{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T15:22:36Z","timestamp":1778685756206,"version":"3.51.4"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012226","name":"Fundamental Research Funds for the Central Universities","doi-asserted-by":"publisher","award":["222201717003"],"award-info":[{"award-number":["222201717003"]}],"id":[{"id":"10.13039\/501100012226","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22176058"],"award-info":[{"award-number":["22176058"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012176","name":"Project 211","doi-asserted-by":"publisher","award":["B16017"],"award-info":[{"award-number":["B16017"]}],"id":[{"id":"10.13039\/501100012176","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1416100"],"award-info":[{"award-number":["23ZR1416100"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["22ZR1416800"],"award-info":[{"award-number":["22ZR1416800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005356","name":"Zhejiang Shuren University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005356","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.saa.2025.125899","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T13:09:06Z","timestamp":1739884146000},"page":"125899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["A dual-reactivity-based surface-enhanced Raman spectroscopy nanosensor for the simultaneous imaging of hypochlorite and nitric oxide in living cells"],"prefix":"10.1016","volume":"334","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8894-9509","authenticated-orcid":false,"given":"Hua-Ying","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kai","family":"Ge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7533-0686","authenticated-orcid":false,"given":"Bin-Bin","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da-Wei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2025.125899_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhazmat.2020.122029","article-title":"Ratiometric and colorimetric fluorescent probe for hypochlorite monitor and application for bioimaging in living cells, bacteria and zebrafish","volume":"388","author":"He","year":"2020","journal-title":"J. Hazard. Mater.,"},{"key":"10.1016\/j.saa.2025.125899_b0010","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0009-2797(02)00003-0","article-title":"Cytotoxicity mechanisms of sodium hypochlorite in cultured human dermal fibroblasts and its bactericidal effectiveness","volume":"139","author":"Hidalgo","year":"2002","journal-title":"Chem. Biol. Interact."},{"key":"10.1016\/j.saa.2025.125899_b0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s00726-003-0016-x","article-title":"Hypochlorite-induced oxidation of amino acids, peptides and proteins","volume":"25","author":"Hawkins","year":"2003","journal-title":"Amino Acids"},{"key":"10.1016\/j.saa.2025.125899_b0020","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1021\/tx010071r","article-title":"Hypochlorite-induced damage to nucleosides formation of chloramines and nitrogen-centered radicals","volume":"14","author":"Hawkins","year":"2001","journal-title":"Chem. Res. Toxicol."},{"key":"10.1016\/j.saa.2025.125899_b0025","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.snb.2018.08.088","article-title":"Surface-enhanced Raman scattering nanoprobes for the simultaneous detection of endogenous hypochlorous acid and peroxynitrite in living cells","volume":"277","author":"Li","year":"2018","journal-title":"Sensor Actuat. B-Chem."},{"key":"10.1016\/j.saa.2025.125899_b0030","doi-asserted-by":"crossref","first-page":"9408","DOI":"10.1021\/acs.analchem.4c00270","article-title":"Dual-emissive detection of ATP and hypochlorite ions for monitoring inflammation-driven liver injury in vitro and in vivo","volume":"96","author":"Fortibui","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125899_b0035","doi-asserted-by":"crossref","unstructured":"H.Y. Chen, E. Kouadio Fodjo, L. Jiang, S. Chang, J.B. Li, D.S. Zhan, H.X. Gu, D.W. Li, Simultaneous detection of intracellular nitric oxide and peroxynitrite by a surface-enhanced Raman scattering nanosensor with dual reactivity, ACS Sens., 4 (2019) 3234-3239.","DOI":"10.1021\/acssensors.9b01740"},{"key":"10.1016\/j.saa.2025.125899_b0040","doi-asserted-by":"crossref","first-page":"7763","DOI":"10.1021\/acs.analchem.4c01516","article-title":"Hemin as a molecular probe for nitric oxide detection in physiological solutions: Experimental and theoretical assessment","volume":"96","author":"Alsharabasy","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125899_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136636","article-title":"A multi-functional core-shell surface-enhanced Raman scattering nanosensor for simultaneous imaging of epidermal growth factor receptor on cell membranes and ROS secreted from living cells","volume":"422","author":"Chen","year":"2025","journal-title":"Sensor Actuat. B-Chem."},{"key":"10.1016\/j.saa.2025.125899_b0050","doi-asserted-by":"crossref","first-page":"16964","DOI":"10.1021\/acs.analchem.4c04201","article-title":"Activatable near-infrared fluorescence probe for hypochlorous acid detection in early diagnosis of keloids","volume":"96","author":"Yuan","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125899_b0055","doi-asserted-by":"crossref","first-page":"13055","DOI":"10.1021\/jacs.7b06476","article-title":"Direct electrochemical measurements of reactive oxygen and nitrogen species in nontransformed and metastatic human breast cells","volume":"139","author":"Li","year":"2017","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2025.125899_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2021.113052","article-title":"Recent advances of electrochemical sensors for detecting and monitoring ROS\/RNS","volume":"179","author":"Zhao","year":"2021","journal-title":"Biosens.bioelectron."},{"key":"10.1016\/j.saa.2025.125899_b0065","doi-asserted-by":"crossref","first-page":"13263","DOI":"10.1039\/C6NR01257D","article-title":"3D multiplexed immunoplasmonics microscopy","volume":"8","author":"Bergeron","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2025.125899_b0070","doi-asserted-by":"crossref","first-page":"6818","DOI":"10.7150\/thno.100298","article-title":"Real-time monitoring of single dendritic cell maturation using deep learning-assisted surface-enhanced Raman spectroscopy","volume":"14","author":"Zhang","year":"2024","journal-title":"Theranostics"},{"key":"10.1016\/j.saa.2025.125899_b0075","doi-asserted-by":"crossref","first-page":"5331","DOI":"10.1021\/acs.analchem.4c00395","article-title":"Simultaneous SERS sensing of cysteine and homocysteine in blood based on the CBT-cys click reaction: Toward precisive diagnosis of schizophrenia","volume":"96","author":"Zhang","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125899_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114194","article-title":"In situ ratiometric SERS imaging of intracellular protease activity for subtype discrimination of human breast cancer","volume":"207","author":"Zhong","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2025.125899_b0085","doi-asserted-by":"crossref","first-page":"14000","DOI":"10.1021\/acsnano.4c02670","article-title":"Surface-enhanced Raman spectroscopy: current understanding, challenges, and opportunities","volume":"18","author":"Ma","year":"2024","journal-title":"ACS Nano"},{"key":"10.1016\/j.saa.2025.125899_b0090","doi-asserted-by":"crossref","first-page":"7769","DOI":"10.1021\/jacs.1c02169","article-title":"General surface-enhanced Raman spectroscopy method for actively capturing target molecules in small gaps","volume":"143","author":"Ge","year":"2021","journal-title":"J. Am. Chem. Soc"},{"key":"10.1016\/j.saa.2025.125899_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.123983","article-title":"A stable and sensitive 2D SERS sensor for bioanalytical applications","volume":"311","author":"Pannico","year":"2024","journal-title":"Spectrochim. Acta A."},{"key":"10.1016\/j.saa.2025.125899_b0100","doi-asserted-by":"crossref","first-page":"2072","DOI":"10.1021\/acs.accounts.3c00207","article-title":"SERS as a probe of surface chemistry enabled by surface-accessible plasmonic nanomaterials","volume":"56","author":"Xu","year":"2023","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.saa.2025.125899_b0105","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s40580-018-0143-4","article-title":"Nanostructured surfaces for analysis of anticancer drug and cell diagnosis based on electrochemical and SERS tools","volume":"5","author":"El-Said","year":"2018","journal-title":"Nano Converg."},{"key":"10.1016\/j.saa.2025.125899_b0110","doi-asserted-by":"crossref","first-page":"17365","DOI":"10.1039\/C6NR05504D","article-title":"An ultrasensitive SERS sensor for simultaneous detection of multiple cancer-related miRNAs","volume":"8","author":"Song","year":"2016","journal-title":"Nanoscale"},{"key":"10.1016\/j.saa.2025.125899_b0115","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1021\/acssensors.1c00395","article-title":"Single-cell oxidative stress events revealed by a renewable SERS nanotip","volume":"6","author":"Chen","year":"2021","journal-title":"ACS Sens."},{"key":"10.1016\/j.saa.2025.125899_b0120","doi-asserted-by":"crossref","first-page":"11214","DOI":"10.1002\/anie.201204438","article-title":"SERS detection of small inorganic molecules and ions","volume":"51","author":"Alvarez-Puebla","year":"2012","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.125899_b0125","doi-asserted-by":"crossref","first-page":"12758","DOI":"10.1002\/anie.201505025","article-title":"Monitoring of endogenous hydrogen sulfide in living cells using surface-enhanced Raman scattering","volume":"54","author":"Li","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.125899_b0130","doi-asserted-by":"crossref","first-page":"21351","DOI":"10.1002\/anie.202106193","article-title":"Real-time tracking and sensing of Cu(+) and Cu(2+) with a single SERS probe in the live brain: toward understanding why copper ions were increased upon ischemia","volume":"60","author":"Liu","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.125899_b0135","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/ppsc.201600188","article-title":"High-yield production of uniform gold nanoparticles with sizes from 31 to 577 nm via one-pot seeded growth and size-dependent SERS property","volume":"33","author":"Zhang","year":"2016","journal-title":"Part. Part. Syst. Char."},{"key":"10.1016\/j.saa.2025.125899_b0140","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.bios.2016.04.094","article-title":"SERS nanoprobes for the monitoring of endogenous nitric oxide in living cells","volume":"85","author":"Cui","year":"2016","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2025.125899_b0145","doi-asserted-by":"crossref","first-page":"1567","DOI":"10.1002\/anie.201711188","article-title":"N-heterocyclic carbene boranes as reactive oxygen species-responsive materials: application to the two-photon imaging of hypochlorous acid in living cells and tissues","volume":"57","author":"Pak","year":"2018","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.125899_b0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.ihj.2024.01.017","article-title":"Endothelial nitric oxide synthase (eNOS) gene polymorphism (Glu298asp) and nitric oxide (NO) levels in patients with ST-segment elevation myocardial infarction (STEMI)","volume":"76","author":"Gupta","year":"2024","journal-title":"Indian Heart J."},{"key":"10.1016\/j.saa.2025.125899_b0155","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1021\/acs.analchem.3c04513","article-title":"Self-assembled activatable probes to monitor interactive dynamics of intracellular nitric oxide and hydrogen sulfide","volume":"96","author":"Dong","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.125899_b0160","doi-asserted-by":"crossref","first-page":"9435","DOI":"10.1039\/D4TB01227E","article-title":"Endocytosis: the match point of nanoparticle-based cancer therapy","volume":"12","author":"Li","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2025.125899_b0165","doi-asserted-by":"crossref","unstructured":"G. Bauer, Iron-catalyzed antagonism between NO and H2O2\/HOCl causes mutual exclusivity of HOCl- and NO\/peroxynitrite-mediated apoptosis-inducing signaling, bioRxiv, (2022), doi: 10.1101\/2022.07.03.498603.","DOI":"10.1101\/2022.07.03.498603"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525002057?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525002057?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T19:03:28Z","timestamp":1778612608000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142525002057"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":33,"alternative-id":["S1386142525002057"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2025.125899","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual-reactivity-based surface-enhanced Raman spectroscopy nanosensor for the simultaneous imaging of hypochlorite and nitric oxide in living cells","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2025.125899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"125899"}}