{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T20:56:38Z","timestamp":1781211398075,"version":"3.54.1"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.saa.2024.125337","type":"journal-article","created":{"date-parts":[[2024,10,30]],"date-time":"2024-10-30T07:33:59Z","timestamp":1730273639000},"page":"125337","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Accuracy of COVID-19 diagnostic tests via infrared spectroscopy: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"327","author":[{"given":"Alexandre de F\u00e1tima","family":"Cobre","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Millan","family":"Fachi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karime Zeraik Abdalla","family":"Domingues","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raul Edison Luna","family":"Lazo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luana Mota","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernanda Stumpf","family":"Tonin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Pontarolo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2024.125337_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123409","article-title":"Review of COVID-19 testing and diagnostic methods","volume":"244","author":"Filchakova","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2024.125337_b0010","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.3390\/mi13081349","article-title":"Diagnosis methods for COVID-19: a systematic review","volume":"13","author":"Maia","year":"2022","journal-title":"Micromachines (Basel)"},{"key":"10.1016\/j.saa.2024.125337_b0015","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1016\/S0140-6736(21)02346-1","article-title":"Diagnostics for COVID-19: moving from pandemic response to control","volume":"399","author":"Peeling","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.saa.2024.125337_b0020","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1039\/C8AN90029A","article-title":"Correction: clinical applications of infrared and Raman spectroscopy: state of play and future challenges","volume":"143","author":"Baker","year":"2018","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2024.125337_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/10408363.2017.1414142","article-title":"Applications of mid-infrared spectroscopy in the clinical laboratory setting","volume":"55","author":"De Bruyne","year":"2018","journal-title":"Crit. Rev. Clin. Lab. Sci."},{"key":"10.1016\/j.saa.2024.125337_b0030","doi-asserted-by":"crossref","first-page":"2425","DOI":"10.1021\/acs.analchem.1c04162","article-title":"Noninvasive diagnostic for COVID-19 from Saliva biofluid via FTIR spectroscopy and multivariate analysis","volume":"94","author":"Nascimento","year":"2022","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2024.125337_b0035","doi-asserted-by":"crossref","first-page":"19980","DOI":"10.1038\/s41598-021-99529-w","article-title":"ATR-FTIR spectrum analysis of saliva samples from COVID-19 positive patients","volume":"11","author":"Martinez-Cuazitl","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2024.125337_b0040","doi-asserted-by":"crossref","first-page":"16740","DOI":"10.1038\/s41598-021-95568-5","article-title":"A simple and fast spectroscopy-based technique for Covid-19 diagnosis","volume":"11","author":"Kitane","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2024.125337_b0045","doi-asserted-by":"crossref","first-page":"351","DOI":"10.3390\/biomedicines10020351","article-title":"Pathophysiological response to SARS-CoV-2 infection detected by infrared spectroscopy enables rapid and robust saliva screening for COVID-19","volume":"10","author":"Kazmer","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.saa.2024.125337_b0050","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.202200166","article-title":"<scp>ATR-FTIR<\/scp> spectrum analysis of plasma samples for rapid identification of recovered <scp>COVID<\/scp> -19 individuals","volume":"16","author":"Karas","year":"2023","journal-title":"J. Biophoton."},{"key":"10.1016\/j.saa.2024.125337_b0055","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1186\/s12936-023-04780-3","article-title":"Key considerations, target product profiles, and research gaps in the application of infrared spectroscopy and artificial intelligence for malaria surveillance and diagnosis","volume":"22","author":"Mshani","year":"2023","journal-title":"Malar. J."},{"key":"10.1016\/j.saa.2024.125337_b0060","series-title":"Cochrane Handbook for Systematic Reviews of Interventions","author":"Higgins","year":"2019"},{"key":"10.1016\/j.saa.2024.125337_b0065","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1001\/jama.2017.19163","article-title":"Preferred reporting items for a systematic review and meta-analysis of diagnostic test accuracy studies","volume":"319","author":"McInnes","year":"2018","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.saa.2024.125337_b0070","doi-asserted-by":"crossref","first-page":"529","DOI":"10.7326\/0003-4819-155-8-201110180-00009","article-title":"QUADAS-2: a revised tool for the quality assessment of diagnostic accuracy studies","volume":"155","author":"Whiting","year":"2011","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.saa.2024.125337_b0075","doi-asserted-by":"crossref","first-page":"4269","DOI":"10.1038\/s41598-022-08156-6","article-title":"Micro-Fourier-transform infrared reflectance spectroscopy as tool for probing IgG glycosylation in COVID-19 patients","volume":"12","author":"Bandeira","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2024.125337_b0080","doi-asserted-by":"crossref","first-page":"2950","DOI":"10.1021\/acs.analchem.0c04608","article-title":"Ultrarapid on-site detection of SARS-CoV-2 infection using simple ATR-FTIR spectroscopy and an analysis algorithm: high sensitivity and specificity","volume":"93","author":"Barauna","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2024.125337_b0085","doi-asserted-by":"crossref","first-page":"30756","DOI":"10.1021\/acsomega.2c01374","article-title":"Potential of ATR-FTIR\u2013chemometrics in Covid-19: disease recognition","volume":"7","author":"Calvo-Gomez","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.saa.2024.125337_b0090","doi-asserted-by":"crossref","first-page":"e31200","DOI":"10.2196\/31200","article-title":"Remote analysis of respiratory sounds in patients with COVID-19: development of fast Fourier transform-based computer-assisted diagnostic methods","volume":"6","author":"Furman","year":"2022","journal-title":"JMIR Form. Res."},{"key":"10.1016\/j.saa.2024.125337_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2021.122916","article-title":"Characterization of Covid-19 infected pregnant women sera using laboratory indexes, vibrational spectroscopy, and machine learning classifications","volume":"237","author":"Guleken","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2024.125337_b0100","doi-asserted-by":"crossref","first-page":"20358","DOI":"10.1038\/s41598-022-24751-z","article-title":"Diagnostic performance of attenuated total reflection Fourier-transform infrared spectroscopy for detecting COVID-19 from routine nasopharyngeal swab samples","volume":"12","author":"Heino","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2024.125337_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbadis.2023.166799","article-title":"Dynamic response antibodies SARS-CoV-2 human saliva studied using two-dimensional correlation (2DCOS) infrared spectral analysis coupled with receiver operation characteristics analysis","volume":"1869","author":"Karthikeyan","year":"2023","journal-title":"Biochim. Biophys. Acta (BBA) \u2013 Mol. Basis Dis."},{"key":"10.1016\/j.saa.2024.125337_b0110","doi-asserted-by":"crossref","first-page":"165","DOI":"10.3390\/bios13020165","article-title":"Breath analysis of COVID-19 patients in a tertiary UK hospital by optical spectrometry: the E-nose CoVal study","volume":"13","author":"Laird","year":"2023","journal-title":"Biosensors (Basel)"},{"key":"10.1016\/j.saa.2024.125337_b0115","doi-asserted-by":"crossref","first-page":"15409","DOI":"10.1038\/s41598-021-93511-2","article-title":"Rapid diagnosis of COVID-19 using FT-IR ATR spectroscopy and machine learning","volume":"11","author":"Nogueira","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2024.125337_b0120","article-title":"Detection of SARS-CoV-2 infection by exhaled breath spectral analysis: introducing a ready-to-use point-of-care mass screening method","volume":"45","author":"Ben Shlomo","year":"2022","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.saa.2024.125337_b0125","doi-asserted-by":"crossref","first-page":"17102","DOI":"10.1002\/anie.202104453","article-title":"Infrared based saliva screening test for COVID-19","volume":"60","author":"Wood","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2024.125337_b0130","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1021\/acs.analchem.0c04049","article-title":"Fast screening and primary diagnosis of COVID-19 by ATR\u2013FT-IR","volume":"93","author":"Zhang","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2024.125337_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.cmpb.2022.107295","article-title":"Potential of vibrational spectroscopy coupled with machine learning as a non-invasive diagnostic method for COVID-19","volume":"229","author":"Zhao","year":"2023","journal-title":"Comput. Methods Programs Biomed."},{"key":"10.1016\/j.saa.2024.125337_b0140","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s11426-016-0092-6","article-title":"Near-infrared spectroscopy and chemometric modelling for rapid diagnosis of kidney disease","volume":"60","author":"Fan","year":"2017","journal-title":"Sci. China Chem."},{"key":"10.1016\/j.saa.2024.125337_b0145","article-title":"Diagnosis of lung cancer by ATR-FTIR spectroscopy and chemometrics","volume":"11","author":"Yang","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.saa.2024.125337_b0150","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.aca.2015.02.012","article-title":"A tutorial review: metabolomics and partial least squares-discriminant analysis \u2013 a marriage of convenience or a shotgun wedding","volume":"879","author":"Gromski","year":"2015","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2024.125337_b0155","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1007\/s11306-019-1612-4","article-title":"A comparative evaluation of the generalised predictive ability of eight machine learning algorithms across ten clinical metabolomics data sets for binary classification","volume":"15","author":"Mendez","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.saa.2024.125337_b0160","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1007\/s11306-019-1608-0","article-title":"The application of artificial neural networks in metabolomics: a historical perspective","volume":"15","author":"Mendez","year":"2019","journal-title":"Metabolomics"},{"key":"10.1016\/j.saa.2024.125337_b0165","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1039\/B906712B","article-title":"Systems level studies of mammalian metabolomes: the roles of mass spectrometry and nuclear magnetic resonance spectroscopy","volume":"40","author":"Dunn","year":"2011","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2024.125337_b0170","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1016\/j.dsx.2020.04.012","article-title":"Artificial intelligence (AI) applications for COVID-19 pandemic","volume":"14","author":"Vaishya","year":"2020","journal-title":"Diabetes Metab. Syndr."},{"key":"10.1016\/j.saa.2024.125337_b0175","doi-asserted-by":"crossref","first-page":"e667","DOI":"10.1016\/S2589-7500(20)30192-8","article-title":"Artificial intelligence in COVID-19 drug repurposing","volume":"2","author":"Zhou","year":"2020","journal-title":"Lancet Digit. Health"},{"key":"10.1016\/j.saa.2024.125337_b0180","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jocm.2018.07.002","article-title":"Is your dataset big enough? Sample size requirements when using artificial neural networks for discrete choice analysis","volume":"28","author":"Alwosheel","year":"2018","journal-title":"J. Choice Modell."},{"key":"10.1016\/j.saa.2024.125337_b0185","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/s41586-018-0337-2","article-title":"Machine learning for molecular and materials science","volume":"559","author":"Butler","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.saa.2024.125337_b0190","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/j.compchemeng.2019.04.003","article-title":"Advances and opportunities in machine learning for process data analytics","volume":"126","author":"Qin","year":"2019","journal-title":"Comput. Chem. Eng."},{"key":"10.1016\/j.saa.2024.125337_b0195","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.csbj.2019.12.006","article-title":"Machine learning applications in drug development","volume":"18","author":"R\u00e9da","year":"2020","journal-title":"Comput. Struct. Biotechnol. J."},{"key":"10.1016\/j.saa.2024.125337_b0200","doi-asserted-by":"crossref","DOI":"10.1128\/jcm.01785-21","article-title":"Quantitative SARS-CoV-2 viral-load curves in paired saliva samples and nasal swabs inform appropriate respiratory sampling site and analytical test sensitivity required for earliest viral detection","volume":"60","author":"Savela","year":"2022","journal-title":"J. Clin. Microbiol."},{"key":"10.1016\/j.saa.2024.125337_b0205","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ajic.2020.07.011","article-title":"Systematic review with meta-analysis of the accuracy of diagnostic tests for COVID-19","volume":"49","author":"B\u00f6ger","year":"2021","journal-title":"Am. J. Infect. Control"},{"key":"10.1016\/j.saa.2024.125337_b0210","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1002\/jmv.27531","article-title":"Antibody responses to COVID-19 vaccines in older adults","volume":"94","author":"Bag Soytas","year":"2022","journal-title":"J. Med. Virol."},{"key":"10.1016\/j.saa.2024.125337_b0215","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.00396-22","article-title":"Rapid quantitative point-of-care diagnostic test for post COVID-19 vaccination antibody monitoring","volume":"10","author":"Moeller","year":"2022","journal-title":"Microbiol. Spectr."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524015038?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142524015038?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,12,6]],"date-time":"2024-12-06T15:47:38Z","timestamp":1733500058000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142524015038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":43,"alternative-id":["S1386142524015038"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2024.125337","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accuracy of COVID-19 diagnostic tests via infrared spectroscopy: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2024.125337","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125337"}}