{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:16:23Z","timestamp":1784240183101,"version":"3.55.0"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22575177"],"award-info":[{"award-number":["22575177"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.saa.2026.128081","type":"journal-article","created":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T14:49:52Z","timestamp":1779029392000},"page":"128081","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A dual-response near-infrared-emitting fluorescent probe for the evaluation of liver disease-related drugs and multi-level monitoring of lipid droplet abnormalities"],"prefix":"10.1016","volume":"361","author":[{"given":"Yuqing","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kun","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fan","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sichen","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyue","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128081_bb0005","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1021\/acs.chemrev.3c00573","article-title":"Design and application of fluorescent probes to detect cellular physical microenvironments","volume":"124","author":"Ma","year":"2024","journal-title":"Chem. Rev."},{"key":"10.1016\/j.saa.2026.128081_bb0010","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1038\/s41375-025-02601-x","article-title":"Cell polarity: cell type-specific regulators, common pathways, and polarized vesicle transport","volume":"39","author":"Bera","year":"2025","journal-title":"Leukemia"},{"key":"10.1016\/j.saa.2026.128081_bb0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127430","article-title":"Viscosity-sensitive NIR probe for detecting cellular state transitions in normal, cancer and apoptotic cells","volume":"350","author":"Kiran","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0020","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.115245","article-title":"A dual-targeted fluorescent probe reveals the changes in the polarity of endosomes and mitochondria during ferroptosis","volume":"218","author":"Chen","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2026.128081_bb0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochem.2024.115900","article-title":"Boronate-based fluorescence probes image viscosity and hydrogen peroxide in living cells","volume":"457","author":"Wang","year":"2024","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117494","article-title":"Rational development of Nile red derivatives with significantly improved specificity and photostability for advanced fluorescence imaging of lipid droplets","volume":"282","author":"Zheng","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2026.128081_bb0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.143118","article-title":"BODIPY-based large stokes shift NIR fluorescent probe for illuminating lipid droplets","volume":"1345","author":"Hui","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128081_bb0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102194","article-title":"Lipid droplets, autophagy, and ageing: a cell-specific tale","volume":"94","author":"Maestri","year":"2024","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.saa.2026.128081_bb0045","doi-asserted-by":"crossref","first-page":"2417326","DOI":"10.1002\/advs.202417326","article-title":"Lipid droplets metabolism mediated by ANXA7-PPAR\u03b3 signaling axis regulates spinal cord injury repair in mice","volume":"12","author":"Chen","year":"2025","journal-title":"Adv. Sci."},{"key":"10.1016\/j.saa.2026.128081_bb0050","doi-asserted-by":"crossref","DOI":"10.1002\/anie.202502159","article-title":"Spatiotemporal super-resolution imaging of lipid metabolism dynamics in physiological\/pathological conditions","volume":"64","author":"Cao","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2026.128081_bb0055","doi-asserted-by":"crossref","first-page":"14256","DOI":"10.1021\/acs.analchem.5c00894","article-title":"Lipid droplet-targeted BODIPY-hemicyanine hybrid fluorescent probes for real-time monitoring of pH and viscosity","volume":"97","author":"Zuo","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0060","doi-asserted-by":"crossref","first-page":"2303627","DOI":"10.1002\/adfm.202303627","article-title":"A bright two-photon lipid droplets probe with viscosity-enhanced solvatochromic emission for visualizing lipid metabolic disorders in deep tissues","volume":"33","author":"Zheng","year":"2023","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.saa.2026.128081_bb0065","doi-asserted-by":"crossref","DOI":"10.1002\/bio.4749","article-title":"An efficient lipid droplet-targeted fluorescent probe for detection of intracellular viscosity","volume":"39","author":"Yang","year":"2024","journal-title":"Luminescence"},{"key":"10.1016\/j.saa.2026.128081_bb0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.114767","article-title":"A near-infrared fluorescent probe for monitoring abnormal lipid droplets viscosity in NAFLD mice model","volume":"216","author":"Fu","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2026.128081_bb0075","doi-asserted-by":"crossref","first-page":"15165","DOI":"10.1021\/acs.jmedchem.5c01403","article-title":"Lipid droplet-targeted NIR polarity probe for the imaging of acute asthma in vivo","volume":"68","author":"Li","year":"2025","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0080","doi-asserted-by":"crossref","first-page":"6873","DOI":"10.1039\/D5TB00521C","article-title":"Rational design of near-infrared carbon dots as polarity-sensitive fluorescent probes for imaging of lipid droplets","volume":"13","author":"Yang","year":"2025","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2026.128081_bb0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126430","article-title":"Near-infrared lipid droplet polarity fluorescent probe based on phenothiazine derivative for diagnosis of non-alcoholic fatty liver and tumors","volume":"341","author":"Sun","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0090","article-title":"Dual-responsive fluorescent probes: advances in biosensing, diagnosis and therapy","volume":"36","author":"Liu","year":"2026","journal-title":"Adv. Funct. Mater."},{"key":"10.1016\/j.saa.2026.128081_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.talanta.2025.128191","article-title":"Developing a polarity-specialized TICT fluorescent probe for wash-free and long-term monitoring lipid droplets dynamics","volume":"294","author":"Wang","year":"2025","journal-title":"Talanta"},{"key":"10.1016\/j.saa.2026.128081_bb0100","doi-asserted-by":"crossref","first-page":"2062","DOI":"10.1021\/acs.analchem.2c04894","article-title":"\u03b3-Glutamyltransferase-activatable fluoro-photoacoustic reporter for highly sensitive diagnosis of acute liver injury and tumor","volume":"95","author":"Liu","year":"2023","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134042","article-title":"A NIR fluorescent probe for the selective detection of hydrogen peroxide by acetyl-hydrolyzing in cells","volume":"1271","author":"Li","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128081_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.123102","article-title":"A NIR ratiometric fluorescence probe for rapid, sensitive detection and bioimaging of hypochlorous acid","volume":"302","author":"Li","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2025.143214","article-title":"A highly selective NIR fluorescent probe for Hg2+ and its multiple application in biological and environmental systems","volume":"1346","author":"Ma","year":"2025","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128081_bb0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.125598","article-title":"Engineered DR\/NIR dual-emission carbonized polymer dots for simultaneous tracking of lipid droplets and lysosomes","volume":"329","author":"Miao","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0125","doi-asserted-by":"crossref","first-page":"37926","DOI":"10.1021\/jacs.5c04392","article-title":"Granzyme B-targeting quenched activity-based probes for assessing tumor response to immunotherapy","volume":"147","author":"Kazim","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2026.128081_bb0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.125694","article-title":"Polarity-sensitive fluorescent probes based on triphenylamine for fluorescence lifetime imaging of lipid droplets","volume":"330","author":"Wang","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137936","article-title":"A bright lipid drop-targeted probe for dual channel visualizing of colorectal cancer","volume":"440","author":"Cui","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0140","doi-asserted-by":"crossref","DOI":"10.1002\/agt2.735","article-title":"New AIE emitters from the unexpected boron tribromide\/boron trichloride-mediated cyclization reaction and application for fluorescence imaging of lipid droplets","volume":"6","author":"Hu","year":"2025","journal-title":"Aggregate"},{"key":"10.1016\/j.saa.2026.128081_bb0145","doi-asserted-by":"crossref","first-page":"3633","DOI":"10.1039\/C9TB00512A","article-title":"Dual-channel fluorescent probe bearing two-photon activity for cell viability monitoring","volume":"7","author":"Zhao","year":"2019","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2026.128081_bb0150","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126569","article-title":"Monitoring of carboxylesterases using a tricyanofuran-based near-infrared fluorophore in living organisms","volume":"343","author":"Tang","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0155","doi-asserted-by":"crossref","first-page":"9273","DOI":"10.1021\/jacs.3c01933","article-title":"Modulating liquid-liquid transitions and glass formation in zeolitic imidazolate frameworks by decoration with electron-withdrawing cyano groups","volume":"145","author":"Song","year":"2023","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2026.128081_bb0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.polymer.2021.124236","article-title":"Self-compatibilization effect of phosphonate with cyano group on flame retardancy and mechanical properties of epoxy","volume":"234","author":"Ma","year":"2021","journal-title":"Polymer"},{"key":"10.1016\/j.saa.2026.128081_bb0165","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.112824","article-title":"A novel fluorescent probe for based on carbazole for detection formaldehyde and its imaging in live cells applications","volume":"209","author":"Shao","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2026.128081_bb0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2025.117874","article-title":"The role of quinoline in the development of near-infrared fluorescent probes for diagnosis of Alzheimer's disease","volume":"296","author":"Melo","year":"2025","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2025.126855","article-title":"AIE functionality ratiometric fluorescent probe based on quinoline-malononitrile for detection of ONOO- and its application in bioimaging","volume":"346","author":"Huang","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0180","article-title":"Modular assembly of B(III)-coordinated fluorophores with quantitatively predictable photoinduced electron transfer for chemosensing and bioimaging","volume":"64","author":"Li","year":"2025","journal-title":"Angew. Chem. Int. Ed."},{"key":"10.1016\/j.saa.2026.128081_bb0185","doi-asserted-by":"crossref","first-page":"18936","DOI":"10.1021\/acs.analchem.5c01048","article-title":"De novo design of photosensitizers activated by tumor microenvironments for NIR imaging and photodynamic therapy of tumor","volume":"97","author":"Zhong","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.bios.2025.117881","article-title":"A near-infrared ratiometric optical sensor for real-time monitoring hydroxyl radical levels in ferroptosis-mediated Parkinson's disease","volume":"289","author":"Deng","year":"2025","journal-title":"Biosens. Bioelectron."},{"key":"10.1016\/j.saa.2026.128081_bb0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2023.134825","article-title":"Harnessing polarity-dependent fluorescent probe for lipid droplet metabolism dissection and in vivo nonalcoholic fatty liver disease diagnosis","volume":"399","author":"Liu","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0200","doi-asserted-by":"crossref","first-page":"17102","DOI":"10.1021\/acs.analchem.5c02887","article-title":"Decreased lysosomal polarity during acute alcoholic liver injury revealed by a near-infrared fluorescent probe","volume":"97","author":"Dai","year":"2025","journal-title":"Anal. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0205","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2026.127437","article-title":"Toward anti-bluing shift: a rationally designed photo-induced electron transfer-based polarity responsive lipid droplets-targeting fluorescent probe for real-time monitoring of drug-induced liver injury","volume":"350","author":"Cao","year":"2026","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0210","doi-asserted-by":"crossref","DOI":"10.1002\/cptc.202500176","article-title":"Polarity and viscosity-sensitive fluorescent probe for lipid droplet imaging","volume":"9","author":"Leewongwat","year":"2025","journal-title":"ChemPhotoChem"},{"key":"10.1016\/j.saa.2026.128081_bb0215","doi-asserted-by":"crossref","first-page":"8246","DOI":"10.1039\/C9CC04179F","article-title":"Organotin(iv) differential fluorescent probe for controlled subcellular localization and nuclear microviscosity monitoring","volume":"55","author":"Bernal-Escalante","year":"2019","journal-title":"Chem. Commun."},{"key":"10.1016\/j.saa.2026.128081_bb0220","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.1021\/acschembio.0c00100","article-title":"Fluorescence probes exhibit photoinduced structural planarization: sensing in vitro and in vivo microscopic dynamics of viscosity free from polarity interference","volume":"15","author":"Wu","year":"2020","journal-title":"ACS Chem. Biol."},{"key":"10.1016\/j.saa.2026.128081_bb0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2025.137614","article-title":"A triple-targeting and viscosity-sensitive fluorescence probe for visualization of liver injury and tumor models","volume":"434","author":"Lei","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136441","article-title":"A lipid droplet-targeted NIR fluorescent probe for viscosity detection in Parkinson's disease","volume":"420","author":"Ma","year":"2024","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0235","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/1754-1611-4-11","article-title":"Environment-sensitive behavior of fluorescent molecular rotors","volume":"4","author":"Haidekker","year":"2010","journal-title":"J. Biol. Eng."},{"key":"10.1016\/j.saa.2026.128081_bb0240","doi-asserted-by":"crossref","first-page":"36604","DOI":"10.1021\/acsomega.3c06428","article-title":"Thioflavin-T: a quantum yield-based molecular viscometer for glycerol-monohydroxy alcohol mixtures","volume":"8","author":"Mukherjee","year":"2023","journal-title":"ACS Omega"},{"key":"10.1016\/j.saa.2026.128081_bb0245","doi-asserted-by":"crossref","first-page":"4147","DOI":"10.1021\/jacs.4c13516","article-title":"Lipophilicity modulation of fluorescent probes for in situ imaging of cellular microvesicle dynamics","volume":"147","author":"Huang","year":"2025","journal-title":"J. Am. Chem. Soc."},{"key":"10.1016\/j.saa.2026.128081_bb0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccr.2024.216181","article-title":"Versatile organic fluorescent probes for visualizing the dynamics of lipid droplets","volume":"522","author":"Cao","year":"2025","journal-title":"Coord. Chem. Rev."},{"key":"10.1016\/j.saa.2026.128081_bb0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2025.112835","article-title":"An indole-fused quinacridone-based fluorescent probe with high photostability and specificity for cellular lipid droplets","volume":"240","author":"Ouyang","year":"2025","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128081_bb0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2025.112879","article-title":"Lipid droplets-targetable fluorescent probe for monitoring polarity changes during ferroptosis","volume":"241","author":"Zhou","year":"2025","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128081_bb0265","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2024.110591","article-title":"Brominated alkyl promotes a red-emissive probe track lipid droplets in cells and fatty liver","volume":"201","author":"Wang","year":"2024","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2026.128081_bb0270","doi-asserted-by":"crossref","first-page":"2303212","DOI":"10.1002\/adhm.202303212","article-title":"Ketocyanine-based fluorescent probe revealing the polarity heterogeneity of lipid droplets and enabling accurate diagnosis of hepatocellular carcinoma","volume":"13","author":"He","year":"2024","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.saa.2026.128081_bb0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2019.107718","article-title":"A rationally designed polarity-viscosity sensitive probe for imaging lipid droplets","volume":"171","author":"Song","year":"2019","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128081_bb0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.molstruc.2022.134847","article-title":"A deep-red emission AIE fluorescent probes based on coumarin for imaging lipid droplets in living cells","volume":"1277","author":"Yang","year":"2023","journal-title":"J. Mol. Struct."},{"key":"10.1016\/j.saa.2026.128081_bb0285","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1111\/apt.17833","article-title":"Global perspectives on nonalcoholic fatty liver disease and nonalcoholic steatohepatitis","volume":"59","author":"Golabi","year":"2024","journal-title":"aliment. Pharm. Ther."},{"key":"10.1016\/j.saa.2026.128081_bb0290","doi-asserted-by":"crossref","first-page":"2212","DOI":"10.1016\/S0140-6736(20)32511-3","article-title":"Non-alcoholic fatty liver disease","volume":"397","author":"Powell","year":"2021","journal-title":"Lancet"},{"key":"10.1016\/j.saa.2026.128081_bb0295","doi-asserted-by":"crossref","first-page":"1002916","DOI":"10.3389\/fendo.2022.1002916","article-title":"Current insights in molecular characterization of non-alcoholic fatty liver disease and treatment","volume":"13","author":"Che","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.saa.2026.128081_bb0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.jhepr.2023.100984","article-title":"Prevention of lipid droplet accumulation by DGAT1 inhibition ameliorates sepsis-induced liver injury and inflammation","volume":"6","author":"Teixeira","year":"2024","journal-title":"JHEP Reports"},{"key":"10.1016\/j.saa.2026.128081_bb0305","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.3390\/nu16071036","article-title":"Proanthocyanidins and phenolic compounds from the twigs of salix chaenomeloides and their anti-lipogenic effects on 3T3-L1 preadipocytes","volume":"16","author":"Kim","year":"2024","journal-title":"Nutrients"},{"key":"10.1016\/j.saa.2026.128081_bb0310","doi-asserted-by":"crossref","first-page":"1512","DOI":"10.1016\/j.bbalip.2017.09.007","article-title":"Atorvastatin reduces lipid accumulation in the liver by activating protein kinase A-mediated phosphorylation of perilipin 5","volume":"1862","author":"Gao","year":"2017","journal-title":"Biochimica et Biophysica Acta (BBA)"},{"key":"10.1016\/j.saa.2026.128081_bb0315","article-title":"Statins lower lipid synthesis but promote secretion of cholesterol-enriched extracellular vesicles and particles","volume":"12","author":"Chen","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.saa.2026.128081_bb0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.aca.2025.343790","article-title":"Lipid droplet-targeting carbonized polymer dots for intracellular polarity visualization under wash-free conditions","volume":"1346","author":"Wang","year":"2025","journal-title":"Anal. Chim. Acta"},{"key":"10.1016\/j.saa.2026.128081_bb0325","doi-asserted-by":"crossref","DOI":"10.1016\/j.trac.2025.118287","article-title":"Trends in small-molecule probes for lipid droplets","volume":"190","author":"Tu","year":"2025","journal-title":"Trends Anal. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0330","doi-asserted-by":"crossref","DOI":"10.1016\/j.cclet.2024.110020","article-title":"Imaging polarity changes in pneumonia and lung cancer using a lipid droplet-targeted near-infrared fluorescent probe","volume":"35","author":"Zhang","year":"2024","journal-title":"Chin. Chem. Lett."},{"key":"10.1016\/j.saa.2026.128081_bb0335","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1002\/hep4.1801","article-title":"Role of cholesterol-associated steatohepatitis in the development of NASH","volume":"6","author":"Horn","year":"2022","journal-title":"Hepatol. Commun."},{"key":"10.1016\/j.saa.2026.128081_bb0340","doi-asserted-by":"crossref","first-page":"5203","DOI":"10.3390\/ijms25105203","article-title":"Drug-induced fatty liver disease (DIFLD): a comprehensive analysis of clinical, biochemical, and histopathological data for mechanisms identification and consistency with current adverse outcome pathways","volume":"25","author":"L\u00f3pez-Pascual","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2026.128081_bb0345","doi-asserted-by":"crossref","first-page":"5075","DOI":"10.1007\/s00204-025-04178-x","article-title":"Ontogeny of drug-induced fatty liver disease (DIFLD): from key initiating events to disease phenotypes","volume":"99","author":"L\u00f3pez-Pascual","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.saa.2026.128081_bb0350","first-page":"731","article-title":"Drug-induced fatty liver disease: pathogenesis and treatment","volume":"9","author":"Kolaric","year":"2021","journal-title":"J. Clin. Transl. Hepatol."},{"key":"10.1016\/j.saa.2026.128081_bb0355","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1007\/s12602-022-09994-6","article-title":"Exercise training and probiotic Lacticaseibacillus rhamnosus GG reduce tetracycline induced liver oxidative stress and inflammation in rats with hepatic steatosis","volume":"15","author":"Aghaei","year":"2023","journal-title":"Probiotics Antimicrob. Proteins"},{"key":"10.1016\/j.saa.2026.128081_bb0360","doi-asserted-by":"crossref","DOI":"10.1186\/2050-6511-15-27","article-title":"Uridine prevents tamoxifen-induced liver lipid droplet accumulation","volume":"15","author":"Le","year":"2014","journal-title":"BMC Pharmacol. Toxicol."},{"key":"10.1016\/j.saa.2026.128081_bb0365","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0087179","article-title":"Uridine prevents fenofibrate-induced fatty liver","volume":"9","author":"Le","year":"2014","journal-title":"PloS One"},{"key":"10.1016\/j.saa.2026.128081_bb0370","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1080\/1061186X.2025.2546487","article-title":"Targeting lipopolysaccharides in gram-negative sepsis: therapeutic advances and challenges","volume":"34","author":"Akele","year":"2026","journal-title":"J. Drug Target."},{"key":"10.1016\/j.saa.2026.128081_bb0375","doi-asserted-by":"crossref","first-page":"79","DOI":"10.3390\/cimb47020079","article-title":"Advances in understanding lipopolysaccharide-mediated hepatitis: mechanisms and pathological features","volume":"47","author":"Nakadate","year":"2025","journal-title":"Curr. Issues Mol. Biol."},{"key":"10.1016\/j.saa.2026.128081_bb0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.fct.2020.111186","article-title":"Comparison of liver regeneration after partial hepatectomy and acetaminophen-induced acute liver failure: a global picture based on transcriptome analysis","volume":"139","author":"Bhushan","year":"2020","journal-title":"Food Chem. Toxicol."},{"key":"10.1016\/j.saa.2026.128081_bb0385","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.1016\/j.biopha.2018.07.125","article-title":"A comparison of the effects of thymoquinone, silymarin and N-acetylcysteine in an experimental hepatotoxicity","volume":"106","author":"Demiroren","year":"2018","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.saa.2026.128081_bb0390","doi-asserted-by":"crossref","DOI":"10.1002\/jbt.23560","article-title":"Are silymarin and N-acetylcysteine able to prevent liver damage mediated by multiple factors? Findings against ethanol plus LPS-induced liver injury in mice","volume":"38","author":"dos Santos","year":"2024","journal-title":"J. Biochem. Mol. Toxicol."},{"key":"10.1016\/j.saa.2026.128081_bb0395","doi-asserted-by":"crossref","DOI":"10.1002\/adhm.202500507","article-title":"Lipoprotein-based nanocatalyst enables targeted treatment of APAP-induced liver injury via enhanced macropinocytosis","volume":"14","author":"Chen","year":"2025","journal-title":"Adv. Healthc. Mater."},{"key":"10.1016\/j.saa.2026.128081_bb0400","doi-asserted-by":"crossref","first-page":"3590","DOI":"10.1021\/acsbiomaterials.3c00409","article-title":"Synthesis of a red-emitting polarity-sensitive fluorescent probe based on ict and visualization for lipid droplet dynamic processes","volume":"9","author":"Pei","year":"2023","journal-title":"ACS. Biomater. Sci. Eng."},{"key":"10.1016\/j.saa.2026.128081_bb0405","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1007\/s11033-025-10839-y","article-title":"Effects of safranal on antidiabetic and endothelial dysfunction in streptozotocin-induced diabetic rats","volume":"52","author":"Demirci","year":"2025","journal-title":"Mol. Biol. Rep."},{"key":"10.1016\/j.saa.2026.128081_bb0410","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotobiol.2025.113226","article-title":"Dual-functional fluorescence probe for revealing metabolism during cellular cuproptosis","volume":"270","author":"Ma","year":"2025","journal-title":"J. Photochem. Photobiol. B Biol."},{"key":"10.1016\/j.saa.2026.128081_bb0415","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/978-3-031-92785-0_8","article-title":"For better or worse: the impact of necrotic cell death modalities","volume":"1481","author":"Vandenabeele","year":"2025","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.saa.2026.128081_bb0420","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s10495-026-02261-x","article-title":"Looking at the fraction with Annexin V+ and propidium iodide+: insights into cell death types from preclinical studies in solid and haematological cancers","volume":"31","author":"Hassan","year":"2026","journal-title":"Apoptosis"},{"key":"10.1016\/j.saa.2026.128081_bb0425","doi-asserted-by":"crossref","DOI":"10.1097\/PPO.0000000000000780","article-title":"Harnessing immunogenic cell death to boost the impact of radiation therapy","volume":"31","author":"Mannion","year":"2025","journal-title":"Cancer J."},{"key":"10.1016\/j.saa.2026.128081_bb0430","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2023.122602","article-title":"Comprehensive monitoring of mitochondrial viscosity variation during different cell death processes by a NIR mitochondria-targeting fluorescence probe","volume":"295","author":"Liu","year":"2023","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128081_bb0435","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1039\/D3TB02979D","article-title":"Bimodal effects on lipid droplets induced in cancer and non-cancer cells by chemotherapy drugs as revealed with a green-emitting BODIPY fluorescent probe","volume":"12","author":"Polita","year":"2024","journal-title":"J. Mater. Chem. B"},{"key":"10.1016\/j.saa.2026.128081_bb0440","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2024.112408","article-title":"Construction and application of bifunctional AIE fluorescent probe for the detection of Cys and viscosity","volume":"231","author":"Sun","year":"2024","journal-title":"Dyes Pigments"},{"key":"10.1016\/j.saa.2026.128081_bb0445","doi-asserted-by":"crossref","DOI":"10.1016\/j.jinorgbio.2024.112609","article-title":"Synthesis and anti-tumor activities of three newly designed organotin(IV) carboxylates complexes","volume":"258","author":"He","year":"2024","journal-title":"J. Inorg. Biochem."},{"key":"10.1016\/j.saa.2026.128081_bb0450","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2024.107676","article-title":"Classical apoptotic stimulus, staurosporine, induces lytic inflammatory cell death, PANoptosis","volume":"300","author":"Sarkar","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2024.136745","article-title":"Exploration of glyoxals\u2019 level changes in endoplasmic reticulum during ferroptosis by a photocaged fluorescent probe","volume":"423","author":"Xing","year":"2025","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0460","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.117769","article-title":"Ferroptosis in hepatocellular carcinoma: mechanisms and therapeutic implications","volume":"182","author":"Tu","year":"2025","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.saa.2026.128081_bb0465","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1650219","article-title":"Ferroptosis in the tumor microenvironment: mechanisms, advances, and therapeutic perspectives","volume":"15","author":"Gao","year":"2025","journal-title":"Front. Oncol."},{"key":"10.1016\/j.saa.2026.128081_bb0470","doi-asserted-by":"crossref","unstructured":"N. Goswami, L. Kinkpe, L. Hua, Y. Zhuo, Z.F. Fang, L.Q. Che, Y. Lin, SY. Xu, X.M. Jiang, B. Feng, D. Wu, Farnesol improves endoplasmic reticulum stress and hepatic metabolic dysfunction induced by tunicamycin in mice, Biology 14 (2025) 213.","DOI":"10.3390\/biology14020213"},{"key":"10.1016\/j.saa.2026.128081_bb0475","doi-asserted-by":"crossref","DOI":"10.1016\/j.snb.2022.132403","article-title":"Real-time monitoring viscosity changes in lipid droplets in response to ER stress via a viscosity-sensitive ruthenium (II) fluorescent probe","volume":"370","author":"Yang","year":"2022","journal-title":"Sens. Actuators B Chem."},{"key":"10.1016\/j.saa.2026.128081_bb0480","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-026-47754-6","article-title":"4-Phenylbutyrate mitigates renal pathology linked to ER stress related pathways in C57BL\/6J mice with hindlimb unloading","volume":"16","author":"Ranade","year":"2026","journal-title":"Sci. Rep."},{"key":"10.1016\/j.saa.2026.128081_bb0485","doi-asserted-by":"crossref","first-page":"2744","DOI":"10.1007\/s10904-020-01483-z","article-title":"Cu(II)-coordination polymer nanostructures induce human lung cancer cell carcinoma apoptotic cell death in vitro and in vivo","volume":"30","author":"Quan","year":"2020","journal-title":"J. Inorg. Organomet. Polym. Mater."},{"key":"10.1016\/j.saa.2026.128081_bb0490","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27062681","article-title":"Oxidative stress in health and disease: mechanisms and therapeutic perspectives","volume":"27","author":"Anwar","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.saa.2026.128081_bb0495","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1186\/s12964-025-02459-7","article-title":"Challenges in mimicking hypoxia: insights into HIF-regulated MiRNA expression induced by DMOG and CoCl2","volume":"23","author":"Barton","year":"2025","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.saa.2026.128081_bb0500","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2024.112305","article-title":"A red probe with large stokes shift for imaging the viscosity of lipid droplets","volume":"229","author":"Li","year":"2024","journal-title":"Dyes Pigments"}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526006529?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526006529?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:54:31Z","timestamp":1784238871000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526006529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":100,"alternative-id":["S1386142526006529"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128081","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A dual-response near-infrared-emitting fluorescent probe for the evaluation of liver disease-related drugs and multi-level monitoring of lipid droplet abnormalities","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128081","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128081"}}