{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T14:52:39Z","timestamp":1788792759983,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100023674","name":"Deanship of Scientific Research, King Khalid University","doi-asserted-by":"publisher","award":["RGP-2\/614\/45"],"award-info":[{"award-number":["RGP-2\/614\/45"]}],"id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023674","name":"Deanship of Scientific Research, King Khalid University","doi-asserted-by":"publisher","award":["RGP-2\/459\/45"],"award-info":[{"award-number":["RGP-2\/459\/45"]}],"id":[{"id":"10.13039\/501100023674","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004504","name":"Research Council of Lithuania","doi-asserted-by":"publisher","award":["S-PD-24-24"],"award-info":[{"award-number":["S-PD-24-24"]}],"id":[{"id":"10.13039\/501100004504","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.saa.2025.125700","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T10:08:18Z","timestamp":1736071698000},"page":"125700","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Trace detection of antibiotics in wastewater using tunable core\u2013shell nanoparticles SERS substrate combined with machine learning algorithms"],"prefix":"10.1016","volume":"330","author":[{"given":"Muhammad","family":"Usman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wajid","family":"Ali","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saleh S.","family":"Alarfaji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9965-2724","authenticated-orcid":false,"given":"S.","family":"Tamulevi\u010dius","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2025.125700_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.scitotenv.2019.134023","article-title":"Antibiotic resistance genes identified in wastewater treatment plant systems\u2013a review","volume":"697","author":"Pazda","year":"2019","journal-title":"Sci. Total Environ."},{"key":"10.1016\/j.saa.2025.125700_b0010","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.chemosphere.2018.04.163","article-title":"Antibiotic resistance in urban and hospital wastewaters and their impact on a receiving freshwater ecosystem","volume":"206","author":"Lorenzo","year":"2018","journal-title":"Chemosphere"},{"key":"10.1016\/j.saa.2025.125700_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2021.116415","article-title":"Raman biosensor and molecular tools for integrated monitoring of pathogens and antimicrobial resistance in wastewater","volume":"143","author":"Cui","year":"2021","journal-title":"TrAC Trends Anal. Chem."},{"key":"10.1016\/j.saa.2025.125700_b0020","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.gene.2016.07.035","article-title":"Riboswitches: from living biosensors to novel targets of antibiotics","volume":"592","author":"Aghdam","year":"2016","journal-title":"Gene"},{"key":"10.1016\/j.saa.2025.125700_b0025","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1289\/ehp.11776","article-title":"Review of the occurrence of anti-infectives in contaminated wastewaters and natural and drinking waters","volume":"117","author":"Segura","year":"2009","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.saa.2025.125700_b0030","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.envint.2017.10.016","article-title":"Review of antibiotic resistance in China and its environment","volume":"110","author":"Qiao","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.saa.2025.125700_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.envpol.2020.115147","article-title":"Antibiotics in soil and water in China\u2013a systematic review and source analysis","volume":"266","author":"Lyu","year":"2020","journal-title":"Environ. Pollut."},{"key":"10.1016\/j.saa.2025.125700_b0040","doi-asserted-by":"crossref","first-page":"2357","DOI":"10.1039\/a805488f","article-title":"Determination of sulfadiazine and sulfamethoxazole by capillary electrophoresis with end-column electrochemical detection","volume":"123","author":"You","year":"1998","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2025.125700_b0045","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1016\/S0731-7085(01)00706-3","article-title":"HPLC separation of antibiotics present in formulated and unformulated samples","volume":"28","author":"Joshi","year":"2002","journal-title":"J. Pharm. Biomed. Anal."},{"key":"10.1016\/j.saa.2025.125700_b0050","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/jac\/28.4.515","article-title":"Quantification of in-vitro post-antibiotic effect based on the mean recovery-time. II: a comparison of colony counting versus photometric methods for the determination of bacterial growth","volume":"28","author":"Meng","year":"1991","journal-title":"J. Antimicrob. Chemother."},{"key":"10.1016\/j.saa.2025.125700_b0055","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1016\/j.aca.2009.07.031","article-title":"An overview of analytical methodologies for the determination of antibiotics in environmental waters","volume":"649","author":"Seifrtov\u00e1","year":"2009","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2025.125700_b0060","doi-asserted-by":"crossref","first-page":"5002","DOI":"10.1021\/acs.chemrev.6b00596","article-title":"Core\u2013shell nanoparticle-enhanced Raman spectroscopy","volume":"117","author":"Li","year":"2017","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2025.125700_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134418","article-title":"Wavelength-tailored enhancement of Raman scattering on a resonant plasmonic lattice","volume":"394","author":"Khinevich","year":"2023","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2025.125700_b0070","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1021\/acs.analchem.5b04131","article-title":"Review of surface enhanced Raman scattering applications in forensic science","volume":"88","author":"Muehlethaler","year":"2016","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125700_b0075","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1021\/acs.chemrev.8b00341","article-title":"Stabilization of silver and gold nanoparticles: preservation and improvement of plasmonic functionalities","volume":"119","author":"Kang","year":"2018","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2025.125700_b0080","doi-asserted-by":"crossref","first-page":"401A","DOI":"10.1021\/ac00181a001","article-title":"Surface-enhanced Raman spectroscopy","volume":"61","author":"Garrell","year":"1989","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125700_b0085","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.chemolab.2018.04.014","article-title":"Quantitative SERS analysis based on multiple-internal-standard embedded core-shell nanoparticles and spectral shape deformation quantitative theory","volume":"177","author":"Zhang","year":"2018","journal-title":"Chemom. Intel. Lab. Syst."},{"key":"10.1016\/j.saa.2025.125700_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20194841","article-title":"4-Mercaptobenzoic acid labeled gold-silver-alloy-embedded silica nanoparticles as an internal standard containing nanostructures for sensitive quantitative thiram detection","volume":"20","author":"Pham","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2025.125700_b0095","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.jallcom.2018.11.270","article-title":"Gold-silver bimetallic nanoparticles with a Raman labeling chemical assembled on silica nanoparticles as an internal-standard-containing nanoprobe","volume":"779","author":"Pham","year":"2019","journal-title":"J. Alloys Compd."},{"key":"10.1016\/j.saa.2025.125700_b0100","doi-asserted-by":"crossref","first-page":"14109","DOI":"10.1039\/C9RA00817A","article-title":"Facile silicone oil-coated hydrophobic surface for surface enhanced Raman spectroscopy of antibiotics","volume":"9","author":"Usman","year":"2019","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2025.125700_b0105","doi-asserted-by":"crossref","first-page":"15076","DOI":"10.1021\/la403707j","article-title":"Size tunable Au@ Ag core\u2013shell nanoparticles: synthesis and surface-enhanced raman scattering properties","volume":"29","author":"Samal","year":"2013","journal-title":"Langmuir"},{"key":"10.1016\/j.saa.2025.125700_b0110","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1021\/jz400496n","article-title":"Single-molecule surface-enhanced Raman scattering sensitivity of Ag-core Au-shell nanoparticles: revealed by bi-analyte method","volume":"4","author":"Patra","year":"2013","journal-title":"J. Phys. Chem. Lett."},{"key":"10.1016\/j.saa.2025.125700_b0115","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.vibspec.2017.04.001","article-title":"Au@ 1, 4-benzenedithiol@ Au core-shell SERS immunosensor for ultra-sensitive and high specific biomarker detection","volume":"90","author":"Wan","year":"2017","journal-title":"Vib. Spectrosc."},{"key":"10.1016\/j.saa.2025.125700_b0120","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/s12274-018-2238-y","article-title":"Plasmon-tunable Au@ Ag core-shell spiky nanoparticles for surface-enhanced Raman scattering","volume":"12","author":"Huang","year":"2019","journal-title":"Nano Res."},{"key":"10.1016\/j.saa.2025.125700_b0125","doi-asserted-by":"crossref","first-page":"6288","DOI":"10.1021\/acs.analchem.9b04946","article-title":"Combination of an artificial intelligence approach and laser tweezers Raman spectroscopy for microbial identification","volume":"92","author":"Lu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125700_b0130","series-title":"Data Clustering","first-page":"1","article-title":"An introduction to cluster analysis","author":"Aggarwal","year":"2018"},{"key":"10.1016\/j.saa.2025.125700_b0135","article-title":"Rapid discrimination of Shigella spp. and Escherichia coli via label-free surface enhanced Raman spectroscopy coupled with machine learning algorithms","volume":"14","author":"Liu","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.saa.2025.125700_b0140","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1039\/C6NR08501F","article-title":"Quantifying the reflective index of nanometer-thick thiolated molecular layers on nanoparticles","volume":"9","author":"Lin","year":"2017","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2025.125700_b0145","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/nmeth0509-389","article-title":"Proteins and proteomics: life on the surface","volume":"6","author":"Blow","year":"2009","journal-title":"Nat. Methods"},{"key":"10.1016\/j.saa.2025.125700_b0150","doi-asserted-by":"crossref","DOI":"10.1002\/smtd.201800182","article-title":"Surface\u2010enhanced Raman nanoprobes with embedded standards for quantitative cholesterol detection","volume":"2","author":"Jiang","year":"2018","journal-title":"Small Methods"},{"key":"10.1016\/j.saa.2025.125700_b0155","article-title":"Roughened silver microtubes for reproducible and quantitative SERS using a template-assisted electrosynthesis approach","volume":"20","author":"Perales-Rondon","year":"2020","journal-title":"Appl. Mater. Today"},{"key":"10.1016\/j.saa.2025.125700_b0160","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202103287","article-title":"Raman molecular fingerprints of SARS\u2010CoV\u20102 British variant and the concept of Raman barcode","volume":"9","author":"Pezzotti","year":"2022","journal-title":"Adv. Sci."},{"key":"10.1016\/j.saa.2025.125700_b0165","doi-asserted-by":"crossref","first-page":"8840","DOI":"10.1021\/acs.est.6b00998","article-title":"Mechanistic study of the synergistic antibacterial activity of combined silver nanoparticles and common antibiotics","volume":"50","author":"Deng","year":"2016","journal-title":"Environ. Sci. Technol."},{"key":"10.1016\/j.saa.2025.125700_b0170","doi-asserted-by":"crossref","DOI":"10.3390\/cryst10050349","article-title":"A comprehensive study of a new 1.75 hydrate of ciprofloxacin salicylate: SCXRD structure determination, solid characterization, water stability, solubility, and dissolution study","volume":"10","author":"Nugrahani","year":"2020","journal-title":"Crystals"},{"key":"10.1016\/j.saa.2025.125700_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2020.104766","article-title":"Raman and ATR FT-IR investigations of innovative silica nanocontainers loaded with a biocide for stone conservation treatments","volume":"155","author":"Ruggiero","year":"2020","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2025.125700_b0180","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.reactfunctpolym.2018.01.002","article-title":"Block copolymer mediated generation of bimetallic Ni-Pd nanoparticles: Raman sensors of ethyl paraben and ciprofloxacin","volume":"124","author":"Ansari","year":"2018","journal-title":"React. Funct. Polym."},{"key":"10.1016\/j.saa.2025.125700_b0185","doi-asserted-by":"crossref","first-page":"2590","DOI":"10.1139\/v83-445","article-title":"Vibrations of the scissile C\u2014O bond in an acyl-chymotrypsin observed by resonance Raman spectroscopy","volume":"61","author":"Carey","year":"1983","journal-title":"Can. J. Chem."},{"key":"10.1016\/j.saa.2025.125700_b0190","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s12648-014-0468-8","article-title":"Vibrational spectra, electronic and quantum mechanical investigations on ciprofloxacin","volume":"88","author":"Rajalakshmi","year":"2014","journal-title":"Indian J. Phys."},{"key":"10.1016\/j.saa.2025.125700_b0195","doi-asserted-by":"crossref","DOI":"10.3390\/ijms231911736","article-title":"Raman metabolomics of Candida auris clades: profiling and barcode identification","volume":"23","author":"Pezzotti","year":"2022","journal-title":"Int. J. Mol. Sci."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252500006X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252500006X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:03:40Z","timestamp":1778612620000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138614252500006X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":39,"alternative-id":["S138614252500006X"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2025.125700","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Trace detection of antibiotics in wastewater using tunable core\u2013shell nanoparticles SERS substrate combined with machine learning algorithms","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2025.125700","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125700"}}