{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T03:45:59Z","timestamp":1793159159175,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.saa.2025.126430","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:04:39Z","timestamp":1747652679000},"page":"126430","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"special_numbering":"C","title":["Near-infrared lipid droplet polarity fluorescent probe based on phenothiazine derivative for diagnosis of non-alcoholic fatty liver and tumors"],"prefix":"10.1016","volume":"341","author":[{"given":"Aobo","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiale","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yeming","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunfei","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2025.126430_b0005","doi-asserted-by":"crossref","first-page":"10706","DOI":"10.1021\/acsami.8b00278","article-title":"Interface-targeting strategy enables two-photon fluorescent lipid droplet probes for high-fidelity imaging of turbid tissues and detecting fatty liver","volume":"10","author":"Guo","year":"2018","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2025.126430_b0010","doi-asserted-by":"crossref","first-page":"4709","DOI":"10.1021\/acs.analchem.4c00292","article-title":"Solvatochromic buffering fluorescent probe resolves the lipid transport and morphological changes during lipid droplet fusion by super-resolution imaging","volume":"96","author":"Xu","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.126430_b0015","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3390\/bios12100851","article-title":"Viscosity-sensitive solvatochromic fluorescent probes for lipid droplets staining","volume":"12","author":"Wang","year":"2022","journal-title":"Biosensors"},{"key":"10.1016\/j.saa.2025.126430_b0020","doi-asserted-by":"crossref","first-page":"12908","DOI":"10.1021\/acs.analchem.4c03370","article-title":"3D imaging of lipid droplet-nuclear membrane contact sites and cirrhotic lipid droplet overexpression","volume":"96","author":"Ma","year":"2024","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2025.126430_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134347","article-title":"A near-infrared aggregation-induced emission probe for imaging lipid droplet and in vivo visualization of diabetes-related viscosity variations","volume":"394","author":"Wang","year":"2023","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2025.126430_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342748","article-title":"A fluorescence probe for imaging lipid droplet and visualization of diabetes-related polarity variations","volume":"1312","author":"Chen","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2025.126430_b0035","doi-asserted-by":"crossref","first-page":"5090","DOI":"10.1038\/s41377-022-00873-x","article-title":"High-fidelity carbon dots polarity probes: Revealing the heterogeneity of lipids in oncology","volume":"11","author":"Hu","year":"2022","journal-title":"Light Sci. Appl."},{"key":"10.1016\/j.saa.2025.126430_b0040","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1021\/acs.accounts.2c00586","article-title":"Fluorescent probes for lipid membranes: From the cell surface to organelles","volume":"56","author":"Klymchenko","year":"2022","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.saa.2025.126430_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136509","article-title":"Unveiling dynamic alterations of lipid droplet polarity during NAFLD-triggered lipophagy utilizing a far-red fluorescent probe with large Stokes shift","volume":"422","author":"Hu","year":"2025","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2025.126430_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.111236","article-title":"Near-infrared polarity fluorescent probe for wash-free imaging lipid droplets and the application in the diagnosis of non-alcoholic fatty liver tissue","volume":"205","author":"Wang","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2025.126430_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.342747","article-title":"Multifunctional lipid droplet probes for observing the polarity change of ferroptosis, inflammation, fatty liver and evaluating the efficacy of drugs","volume":"1312","author":"Yang","year":"2024","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2025.126430_b0060","doi-asserted-by":"crossref","first-page":"12098","DOI":"10.1039\/D1CS00645B","article-title":"Small molecule based fluorescent chemosensors for imaging the microenvironment within specific cellular regions","volume":"50","author":"Yin","year":"2021","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2025.126430_b0065","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1021\/acsami.6b01282","article-title":"Specific fluorescence probes for lipid droplets based on simple AIEgens","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2025.126430_b0070","doi-asserted-by":"crossref","first-page":"3285","DOI":"10.1039\/D3AN00551H","article-title":"A fluorescent probe for lipid droplet polarity imaging with low viscosity crosstalk","volume":"148","author":"Lin","year":"2023","journal-title":"Analyst"},{"key":"10.1016\/j.saa.2025.126430_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132267","article-title":"Quantification of lipid droplets polarity for evaluating non-alcoholic fatty liver disease via fluorescence lifetime imaging","volume":"369","author":"Lai","year":"2022","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2025.126430_b0080","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1083\/jcb.100.3.965","article-title":"Nile red: A selective fluorescent stain for intracellular lipid droplets","volume":"100","author":"Greenspan","year":"1985","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.saa.2025.126430_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134740","article-title":"A stable NIR fluorescent probe for imaging lipid droplets in triple-negative breast cancer","volume":"398","author":"Chen","year":"2024","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2025.126430_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2023.341181","article-title":"A multifunctionally reversible detector: Photoacoustic and dual-channel fluorescence sensing for SO2\/H2O2","volume":"1263","author":"Zhu","year":"2023","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2025.126430_b0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2019.117675","article-title":"Phenothiazine-based fluorescence probe for ratiometric imaging of hydrazine in living cells with remarkable Stokes shift","volume":"227","author":"Qiu","year":"2020","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2025.126430_b0100","doi-asserted-by":"crossref","first-page":"7767","DOI":"10.7150\/thno.59848","article-title":"Long-term live-cell lipid droplet-targeted biosensor development for nanoscopic tracking of lipid droplet-mitochondria contact sites","volume":"11","author":"Zhang","year":"2021","journal-title":"Theranostics."},{"key":"10.1016\/j.saa.2025.126430_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138202","article-title":"Synthesis of multi-stimuli-responsive solid-state red-emitting phenothiazine-based D-\u03c0-D-\u03c0-A' derivatives and their applications","volume":"1309","author":"Kumari","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2025.126430_b0110","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.synthmet.2010.10.036","article-title":"Synthesis and properties of phenothiazylene vinylene and bithiophene-based copolymers for organic thin film transistors","volume":"161","author":"Kim","year":"2011","journal-title":"Synth. Met."},{"key":"10.1016\/j.saa.2025.126430_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2021.109982","article-title":"Synthesis and evaluation of photophysical and electrochemical properties of vinyl chalcogenide derivatives of phenothiazines","volume":"198","author":"Dilelio","year":"2022","journal-title":"Dyes Pigm."},{"key":"10.1016\/j.saa.2025.126430_b0120","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.dyepig.2017.04.049","article-title":"3-phenothiazinyl propiolates - fluorescent electrophores by sonogashira coupling of ethyl propiolate","volume":"143","author":"G\u00f6tzinger","year":"2017","journal-title":"Dyes Pigm."},{"key":"10.1016\/j.saa.2025.126430_b0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2022.123370","article-title":"Pegylated near-infrared fluorescence probe for mitochondria-targetable hydrogen peroxide detection","volume":"243","author":"Zang","year":"2022","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2025.126430_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2020.121000","article-title":"A novel colorimetric and near-infrared fluorescence probe for detecting and imaging exogenous and endogenous hydrogen peroxide in living cells","volume":"217","author":"Han","year":"2020","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2025.126430_b0135","doi-asserted-by":"crossref","first-page":"2510","DOI":"10.1002\/anie.201410645","article-title":"Ratiometric fluorescence imaging of cellular polarity: decrease in mitochondrial polarity in cancer cells","volume":"54","author":"Jiang","year":"2015","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.126430_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2022.114618","article-title":"Polarity-sensitive and lipid droplet-specific red emission fluorophore for identifying fatty liver of living mice through in vivo imaging","volume":"216","author":"Hu","year":"2022","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2025.126430_b0145","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1021\/acsbiomaterials.3c00409","article-title":"Synthesis of a red-emitting polarity-sensitive fluorescent probe based on ICT and visualization for lipid droplet dynamic processes","volume":"9","author":"Pei","year":"2023","journal-title":"ACS Biomater Sci. Eng."},{"key":"10.1016\/j.saa.2025.126430_b0150","first-page":"5796","article-title":"Cytoplasmic endonuclease g promotes nonalcoholic fatty liver disease via mtorc2-akt-acly and endoplasmic reticulum stress","volume":"14","author":"Wang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.saa.2025.126430_b0155","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2024.138843","article-title":"Polarity-sensitive fluorescent probe based on coumarin derivatives for imaging lipid droplets and diagnosis of non-alcoholic fatty liver","volume":"1314","author":"Wang","year":"2024","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2025.126430_b0160","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.carbon.2022.10.078","article-title":"Facile synthesis of dual-labeling carbon dots for simultaneous visualization of lipid droplets and lysosomes","volume":"202","author":"Gao","year":"2023","journal-title":"Carbon"},{"key":"10.1016\/j.saa.2025.126430_b0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134825","article-title":"Harnessing polarity-dependent fluorescent probe for lipid droplet metabolism dissection and in vivo nonalcoholic fatty liver disease diagnosis","volume":"399","author":"Liu","year":"2024","journal-title":"Sens. Actuators B"},{"key":"10.1016\/j.saa.2025.126430_b0170","doi-asserted-by":"crossref","first-page":"16710","DOI":"10.1039\/D4NJ02986K","article-title":"A lipid droplet-targeted fluorescent probe for fluorescence imaging of cell and zebrafish viscosity","volume":"48","author":"Zheng","year":"2024","journal-title":"New J. Chem."},{"key":"10.1016\/j.saa.2025.126430_b0175","doi-asserted-by":"crossref","first-page":"4749","DOI":"10.1002\/bio.4749","article-title":"An efficient lipid droplet\u2010targeted fluorescent probe for detection of intracellular viscosity","volume":"39","author":"Yang","year":"2024","journal-title":"Luminescence"},{"key":"10.1016\/j.saa.2025.126430_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.124356","article-title":"Construction and evaluation of near-infrared fluorescent probes for imaging lipid droplet and lysosomal viscosity","volume":"316","author":"Li","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2025.126430_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2022.112589","article-title":"Imaging of lipid droplets using coumarin fluorophores in live cells and C. elegans","volume":"237","author":"Singh","year":"2022","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2025.126430_b0190","doi-asserted-by":"crossref","first-page":"15095","DOI":"10.1002\/anie.202104163","article-title":"A polarity\u2010sensitive ratiometric fluorescence probe for monitoring changes in lipid droplets and nucleus during ferroptosis","volume":"60","author":"Wang","year":"2021","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2025.126430_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.124304","article-title":"Two-photon imaging for visualizing polarity in lipid droplets during chemotherapy induced ferroptosis","volume":"256","author":"Zhai","year":"2023","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2025.126430_b0200","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/s00535-023-02054-y","article-title":"Induction of ferroptosis by photodynamic therapy and enhancement of antitumor effect with ferroptosis inducers","volume":"59","author":"Kojima","year":"2023","journal-title":"J. Gastroenterol."},{"key":"10.1016\/j.saa.2025.126430_b0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.110020","article-title":"Imaging polarity changes in pneumonia and lung cancer using a lipid droplet-targeted near-infrared fluorescent probe","volume":"35","author":"Zhang","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.saa.2025.126430_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.bioorg.2023.106800","article-title":"Lipid droplet-specific near-infrared fluorescent probe for discriminating cancer and normal cells and diagnosing fatty liver","volume":"140","author":"Zhang","year":"2023","journal-title":"Bioorg. Chem."},{"key":"10.1016\/j.saa.2025.126430_b0215","doi-asserted-by":"crossref","first-page":"3919","DOI":"10.1039\/D3TB00305A","article-title":"A red-emitting thiophene-modified bodipy probe for fluorescence lifetime-based polarity imaging of lipid droplets in living cells","volume":"11","author":"\u017dvirblis","year":"2023","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2025.126430_b0220","doi-asserted-by":"crossref","DOI":"10.1016\/j.cej.2023.145762","article-title":"Lipid droplet-targeting near-infrared carbon dots with high-specificity dual-report function for diagnosing hepatocellular carcinoma and evaluating its pharmacodynamics","volume":"474","author":"Wang","year":"2023","journal-title":"Chem. Eng. J."},{"key":"10.1016\/j.saa.2025.126430_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123588","article-title":"Isophorone-based AIEgens fluorescent probe with red emission for targeting lipid droplets and identifying non-alcoholic fatty liver disease","volume":"306","author":"Wang","year":"2024","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2025.126430_b0230","doi-asserted-by":"crossref","first-page":"532","DOI":"10.1007\/s00604-024-06613-9","article-title":"Lipid droplets-specific fluorescent probe for wash-free imaging and in vivo diagnosis of non-alcoholic fatty liver disease","volume":"191","author":"Wang","year":"2024","journal-title":"Microchim. Acta"},{"key":"10.1016\/j.saa.2025.126430_b0235","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.133343","article-title":"Multimode evaluating the fluctuation of lipid droplets polarity in acute kidney injury and tumor models","volume":"380","author":"Pu","year":"2023","journal-title":"Sens. Actuators B"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252500736X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252500736X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T01:35:25Z","timestamp":1761183325000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138614252500736X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":47,"alternative-id":["S138614252500736X"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2025.126430","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Near-infrared lipid droplet polarity fluorescent probe based on phenothiazine derivative for diagnosis of non-alcoholic fatty liver and tumors","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2025.126430","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126430"}}