{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T17:21:06Z","timestamp":1787851266684,"version":"build-2784847793"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.saa.2025.126661","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T16:16:15Z","timestamp":1752596175000},"page":"126661","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"P1","title":["Urine-based Raman markers for prostate cancer diagnosis: A machine learning approach using fingerprint and lipid spectral region"],"prefix":"10.1016","volume":"344","author":[{"given":"Przemys\u0142aw","family":"Mitura","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wies\u0142aw","family":"Paja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Grzegorz","family":"M\u0142ynarczyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rados\u0142aw","family":"Kowalski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Krzysztof","family":"Bar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanna","family":"Depciuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2024","key":"10.1016\/j.saa.2025.126661_bb0005","first-page":"229","article-title":"GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2022","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.saa.2025.126661_bb0010","doi-asserted-by":"crossref","first-page":"1807","DOI":"10.1177\/1557988318798279","article-title":"Global trends and prostate cancer: a review of incidence, detection, and mortality as influenced by race, ethnicity, and geographic location","volume":"12","author":"Taitt","year":"2018","journal-title":"Am. J. Mens Health"},{"key":"10.1016\/j.saa.2025.126661_bb0015","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1016\/j.eururo.2012.02.054","article-title":"International variation in prostate cancer incidence and mortality rates","volume":"61","author":"Center","year":"2012","journal-title":"Eur. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0020","doi-asserted-by":"crossref","first-page":"2795","DOI":"10.1002\/ijc.29408","article-title":"The high prevalence of undiagnosed prostate cancer at autopsy: implications for epidemiology and treatment of prostate cancer in the prostate-specific antygen-era","volume":"137","author":"Jahn","year":"2015","journal-title":"Int. J. Cancer"},{"issue":"2019","key":"10.1016\/j.saa.2025.126661_bb0025","first-page":"469","article-title":"Inverse stage migration patterns in North American patients undergoing local prostate cancer treatment: a contemporary population-based update in light of the 2012 USPSTF recommendations","volume":"37","author":"Leyh-Bannurah","year":"2012","journal-title":"World. J. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0030","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/JU.0000000000003492","article-title":"Early detection of prostate cancer: AUA\/SUO guideline part II: considerations for a prostate biopsy","volume":"210","author":"Wei","year":"2023","journal-title":"J. Urol."},{"issue":"2016","key":"10.1016\/j.saa.2025.126661_bb0035","first-page":"16","article-title":"PI-RADS prostate imaging \u2013 reporting and data system","volume":"69","author":"Weinreb","year":"2015","journal-title":"Version 2, Eur. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0040","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/ajcp\/aqaa130","article-title":"Gleason score evolution and the effect on prostate cancer outcomes","volume":"155","author":"Swanson","year":"2021","journal-title":"Am. J. Clin. Pathol."},{"key":"10.1016\/j.saa.2025.126661_bb0045","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.eururo.2015.06.046","article-title":"A contemporary prostate cancer grading system: a validated alternative to the Gleason score","volume":"69","author":"Epstein","year":"2015","journal-title":"Eur. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0050","first-page":"325","article-title":"From Gleason to International Society of Urological Pathology (ISUP) grading of prostate cancer, Scand","volume":"50","author":"Samaratunga","year":"2016","journal-title":"J. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.eururo.2024.03.027","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate cancer-2024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"86","author":"Cornford","year":"2024","journal-title":"Eur. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0060","doi-asserted-by":"crossref","first-page":"2054","DOI":"10.1001\/jama.2015.14905","article-title":"Prostate cancer incidence and PSA testing patterns in relations to USPSTF screening reccomendations","volume":"314","author":"Jemal","year":"2015","journal-title":"JAMA"},{"key":"10.1016\/j.saa.2025.126661_bb0065","doi-asserted-by":"crossref","first-page":"2185","DOI":"10.3390\/ijms24032185","article-title":"Biomarkers of aggressive prostate cancer at diagnosis","volume":"24","author":"Boehm","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2025.126661_bb0070","series-title":"StatPearls [Internet]","article-title":"SW. Prostate-Specific Antigen","author":"David","year":"2024"},{"issue":"24","key":"10.1016\/j.saa.2025.126661_bb0075","first-page":"02251","article-title":"EAU-EANM-ESTRO-ESUR-ISUP-SIOG guidelines on prostate Cancer\u20132024 update. Part I: screening, diagnosis, and local treatment with curative intent","volume":"S0302-2838","author":"Cornford","year":"2024","journal-title":"Eur. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0080","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1080\/14737140.2018.1502086","article-title":"The role of prostate cancer antigen 3 (PCA3) in prostate cancer detection","volume":"18","author":"Ploussard","year":"2018","journal-title":"Expert. Rev. Anticancer. Ther."},{"key":"10.1016\/j.saa.2025.126661_bb0085","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.eururo.2015.04.039","article-title":"Urine TMPRSS2:ERG plus PCA3 for individualized prostate Cancer risk assessment","volume":"70","author":"Tomlins","year":"2016","journal-title":"Eur. Urol."},{"key":"10.1016\/j.saa.2025.126661_bb0090","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.urolonc.2020.02.018","article-title":"Serum and urine biomarkers for detecting clinically significant prostate cancer","volume":"39","author":"Becerra","year":"2021","journal-title":"Urol. Oncol."},{"key":"10.1016\/j.saa.2025.126661_bb0095","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/j.annonc.2021.01.074","article-title":"Exosome-based liquid biopsies in cancer: opportunities and challenges","volume":"32","author":"Yu","year":"2021","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.saa.2025.126661_bb0100","doi-asserted-by":"crossref","first-page":"1051","DOI":"10.3390\/biomedicines11041051","article-title":"Urinary biomarkers and point-of-care urinalysis devices for early diagnosis and Management of Disease: a review","volume":"11","author":"Sequeira-Antunes","year":"2023","journal-title":"Biomedicines"},{"key":"10.1016\/j.saa.2025.126661_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.pdpdt.2025.104477","article-title":"Application of Raman spectroscopy in the non-invasive diagnosis of urological diseases via urine","volume":"52","author":"Ainiwaer","year":"2025","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.saa.2025.126661_bb0110","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1177\/0003702818791939","article-title":"Application of vibrational spectroscopy and imaging to point-of-care medicine: a review","volume":"72","author":"Pahlow","year":"2018","journal-title":"Appl. Spectrosc."},{"key":"10.1016\/j.saa.2025.126661_bb0115","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1080\/05704920701551530","article-title":"Raman spectroscopy of biological tissues","volume":"42","author":"Movasaghi","year":"2007","journal-title":"Appl. Spectrosc. Rev."},{"issue":"3","key":"10.1016\/j.saa.2025.126661_bb0120","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/jrs.1653","article-title":"Food additives characterization by infrared, Raman, and surface-enhanced Raman spectroscopies","volume":"38","author":"Podstawka","year":"2007","journal-title":"J. Raman Spectrosc."},{"issue":"3","key":"10.1016\/j.saa.2025.126661_bb0125","doi-asserted-by":"crossref","first-page":"386","DOI":"10.3390\/cells11030386","article-title":"Raman spectroscopy and its modifications applied to biological and medical research","volume":"11","author":"Allakhverdiev","year":"2022","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.saa.2025.126661_bb0130","doi-asserted-by":"crossref","first-page":"123","DOI":"10.3390\/cancers13010123","article-title":"In vitro spectroscopy-based profiling of urothelial carcinoma: a Fourier transform infrared and Raman imaging study","volume":"13","author":"Kujdowicz","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"10","key":"10.1016\/j.saa.2025.126661_bb0135","doi-asserted-by":"crossref","first-page":"500","DOI":"10.3390\/bioengineering9100500","article-title":"Biochemical analysis of urine samples from diabetic and hypertensive patients without renal dysfunction using spectrophotometry and Raman spectroscopy techniques aiming classification and diagnosis","volume":"9","author":"de Sousa Vieira","year":"2022","journal-title":"Bioengineering (Basel)"},{"key":"10.1016\/j.saa.2025.126661_bb0140","article-title":"Detection of prostate cancer by Raman spectroscopy: a multivariate study on patients with normal and altered PSA values","volume":"29","author":"Silveira","year":"2020","journal-title":"Photodiagn. Photodyn. Ther."},{"key":"10.1016\/j.saa.2025.126661_bb0145","doi-asserted-by":"crossref","first-page":"3271","DOI":"10.1007\/s00216-015-8610-9","article-title":"Surface-enhanced Raman spectroscopy of urine for prostate cancer detection: a preliminary study","volume":"407","author":"Stefancu","year":"2015","journal-title":"Anal. Bioanal. Chem."},{"key":"10.1016\/j.saa.2025.126661_bb0150","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1002\/jrs.5770","article-title":"Classifying Raman spectra of extracellular vesicles based on convolutional neural networks for prostate cancer detection","volume":"51","author":"Lee","year":"2020","journal-title":"J. Raman Spectrosc."},{"key":"10.1016\/j.saa.2025.126661_bb0155","first-page":"339","article-title":"Diagnosis of urogenital cancer combining deep learning algorithms and surface-enhanced Raman spectroscopy based on small extracellular vesicles","volume":"1205","author":"Chen","year":"2022","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2025.126661_bb0160","article-title":"Raman spectroscopy system for real-time diagnosis of clinically significant prostate cancer tissue","volume":"16","author":"Zhou","year":"2023","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.saa.2025.126661_bb0165","doi-asserted-by":"crossref","first-page":"574","DOI":"10.21037\/tau-20-924","article-title":"Diagnostic accuracy of Raman spectroscopy for prostate cancer: a systematic review and meta-analysis","volume":"10","author":"Park","year":"2021","journal-title":"Transl. Androl. Urol."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525009680?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525009680?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:14:14Z","timestamp":1769184854000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142525009680"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":33,"alternative-id":["S1386142525009680"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2025.126661","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urine-based Raman markers for prostate cancer diagnosis: A machine learning approach using fingerprint and lipid spectral region","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2025.126661","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126661"}}