{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:11:46Z","timestamp":1787166706624,"version":"build-2736575974"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100004773","name":"Henan University","doi-asserted-by":"publisher","award":["24IRTSTHN003"],"award-info":[{"award-number":["24IRTSTHN003"]}],"id":[{"id":"10.13039\/501100004773","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21505091"],"award-info":[{"award-number":["21505091"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22474072"],"award-info":[{"award-number":["22474072"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.saa.2025.126325","type":"journal-article","created":{"date-parts":[[2025,5,3]],"date-time":"2025-05-03T18:52:09Z","timestamp":1746298329000},"page":"126325","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Dual-ligand Zr-based metal\u2013organic framework for ratiometric fluorescence sensing and imaging of copper ion in biological system"],"prefix":"10.1016","volume":"340","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5800-2709","authenticated-orcid":false,"given":"Xiuhua","family":"Wei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxian","family":"Feng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanli","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuixia","family":"Ling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanqiang","family":"Hao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maotian","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2025.126325_b0005","doi-asserted-by":"crossref","first-page":"2132","DOI":"10.1002\/etc.4166","article-title":"The presence of algae mitigates the toxicity of copper-based algaecides to a nontarget organism","volume":"37","author":"Bishop","year":"2018","journal-title":"Environ. Toxicol. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0010","doi-asserted-by":"crossref","first-page":"4400","DOI":"10.1039\/C4CS00346B","article-title":"Synthetic fluorescent probes for studying copper in biological systems","volume":"44","author":"Cotruvo","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2025.126325_b0015","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1021\/acs.analchem.0c05469","article-title":"Electroanalytical sensor based on gold-nanoparticle-decorated paper for sensitive detection of copper ions in sweat and serum","volume":"93","author":"Bagheri","year":"2021","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0020","doi-asserted-by":"crossref","first-page":"103076","DOI":"10.1016\/j.redox.2024.103076","article-title":"Constructing \u201csmart\u201d chelators by using an activatable prochelator strategy for the treatment of Wilson\u2019s disease","volume":"70","author":"Wang","year":"2024","journal-title":"Redox Biol."},{"key":"10.1016\/j.saa.2025.126325_b0025","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3390\/biomedicines9040391","article-title":"ATP7A-regulated enzyme metalation and trafficking in the menkes disease puzzle","volume":"9","author":"Horn","year":"2021","journal-title":"Biomedicines."},{"key":"10.1016\/j.saa.2025.126325_b0030","doi-asserted-by":"crossref","first-page":"121745","DOI":"10.1016\/j.talanta.2020.121745","article-title":"Fluorescence switch of gold nanoclusters stabilized with bovine serum albumin for efficient and sensitive detection of cysteine and copper ion in mice with Alzheimer\u2019s disease","volume":"223","author":"Niu","year":"2021","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2025.126325_b0035","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1039\/D1RA07482B","article-title":"Magnetic nanoprobes for rapid detection of copper ion in aqueous environment by surface-enhanced Raman spectroscopy","volume":"12","author":"Hsieha","year":"2022","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2025.126325_b0040","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.jtemb.2017.11.005","article-title":"Copper dyshomeostasis in Wilson disease and Alzheimer\u2019s disease as shown by serum and urine copper indicators","volume":"45","author":"Squitti","year":"2018","journal-title":"J. Trace Elem. Med. Biol."},{"key":"10.1016\/j.saa.2025.126325_b0045","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/app10238722","article-title":"Multi-element determination of toxic and nutrient elements by ICP-AES after dispersive solid-phase extraction with modified graphene oxide","volume":"10","author":"Manousi","year":"2020","journal-title":"Appl. Sci."},{"key":"10.1016\/j.saa.2025.126325_b0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2020.07.009","article-title":"Preparation and in vitro activity of single chain antibodies against Alzheimer\u2019s disease","volume":"227","author":"Fu","year":"2020","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.saa.2025.126325_b0055","doi-asserted-by":"crossref","first-page":"122229","DOI":"10.1016\/j.saa.2022.122229","article-title":"Colorimetric detection of Cu2+ based on the inhibition strategy for etching reaction of AgNCs","volume":"289","author":"Wang","year":"2023","journal-title":"Spectrochim. Acta - Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2025.126325_b0060","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.snb.2019.04.060","article-title":"4-mercaptobenzoic acid modified silver nanoparticles-enhanced electrochemical sensor for highly sensitive detection of Cu2+","volume":"291","author":"Zhou","year":"2019","journal-title":"Sens. Actuat., B Chem."},{"key":"10.1016\/j.saa.2025.126325_b0065","doi-asserted-by":"crossref","first-page":"123698","DOI":"10.1016\/j.jhazmat.2020.123698","article-title":"Selective dual detection of H2S and Cu2+ by a post-modified MOF sensor following a tandem process","volume":"403","author":"Yang","year":"2021","journal-title":"J. Hazard. Mater."},{"key":"10.1016\/j.saa.2025.126325_b0070","doi-asserted-by":"crossref","first-page":"6698","DOI":"10.1021\/acs.chemmater.6b03030","article-title":"Porphyrinic metal-organic framework catalyzed heck-reaction: fluorescence \u201cturn-on\u201d sensing of Cu(II) Ion","volume":"28","author":"Chen","year":"2016","journal-title":"Chem. Mater."},{"key":"10.1016\/j.saa.2025.126325_b0075","doi-asserted-by":"crossref","first-page":"9986","DOI":"10.1039\/C7CC04250G","article-title":"Rapid and specific luminescence sensing of Cu(II) ions with a porphyrinic metal-organic framework","volume":"53","author":"Li","year":"2017","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2025.126325_b0080","doi-asserted-by":"crossref","first-page":"339731","DOI":"10.1016\/j.aca.2022.339731","article-title":"Rational design of dual-ligand Eu-MOF for ratiometric fluorescence sensing Cu2+ ions in human serum to diagnose Wilson\u2019s disease","volume":"1204","author":"Xia","year":"2022","journal-title":"Anal. Chim. Acta."},{"key":"10.1016\/j.saa.2025.126325_b0085","doi-asserted-by":"crossref","first-page":"4331","DOI":"10.1021\/acs.analchem.8b03924","article-title":"Copper ion fluorescent probe based on Zr-MOFs composite material","volume":"91","author":"Chen","year":"2019","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0090","doi-asserted-by":"crossref","first-page":"12706","DOI":"10.1021\/acsami.9b21122","article-title":"In Situ synthesis of defect-engineered MOFs as a photoregenerable catalytic adsorbent: understanding the effect of LML, adsorption behavior, and photoreaction process","volume":"12","author":"Gao","year":"2020","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2025.126325_b0095","doi-asserted-by":"crossref","first-page":"24351","DOI":"10.1021\/acsami.2c03607","article-title":"Imparting multifunctionality in Zr-MOFs using the one-pot mixed-linker strategy: the effect of linker environment and enhanced pollutant removal","volume":"14","author":"Gao","year":"2022","journal-title":"ACS Appl. Mater. Interfaces."},{"key":"10.1016\/j.saa.2025.126325_b0100","doi-asserted-by":"crossref","first-page":"4068","DOI":"10.1021\/cm501859p","article-title":"Tuned to perfection: Ironing out the defects in metal-organic framework UiO-66","volume":"26","author":"Shearer","year":"2014","journal-title":"Chem. Mater."},{"key":"10.1016\/j.saa.2025.126325_b0105","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/ncomms5176","article-title":"Correlated defect nanoregions in a metal-organic framework","volume":"5","author":"Cliffe","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.saa.2025.126325_b0110","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1039\/C4CS00436A","article-title":"Fluorescent and colorimetric ion probes based on conjugated oligopyrroles","volume":"44","author":"Ding","year":"2015","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2025.126325_b0115","doi-asserted-by":"crossref","first-page":"8952","DOI":"10.1021\/acs.analchem.0c00925","article-title":"Evaluating hyperthyroidism-induced liver injury based on in situ fluorescence imaging of glutathione and phosphate via nano-MOFs sensor","volume":"92","author":"Zhang","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0120","doi-asserted-by":"crossref","first-page":"6471","DOI":"10.1002\/anie.201602274","article-title":"Communications metal \u2013 organic frameworks an in situ one-pot synthetic approach towards multivariate zirconium MOFs","volume":"541004","author":"Sun","year":"2016","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.126325_b0125","doi-asserted-by":"crossref","first-page":"124961","DOI":"10.1016\/j.talanta.2023.124961","article-title":"Talanta One master and two servants\u00a0: One Zr (IV) with two ligands of TCPP and NH2 -BDC form the MOF as the electrochemiluminescence emitter for the biosensing application","volume":"266","author":"Wang","year":"2024","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2025.126325_b0130","doi-asserted-by":"crossref","first-page":"106087","DOI":"10.1016\/j.jece.2021.106087","article-title":"UiO-66-based metal organic frameworks for the photodegradation of acetaminophen under simulated solar irradiation","volume":"9","author":"Wang","year":"2021","journal-title":"J. Environ. Chem. Eng."},{"key":"10.1016\/j.saa.2025.126325_b0135","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.cej.2018.09.084","article-title":"Robust photocatalytic reduction of Cr (VI) on UiO-66-NH 2 (Zr \/ Hf) metal- organic framework membrane under sunlight irradiation","volume":"356","author":"Du","year":"2019","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.saa.2025.126325_b0140","doi-asserted-by":"crossref","first-page":"14574","DOI":"10.1021\/acs.inorgchem.8b02240","article-title":"Selective and sensitive sensing of hydrogen peroxide by a boronic acid functionalized metal \u2212 organic framework and its application in live-cell imaging","volume":"57","author":"Banesh","year":"2018","journal-title":"Inorg. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0145","doi-asserted-by":"crossref","first-page":"10584","DOI":"10.1039\/D3DT01590D","article-title":"Xin, framework for ratiometric luminescence detection","author":"Wen","year":"2023","journal-title":"Dalt. Trans."},{"key":"10.1016\/j.saa.2025.126325_b0150","doi-asserted-by":"crossref","first-page":"13031","DOI":"10.1021\/acsomega.2c00416","volume":"7","author":"Asadevi","year":"2022","journal-title":"ACS Omega"},{"key":"10.1016\/j.saa.2025.126325_b0155","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1021\/acs.analchem.9b04900","article-title":"Selective sensing of copper ions by mesoporous porphyrinic metal \u2212 organic framework nanoovals","volume":"92","author":"Xu","year":"2020","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0160","doi-asserted-by":"crossref","first-page":"123367","DOI":"10.1016\/j.saa.2023.123367","article-title":"Eu-MOF based fluorescence probe for ratiometric and visualization detection of Cu2+","volume":"304","author":"Li","year":"2024","journal-title":"Spectrochim Acta Part A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2025.126325_b0165","doi-asserted-by":"crossref","first-page":"123539","DOI":"10.1016\/j.matchemphys.2020.123539","article-title":"Amine-functionalized titanium metal-organic framework (NH2 -MIL-125 (Ti)): A novel fluorescent sensor for the highly selective sensing of copper ions","volume":"254","author":"Kaur","year":"2020","journal-title":"Mater. Chem. Phys."},{"key":"10.1016\/j.saa.2025.126325_b0170","doi-asserted-by":"crossref","first-page":"101221","DOI":"10.1016\/j.coco.2022.101221","article-title":"A ratiometric fluorescent probe based on PCN-224 for rapid and ultrasensitive detection of copper ions","volume":"33","author":"Zhou","year":"2022","journal-title":"Compos. Commun."},{"key":"10.1016\/j.saa.2025.126325_b0175","doi-asserted-by":"crossref","first-page":"136226","DOI":"10.1016\/j.snb.2024.136226","article-title":"A dual-channel sensing platform for ATP and copper ions via the target-induced peroxidase mimics activity and fluorescence variations of iron oxide nanoparticles-modified metal-organic frameworks","volume":"418","author":"Liu","year":"2024","journal-title":"Sens. Actuat. B. Chem."},{"key":"10.1016\/j.saa.2025.126325_b0180","doi-asserted-by":"crossref","first-page":"3782","DOI":"10.1016\/j.cclet.2021.11.012","article-title":"A multifunctional upconversion nanoparticles probe for Cu2+ sensing and pattern recognition of biothiols","volume":"33","author":"Wang","year":"2022","journal-title":"Chinese Chem. Lett."},{"key":"10.1016\/j.saa.2025.126325_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.122876","article-title":"A two-photon iridium(III) complex probe for sensitive detection of SO2 derivatives in living cell mitochondria","volume":"299","author":"Xin","year":"2023","journal-title":"Spectrochim. Acta Part A"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525006316?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525006316?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T19:31:40Z","timestamp":1762543900000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142525006316"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":37,"alternative-id":["S1386142525006316"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2025.126325","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dual-ligand Zr-based metal\u2013organic framework for ratiometric fluorescence sensing and imaging of copper ion in biological system","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2025.126325","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126325"}}