{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T22:15:58Z","timestamp":1784240158620,"version":"3.55.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100008325","name":"Shanghai University of Engineering and Science","doi-asserted-by":"publisher","award":["2024-2025"],"award-info":[{"award-number":["2024-2025"]}],"id":[{"id":"10.13039\/501100008325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["232102231040"],"award-info":[{"award-number":["232102231040"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017700","name":"Henan Provincial Science and Technology Research Project","doi-asserted-by":"publisher","award":["HNCDCYC202515"],"award-info":[{"award-number":["HNCDCYC202515"]}],"id":[{"id":"10.13039\/501100017700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.saa.2026.128109","type":"journal-article","created":{"date-parts":[[2026,5,22]],"date-time":"2026-05-22T23:38:30Z","timestamp":1779493110000},"page":"128109","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A deep learning-assisted turn-on fluorescent probe for L-BPA detection with mechanistic insight"],"prefix":"10.1016","volume":"361","author":[{"given":"Yuanfeng","family":"Qi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibo","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuting","family":"Leng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yujiao","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenqi","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjie","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhang","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingbo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weixia","family":"Chong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junfeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.saa.2026.128109_bb0005","doi-asserted-by":"crossref","DOI":"10.3390\/antiox12061302","article-title":"Redox mechanisms underlying the cytostatic effects of boric acid on cancer cells-an issue still open","volume":"12","author":"Paties Montagner","year":"2023","journal-title":"Antioxidants"},{"issue":"100","key":"10.1016\/j.saa.2026.128109_bb0010","doi-asserted-by":"crossref","first-page":"13629","DOI":"10.1039\/D1CC05481C","article-title":"The modern role of boron as a \u2018magic element\u2019 in biomedical science: chemistry perspective","volume":"57","author":"Chatterjee","year":"2021","journal-title":"Chem. Commun. (Camb.)"},{"key":"10.1016\/j.saa.2026.128109_bb0015","doi-asserted-by":"crossref","unstructured":"T. Robak, H. Huang, J. Jin, J. Zhu, T. Liu, O. Samoilova, H. Pylypenko, G. Verhoef, N. Siritanaratkul, E. Osmanov, J. Alexeeva, J. Pereira, J. Drach, J. Mayer, X. Hong, R. Okamoto, L. Pei, B. Rooney, H. van de Velde, F. Cavalli, Bortezomib-based therapy for newly diagnosed mantle-cell lymphoma, N. Engl. J. Med. 372(10)944\u2013953.","DOI":"10.1056\/NEJMoa1412096"},{"issue":"5","key":"10.1016\/j.saa.2026.128109_bb0020","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1177\/1091581814545245","article-title":"Tavaborole, a novel boron-containing small molecule for the topical treatment of onychomycosis, is noncarcinogenic in 2-year carcinogenicity studies","volume":"33","author":"Ciaravino","year":"2014","journal-title":"Int. J. Toxicol."},{"issue":"3","key":"10.1016\/j.saa.2026.128109_bb0025","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1080\/10428194.2018.1523398","article-title":"Ixazomib \u2013 the first oral proteasome inhibitor","volume":"60","author":"Xie","year":"2019","journal-title":"Leuk. Lymphoma"},{"issue":"4","key":"10.1016\/j.saa.2026.128109_bb0030","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1111\/exd.14722","article-title":"Crisaborole efficacy in murine models of skin inflammation and Staphylococcus aureus infection","volume":"32","author":"Youn","year":"2023","journal-title":"Exp. Dermatol."},{"key":"10.1016\/j.saa.2026.128109_bb0035","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.00398-20","article-title":"Structural basis and binding kinetics of Vaborbactam in class A \u03b2-lactamase inhibition","volume":"64","author":"Pemberton","year":"2020","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.saa.2026.128109_bb0040","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1093\/jrr\/rrad064","article-title":"Proposal of recommended experimental protocols for in vitro and in vivo evaluation methods of boron agents for neutron capture therapy","volume":"64","author":"Hattori","year":"2023","journal-title":"J. Radiat. Res."},{"issue":"1","key":"10.1016\/j.saa.2026.128109_bb0045","article-title":"Boron delivery agents for neutron capture therapy of cancer","volume":"38","author":"Barth","year":"2018","journal-title":"Cancer Communications (London, England)"},{"issue":"1","key":"10.1016\/j.saa.2026.128109_bb0050","doi-asserted-by":"crossref","DOI":"10.3390\/genes14010127","article-title":"DNA damage response and repair in boron neutron capture therapy","volume":"14","author":"Mechetin","year":"2023","journal-title":"Genes"},{"issue":"10","key":"10.1016\/j.saa.2026.128109_bb0055","article-title":"Advancements in the synthesis and biological properties of carboranes and high-boron related compounds: a comprehensive exploration with emphasis on BNCT applications","volume":"35","author":"Couto","year":"2024","journal-title":"J. Braz. Chem. Soc."},{"key":"10.1016\/j.saa.2026.128109_bb0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2024.112561","article-title":"Fluorescent sensing for boronic acid derivatives: design, synthesis, mechanism, application and perspective in boron neutron capture therapy (BNCT)","volume":"235","author":"Qi","year":"2025","journal-title":"Dyes Pigments"},{"issue":"3","key":"10.1016\/j.saa.2026.128109_bb0065","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1093\/jrr\/rrac012","article-title":"Profile analysis of adverse events after boron neutron capture therapy for head and neck cancer: a sub-analysis of the JHN002 study","volume":"63","author":"Hirose","year":"2022","journal-title":"J. Radiat. Res."},{"issue":"9","key":"10.1016\/j.saa.2026.128109_bb0070","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1002\/cac2.12089","article-title":"Boron neutron capture therapy: current status and future perspectives","volume":"40","author":"Dymova","year":"2020","journal-title":"Cancer Commun. (Lond.)"},{"key":"10.1016\/j.saa.2026.128109_bb0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.apradiso.2025.111720","article-title":"Comparison of dose distribution with and without reflecting heterogeneous boron distribution using F-BPA positron emission tomography in boron neutron capture therapy","volume":"219","author":"Kobayashi","year":"2025","journal-title":"Appl. Radiat. Isot."},{"key":"10.1016\/j.saa.2026.128109_bb0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2020.104875","article-title":"Application of a lab-made ternary Fe-Cr-Al coil vaporizer coupled to ICP OES for boron determination in powdered food after the sample preparation in alkaline media","volume":"157","author":"Cez\u00e1rio","year":"2020","journal-title":"Microchem. J."},{"issue":"2","key":"10.1016\/j.saa.2026.128109_bb0085","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1021\/acs.oprd.6b00325","article-title":"Trace analysis of potentially mutagenic Boronic acids and esters in drug substance by ICP-MS","volume":"21","author":"Patel","year":"2017","journal-title":"Org. Process. Res. Dev."},{"issue":"9","key":"10.1016\/j.saa.2026.128109_bb0090","doi-asserted-by":"crossref","first-page":"6962","DOI":"10.1039\/D5RA00448A","article-title":"Smart fluorometric sensing of metal contaminants in canned foods: a carbon dot-based dual-response system for quantifying aluminum and cobalt ions","volume":"15","author":"Ali","year":"2025","journal-title":"RSC Adv."},{"key":"10.1016\/j.saa.2026.128109_bb0095","doi-asserted-by":"crossref","DOI":"10.1016\/j.microc.2025.113704","article-title":"Copper-chelation-induced ratiometric fluorescence response for sensitive ratiometric detection of zoledronic acid: implications for monitoring in renal impairment","volume":"213","author":"Ali","year":"2025","journal-title":"Microchem. J."},{"key":"10.1016\/j.saa.2026.128109_bb0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.jphotochem.2025.116416","article-title":"Engineering a pH-responsive fluorometric system: dual-emission carbon dots and BTB for selective urea sensing","volume":"466","author":"Ali","year":"2025","journal-title":"J. Photochem. Photobiol. A Chem."},{"key":"10.1016\/j.saa.2026.128109_bb0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.saa.2024.125318","article-title":"Synthesis and mechanistic investigation of BPA fluorescent probes targeting BPA for potential application in boron neutron capture therapy (BNCT)","volume":"327","author":"Sun","year":"2025","journal-title":"Spectrochim. Acta A Mol. Biomol. Spectrosc."},{"key":"10.1016\/j.saa.2026.128109_bb0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.dyepig.2024.112561","article-title":"Fluorescent sensing for boronic acid derivatives: design, synthesis, mechanism, application and perspective in boron neutron capture therapy (BNCT)","volume":"235","author":"Qi","year":"2025","journal-title":"Dyes Pigments"},{"issue":"4","key":"10.1016\/j.saa.2026.128109_bb0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpha.2023.11.010","article-title":"An environmentally sensitive zinc-selective two-photon NIR fluorescent turn-on probe and zinc sensing in stroke","volume":"14","author":"Wang","year":"2024","journal-title":"Journal of pharmaceutical analysis"},{"key":"10.1016\/j.saa.2026.128109_bb0120","series-title":"Ethical Review Measures for Biomedical Research Involving Humans","author":"Li","year":"2022"},{"issue":"1","key":"10.1016\/j.saa.2026.128109_bb0125","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/0167-8140(93)90043-8","article-title":"Selectivity of boron carriers for boron neutron capture therapy: pharmacological studies with borocaptate sodium, L-boronophenylalanine and boric acid in murine tumors","volume":"27","author":"Gregoire","year":"1993","journal-title":"Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology"},{"key":"10.1016\/j.saa.2026.128109_bb0130","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.apradiso.2017.02.014","article-title":"Calculation of the detection limits by explicit expressions","volume":"126","author":"Glavi\u010d-Cindro","year":"2017","journal-title":"Appl. Radiat. Isot."},{"issue":"12","key":"10.1016\/j.saa.2026.128109_bb0135","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1021\/acssensors.6b00522","article-title":"Visualization of Boronic acid containing Pharmaceuticals in Live Tumor Cells Using a fluorescent Boronic acid sensor","volume":"1","author":"Hattori","year":"2016","journal-title":"ACS Sens."},{"key":"10.1016\/j.saa.2026.128109_bb0140","doi-asserted-by":"crossref","first-page":"7671","DOI":"10.3390\/s22197671","article-title":"A red-emitting fluorescence sensor for detecting Boronic acid-containing agents in cells","volume":"22","author":"Kondo","year":"2022","journal-title":"Sensors"},{"key":"10.1016\/j.saa.2026.128109_bb0145","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15061862","article-title":"Development of a 2-(2-Hydroxyphenyl)-1H-benzimidazole-based fluorescence sensor targeting boronic acids for versatile application in boron neutron capture therapy","volume":"15","author":"Kondo","year":"2023","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.saa.2026.128109_bb0150","doi-asserted-by":"crossref","first-page":"1289","DOI":"10.1007\/s44211-022-00158-8","article-title":"Development of a switching-type fluorescence sensor for the detection of boronic acid-containing agents","volume":"38","author":"Takada","year":"2022","journal-title":"Anal. Sci."},{"key":"10.1016\/j.saa.2026.128109_bb0155","doi-asserted-by":"crossref","first-page":"283","DOI":"10.3390\/chemosensors13080283","article-title":"A long-wavelength fluorescent probe for efficient dual-color imaging of boronic-acid-containing agents in living cells","volume":"13","author":"Takada","year":"2025","journal-title":"Chemosensors"},{"key":"10.1016\/j.saa.2026.128109_bb0160","doi-asserted-by":"crossref","DOI":"10.3390\/molecules26113289","article-title":"Electrostatic potential topology for probing molecular structure, bonding and reactivity","volume":"26","author":"Gadre","year":"2021","journal-title":"Molecules"},{"key":"10.1016\/j.saa.2026.128109_bb0165","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/0263-7855(96)00018-5","article-title":"VMD - Visual Molecular Dynamics","volume":"14","author":"Humphrey","year":"1996","journal-title":"J. Mol. Graph."},{"issue":"16","key":"10.1016\/j.saa.2026.128109_bb0170","doi-asserted-by":"crossref","first-page":"8778","DOI":"10.1021\/acs.jmedchem.9b01129","article-title":"Practical high-quality electrostatic potential surfaces for drug discovery using a graph-convolutional deep neural network","volume":"63","author":"Rathi","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.saa.2026.128109_bb0175","doi-asserted-by":"crossref","first-page":"314","DOI":"10.1016\/j.jmgm.2012.07.004","article-title":"Quantitative analysis of molecular surface based on improved marching Tetrahedra algorithm","volume":"38","author":"Lu","year":"2012","journal-title":"J. Mol. Graph. Model."},{"key":"10.1016\/j.saa.2026.128109_bb0180","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.carbon.2020.05.023","article-title":"An sp-hybridized all-carboatomic ring, cyclo[18]carbon: electronic structure, electronic spectrum, and optical nonlinearity","volume":"165","author":"Liu","year":"2020","journal-title":"Carbon"},{"issue":"5","key":"10.1016\/j.saa.2026.128109_bb0185","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1002\/jcc.22885","article-title":"Multiwfn: a multifunctional wavefunction analyzer","volume":"33","author":"Lu","year":"2012","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.saa.2026.128109_bb0190","first-page":"171","article-title":"Pharamacokinetic modeling for boronophenylalanine-fructose mediated neutron capture therapy: 10 B concentration predictions and dosimetric consequences","volume":"62","author":"Kiger","year":"2003","journal-title":"J. Neuro-Oncol."}],"container-title":["Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526006803?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1386142526006803?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:54:17Z","timestamp":1784238857000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S1386142526006803"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":38,"alternative-id":["S1386142526006803"],"URL":"https:\/\/doi.org\/10.1016\/j.saa.2026.128109","relation":{},"ISSN":["1386-1425"],"issn-type":[{"value":"1386-1425","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A deep learning-assisted turn-on fluorescent probe for L-BPA detection with mechanistic insight","name":"articletitle","label":"Article Title"},{"value":"Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.saa.2026.128109","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"128109"}}