{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:35:04Z","timestamp":1790962504949,"version":"4.1.0"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100013066","name":"Key Scientific Research Project of Colleges and Universities in Henan Province","doi-asserted-by":"publisher","award":["23A350001"],"award-info":[{"award-number":["23A350001"]}],"id":[{"id":"10.13039\/501100013066","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.saa.2025.126695","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T05:16:41Z","timestamp":1752643001000},"page":"126695","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"P1","title":["Oxidative stress-responsive fluorescent polymer nanoplatform regulate lipid metabolism through lipophagy"],"prefix":"10.1016","volume":"344","author":[{"given":"Qi","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziyi","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.saa.2025.126695_bb0005","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1038\/s41556-024-01364-4","article-title":"Lipid droplets and cellular lipid flux","volume":"26","author":"Mathiowetz","year":"2024","journal-title":"Nat. Cell Biol."},{"issue":"4","key":"10.1016\/j.saa.2025.126695_bb0010","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1016\/j.jhep.2021.11.009","article-title":"A new perspective on NAFLD: focusing on lipid droplets","volume":"76","author":"Scorletti","year":"2022","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.saa.2025.126695_bb0015","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1038\/s41574-023-00845-0","article-title":"Lipid droplet biogenesis and functions in health and disease","volume":"19","author":"Zadoorian","year":"2023","journal-title":"Nat. Rev. Endocrinol."},{"issue":"6","key":"10.1016\/j.saa.2025.126695_bb0020","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1038\/nrgastro.2017.32","article-title":"Lipid droplets and liver disease: from basic biology to clinical implications","volume":"14","author":"Gluchowski","year":"2017","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.saa.2025.126695_bb0025","article-title":"Oxidative stress is a key modulator in the development of nonalcoholic fatty liver disease","volume":"11","author":"Ma","year":"2021","journal-title":"Antioxidants (Basel)"},{"issue":"2","key":"10.1016\/j.saa.2025.126695_bb0030","first-page":"91","article-title":"Lipid droplets in steatotic liver disease","volume":"27","author":"Bilson","year":"2023","journal-title":"Curr. Opin. Clin. Nutr. Metab. Care"},{"issue":"4","key":"10.1016\/j.saa.2025.126695_bb0035","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1021\/acssensors.1c02679","article-title":"Highly sensitive two-photon lipid droplet tracker for in vivo screening of drug induced liver injury","volume":"7","author":"Lee","year":"2022","journal-title":"ACS Sensors"},{"issue":"1","key":"10.1016\/j.saa.2025.126695_bb0040","doi-asserted-by":"crossref","DOI":"10.1186\/s12986-023-00748-x","article-title":"Pharmacotherapies of NAFLD: updated opportunities based on metabolic intervention","volume":"20","author":"Shao","year":"2023","journal-title":"Nutr. Metab."},{"issue":"2","key":"10.1016\/j.saa.2025.126695_bb0045","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.jhep.2023.10.042","article-title":"Pharmacologic inhibition of lipogenesis for the treatment of NAFLD","volume":"80","author":"Esler","year":"2024","journal-title":"J. Hepatol."},{"issue":"8","key":"10.1016\/j.saa.2025.126695_bb0050","doi-asserted-by":"crossref","first-page":"2462","DOI":"10.1016\/j.jmb.2019.10.028","article-title":"Autophagosome-lysosome fusion","volume":"432","author":"L\u0151rincz","year":"2020","journal-title":"J. Mol. Biol."},{"key":"10.1016\/j.saa.2025.126695_bb0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2020.00850","article-title":"Lipophagy impairment is associated with disease progression in NAFLD","volume":"11","author":"Carotti","year":"2020","journal-title":"Front. Physiol."},{"issue":"19","key":"10.1016\/j.saa.2025.126695_bb0060","doi-asserted-by":"crossref","first-page":"10186","DOI":"10.1039\/D2FO01682F","article-title":"Nobiletin mitigates NAFLD via lipophagy and inflammation","volume":"13","author":"Yang","year":"2022","journal-title":"Food Funct."},{"key":"10.1016\/j.saa.2025.126695_bb0065","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2020.601627","article-title":"The role of Lipophagy in the development and treatment of non-alcoholic fatty liver disease","volume":"11","author":"Grefhorst","year":"2021","journal-title":"Front. Endocrinol."},{"issue":"1","key":"10.1016\/j.saa.2025.126695_bb0070","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-30977-7","article-title":"AMPK contributes to autophagosome maturation and lysosomal fusion","volume":"8","author":"Jang","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2025.126695_bb0075","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2022.1015500","article-title":"Role of AMPK in autophagy","volume":"13","author":"Wang","year":"2022","journal-title":"Front. Physiol."},{"issue":"2","key":"10.1016\/j.saa.2025.126695_bb0080","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.jpha.2023.09.001","article-title":"The potential of herbal drugs to treat heart failure: the roles of Sirt1\/AMPK","volume":"14","author":"Zhang","year":"2024","journal-title":"J. Pharm. Anal."},{"issue":"4","key":"10.1016\/j.saa.2025.126695_bb0085","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00745.2009","article-title":"AMPK and SIRT1: a long-standing partnership?","volume":"298","author":"Ruderman","year":"2010","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.saa.2025.126695_bb0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.jff.2021.104686","article-title":"Arjunolic acid from Cyclocarya paliurus ameliorates nonalcoholic fatty liver disease in mice via activating Sirt1\/AMPK, triggering autophagy and improving gut barrier function","volume":"86","author":"Zheng","year":"2021","journal-title":"J. Funct. Foods"},{"key":"10.1016\/j.saa.2025.126695_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114319","article-title":"Protopanaxadiol ameliorates NAFLD by regulating hepatocyte lipid metabolism through AMPK\/SIRT1 signaling pathway","volume":"160","author":"Li","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.saa.2025.126695_bb0100","doi-asserted-by":"crossref","first-page":"3047","DOI":"10.2147\/DDDT.S417378","article-title":"Si-Ni-san reduces hepatic lipid deposition in rats with metabolic associated fatty liver disease by AMPK\/SIRT1 pathway","volume":"17","author":"Zhang","year":"2023","journal-title":"Drug Des. Devel. Ther."},{"issue":"1","key":"10.1016\/j.saa.2025.126695_bb0105","doi-asserted-by":"crossref","DOI":"10.1186\/s12906-022-03697-9","article-title":"Salvia-Nelumbinis naturalis improves lipid metabolism of NAFLD by regulating the SIRT1\/AMPK signaling pathway","volume":"22","author":"Liu","year":"2022","journal-title":"BMC Complement. Altern. Med."},{"issue":"1","key":"10.1016\/j.saa.2025.126695_bb0110","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-16119-0","article-title":"Therapeutic effects of isosteviol sodium on non-alcoholic fatty liver disease by regulating autophagy via Sirt1\/AMPK pathway","volume":"12","author":"Mei","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2025.126695_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119314","article-title":"Exercise improves lipid droplet metabolism disorder through activation of AMPK-mediated lipophagy in NAFLD","volume":"273","author":"Li","year":"2021","journal-title":"Life Sci."},{"issue":"2","key":"10.1016\/j.saa.2025.126695_bb0120","doi-asserted-by":"crossref","DOI":"10.3892\/mmr.2022.12922","article-title":"Role of the AMPK\/SIRT1 pathway in non-alcoholic fatty liver disease (review)","volume":"27","author":"Anggreini","year":"2022","journal-title":"Mol. Med. Rep."},{"issue":"6","key":"10.1016\/j.saa.2025.126695_bb0125","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2023.108912","article-title":"A lipid droplets-targetable fluorescent probe for polarity detection in cells of iron death, inflammation and fatty liver tissue","volume":"35","author":"Tian","year":"2024","journal-title":"Chin. Chem. Lett."},{"issue":"22","key":"10.1016\/j.saa.2025.126695_bb0130","doi-asserted-by":"crossref","first-page":"8019","DOI":"10.1021\/acs.analchem.1c01125","article-title":"Lipid droplet-specific fluorescent probe for in vivo visualization of polarity in fatty liver, inflammation, and Cancer models","volume":"93","author":"Fan","year":"2021","journal-title":"Anal. Chem."},{"issue":"16","key":"10.1016\/j.saa.2025.126695_bb0135","doi-asserted-by":"crossref","first-page":"10193","DOI":"10.1021\/acsami.6b01282","article-title":"Specific fluorescence probes for lipid droplets based on simple AIEgens","volume":"8","author":"Wang","year":"2016","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"10.1016\/j.saa.2025.126695_bb0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2024.343442","article-title":"An activatable \u201cAIE + ESIPT\u201d fluorescent probe for dual imaging of lipid droplets and hydrogen peroxide in drug-induced liver injury model","volume":"1335","author":"Liao","year":"2025","journal-title":"Anal. Chim. Acta"},{"issue":"5","key":"10.1016\/j.saa.2025.126695_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/antiox11050961","article-title":"18\u03b2-Glycyrrhetinic acid protects against Cholestatic liver injury in bile duct-ligated rats","volume":"11","author":"Pan","year":"2022","journal-title":"Antioxidants"},{"issue":"1","key":"10.1016\/j.saa.2025.126695_bb0150","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41401-020-0383-9","article-title":"Research progress on the protective effects of licorice-derived 18\u03b2-glycyrrhetinic acid against liver injury","volume":"42","author":"Wu","year":"2020","journal-title":"Acta Pharmacol. Sin."},{"issue":"6","key":"10.1016\/j.saa.2025.126695_bb0155","first-page":"1154","article-title":"Recent advances in the pharmacological activities of glycyrrhizin, Glycyrrhetinic acid, and their analogs","volume":"33","author":"Mittal","year":"2023","journal-title":"Rev. Bras"},{"key":"10.1016\/j.saa.2025.126695_bb0160","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.procbio.2023.10.005","article-title":"Derivatives of glycyrrhetinic acid with amino acid: modifications, structural characterization, hypoglycemic activity and mechanism","volume":"134","author":"Wang","year":"2023","journal-title":"Process Biochem."},{"key":"10.1016\/j.saa.2025.126695_bb0165","article-title":"Glycyrrhetinic acid regulates impaired macrophage autophagic flux in the treatment of non-alcoholic fatty liver disease","volume":"13","author":"Fan","year":"2022","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.saa.2025.126695_bb0180","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1080\/15548627.2018.1474314","article-title":"Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusion","volume":"14","author":"Mauthe","year":"2018","journal-title":"Autophagy"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525010029?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142525010029?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,1,23]],"date-time":"2026-01-23T16:14:03Z","timestamp":1769184843000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142525010029"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":34,"alternative-id":["S1386142525010029"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2025.126695","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Oxidative stress-responsive fluorescent polymer nanoplatform regulate lipid metabolism through lipophagy","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2025.126695","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"126695"}}