{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T10:44:04Z","timestamp":1777891444829,"version":"3.51.4"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.saa.2026.127686","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T17:06:18Z","timestamp":1773335178000},"page":"127686","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["FTIR spectroscopy of peripheral blood mononuclear cells and machine learning: Spectral biomarkers for bacteremia, focal bacterial, and viral infections"],"prefix":"10.1016","volume":"356","author":[{"given":"Uraib","family":"Sharaha","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yotam D.","family":"Eshel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dima","family":"Bykhovsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mishel","family":"Chernyak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahdi","family":"Asleh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hagit","family":"Miskin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itshak","family":"Lapidot","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaul","family":"Mordechai","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseph","family":"Kapelushnik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Salman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"10369","key":"10.1016\/j.saa.2026.127686_bb0005","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global mortality associated with 33 bacterial pathogens in 2019: a systematic analysis for the global burden of disease study 2019","volume":"400","year":"2022","journal-title":"Lancet"},{"issue":"10459","key":"10.1016\/j.saa.2026.127686_bb0010","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990\u20132021: a systematic analysis with forecasts to 2050","volume":"404","author":"Naghavi","year":"2024","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0015","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/jac\/dkq494","article-title":"Bacteraemia due to multidrug-resistant gram-negative bacilli in cancer patients: risk factors, antibiotic therapy and outcomes","volume":"66","author":"Gudiol","year":"2010","journal-title":"J. Antimicrob. Chemother."},{"issue":"12","key":"10.1016\/j.saa.2026.127686_bb0020","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.3324\/haematol.2013.091025","article-title":"European guidelines for empirical antibacterial therapy for febrile neutropenic patients in the era of growing resistance: summary of the 2011 4th European conference on infections in Leukemia","volume":"98","author":"Averbuch","year":"2013","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0025","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1089\/sur.2015.099","article-title":"Beyond blood culture and gram stain analysis: a review of molecular techniques for the early detection of Bacteremia in surgical patients","volume":"17","author":"Scerbo","year":"2016","journal-title":"Surg. Infect. (Larchmt.)"},{"key":"10.1016\/j.saa.2026.127686_bb0030","unstructured":"D.M. Wolk, J.S. Parrott, N.E. Babady, A.B. Mochon, R. Tom, C. Diel, J.D. Bard, A. Harrington, D.J. Hata, A.L. Roberts, L. Boyce, J.K. Johnson, The American Society for Microbiology's Evidence-based laboratory medicine practice guidelines for the diagnosis of bloodstream infections using rapid tests: a systematic review and meta-analysis, Clin. Microbiol. Rev. 0(0) e00137\u201324."},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0035","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1186\/s12879-022-07772-x","article-title":"Performance of BioFire blood culture identification 2 panel (BCID2) for the detection of bloodstream pathogens and their associated resistance markers: a systematic review and meta-analysis of diagnostic test accuracy studies","volume":"22","author":"Peri","year":"2022","journal-title":"BMC Infect. Dis."},{"issue":"7164","key":"10.1016\/j.saa.2026.127686_bb0040","doi-asserted-by":"crossref","first-page":"819","DOI":"10.1038\/nature06246","article-title":"Recognition of microorganisms and activation of the immune response","volume":"449","author":"Medzhitov","year":"2007","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.saa.2026.127686_bb0045","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.cell.2010.01.022","article-title":"Pattern recognition receptors and inflammation","volume":"140","author":"Takeuchi","year":"2010","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0050","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/nri3581","article-title":"Regulation of type I interferon responses","volume":"14","author":"Ivashkiv","year":"2014","journal-title":"Nat. Rev. Immunol."},{"issue":"7","key":"10.1016\/j.saa.2026.127686_bb0055","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1038\/nri.2017.36","article-title":"The immunopathology of sepsis and potential therapeutic targets","volume":"17","author":"van der Poll","year":"2017","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0060","doi-asserted-by":"crossref","first-page":"16045","DOI":"10.1038\/nrdp.2016.45","article-title":"Sepsis and septic shock","volume":"2","author":"Hotchkiss","year":"2016","journal-title":"Nat. Rev. Dis. Primers."},{"issue":"2","key":"10.1016\/j.saa.2026.127686_bb0065","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"4","key":"10.1016\/j.saa.2026.127686_bb0070","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1007\/s00424-024-02997-y","article-title":"Explainable artificial intelligence for spectroscopy data: a review","volume":"477","author":"Contreras","year":"2025","journal-title":"Pfl\u00fcgers Archiv-European Journal of Physiology"},{"issue":"8","key":"10.1016\/j.saa.2026.127686_bb0075","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/nprot.2014.110","article-title":"Using Fourier transform IR spectroscopy to analyze biological materials","volume":"9","author":"Baker","year":"2014","journal-title":"Nat. Protoc."},{"issue":"7","key":"10.1016\/j.saa.2026.127686_bb0080","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1039\/C5CS00585J","article-title":"Developing and understanding biofluid vibrational spectroscopy: a critical review","volume":"45","author":"Baker","year":"2016","journal-title":"Chem. Soc. Rev."},{"key":"10.1016\/j.saa.2026.127686_bb0085","first-page":"21","article-title":"IEEE 7th Portuguese meeting on bioengineering (ENBENG)","volume":"2023","author":"Ara\u00fajo","year":"2023","journal-title":"IEEE"},{"issue":"13","key":"10.1016\/j.saa.2026.127686_bb0090","doi-asserted-by":"crossref","first-page":"7888","DOI":"10.1021\/acs.analchem.8b00017","article-title":"Differential diagnosis of the Etiologies of bacterial and viral infections using infrared microscopy of peripheral human blood samples and multivariate analysis","volume":"90","author":"Agbaria","year":"2018","journal-title":"Anal. Chem."},{"issue":"25","key":"10.1016\/j.saa.2026.127686_bb0095","doi-asserted-by":"crossref","first-page":"13386","DOI":"10.1021\/acs.analchem.5c01728","article-title":"Augmentation of infrared microscopy of white blood cells and medical measures for rapid and accurate diagnosis of bacterial or viral infections in febrile Pediatric oncology patients: an expert system-based study","volume":"97","author":"Sharaha","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.127686_bb0100","series-title":"Seminars in Thrombosis and Hemostasis","first-page":"565","article-title":"Quality Standards for Sample Collection in Coagulation Testing","author":"Lippi","year":"2012"},{"issue":"8","key":"10.1016\/j.saa.2026.127686_bb0105","doi-asserted-by":"crossref","first-page":"1771","DOI":"10.1038\/nprot.2014.110","article-title":"Using Fourier transform IR spectroscopy to analyze biological materials","volume":"9","author":"Baker","year":"2014","journal-title":"Nat. Protoc."},{"issue":"21","key":"10.1016\/j.saa.2026.127686_bb0110","doi-asserted-by":"crossref","first-page":"6955","DOI":"10.1039\/D0AN00752H","article-title":"Diagnosis of inaccessible infections using infrared microscopy of white blood cells and machine learning algorithms","volume":"145","author":"Agbaria","year":"2020","journal-title":"Analyst"},{"issue":"2","key":"10.1016\/j.saa.2026.127686_bb0115","doi-asserted-by":"crossref","DOI":"10.1002\/jbio.201900215","article-title":"Rapid diagnosis of infection etiology in febrile pediatric oncology patients using infrared spectroscopy of leukocytes","volume":"13","author":"Agbaria","year":"2020","journal-title":"J. Biophotonics"},{"key":"10.1016\/j.saa.2026.127686_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2023.125619","article-title":"Monitoring the efficacy of antibiotic therapy in febrile pediatric oncology patients with bacteremia using infrared spectroscopy of white blood cells-based machine learning","volume":"270","author":"Eshel","year":"2024","journal-title":"Talanta"},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0125","doi-asserted-by":"crossref","DOI":"10.1117\/1.JBO.17.1.017002","article-title":"Identification of fungal phytopathogens using Fourier transform infrared-attenuated total reflection spectroscopy and advanced statistical methods","volume":"17","author":"Salman","year":"2012","journal-title":"J. Biomed. Opt."},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0130","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1118\/1.3298013","article-title":"Advanced statistical techniques applied to comprehensive FTIR spectra on human colonic tissues","volume":"37","author":"Zwielly","year":"2010","journal-title":"Med. Phys."},{"issue":"10","key":"10.1016\/j.saa.2026.127686_bb0135","doi-asserted-by":"crossref","first-page":"4259","DOI":"10.1021\/ac1006987","article-title":"Micro-Raman detection of nuclear membrane lipid fluctuations in senescent epithelial breast cancer cells","volume":"82","author":"Mariani","year":"2010","journal-title":"Anal. Chem."},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0140","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41598-017-18477-6","article-title":"Fourier transform infrared microscopy enables guidance of automated mass spectrometry imaging to predefined tissue morphologies","volume":"8","author":"Rabe","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2026.127686_bb0145","unstructured":"R.O. Duda, P.E. Hart, Pattern Classification, John Wiley & Sons2006."},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0150","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.1007\/s12652-020-02592-w","article-title":"A novel optimal feature selection technique for medical data classification using ANOVA based whale optimization","volume":"12","author":"Moorthy","year":"2021","journal-title":"J. Ambient. Intell. Humaniz. Comput."},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0155","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1016\/j.bbe.2022.06.007","article-title":"Diagnosis of Parkinson's disease based on SHAP value feature selection","volume":"42","author":"Liu","year":"2022","journal-title":"Biocybernetics and Biomedical Engineering"},{"issue":"7","key":"10.1016\/j.saa.2026.127686_bb0160","doi-asserted-by":"crossref","first-page":"10367","DOI":"10.1016\/j.eswa.2009.01.041","article-title":"A new feature selection method on classification of medical datasets: kernel F-score feature selection","volume":"36","author":"Polat","year":"2009","journal-title":"Expert Syst. Appl."},{"issue":"2","key":"10.1016\/j.saa.2026.127686_bb0165","doi-asserted-by":"crossref","first-page":"363","DOI":"10.12720\/jait.14.2.363-372","article-title":"Breast cancer classification using an extreme gradient boosting model with F-score feature selection technique","volume":"14","author":"Mathew","year":"2023","journal-title":"Journal of Advances in Information Technology"},{"key":"10.1016\/j.saa.2026.127686_bb0170","unstructured":"C.M. Bishop, N.M. Nasrabadi, Pattern Recognition and Machine Learning, Springer2006."},{"key":"10.1016\/j.saa.2026.127686_bb0175","unstructured":"P. Jeganathan, On the asymptotic theory of estimation when the limit of the log-likelihood ratios is mixed Normal, Sankhy\u0101: The Indian Journal of Statistics, Series A (1961\u20132002) 44(2) (1982) 173\u2013212."},{"issue":"201","key":"10.1016\/j.saa.2026.127686_bb0180","first-page":"1","article-title":"Understanding how dimension reduction tools work: an empirical approach to deciphering t-SNE, UMAP, TriMAP, and PaCMAP for data visualization","volume":"22","author":"Wang","year":"2021","journal-title":"J. Mach. Learn. Res."},{"key":"10.1016\/j.saa.2026.127686_bb0185","doi-asserted-by":"crossref","unstructured":"Z. Movasaghi, S. Rehman, D.I. ur Rehman, Fourier transform infrared (FTIR) spectroscopy of biological tissues, Appl. Spectrosc. Rev. 43(2) (2008) 134\u2013179.","DOI":"10.1080\/05704920701829043"},{"issue":"8","key":"10.1016\/j.saa.2026.127686_bb0190","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1111\/j.1745-7270.2007.00320.x","article-title":"Fourier transform infrared spectroscopic analysis of protein secondary structures","volume":"39","author":"Kong","year":"2007","journal-title":"Acta Biochim. Biophys. Sin."},{"issue":"6","key":"10.1016\/j.saa.2026.127686_bb0195","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1002\/bip.10165","article-title":"Surface enhanced IR absorption of nucleic acids from tumor cells: FTIR reflectance study","volume":"67","author":"Dovbeshko","year":"2002","journal-title":"Biopolymers: Original Research on Biomolecules"},{"key":"10.1016\/j.saa.2026.127686_bb0200","doi-asserted-by":"crossref","first-page":"1254948","DOI":"10.3389\/fimmu.2023.1254948","article-title":"Advances in proteomics: characterization of the innate immune system after birth and during inflammation","volume":"14","author":"Bennike","year":"2023","journal-title":"Front. Immunol."},{"key":"10.1016\/j.saa.2026.127686_bb0205","article-title":"Transcriptome analysis of peripheral blood mononuclear cells reveals distinct immune response in asymptomatic and re-detectable positive COVID-19 patients","volume":"12","author":"Zhang","year":"2021","journal-title":"Front. Immunol."},{"issue":"15\u201316","key":"10.1016\/j.saa.2026.127686_bb0210","doi-asserted-by":"crossref","first-page":"2200026","DOI":"10.1002\/pmic.202200026","article-title":"Human peripheral blood mononuclear cells: a review of recent proteomic applications","volume":"22","author":"Alexovi\u010d","year":"2022","journal-title":"PROTEOMICS"},{"issue":"8","key":"10.1016\/j.saa.2026.127686_bb0215","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1039\/C7AN01871A","article-title":"Clinical applications of infrared and Raman spectroscopy: state of play and future challenges","volume":"143","author":"Baker","year":"2018","journal-title":"Analyst"},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0220","doi-asserted-by":"crossref","first-page":"2720","DOI":"10.1016\/j.bbagen.2012.11.023","article-title":"Detection and identification of cancerous murine fibroblasts, transformed by murine sarcoma virus in culture, using Raman spectroscopy and advanced statistical methods","volume":"1830","author":"Salman","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"issue":"11","key":"10.1016\/j.saa.2026.127686_bb0225","doi-asserted-by":"crossref","first-page":"1119","DOI":"10.1016\/0167-8655(94)90127-9","article-title":"Floating search methods in feature selection","volume":"15","author":"Pudil","year":"1994","journal-title":"Pattern Recogn. Lett."},{"key":"10.1016\/j.saa.2026.127686_bb0230","doi-asserted-by":"crossref","unstructured":"K. Gajjar, L.D. Heppenstall, W. Pang, K.M. Ashton, J. Trevisan, Patel, II, V. Llabjani, H.F. Stringfellow, P.L. Martin-Hirsch, T. Dawson, F.L. Martin, Diagnostic segregation of human brain tumours using Fourier-transform infrared and\/or Raman spectroscopy coupled with discriminant analysis, Analytical methods : advancing methods and applications 5 (2012) 89\u2013102.","DOI":"10.1039\/C2AY25544H"},{"key":"10.1016\/j.saa.2026.127686_bb0235","doi-asserted-by":"crossref","unstructured":"Z. Souweidane, A. Llera, S.M. Smith, C.F. Beckmann, Independent filter analysis for group discrimination in fMRI, bioRxiv (2025) 2025.11.20.689235.","DOI":"10.1101\/2025.11.20.689235"},{"issue":"8","key":"10.1016\/j.saa.2026.127686_bb0240","doi-asserted-by":"crossref","DOI":"10.3390\/app14083337","article-title":"Impacts of feature selection on predicting machine failures by machine learning algorithms","volume":"14","author":"Bezerra","year":"2024","journal-title":"Appl. Sci."},{"key":"10.1016\/j.saa.2026.127686_bb0245","first-page":"90","article-title":"On the relationship between feature selection and classification accuracy, new challenges for feature selection in data mining and knowledge discovery","author":"Janecek","year":"2008","journal-title":"PMLR"},{"issue":"6","key":"10.1016\/j.saa.2026.127686_bb0250","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.mpaic.2024.04.003","article-title":"Immune response to infection","volume":"25","author":"Cumming","year":"2024","journal-title":"Anaesthesia & Intensive Care Medicine"},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0255","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system\u2019s role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol. Rev."},{"issue":"9","key":"10.1016\/j.saa.2026.127686_bb0260","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1056\/NEJMra1208623","article-title":"Severe sepsis and septic shock","volume":"369","author":"Angus","year":"2013","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.saa.2026.127686_bb0265","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1038\/nri3552","article-title":"Sepsis-induced immunosuppression: from cellular dysfunctions to immunotherapy","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Nat. Rev. Immunol."},{"issue":"3","key":"10.1016\/j.saa.2026.127686_bb0270","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/S1473-3099(13)70001-X","article-title":"Immunosuppression in sepsis: a novel understanding of the disorder and a new therapeutic approach","volume":"13","author":"Hotchkiss","year":"2013","journal-title":"Lancet Infect. Dis."},{"issue":"24","key":"10.1016\/j.saa.2026.127686_bb0275","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10245815","article-title":"Immunomonitoring of monocyte and neutrophil function in critically ill patients: from sepsis and\/or trauma to COVID-19","volume":"10","author":"Udovicic","year":"2021","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0280","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1038\/s41420-023-01766-7","article-title":"Immune dysregulation in sepsis: experiences, lessons and perspectives","volume":"9","author":"Cao","year":"2023","journal-title":"Cell death discovery"},{"issue":"05","key":"10.1016\/j.saa.2026.127686_bb0285","first-page":"53","article-title":"Global burden of viral infectious diseases of poverty based on global burden of diseases study 2021","volume":"13","author":"Li","year":"2024","journal-title":"Infect. Dis. Poverty"},{"issue":"9","key":"10.1016\/j.saa.2026.127686_bb0290","doi-asserted-by":"crossref","first-page":"1386","DOI":"10.1038\/nm.2847","article-title":"Infection-induced NETosis is a dynamic process involving neutrophil multitasking in vivo","volume":"18","author":"Yipp","year":"2012","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.saa.2026.127686_bb0295","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1083\/jcb.200606027","article-title":"Novel cell death program leads to neutrophil extracellular traps","volume":"176","author":"Fuchs","year":"2007","journal-title":"J. Cell Biol."},{"issue":"8","key":"10.1016\/j.saa.2026.127686_bb0300","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/nrmicro1710","article-title":"Beneficial suicide: why neutrophils die to make NETs","volume":"5","author":"Brinkmann","year":"2007","journal-title":"Nat. Rev. Microbiol."},{"issue":"10","key":"10.1016\/j.saa.2026.127686_bb0305","doi-asserted-by":"crossref","first-page":"9405","DOI":"10.1109\/TVCG.2025.3567989","article-title":"A critical analysis of the usage of dimensionality reduction in four domains","volume":"31","author":"Cashman","year":"2025","journal-title":"IEEE Trans. Vis. Comput. Graph."},{"issue":"4","key":"10.1016\/j.saa.2026.127686_bb0310","doi-asserted-by":"crossref","first-page":"949","DOI":"10.1189\/jlb.0108024","article-title":"Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival","volume":"84","author":"MacIver","year":"2008","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.saa.2026.127686_bb0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.mam.2020.100888","article-title":"Metabolic regulation of T lymphocyte motility and migration","volume":"77","author":"Vuononvirta","year":"2021","journal-title":"Mol. Aspects Med."},{"key":"10.1016\/j.saa.2026.127686_bb0320","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1146\/annurev-cellbio-092910-154237","article-title":"Aerobic glycolysis: meeting the metabolic requirements of cell proliferation","volume":"27","author":"Lunt","year":"2011","journal-title":"Annu. Rev. Cell Dev. Biol."},{"issue":"7432","key":"10.1016\/j.saa.2026.127686_bb0325","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1038\/nature11862","article-title":"Metabolism of inflammation limited by AMPK and pseudo-starvation","volume":"493","author":"O\u2019Neill","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.saa.2026.127686_bb0330","doi-asserted-by":"crossref","DOI":"10.3390\/mi13020187","article-title":"Fourier transform infrared (FTIR) spectroscopy to analyse human blood over the last 20 years: a review towards lab-on-a-Chip devices","volume":"13","author":"Fadlelmoula","year":"2022","journal-title":"Micromachines"},{"issue":"9","key":"10.1016\/j.saa.2026.127686_bb0335","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1093\/clinchem\/hvac097","article-title":"Cell-free DNA as biomarker for Sepsis by integration of microbial and host information","volume":"68","author":"Jing","year":"2022","journal-title":"Clin. Chem."},{"issue":"1","key":"10.1016\/j.saa.2026.127686_bb0340","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/s41392-024-01933-x","article-title":"Neutrophil extracellular traps in homeostasis and disease","volume":"9","author":"Wang","year":"2024","journal-title":"Signal Transduct. Target. Ther."},{"issue":"4","key":"10.1016\/j.saa.2026.127686_bb0345","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1056\/NEJMcibr1404664","article-title":"Parallels between cancer and infectious disease","volume":"371","author":"Hotchkiss","year":"2014","journal-title":"N. Engl. J. Med."},{"issue":"4","key":"10.1016\/j.saa.2026.127686_bb0350","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1038\/ni.3398","article-title":"Broad defects in the energy metabolism of leukocytes underlie immunoparalysis in sepsis","volume":"17","author":"Cheng","year":"2016","journal-title":"Nat. Immunol."},{"issue":"6155","key":"10.1016\/j.saa.2026.127686_bb0355","doi-asserted-by":"crossref","DOI":"10.1126\/science.1242454","article-title":"Fueling immunity: insights into metabolism and lymphocyte function","volume":"342","author":"Pearce","year":"2013","journal-title":"Science (N. Y.)"},{"issue":"4","key":"10.1016\/j.saa.2026.127686_bb0360","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1016\/j.cell.2017.04.004","article-title":"Metabolic instruction of immunity","volume":"169","author":"Buck","year":"2017","journal-title":"Cell"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252600257X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S138614252600257X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T06:02:50Z","timestamp":1777615370000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S138614252600257X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":72,"alternative-id":["S138614252600257X"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.127686","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"FTIR spectroscopy of peripheral blood mononuclear cells and machine learning: Spectral biomarkers for bacteremia, focal bacterial, and viral infections","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.127686","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"127686"}}