016\/j.saa.2024.125049_b0115","first-page":"202316487","article-title":"An ER-targeted","volume":"63","author":"Zeng","year":"2024","journal-title":"Viscosity-Sensitive Hemicyanine Dye for the Diagnosis of Nonalcoholic Fatty Liver and Photodynamic Cancer Therapy by Activating Pyroptosis Pathway, Angew Chem Int Ed"},{"key":"10.1016\/j.saa.2024.125049_b0120","first-page":"e202300476","article-title":"Development of Mitochondria-Targeting Photosensitizers via Topoisomerase I Inhibition, Asian","volume":"12","author":"Lim","year":"2023","journal-title":"J Org Chem"},{"key":"10.1016\/j.saa.2024.125049_b0125","doi-asserted-by":"crossref","first-page":"20453","DOI":"10.1021\/acsnano.1c08928","article-title":"High-Performance Near-Infrared Aggregation-Induced Emission Luminogen with Mitophagy Regulating Capability for Multimodal Cancer Theranostics","volume":"15","author":"Li","year":"2021","journal-title":"ACS Nano"},{"key":"10.1016\/j.saa.2024.125049_b0130","doi-asserted-by":"crossref","first-page":"2001240","DOI":"10.1002\/adhm.202001240","article-title":"Mitochondria-Specific Agents for Photodynamic Cancer Therapy: A Key Determinant to Boost the Efficacy","volume":"10","author":"Li","year":"2020","journal-title":"Adv Healthcare Mater"},{"key":"10.1016\/j.saa.2024.125049_b0135","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1039\/D0TB02440F","article-title":"Mitochondria and lysosome-targetable fluorescent probes for hydrogen peroxide","volume":"9","author":"Wei","year":"2021","journal-title":"J MATER CHEM B"},{"key":"10.1016\/j.saa.2024.125049_b0140","doi-asserted-by":"crossref","first-page":"16923","DOI":"10.1021\/acsnano.3c04002","article-title":"Photoactivated DNA Nanodrugs Damage Mitochondria to Improve Gene Therapy for Reversing Chemoresistance","volume":"17","author":"Wang","year":"2023","journal-title":"ACS Nano"},{"key":"10.1016\/j.saa.2024.125049_b0145","doi-asserted-by":"crossref","first-page":"3016","DOI":"10.3390\/molecules23113016","volume":"23","year":"2018","journal-title":"MOLECULES"},{"key":"10.1016\/j.saa.2024.125049_b0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132322","article-title":"NRNC-8, a novel mitochondria-immobilization superoxide radical generator for photodynamic therapy","volume":"369","author":"Zhao","year":"2022","journal-title":"SENSOR ACTUAT B-CHEM"},{"key":"10.1016\/j.saa.2024.125049_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134955","article-title":"Mitochondria-targeting hemicyanine photosensitizer as an inducer for MMP loss and cell apoptosis based on radical enhanced ISC strategy","volume":"401","author":"Xu","year":"2024","journal-title":"SENSOR ACTUAT B-CHEM"},{"key":"10.1016\/j.saa.2024.125049_b0160","article-title":"ZWZ-3, a Fluorescent Probe Targeting Mitochondria for Melanoma Imaging and Therapy","volume":"13","author":"Liu","year":"2022","journal-title":"Front Pharmacol"},{"key":"10.1016\/j.saa.2024.125049_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.131838","article-title":"A multifunctional near-infrared fluorescent probe for in vitro and in vivo imaging of \u03b3-glutamyltranspeptidase and photodynamic cancer therapy","volume":"363","author":"Liu","year":"2022","journal-title":"SENSOR ACTUAT B-CHEM"},{"key":"10.1016\/j.saa.2024.125049_b0170","first-page":"26454","article-title":"Hemicyanine-Based Near-Infrared Activatable Probes for Imaging and Diagnosis of Diseases","volume":"60","author":"Zeng","year":"2021","journal-title":"AngewChem IntEd"},{"key":"10.1016\/j.saa.2024.125049_b0175","doi-asserted-by":"crossref","first-page":"7768","DOI":"10.1021\/acs.chemrev.6b00001","article-title":"Recent Development of Chemosensors Based on Cyanine Platforms","volume":"116","author":"Sun","year":"2016","journal-title":"Chem Rev"},{"key":"10.1016\/j.saa.2024.125049_b0180","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1039\/D2CS90019J","article-title":"Activity-based NIR fluorescent probes based on the versatile hemicyanine scaffold: design strategy, biomedical applications, and outlook","volume":"51","author":"Li","year":"2022","journal-title":"Chem Soc Rev"},{"key":"10.1016\/j.saa.2024.125049_b0185","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1039\/D2SC05982G","article-title":"Single-atom engineering of hemicyanine and its amphiphilic derivative for optimized near infrared phototheranostics","volume":"14","author":"Yao","year":"2023","journal-title":"Chem Sci"},{"key":"10.1016\/j.saa.2024.125049_b0190","doi-asserted-by":"crossref","first-page":"13658","DOI":"10.1002\/anie.201510721","article-title":"Discerning the Chemistry in Individual Organelles with Small-Molecule Fluorescent Probes","volume":"55","author":"Xu","year":"2016","journal-title":"Angew Chem Int Ed"},{"key":"10.1016\/j.saa.2024.125049_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.135619","article-title":"A ClO\u2212 triggered phenol derivative that induced mitochondrial damage for tumor therapy","volume":"409","author":"Sun","year":"2024","journal-title":"SENSOR ACTUAT B-CHEM"},{"key":"10.1016\/j.saa.2024.125049_b0200","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.340813","article-title":"A near-infrared fluorescent probe for monitoring abnormal mitochondrial viscosity in cancer and fatty-liver mice model","volume":"1242","author":"Chao","year":"2023","journal-title":"Anal Chim Acta"},{"key":"10.1016\/j.saa.2024.125049_b0205","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1021\/acsnano.6b07927","article-title":"Diketopyrrolopyrrole-Triphenylamine Organic Nanoparticles as Multifunctional Reagents for Photoacoustic Imaging-Guided Photodynamic\/Photothermal Synergistic Tumor Therapy","volume":"11","author":"Cai","year":"2017","journal-title":"ACS Nano"},{"key":"10.1016\/j.saa.2024.125049_b0210","first-page":"2875","article-title":"A Bifunctional Photosensitizer for Enhanced Fractional Photodynamic Therapy: Singlet Oxygen Generation in the Presence and Absence of Light","volume":"55","author":"Turan","year":"2016","journal-title":"AngewChem IntEd"},{"key":"10.1016\/j.saa.2024.125049_b0215","doi-asserted-by":"crossref","first-page":"12726","DOI":"10.1039\/C5DT01612F","article-title":"Two novel BODIPY\u2013Ru(ii) arene dyads enabling effective photo-inactivation against cancer cells","volume":"44","author":"Wang","year":"2015","journal-title":"Dalton Trans"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524012150?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524012150?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,11,5]],"date-time":"2024-11-05T18:24:16Z","timestamp":1730831056000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142524012150"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":43,"alternative-id":["S1386142524012150"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2024.125049","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Near-infrared hemicyanine photosensitizer for targeted mitochondrial viscosity imaging and efficient photodynamic therapy","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2024.125049","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125049"}}